1X8B
| Structure of human Wee1A kinase: kinase domain complexed with inhibitor PD0407824 | Descriptor: | 9-HYDROXY-4-PHENYLPYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE, MAGNESIUM ION, Wee1-like protein kinase | Authors: | Squire, C.J, Dickson, J.M, Ivanovic, I, Baker, E.N. | Deposit date: | 2004-08-17 | Release date: | 2005-06-07 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Structure and inhibition of the human cell cycle checkpoint kinase, Wee1A kinase: an atypical tyrosine kinase with a key role in CDK1 regulation Structure, 13, 2005
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1XKF
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1XVW
| Crystal Structure of AhpE from Mycobacterium tuberculosis, a 1-Cys peroxiredoxin | Descriptor: | Hypothetical protein Rv2238c/MT2298 | Authors: | Li, S, Peterson, N.A, Kim, M.Y, Kim, C.Y, Hung, L.W, Yu, M, Lekin, T, Segelke, B.W, Lott, J.S, Baker, E.N, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2004-10-28 | Release date: | 2005-02-22 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal Structure of AhpE from Mycobacterium tuberculosis, a 1-Cys Peroxiredoxin J.Mol.Biol., 346, 2005
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1XXU
| Crystal Structure of AhpE from Mycrobacterium tuberculosis, a 1-Cys peroxiredoxin | Descriptor: | Hypothetical protein Rv2238c/MT2298 | Authors: | Li, S, Peterson, N.A, Kim, M.Y, Kim, C.Y, Hung, L.W, Yu, M, Lekin, T, Segelke, B.W, Lott, J.S, Baker, E.N, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2004-11-08 | Release date: | 2005-02-22 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal Structure of AhpE from Mycobacterium tuberculosis, a 1-Cys Peroxiredoxin J.Mol.Biol., 346, 2005
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1Y5H
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1YK3
| Crystal structure of Rv1347c from Mycobacterium tuberculosis | Descriptor: | Hypothetical protein Rv1347c/MT1389, octyl beta-D-glucopyranoside | Authors: | Card, G.L, Peterson, N.A, Smith, C.A, Rupp, B, Schick, B.M, Baker, E.N, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2005-01-16 | Release date: | 2005-02-01 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The crystal structure of Rv1347c, a putative antibiotic resistance protein from Mycobacterium tuberculosis, reveals a GCN5-related fold and suggests an alternative function in siderophore biosynthesis J.Biol.Chem., 280, 2005
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1ZVW
| The Crystal Structure of TrpD (Rv2192c) from Mycobacterium tuberculosis in Complex with PRPP and Magnesium | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, Anthranilate phosphoribosyltransferase, BENZAMIDINE, ... | Authors: | Lee, C.E, Lott, J.S, Baker, E.N, Arcus, V.L, Javid-Majd, F, Goodfellow, C, Hung, L.-W, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2005-06-02 | Release date: | 2006-01-17 | Last modified: | 2021-08-04 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The Crystal Structure of TrpD, a Metabolic Enzyme Essential for Lung Colonization by Mycobacterium tuberculosis, in Complex with its Substrate Phosphoribosylpyrophosphate. J.Mol.Biol., 355, 2006
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2A6P
| Structure Solution to 2.2 Angstrom and Functional Characterisation of the Open Reading Frame Rv3214 from Mycobacterium tuberculosis | Descriptor: | GLYCEROL, POSSIBLE PHOSPHOGLYCERATE MUTASE GPM2, SULFATE ION | Authors: | Watkins, H.A, Yu, M, Baker, E.N, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2005-07-03 | Release date: | 2006-05-16 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural and Functional Analysis of Rv3214 from Mycobacterium tuberculosis, a Protein with Conflicting Functional Annotations, Leads to Its Characterization as a Phosphatase. J.Bacteriol., 188, 2006
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1JMY
| Truncated Recombinant Human Bile Salt Stimulated Lipase | Descriptor: | BILE-SALT-ACTIVATED LIPASE, SULFATE ION | Authors: | Moore, S.A, Kingston, R.L, Loomes, K.M, Hernell, O, Blackberg, L, Baker, H.M, Baker, E.N. | Deposit date: | 2001-07-20 | Release date: | 2001-08-08 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | The structure of truncated recombinant human bile salt-stimulated lipase reveals bile salt-independent conformational flexibility at the active-site loop and provides insights into heparin binding. J.Mol.Biol., 312, 2001
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1JQF
| Human Transferrin N-Lobe Mutant H249Q | Descriptor: | CARBONATE ION, FE (III) ION, POTASSIUM ION, ... | Authors: | Baker, H.M, Mason, A.B, He, Q.-Y, MacGillivray, R.T.A, Baker, E.N. | Deposit date: | 2001-08-06 | Release date: | 2001-10-17 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Ligand variation in the transferrin family: the crystal structure of the H249Q mutant of the human transferrin N-lobe as a model for iron binding in insect transferrins. Biochemistry, 40, 2001
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2BPQ
