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4UY8
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BU of 4uy8 by Molmil
Molecular basis for the ribosome functioning as a L-tryptophan sensor - Cryo-EM structure of a TnaC stalled E.coli ribosome
Descriptor: 50S RIBOSOMAL PROTEIN L10, 50S RIBOSOMAL PROTEIN L11, 50S RIBOSOMAL PROTEIN L13, ...
Authors:Bischoff, L, Berninghausen, O, Beckmann, R.
Deposit date:2014-08-29
Release date:2014-10-29
Last modified:2018-10-03
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Molecular Basis for the Ribosome Functioning as an L-Tryptophan Sensor.
Cell Rep., 9, 2014
5ABB
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BU of 5abb by Molmil
Visualization of a polytopic membrane protein during SecY-mediated membrane insertion
Descriptor: GREEN-LIGHT ABSORBING PROTEORHODOPSIN, PROTEIN TRANSLOCASE SUBUNIT SECE, PROTEIN TRANSLOCASE SUBUNIT SECY
Authors:Bischoff, L, Wickles, S, Berninghausen, O, vanderSluis, E, Beckmann, R.
Deposit date:2015-08-05
Release date:2015-08-19
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (8 Å)
Cite:Visualization of a Polytopic Membrane Protein During Secy-Mediated Membrane Insertion.
Nat.Commun., 5, 2014
8RDP
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BU of 8rdp by Molmil
Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with spiro-isoxazol based compound 8a
Descriptor: (5~{S})-3-(2-chlorophenyl)-1-oxa-2,9-diazaspiro[4.5]dec-2-ene-8,10-dione, Cereblon isoform 4, PHOSPHATE ION, ...
Authors:Bischof, L, Hartmann, M.D.
Deposit date:2023-12-08
Release date:2024-04-10
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Discovery and characterization of potent spiro-isoxazole-based cereblon ligands with a novel binding mode.
Eur.J.Med.Chem., 270, 2024
8RDR
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BU of 8rdr by Molmil
Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with spiro-isoxazol based compound 8g
Descriptor: (5~{S})-3-(2-nitrophenyl)-1-oxa-2,9-diazaspiro[4.5]dec-2-ene-8,10-dione, Cereblon isoform 4, PHOSPHATE ION, ...
Authors:Bischof, L, Hartmann, M.D.
Deposit date:2023-12-08
Release date:2024-04-10
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Discovery and characterization of potent spiro-isoxazole-based cereblon ligands with a novel binding mode.
Eur.J.Med.Chem., 270, 2024
8RDT
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BU of 8rdt by Molmil
Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with spiro-isoxazol based compound 8j
Descriptor: (5~{S})-3-(2,3,4-trimethoxyphenyl)-1-oxa-2,9-diazaspiro[4.5]dec-2-ene-8,10-dione, Cereblon isoform 4, PHOSPHATE ION, ...
Authors:Bischof, L, Hartmann, M.D.
Deposit date:2023-12-08
Release date:2024-04-10
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Discovery and characterization of potent spiro-isoxazole-based cereblon ligands with a novel binding mode.
Eur.J.Med.Chem., 270, 2024
8RDS
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BU of 8rds by Molmil
Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with spiro-isoxazol based compound 8i
Descriptor: (5~{S})-3-(2-methoxyphenyl)-1-oxa-2,9-diazaspiro[4.5]dec-2-ene-8,10-dione, Cereblon isoform 4, PHOSPHATE ION, ...
Authors:Bischof, L, Hartmann, M.D.
Deposit date:2023-12-08
Release date:2024-04-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery and characterization of potent spiro-isoxazole-based cereblon ligands with a novel binding mode.
Eur.J.Med.Chem., 270, 2024
8RDQ
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BU of 8rdq by Molmil
Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with spiro-isoxazol based compound 8b
Descriptor: (5S)-3-(2,4-dichlorophenyl)-1-oxa-2,9-diazaspiro[4.5]dec-2-ene-8,10-dione, Cereblon isoform 4, PHOSPHATE ION, ...
