6MOB

Crystal structure of KIT1 in complex with DP2976 via co-crystallization

Summary for 6MOB

• Entry DOI: 10.2210/pdb6mob/pdb
• Descriptor: Mast/stem cell growth factor receptor Kit, NITRATE ION, N-{4-chloro-5-[1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl]-2-fluorophenyl}-N'-phenylurea, ... (4 entities in total)
• Functional Keywords: deciphera, kit1 kinase, dp2976, decode, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 1
• Total formula weight: 36665.86

Authors

Edwards, T.E.,Abendroth, J.,Safford, K.,Chun, L. (deposition date: 2018-10-04, release date: 2019-07-31, Last modification date: 2024-04-03)

• Primary citation: Smith, B.D.,Kaufman, M.D.,Lu, W.P.,Gupta, A.,Leary, C.B.,Wise, S.C.,Rutkoski, T.J.,Ahn, Y.M.,Al-Ani, G.,Bulfer, S.L.,Caldwell, T.M.,Chun, L.,Ensinger, C.L.,Hood, M.M.,McKinley, A.,Patt, W.C.,Ruiz-Soto, R.,Su, Y.,Telikepalli, H.,Town, A.,Turner, B.A.,Vogeti, L.,Vogeti, S.,Yates, K.,Janku, F.,Abdul Razak, A.R.,Rosen, O.,Heinrich, M.C.,Flynn, D.L.; Ripretinib (DCC-2618) Is a Switch Control Kinase Inhibitor of a Broad Spectrum of Oncogenic and Drug-Resistant KIT and PDGFRA Variants.; Cancer Cell, 35:738-751.e9, 2019; PubMed: 31085175; DOI: 10.1016/j.ccell.2019.04.006

Experimental method

X-RAY DIFFRACTION (1.8 Å)