4JE5
 
 | | Crystal structure of the aromatic aminotransferase Aro8, a putative alpha-aminoadipate aminotransferase in Saccharomyces cerevisiae | | 分子名称: | 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Aromatic/aminoadipate aminotransferase 1, ... | | 著者 | Bulfer, S.L, Brunzelle, J.S, Trievel, R.C. | | 登録日 | 2013-02-26 | | 公開日 | 2013-09-11 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.909 Å) | | 主引用文献 | Crystal structure of Saccharomyces cerevisiae Aro8, a putative alpha-aminoadipate aminotransferase.
Protein Sci., 22, 2013
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3TY3
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3TY4
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3MI3
 | | Homocitrate Synthase Lys4 bound to Lysine | | 分子名称: | Homocitrate synthase, mitochondrial, LYSINE, ... | | 著者 | Bulfer, S.L, Scott, E.M, Pillus, L, Trievel, R.C. | | 登録日 | 2010-04-09 | | 公開日 | 2010-04-28 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | | 主引用文献 | Structural Basis for L-lysine Feedback Inhibition of Homocitrate Synthase
J.Biol.Chem., 285, 2010
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3IVS
 | | Homocitrate Synthase Lys4 | | 分子名称: | COBALT (II) ION, Homocitrate synthase, mitochondrial, ... | | 著者 | Bulfer, S.L, Scott, E.M, Couture, J.-F, Pillus, L, Trievel, R.C. | | 登録日 | 2009-09-01 | | 公開日 | 2009-09-22 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | | 主引用文献 | Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis.
J.Biol.Chem., 284, 2009
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3IVU
 | | Homocitrate Synthase Lys4 bound to 2-OG | | 分子名称: | 2-OXOGLUTARIC ACID, COBALT (II) ION, Homocitrate synthase, ... | | 著者 | Bulfer, S.L, Scott, E.M, Couture, J.-F, Pillus, L, Trievel, R.C. | | 登録日 | 2009-09-01 | | 公開日 | 2009-09-22 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.72 Å) | | 主引用文献 | Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis.
J.Biol.Chem., 284, 2009
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3IVT
 | | Homocitrate Synthase Lys4 bound to 2-OG | | 分子名称: | 2-OXOGLUTARIC ACID, Homocitrate synthase, mitochondrial, ... | | 著者 | Bulfer, S.L, Scott, E.M, Couture, J.-F, Pillus, L, Trievel, R.C. | | 登録日 | 2009-09-01 | | 公開日 | 2009-09-22 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.67 Å) | | 主引用文献 | Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis.
J.Biol.Chem., 284, 2009
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5FTM
 | | Cryo-EM structure of human p97 bound to ATPgS (Conformation II) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | | 著者 | Banerjee, S, Bartesaghi, A, Merk, A, Rao, P, Bulfer, S.L, Yan, Y, Green, N, Mroczkowski, B, Neitz, R.J, Wipf, P, Falconieri, V, Deshaies, R.J, Milne, J.L.S, Huryn, D, Arkin, M, Subramaniam, S. | | 登録日 | 2016-01-14 | | 公開日 | 2016-01-27 | | 最終更新日 | 2018-10-03 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | 2.3 A Resolution Cryo-Em Structure of Human P97 and Mechanism of Allosteric Inhibition
Science, 351, 2016
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5FTK
 | | Cryo-EM structure of human p97 bound to ADP | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE | | 著者 | Banerjee, S, Bartesaghi, A, Merk, A, Rao, P, Bulfer, S.L, Yan, Y, Green, N, Mroczkowski, B, Neitz, R.J, Wipf, P, Falconieri, V, Deshaies, R.J, Milne, J.L.S, Huryn, D, Arkin, M, Subramaniam, S. | | 登録日 | 2016-01-14 | | 公開日 | 2016-01-27 | | 最終更新日 | 2018-10-03 | | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | | 主引用文献 | 2.3 A Resolution Cryo-Em Structure of Human P97 and Mechanism of Allosteric Inhibition
