7TXT
 
 | | Structure of human serotonin transporter bound to small molecule '8090 in lipid nanodisc and NaCl | | Descriptor: | 1-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]piperazine, 15B8 Fab heavy chain, 15B8 Fab light chain, ... | | Authors: | Singh, I, Seth, A, Billesboelle, C.B, Braz, J, Rodriguiz, R.M, Roy, K, Bekele, B, Craik, V, Huang, X.P, Boytsov, D, Lak, P, O'Donnell, H, Sandtner, W, Roth, B.L, Basbaum, A.I, Wetsel, W.C, Manglik, A, Shoichet, B.K, Rudnick, G. | | Deposit date: | 2022-02-09 | | Release date: | 2023-03-15 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structure-based discovery of conformationally selective inhibitors of the serotonin transporter.
Cell, 186, 2023
|
|
9MQK
 | | Inactive Kappa-Opioid Receptor with Nb6M, NabFab, and isoquinuclidine compound #020_E1 | | Descriptor: | Kappa-Opioid Receptor, NabFab Heavy Chain, NabFab Light Chain, ... | | Authors: | Kim, J.Y, Vigneron, S.F, Billesbolle, C, Manglik, A, Shoichet, B.K. | | Deposit date: | 2025-01-03 | | Release date: | 2025-02-12 | | Method: | ELECTRON MICROSCOPY (3.18 Å) | | Cite: | Docking 14 million virtual isoquinuclidines against the mu and kappa opioid receptors reveals dual antagonists-inverse agonists with reduced withdrawal effects.
Biorxiv, 2025
|
|
9MQL
 | | Locally-Refined Inactive Kappa-Opioid Receptor with Nb6M, NabFab, and isoquinuclidine compound #020_E1 | | Descriptor: | Kappa-Opioid Receptor, methyl (1S,3R,4S,6S,8M)-2-[(1-ethyl-1H-pyrazol-4-yl)methyl]-8-(3-hydroxyphenyl)-3,4-dimethyl-2-azabicyclo[2.2.2]oct-7-ene-6-carboxylate | | Authors: | Kim, J.Y, Vigneron, S.F, Billesbolle, C, Manglik, A, Shoichet, B.K. | | Deposit date: | 2025-01-03 | | Release date: | 2025-02-12 | | Method: | ELECTRON MICROSCOPY (2.96 Å) | | Cite: | Docking 14 million virtual isoquinuclidines against the mu and kappa opioid receptors reveals dual antagonists-inverse agonists with reduced withdrawal effects.
Biorxiv, 2025
|
|
9MQH
 | | Inactive Mu-Opioid Receptor with Nb6M, NabFab, and isoquinuclidine compound #33 | | Descriptor: | Mu-type opioid receptor | | Authors: | Kim, J.Y, Vigneron, S.F, Billesbolle, C, Manglik, A, Shoichet, B.K. | | Deposit date: | 2025-01-03 | | Release date: | 2025-02-12 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Docking 14 million virtual isoquinuclidines against the mu and kappa opioid receptors reveals dual antagonists-inverse agonists with reduced withdrawal effects.
Biorxiv, 2025
|
|
9MQI
 | | Inactive Mu-Opioid Receptor with Nb6M, NabFab, and isoquinuclidine compound #020_E1 | | Descriptor: | Mu-type opioid receptor, NabFab Heavy Chain, NabFab Light Chain, ... | | Authors: | Kim, J.Y, Vigneron, S.F, Billesbolle, C, Manglik, A, Shoichet, B.K. | | Deposit date: | 2025-01-03 | | Release date: | 2025-02-12 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Docking 14 million virtual isoquinuclidines against the mu and kappa opioid receptors reveals dual antagonists-inverse agonists with reduced withdrawal effects.
Biorxiv, 2025
|
|
9MQJ
 | | Locally-refined Inactive Mu-Opioid Receptor with Nb6M, NabFab, and isoquinuclidine compound #020_E1 | | Descriptor: | Mu-type opioid receptor, methyl (1S,3R,4S,6S,8M)-2-[(1-ethyl-1H-pyrazol-4-yl)methyl]-8-(3-hydroxyphenyl)-3,4-dimethyl-2-azabicyclo[2.2.2]oct-7-ene-6-carboxylate | | Authors: | Kim, J.Y, Vigneron, S.F, Billesbolle, C, Manglik, A, Shoichet, B.K. | | Deposit date: | 2025-01-03 | | Release date: | 2025-02-12 | | Method: | ELECTRON MICROSCOPY (3.23 Å) | | Cite: | Docking 14 million virtual isoquinuclidines against the mu and kappa opioid receptors reveals dual antagonists-inverse agonists with reduced withdrawal effects.
Biorxiv, 2025
|
|