| Anthranilate phosphoribosyltransferase (TrpD) from Mycobacterium tuberculosis (Apo structure) | Descriptor: | ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE, BENZAMIDINE, GLYCEROL | Authors: | Lee, C.E, Goodfellow, C, Javid-Majd, F, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2005-04-22 | Release date: | 2006-01-04 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The Crystal Structure of Trpd, a Metabolic Enzyme Essential for Lung Colonization by Mycobacterium Tuberculosis, in Complex with its Substrate Phosphoribosylpyrophosphate J.Mol.Biol., 355, 2006
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3PFP
| Structure of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis in complex with an active site inhibitor | Descriptor: | (2R)-2,7-bis(phosphonooxy)heptanoic acid, (2S)-2,7-bis(phosphonooxy)heptanoic acid, CHLORIDE ION, ... | Authors: | Reichau, S, Jiao, W, Walker, S.R, Hutton, R.D, Parker, E.J, Baker, E.N. | Deposit date: | 2010-10-28 | Release date: | 2011-03-16 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Potent inhibitors of a shikimate pathway enzyme from Mycobacterium tuberculosis: combining mechanism- and modeling-based design J.Biol.Chem., 286, 2011
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3PSQ
| Crystal structure of Spy0129, a Streptococcus pyogenes class B sortase involved in pilus biogenesis | Descriptor: | 1,2-ETHANEDIOL, ACETIC ACID, CHLORIDE ION, ... | Authors: | Kang, H.J, Baker, E.N. | Deposit date: | 2010-12-02 | Release date: | 2011-01-19 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.32 Å) | Cite: | Crystal structure of Spy0129, a Streptococcus pyogenes class B sortase involved in pilus assembly Plos One, 6, 2011
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3RPK
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1I08
| CRYSTAL STRUCTURE ANALYSIS OF THE H30A MUTANT OF MANGANESE SUPEROXIDE DISMUTASE FROM E. COLI | Descriptor: | MANGANESE (II) ION, MANGANESE SUPEROXIDE DISMUTASE | Authors: | Edwards, R.A, Whittaker, M.M, Whittaker, J.W, Baker, E.N, Jameson, G.B. | Deposit date: | 2001-01-29 | Release date: | 2001-02-28 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Removing a hydrogen bond in the dimer interface of Escherichia coli manganese superoxide dismutase alters structure and reactivity. Biochemistry, 40, 2001
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1I0H
| CRYSTAL STRUCTURE OF THE E. COLI MANGANESE SUPEROXIDE DISMUTASE MUTANT Y174F AT 1.35 ANGSTROMS RESOLUTION. | Descriptor: | MANGANESE (II) ION, MANGANESE SUPEROXIDE DISMUTASE Y174F MUTANT | Authors: | Edwards, R.A, Whittaker, M.M, Whittaker, J.W, Baker, E.N, Jameson, G.B. | Deposit date: | 2001-01-29 | Release date: | 2001-02-28 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Removing a hydrogen bond in the dimer interface of Escherichia coli manganese superoxide dismutase alters structure and reactivity. Biochemistry, 40, 2001
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4ZTV
| Non-anthranilate-like inhibitor (TAMU-A7) complexed with anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis in absence of PRPP | Descriptor: | 4,4,4-trifluoro-1-(4-methoxyphenyl)butane-1,3-dione, Anthranilate phosphoribosyltransferase | Authors: | Evans, G.L, Eom, J, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2015-05-15 | Release date: | 2016-05-25 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Bioactive non-anthranilate-like fragment-like inhibitor provides alternative starting point for inhibitor design against anthranilate phosphoribosyl transferase from Mycobacterium tuberculosis. To be Published
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5BO3
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5BO2
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5BNE
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5C1R
| Stereoisomer of PRPP bound in the active site of Mycobacterium tuberculosis anthranilate phosphoribosyl (AnPRT; trpD) | Descriptor: | 5-O-[(R)-hydroxy(phosphonooxy)phosphoryl]-1-O-phosphono-alpha-D-ribofuranose, Anthranilate phosphoribosyltransferase, GLYCEROL, ... | Authors: | Evans, G.L, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2015-06-15 | Release date: | 2016-07-20 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.802 Å) | Cite: | Binding and mimicking of the phosphate-rich substrate, PRPP. To Be Published
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5C2L
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5C7S
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5BYT
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5CEV
| ARGINASE FROM BACILLUS CALDEVELOX, L-LYSINE COMPLEX | Descriptor: | GUANIDINE, LYSINE, MANGANESE (II) ION, ... | Authors: | Bewley, M.C, Jeffrey, P.D, Patchett, M.L, Kanyo, Z.F, Baker, E.N. | Deposit date: | 1999-03-16 | Release date: | 1999-04-16 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structures of Bacillus caldovelox arginase in complex with substrate and inhibitors reveal new insights into activation, inhibition and catalysis in the arginase superfamily. Structure Fold.Des., 7, 1999
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