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Crystal Structure of Blood Coagulation Factor VIII C2 Domain Mutant L2251A/L2252A
Descriptor:	Factor VIIIa light chain
Authors:	Avery, N.G, Childers, K.C, Spiegel, P.C.
Deposit date:	2024-08-13
Release date:	2024-09-04
Method:	X-RAY DIFFRACTION (1.83 Å)
Cite:	Biophysical characterization of blood coagulation factor VIII binding to lipid nanodiscs that mimic activated platelet surfaces To Be Published

Coagulation factor VIII bound to a patient-derived anti-C1 domain antibody inhibitor
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Coagulation factor VIII chimera from human and pig, NB33 heavy chain, ...
Authors:	Childers, K.C, Davulcu, O, Haynes, R.M, Lollar, P, Doering, C.B, Coxon, C.H, Spiegel, P.C.
Deposit date:	2023-02-15
Release date:	2023-05-24
Last modified:	2023-07-26
Method:	ELECTRON MICROSCOPY (4.23 Å)
Cite:	Structure of coagulation factor VIII bound to a patient-derived anti-C1 domain antibody inhibitor. Blood, 142, 2023

Crystal structure of Porcine Factor VIII C2 Domain Bound to Phosphatidylserine
Descriptor:	Coagulation factor VIII, PHOSPHOSERINE
Authors:	Peters, S.C, Childers, K.C, Wo, S.W, Brison, C.M, Swanson, C.D, Spiegel, P.C.
Deposit date:	2021-08-30
Release date:	2021-10-27
Last modified:	2023-10-25
Method:	X-RAY DIFFRACTION (1.3 Å)
Cite:	Stable binding to phosphatidylserine-containing membranes requires conserved arginine residues in tandem C domains of blood coagulation factor VIII. Front Mol Biosci, 9, 2022