4KS7
 
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5U4U
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5U4V
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5UPL
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5UPK
 | | CDC42 binds PAK4 via an extended GTPase-effector interface - 3 peptide: PAK4cat, PAK4-N45, CDC42 | | 分子名称: | Cell division control protein 42 homolog, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | 著者 | Ha, B.H, Boggon, T.J. | | 登録日 | 2017-02-03 | | 公開日 | 2017-12-27 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | CDC42 binds PAK4 via an extended GTPase-effector interface.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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5VEF
 | | PAK4 kinase domain in complex with fasudil | | 分子名称: | 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE, ACETATE ION, Serine/threonine-protein kinase PAK 4 | | 著者 | Zhang, E.Y, Ha, B.H, Boggon, T.J. | | 登録日 | 2017-04-04 | | 公開日 | 2017-10-18 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.752 Å) | | 主引用文献 | PAK4 crystal structures suggest unusual kinase conformational movements.
Biochim. Biophys. Acta, 1866, 2018
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5VEE
 | | PAK4 kinase domain in complex with FRAX486 | | 分子名称: | 6-(2,4-dichlorophenyl)-8-ethyl-2-{[3-fluoro-4-(piperazin-1-yl)phenyl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one, Serine/threonine-protein kinase PAK 4 | | 著者 | Zhang, E.Y, Ha, B.H, Boggon, T.J. | | 登録日 | 2017-04-04 | | 公開日 | 2017-10-18 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | PAK4 crystal structures suggest unusual kinase conformational movements.
Biochim. Biophys. Acta, 1866, 2018
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5VED
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4DX9
 | | ICAP1 in complex with integrin beta 1 cytoplasmic tail | | 分子名称: | Integrin beta-1, Integrin beta-1-binding protein 1 | | 著者 | Liu, W, Draheim, K, Zhang, R, Calderwood, D.A, Boggon, T.J. | | 登録日 | 2012-02-27 | | 公開日 | 2013-01-09 | | 最終更新日 | 2020-09-02 | | 実験手法 | X-RAY DIFFRACTION (2.99 Å) | | 主引用文献 | Mechanism for KRIT1 Release of ICAP1-Mediated Suppression of Integrin Activation.
Mol.Cell, 49, 2013
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4DXA
 | | Co-crystal structure of Rap1 in complex with KRIT1 | | 分子名称: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Krev interaction trapped protein 1, MAGNESIUM ION, ... | | 著者 | Li, X, Zhang, R, Boggon, T.J. | | 登録日 | 2012-02-27 | | 公開日 | 2012-05-16 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Structural Basis for Small G Protein Effector Interaction of Ras-related Protein 1 (Rap1) and Adaptor Protein Krev Interaction Trapped 1 (KRIT1).
J.Biol.Chem., 287, 2012
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4DX8
 | | ICAP1 in complex with KRIT1 N-terminus | | 分子名称: | BROMIDE ION, Integrin beta-1-binding protein 1, Krev interaction trapped protein 1 | | 著者 | Liu, W, Draheim, K, Zhang, R, Calderwood, D.A, Boggon, T.J. | | 登録日 | 2012-02-27 | | 公開日 | 2013-01-09 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | | 主引用文献 | Mechanism for KRIT1 Release of ICAP1-Mediated Suppression of Integrin Activation.
Mol.Cell, 49, 2013
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4EDL
 | | Crystal structure of beta-parvin CH2 domain | | 分子名称: | 1,2-ETHANEDIOL, Beta-parvin | | 著者 | Stiegler, A.L, Draheim, K.M, Li, X, Chayen, N.E, Calderwood, D.A, Boggon, T.J. | | 登録日 | 2012-03-27 | | 公開日 | 2012-08-08 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural basis for paxillin binding and focal adhesion targeting of beta-parvin.