Authors:Bischof, L, Hartmann, M.D.
Deposit date:2023-12-08
Release date:2024-04-10
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Discovery and characterization of potent spiro-isoxazole-based cereblon ligands with a novel binding mode.
Eur.J.Med.Chem., 270, 2024
8OU4
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BU of 8ou4 by Molmil
Cereblon isoform 4 in complex with novel Benzamide-Type Cereblon Binder 11a
Descriptor: 4-azanyl-~{N}-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-2-chloranyl-benzamide, Cereblon isoform 4, ZINC ION
Authors:Heim, C, Bischof, L, Hartmann, M.D.
Deposit date:2023-04-21
Release date:2023-11-15
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs.
J.Med.Chem., 66, 2023
8OU3
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BU of 8ou3 by Molmil
Cereblon isoform 4 in complex with novel Benzamide-Type Cereblon Binder 8d
Descriptor: 4-azanyl-~{N}-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-2-fluoranyl-benzamide, Cereblon isoform 4, PHOSPHATE ION, ...
Authors:Heim, C, Bischof, L, Maiwald, S, Hartmann, M.D.
Deposit date:2023-04-21
Release date:2023-11-15
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs.
J.Med.Chem., 66, 2023
8OU6
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BU of 8ou6 by Molmil
Cereblon isoform 4 in complex with novel Benzamide-Type Cereblon Binder 11c
Descriptor: 4-azanyl-~{N}-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-2-methyl-benzamide, Cereblon isoform 4, PHOSPHATE ION, ...
Authors:Heim, C, Bischof, L, Hartmann, M.D.
Deposit date:2023-04-21
Release date:2023-11-15
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs.
J.Med.Chem., 66, 2023
8OU5
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BU of 8ou5 by Molmil
Cereblon isoform 4 in complex with novel Benzamide-Type Cereblon Binder 11b
Descriptor: 4-azanyl-~{N}-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-2-(trifluoromethyl)benzamide, Cereblon isoform 4, ZINC ION
Authors:Heim, C, Bischof, L, Hartmann, M.D.
Deposit date:2023-04-21
Release date:2023-11-15
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs.
J.Med.Chem., 66, 2023
8OU7
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BU of 8ou7 by Molmil
Cereblon isoform 4 in complex with novel Benzamide-Type Cereblon Binder 11d
Descriptor: 4-azanyl-~{N}-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-2-methoxy-benzamide, Cereblon isoform 4, ZINC ION
Authors:Heim, C, Bischof, L, Hartmann, M.D.
Deposit date:2023-04-22
Release date:2023-11-15
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs.
J.Med.Chem., 66, 2023
8OU9
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BU of 8ou9 by Molmil
Cereblon isoform 4 in complex with novel Benzamide-Type Cereblon Binder 11e
Descriptor: 4-azanyl-~{N}-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-2-oxidanyl-benzamide, Cereblon isoform 4, ZINC ION
Authors:Heim, C, Bischof, L, Hartmann, M.D.
Deposit date:2023-04-22
Release date:2023-11-15
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs.
J.Med.Chem., 66, 2023
8OUA
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BU of 8oua by Molmil
Cereblon isoform 4 in complex with novel Benzamide-Type Cereblon Binder 11f
Descriptor: 4-azanyl-~{N}-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-2,5-bis(fluoranyl)-3-methoxy-benzamide, Cereblon isoform 4, PHOSPHATE ION, ...
Authors:Heim, C, Bischof, L, Hartmann, M.D.
Deposit date:2023-04-22
Release date:2023-11-15
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs.
J.Med.Chem., 66, 2023
8PKW
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BU of 8pkw by Molmil
Kelch domain of KEAP1 in complex with a ortho-dimethylbenzene linked cyclic peptide 5 (ortho-WRCDPETaEC).
Descriptor: (2-methylphenyl)methanol, 1,2-ETHANEDIOL, CHLORIDE ION, ...
Authors:Braun, M.B, Bischof, L, Hartmann, M.D.
