1H3L
| N-terminal fragment of SigR from Streptomyces coelicolor | 分子名称: | RNA POLYMERASE SIGMA FACTOR | 著者 | Li, W, Stevenson, C.E.M, Burton, N, Jakimowicz, P, Paget, M.S.B, Buttner, M.J, Lawson, D.M, Kleanthous, C. | 登録日 | 2002-09-10 | 公開日 | 2002-10-03 | 最終更新日 | 2015-09-23 | 実験手法 | X-RAY DIFFRACTION (2.375 Å) | 主引用文献 | Identification and Structure of the Anti-Sigma Factor-Binding Domain of the Disulfide-Stress Regulated Sigma Factor Sigma(R) from Streptomyces Coelicolor J.Mol.Biol., 323, 2002
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2C0Z
| The 1.6 A resolution crystal structure of NovW: a 4-keto-6-deoxy sugar epimerase from the novobiocin biosynthetic gene cluster of Streptomyces spheroides | 分子名称: | 1,2-ETHANEDIOL, NOVW, SULFATE ION | 著者 | Jakimowicz, P, Tello, M, Freel-Meyers, C.L, Walsh, C.T, Buttner, M.J, Field, R.A, Lawson, D.M. | 登録日 | 2005-09-09 | 公開日 | 2006-01-25 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | The 1.6 A Resolution Crystal Structure of Novw: A 4-Keto-6-Deoxy Sugar Epimerase from the Novobiocin Biosynthetic Gene Cluster of Streptomyces Spheroides Proteins, 63, 2006
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3ZQL
| DNA-bound form of TetR-like repressor SimR | 分子名称: | 5'-D(*DTP*TP*CP*GP*TP*AP*CP*GP*CP*CP*GP*TP*AP*DCP *GP*AP*A)-3', 5'-D(*DTP*TP*CP*GP*TP*AP*CP*GP*GP*CP*GP*TP*AP*DCP *GP*AP*A)-3', PUTATIVE REPRESSOR SIMREG2 | 著者 | Le, T.B.K, Schumacher, M.A, Lawson, D.M, Brennan, R.G, Buttner, M.J. | 登録日 | 2011-06-10 | 公開日 | 2011-08-31 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.99 Å) | 主引用文献 | The Crystal Structure of the Tetr Family Transcriptional Repressor Simr Bound to DNA and the Role of a Flexible N-Terminal Extension in Minor Groove Binding. Nucleic Acids Res., 39, 2011
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5L40
| polyketide ketoreductase SimC7 - apo crystal form 1 | 分子名称: | polyketide ketoreductase SimC7 | 著者 | Schafer, M, Stevenson, C.E.M, Wilkinson, B, Lawson, D.M, Buttner, M.J. | 登録日 | 2016-05-24 | 公開日 | 2016-10-05 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Substrate-Assisted Catalysis in Polyketide Reduction Proceeds via a Phenolate Intermediate. Cell Chem Biol, 23, 2016
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5L4L
| polyketide ketoreductase SimC7 - ternary complex with NADP+ and 7-oxo-SD8 | 分子名称: | 7-oxo-simocyclinone D8, GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | Schafer, M, Stevenson, C.E.M, Wilkinson, B, Lawson, D.M, Buttner, M.J. | 登録日 | 2016-05-25 | 公開日 | 2016-10-05 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Substrate-Assisted Catalysis in Polyketide Reduction Proceeds via a Phenolate Intermediate. Cell Chem Biol, 23, 2016
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5L3Z
| polyketide ketoreductase SimC7 - binary complex with NADP+ | 分子名称: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, polyketide ketoreductase SimC7 | 著者 | Schafer, M, Stevenson, C.E.M, Wilkinson, B, Lawson, D.M, Buttner, M.J. | 登録日 | 2016-05-24 | 公開日 | 2016-10-05 | 最終更新日 | 2017-08-30 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Substrate-Assisted Catalysis in Polyketide Reduction Proceeds via a Phenolate Intermediate. Cell Chem Biol, 23, 2016
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5L45
| polyketide ketoreductase SimC7 - apo crystal form 2 | 分子名称: | GLYCEROL, SimC7, TETRAETHYLENE GLYCOL | 著者 | Schafer, M, Stevenson, C.E.M, Wilkinson, B, Lawson, D.M, Buttner, M.J. | 登録日 | 2016-05-25 | 公開日 | 2016-10-05 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Substrate-Assisted Catalysis in Polyketide Reduction Proceeds via a Phenolate Intermediate. Cell Chem Biol, 23, 2016
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2Y3P
