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Crystal structure of the kinase domain of EGFR exon-19 (del-747-749) mutant
Descriptor:	Epidermal growth factor receptor
Authors:	Ashtekar, K.D, Stayrook, S.E, Lemmon, M.A.
Deposit date:	2022-02-04
Release date:	2022-02-16
Last modified:	2023-10-25
Method:	X-RAY DIFFRACTION (2.96 Å)
Cite:	Biochemical and structural basis for differential inhibitor sensitivity of EGFR with distinct exon 19 mutations. Nat Commun, 13, 2022

Ralimetinib (LY2228820) in complex with wild type EGFR
Descriptor:	Epidermal growth factor receptor, ralimetinib
Authors:	Chitnis, S.P, Heppner, D.E.
Deposit date:	2023-02-14
Release date:	2023-10-11
Last modified:	2024-04-24
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Inhibition of a lower potency target drives the anticancer activity of a clinical p38 inhibitor. Cell Chem Biol, 30, 2023