J.Biol.Chem., 287, 2012
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4EIH
 | | Crystal structure of Arg SH2 domain | | 分子名称: | Abelson tyrosine-protein kinase 2, CHLORIDE ION | | 著者 | Liu, W, MacGrath, S.M, Koleske, A.J, Boggon, T.J. | | 登録日 | 2012-04-05 | | 公開日 | 2013-04-10 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Two Amino Acid Residues Confer Different Binding Affinities of Abelson Family Kinase Src Homology 2 Domains for Phosphorylated Cortactin.
J.Biol.Chem., 289, 2014
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4EDN
 | | Crystal structure of beta-parvin CH2 domain in complex with paxillin LD1 motif | | 分子名称: | Beta-parvin, Paxillin, SULFATE ION | | 著者 | Stiegler, A.L, Draheim, K.M, Li, X, Chayen, N.E, Calderwood, D.A, Boggon, T.J. | | 登録日 | 2012-03-27 | | 公開日 | 2012-08-08 | | 最終更新日 | 2013-06-19 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structural basis for paxillin binding and focal adhesion targeting of beta-parvin.
J.Biol.Chem., 287, 2012
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4EDM
 | | Crystal structure of beta-parvin CH2 domain | | 分子名称: | 1,2-ETHANEDIOL, Beta-parvin | | 著者 | Stiegler, A.L, Draheim, K.M, Li, X, Chayen, N.E, Calderwood, D.A, Boggon, T.J. | | 登録日 | 2012-03-27 | | 公開日 | 2012-08-08 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural basis for paxillin binding and focal adhesion targeting of beta-parvin.
J.Biol.Chem., 287, 2012
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4FIH
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4FIJ
 | | Catalytic domain of human PAK4 | | 分子名称: | Serine/threonine-protein kinase PAK 4 | | 著者 | Ha, B.H, Boggon, T.J. | | 登録日 | 2012-06-08 | | 公開日 | 2012-09-12 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate.
Proc.Natl.Acad.Sci.USA, 109, 2012
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4FIE
 | | Full-length human PAK4 | | 分子名称: | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase PAK 4 | | 著者 | Ha, B.H, Boggon, T.J. | | 登録日 | 2012-06-08 | | 公開日 | 2012-09-12 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (3.11 Å) | | 主引用文献 | Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate.
Proc.Natl.Acad.Sci.USA, 109, 2012
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4FIG
 | | Catalytic domain of human PAK4 | | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase PAK 4 | | 著者 | Ha, B.H, Boggon, T.J. | | 登録日 | 2012-06-08 | | 公開日 | 2012-09-12 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (3.01 Å) | | 主引用文献 | Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate.
Proc.Natl.Acad.Sci.USA, 109, 2012
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4FIF
 | | Catalytic domain of human PAK4 with RPKPLVDP peptide | | 分子名称: | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase PAK 4 | | 著者 | Ha, B.H, Boggon, T.J. | | 登録日 | 2012-06-08 | | 公開日 | 2012-09-12 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate.
Proc.Natl.Acad.Sci.USA, 109, 2012
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4FII
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4FQN
 | | Crystal structure of the CCM2 C-terminal Harmonin Homology Domain (HHD) | | 分子名称: | Malcavernin | | 著者 | Fisher, O.S, Zhang, R, Li, X, Murphy, J.W, Boggon, T.J. | | 登録日 | 2012-06-25 | | 公開日 | 2012-12-19 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural studies of cerebral cavernous malformations 2 (CCM2) reveal a folded helical domain at its C-terminus.
Febs Lett., 587, 2013
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4GZM
 | | Crystal structure of RAC1 F28L mutant | | 分子名称: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, Ras-related C3 botulinum toxin substrate 1 | | 著者 | Ha, B.H, Boggon, T.J. | | 登録日 | 2012-09-06 | | 公開日 | 2012-12-12 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | RAC1P29S is a spontaneously activating cancer-associated GTPase.
Proc.Natl.Acad.Sci.USA, 110, 2013
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4GRZ
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4GS0
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