| Crystal structure of N-terminal domain of GyrA with the antibiotic simocyclinone D8 | 分子名称: | DNA GYRASE SUBUNIT A, MAGNESIUM ION, SIMOCYCLINONE D8 | 著者 | Edwards, M.J, Flatman, R.H, Mitchenall, L.A, Stevenson, C.E.M, Le, T.B.K, Clarke, T.A, McKay, A.R, Fiedler, H.-P, Buttner, M.J, Lawson, D.M, Maxwell, A. | 登録日 | 2010-12-22 | 公開日 | 2010-12-29 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | 主引用文献 | A Crystal Structure of the Bifunctional Antibiotic Simocyclinone D8, Bound to DNA Gyrase. Science, 326, 2009
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2Y30
| Simocyclinone D8 bound form of TetR-like repressor SimR | 分子名称: | CHLORIDE ION, PUTATIVE REPRESSOR SIMREG2, SIMOCYCLINONE D8 | 著者 | Le, T.B.K, Stevenson, C.E.M, Fiedler, H.-P, Maxwell, A, Lawson, D.M, Buttner, M.J. | 登録日 | 2010-12-17 | 公開日 | 2011-03-09 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structures of the Tetr-Like Simocyclinone Efflux Pump Repressor, Simr, and the Mechanism of Ligand-Mediated Derepression. J.Mol.Biol., 408, 2011
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2Y2Z
| ligand-free form of TetR-like repressor SimR | 分子名称: | PUTATIVE REPRESSOR SIMREG2 | 著者 | Le, T.B.K, Stevenson, C.E.M, Fiedler, H.-P, Maxwell, A, Lawson, D.M, Buttner, M.J. | 登録日 | 2010-12-17 | 公開日 | 2011-03-09 | 最終更新日 | 2019-05-08 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structures of the Tetr-Like Simocyclinone Efflux Pump Repressor, Simr, and the Mechanism of Ligand-Mediated Derepression. J.Mol.Biol., 408, 2011
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2Y31
| Simocyclinone C4 bound form of TetR-like repressor SimR | 分子名称: | CALCIUM ION, CHLORIDE ION, PENTAETHYLENE GLYCOL, ... | 著者 | Le, T.B.K, Stevenson, C.E.M, Fiedler, H.-P, Maxwell, A, Lawson, D.M, Buttner, M.J. | 登録日 | 2010-12-17 | 公開日 | 2011-03-09 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structures of the Tetr-Like Simocyclinone Efflux Pump Repressor, Simr, and the Mechanism of Ligand-Mediated Derepression. J.Mol.Biol., 408, 2011
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6PFJ
| Structure of S. venezuelae RsiG-WhiG-(ci-di-GMP) complex, P64 crystal form | 分子名称: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), AmfC protein, RNA polymerase sigma factor | 著者 | Schumacher, M.A. | 登録日 | 2019-06-21 | 公開日 | 2019-11-13 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | 主引用文献 | c-di-GMP Arms an Anti-sigma to Control Progression of Multicellular Differentiation in Streptomyces. Mol.Cell, 77, 2020
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6PFV
| Structure of S. venezuelae RisG-WhiG-c-di-GMP complex: orthorhombic crystal form | 分子名称: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), AmfC protein, RNA polymerase sigma factor | 著者 | Schumacher, M.A. | 登録日 | 2019-06-22 | 公開日 | 2019-11-13 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | c-di-GMP Arms an Anti-sigma to Control Progression of Multicellular Differentiation in Streptomyces. Mol.Cell, 77, 2020
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8DY7
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8DY9
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6AMK
| Structure of Streptomyces venezuelae BldC-whiI opt complex | 分子名称: | DNA (5'-D(*AP*AP*TP*GP*TP*CP*CP*GP*AP*AP*TP*TP*AP*CP*CP*CP*GP*AP*AP*TP*TP*G)-3'), DNA (5'-D(*TP*TP*CP*AP*AP*TP*TP*CP*GP*GP*GP*TP*AP*AP*TP*TP*CP*GP*GP*GP*CP*A)-3'), Putative DNA-binding protein | 著者 | Schumacher, M.A. | 登録日 | 2017-08-09 | 公開日 | 2018-03-28 | 最終更新日 | 2018-11-07 | 実験手法 | X-RAY DIFFRACTION (3.288 Å) | 主引用文献 | The MerR-like protein BldC binds DNA direct repeats as cooperative multimers to regulate Streptomyces development. Nat Commun, 9, 2018
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6AMA