Science, 351, 2016
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5FTL
 | | Cryo-EM structure of human p97 bound to ATPgS (Conformation I) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE | | 著者 | Banerjee, S, Bartesaghi, A, Merk, A, Rao, P, Bulfer, S.L, Yan, Y, Green, N, Mroczkowski, B, Neitz, R.J, Wipf, P, Falconieri, V, Deshaies, R.J, Milne, J.L.S, Huryn, D, Arkin, M, Subramaniam, S. | | 登録日 | 2016-01-14 | | 公開日 | 2016-01-27 | | 最終更新日 | 2018-10-03 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | 2.3 A Resolution Cryo-Em Structure of Human P97 and Mechanism of Allosteric Inhibition
Science, 351, 2016
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5FTN
 | | Cryo-EM structure of human p97 bound to ATPgS (Conformation III) | | 分子名称: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE | | 著者 | Banerjee, S, Bartesaghi, A, Merk, A, Rao, P, Bulfer, S.L, Yan, Y, Green, N, Mroczkowski, B, Neitz, R.J, Wipf, P, Falconieri, V, Deshaies, R.J, Milne, J.L.S, Huryn, D, Arkin, M, Subramaniam, S. | | 登録日 | 2016-01-14 | | 公開日 | 2016-01-27 | | 最終更新日 | 2018-10-03 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | 2.3 A Resolution Cryo-Em Structure of Human P97 and Mechanism of Allosteric Inhibition
Science, 351, 2016
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5FTJ
 | | Cryo-EM structure of human p97 bound to UPCDC30245 inhibitor | | 分子名称: | 1-(3-(5-FLUORO-1H-INDOL-2-YL)PHENYL)PIPERIDIN-4-YL)(2-(4-ISOPROPYL-PIPERAZIN1-YL)ETHYL)-CARBAMATE, ADENOSINE-5'-DIPHOSPHATE, TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE | | 著者 | Banerjee, S, Bartesaghi, A, Merk, A, Rao, P, Bulfer, S.L, Yan, Y, Green, N, Mroczkowski, B, Neitz, R.J, Wipf, P, Falconieri, V, Deshaies, R.J, Milne, J.L.S, Huryn, D, Arkin, M, Subramaniam, S. | | 登録日 | 2016-01-14 | | 公開日 | 2016-01-27 | | 最終更新日 | 2018-10-03 | | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | | 主引用文献 | 2.3 A Resolution Cryo-Em Structure of Human P97 and Mechanism of Allosteric Inhibition
Science, 351, 2016
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7TNH
 | | Crystal structure of CSF1R kinase domain in complex with DP-6233 | | 分子名称: | 2,2-dimethyl-N-[(6-methyl-5-{[2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl]oxy}pyridin-2-yl)carbamoyl]propanamide, CHLORIDE ION, Macrophage colony-stimulating factor 1 receptor,Fibroblast growth factor receptor 1 chimera, ... | | 著者 | Edwards, T.E, Arakaki, T.L, Chun, L, Flynn, D.L. | | 登録日 | 2022-01-21 | | 公開日 | 2022-08-24 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Discovery of acyl ureas as highly selective small molecule CSF1R kinase inhibitors.
Bioorg.Med.Chem.Lett., 74, 2022
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6MOB
 | | Crystal structure of KIT1 in complex with DP2976 via co-crystallization | | 分子名称: | Mast/stem cell growth factor receptor Kit, N-{4-chloro-5-[1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl]-2-fluorophenyl}-N'-phenylurea, NITRATE ION | | 著者 | Edwards, T.E, Abendroth, J, Safford, K, Chun, L. | | 登録日 | 2018-10-04 | | 公開日 | 2019-07-31 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Ripretinib (DCC-2618) Is a Switch Control Kinase Inhibitor of a Broad Spectrum of Oncogenic and Drug-Resistant KIT and PDGFRA Variants.
Cancer Cell, 35, 2019
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