Deposit date:2023-06-27
Release date:2023-11-15
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Computational Prediction of Cyclic Peptide Structural Ensembles and Application to the Design of Keap1 Binders.
J.Chem.Inf.Model., 63, 2023
8PKX
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BU of 8pkx by Molmil
Kelch domain of KEAP1 in complex with a ortho-dimethylbenzene linked cyclic peptide 11 (ortho-WRCNPETaEC).
Descriptor: (2-methylphenyl)methanol, 1,2-ETHANEDIOL, CHLORIDE ION, ...
Authors:Braun, M.B, Bischof, L, Hartmann, M.D.
Deposit date:2023-06-27
Release date:2023-11-15
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Computational Prediction of Cyclic Peptide Structural Ensembles and Application to the Design of Keap1 Binders.
J.Chem.Inf.Model., 63, 2023
8PKU
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BU of 8pku by Molmil
Kelch domain of KEAP1 in complex with ortho-dimethylbenzene linked cyclic peptide 3 (ortho-WRCDEETGEC).
Descriptor: (2-methylphenyl)methanol, 1,2-ETHANEDIOL, CHLORIDE ION, ...
Authors:Braun, M.B, Bischof, L, Hartmann, M.D.
Deposit date:2023-06-27
Release date:2023-11-15
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Computational Prediction of Cyclic Peptide Structural Ensembles and Application to the Design of Keap1 Binders.
J.Chem.Inf.Model., 63, 2023
8PKV
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BU of 8pkv by Molmil
Kelch domain of KEAP1 in complex with a ortho-dimethylbenzene linked cyclic peptide 4 (ortho-WRCDEETGEC).
Descriptor: (2-methylphenyl)methanol, 1,2-ETHANEDIOL, CHLORIDE ION, ...
Authors:Braun, M.B, Bischof, L, Hartmann, M.D.
Deposit date:2023-06-27
Release date:2023-11-15
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Computational Prediction of Cyclic Peptide Structural Ensembles and Application to the Design of Keap1 Binders.
J.Chem.Inf.Model., 63, 2023
5A7U
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BU of 5a7u by Molmil
Single-particle cryo-EM of co-translational folded adr1 domain inside the E. coli ribosome exit tunnel.
Descriptor: REGULATORY PROTEIN ADR1, ZINC ION
Authors:Nilsson, O.B, Hedman, R, Marino, J, Wickles, S, Bischoff, L, Johansson, M, Muller-Lucks, A, Trovato, F, Puglisi, J.D, O'Brien, E, Beckmann, R, von Heijne, G.
Deposit date:2015-07-10
Release date:2015-09-16
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Cotranslational Protein Folding Inside the Ribosome Exit Tunnel.
Cell Rep., 12, 2015
4UTQ
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BU of 4utq by Molmil
A structural model of the active ribosome-bound membrane protein insertase YidC
Descriptor: ATP SYNTHASE SUBUNIT C, MEMBRANE PROTEIN INSERTASE YIDC
Authors:Wickles, S, Singharoy, A, Andreani, J, Seemayer, S, Bischoff, L, Berninghausen, O, Soeding, J, Schulten, K, vanderSluis, E.O, Beckmann, R.
Deposit date:2014-07-22
Release date:2014-07-30
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (8 Å)
Cite:A Structural Model of the Active Ribosome-Bound Membrane Protein Insertase Yidc.
Elife, 3, 2014
4URD
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BU of 4urd by Molmil
Cryo-EM map of Trigger Factor bound to a translating ribosome
Descriptor: TRIGGER FACTOR
Authors:Deeng, J, Chan, K.Y, van der Sluis, E, Bischoff, L, Berninghausen, O, Han, W, Gumbart, J, Schulten, K, Beatrix, B, Beckmann, R.
Deposit date:2014-06-27
Release date:2016-01-13
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (7.7 Å)
Cite:Dynamic Behavior of Trigger Factor on the Ribosome.
J.Mol.Biol., 428, 2016

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