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4OB4
| Structure of the S. venezulae BldD DNA-binding domain | 分子名称: | Putative DNA-binding protein | 著者 | schumacher, M.A, Tschowri, N, Buttner, M, Brennan, R. | 登録日 | 2014-01-06 | 公開日 | 2014-11-19 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Tetrameric c-di-GMP mediates effective transcription factor dimerization to control Streptomyces development. Cell(Cambridge,Mass.), 158, 2014
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4OAY
| BldD CTD-c-di-GMP complex | 分子名称: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), DNA-binding protein | 著者 | Schumacher, M.A, Tschowri, N, Buttner, M, Brennan, R.G. | 登録日 | 2014-01-06 | 公開日 | 2014-11-19 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Tetrameric c-di-GMP mediates effective transcription factor dimerization to control Streptomyces development. Cell(Cambridge,Mass.), 158, 2014
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4OAZ
| BldD CTD-c-di-GMP complex | 分子名称: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), Putative DNA-binding protein | 著者 | Schumacher, M.A, Tschowri, N, Buttner, M, Brennan, R.G. | 登録日 | 2014-01-06 | 公開日 | 2014-11-19 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Tetrameric c-di-GMP mediates effective transcription factor dimerization to control Streptomyces development. Cell(Cambridge,Mass.), 158, 2014
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6DXO
| 1.8 A structure of RsbN-BldN complex. | 分子名称: | BldN, RNA polymerase ECF-subfamily sigma factor | 著者 | Schumacher, M.A. | 登録日 | 2018-06-29 | 公開日 | 2018-07-11 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | The crystal structure of the RsbN-sigma BldN complex from Streptomyces venezuelae defines a new structural class of anti-sigma factor. Nucleic Acids Res., 46, 2018
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5TZF
| Structure of the BldD CTD(D116A)-(c-di-GMP)2 intermediate, form 1 | 分子名称: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), DNA-binding protein | 著者 | Schumacher, M.A. | 登録日 | 2016-11-21 | 公開日 | 2017-04-19 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | The Streptomyces master regulator BldD binds c-di-GMP sequentially to create a functional BldD2-(c-di-GMP)4 complex. Nucleic Acids Res., 45, 2017
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5TZD
| Structure of the WT S. venezulae BldD-(CTD-c-di-GMP)2 assembly intermediate | 分子名称: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), DNA-binding protein | 著者 | Schumacher, M. | 登録日 | 2016-11-21 | 公開日 | 2017-04-19 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.749 Å) | 主引用文献 | The Streptomyces master regulator BldD binds c-di-GMP sequentially to create a functional BldD2-(c-di-GMP)4 complex. Nucleic Acids Res., 45, 2017
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5TZG
| Structure of the BldD CTD(D116A)-(c-di-GMP)2, form 2 | 分子名称: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), DNA-binding protein, ZINC ION | 著者 | Schumacher, M.A. | 登録日 | 2016-11-21 | 公開日 | 2017-04-19 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | The Streptomyces master regulator BldD binds c-di-GMP sequentially to create a functional BldD2-(c-di-GMP)4 complex. Nucleic Acids Res., 45, 2017
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5KHD
| Structure of 1.75 A BldD C-domain-c-di-GMP complex | 分子名称: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), DNA-binding protein | 著者 | Schumacher, M. | 登録日 | 2016-06-14 | 公開日 | 2016-06-29 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.7501 Å) | 主引用文献 | Tetrameric c-di-GMP mediates effective transcription factor dimerization to control Streptomyces development. Cell, 158, 2014
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