4Q8I
 
 | | Crystal Structure of beta-lactamase from M.tuberculosis covalently complexed with Tebipenem | | 分子名称: | (4R,5S)-3-(1-(4,5-dihydrothiazol-2-yl)azetidin-3-ylthio)-5-((2S,3R)-3-hydroxy-1-oxobutan-2-yl)-4-methyl-4,5- dihydro-1H-pyrrole-2-carboxylic acid, Beta-lactamase, PHOSPHATE ION | | 著者 | Hazra, S, Blanchard, J. | | 登録日 | 2014-04-27 | | 公開日 | 2014-08-20 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.901 Å) | | 主引用文献 | Tebipenem, a new carbapenem antibiotic, is a slow substrate that inhibits the beta-lactamase from Mycobacterium tuberculosis.
Biochemistry, 53, 2014
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4QHC
 | | Structure of M.Tuberculosis Betalactamase (Blac) with inhibitor having novel mechanism | | 分子名称: | (3R,6R,7S)-7-[(2R,3aR)-hexahydropyrazolo[1,5-c][1,3]thiazin-2-yl]-6-(hydroxymethyl)-1,4-thiazepane-3-carboxylic acid, Beta-lactamase, PHOSPHATE ION | | 著者 | Hazra, S, Blanchard, J. | | 登録日 | 2014-05-28 | | 公開日 | 2015-07-22 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.899 Å) | | 主引用文献 | Kinetic and Structural Characterization of the Interaction of 6-Methylidene Penem 2 with the beta-Lactamase from Mycobacterium tuberculosis.
Biochemistry, 54, 2015
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4QB8
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4DF6
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4HCX
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1S60
 | | Aminoglycoside N-Acetyltransferase AAC(6')-Iy in Complex with CoA and N-terminal His(6)-tag (crystal form 2) | | 分子名称: | COENZYME A, SULFATE ION, aminoglycoside 6'-N-acetyltransferase | | 著者 | Vetting, M.W, Magnet, S, Nieves, E, Roderick, S.L, Blanchard, J.S. | | 登録日 | 2004-01-22 | | 公開日 | 2004-05-18 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | A bacterial acetyltransferase capable of regioselective N-acetylation of antibiotics and histones
Chem.Biol., 11, 2004
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1S5K
 | | Aminoglycoside N-Acetyltransferase AAC(6')-Iy in Complex with CoA and N-terminal His(6)-tag (crystal form 1) | | 分子名称: | COENZYME A, SULFATE ION, aminoglycoside 6'-N-acetyltransferase | | 著者 | Vetting, M.W, Magnet, S, Nieves, E, Roderick, S.L, Blanchard, J.S. | | 登録日 | 2004-01-21 | | 公開日 | 2004-05-18 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | A bacterial acetyltransferase capable of regioselective N-acetylation of antibiotics and histones
Chem.Biol., 11, 2004
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4JLF
 | | Inhibitor resistant (R220A) substitution in the Mycobacterium tuberculosis beta-lactamase | | 分子名称: | Beta-lactamase, PHOSPHATE ION | | 著者 | Hazra, S, Kurz, S, Blanchard, J, Bonomo, R. | | 登録日 | 2013-03-12 | | 公開日 | 2013-10-30 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Can inhibitor-resistant substitutions in the Mycobacterium tuberculosis beta-Lactamase BlaC lead to clavulanate resistance?: a biochemical rationale for the use of beta-lactam-beta-lactamase inhibitor combinations.
Antimicrob.Agents Chemother., 57, 2013
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4M0D
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4LZJ
 | | Crystal Structure of MurQ from H.influenzae with bound inhibitor | | 分子名称: | 2-(acetylamino)-3-O-[(1R)-1-carboxyethyl]-2-deoxy-6-O-phosphono-D-glucitol, N-acetylmuramic acid 6-phosphate etherase, PHOSPHATE ION | | 著者 | Hazra, S, Blanchard, J. | | 登録日 | 2013-07-31 | | 公開日 | 2014-02-26 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.405 Å) | | 主引用文献 | Structure of MurNAc 6-phosphate hydrolase (MurQ) from Haemophilus influenzae with a bound inhibitor.
Biochemistry, 52, 2013
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