8XW0
| Cryo-EM structure of OSCA3.1-GDN state | 分子名称: | CSC1-like protein ERD4, O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine | 著者 | Zhang, Y, Han, Y. | 登録日 | 2024-01-15 | 公開日 | 2024-04-10 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | 主引用文献 | Mechanical activation opens a lipid-lined pore in OSCA ion channels. Nature, 628, 2024
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8XW3
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8XRY
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8XW2
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4XV2
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4XV3
| B-Raf Kinase V600E oncogenic mutant in complex with PLX7922 | 分子名称: | N'-{3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl}-N-ethyl-N-methylsulfuric diamide, Serine/threonine-protein kinase B-raf | 著者 | Zhang, Y, Zhang, C. | 登録日 | 2015-01-26 | 公開日 | 2015-10-28 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | RAF inhibitors that evade paradoxical MAPK pathway activation. Nature, 526, 2015
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4XV9
| B-Raf Kinase domain in complex with PLX5568 | 分子名称: | N-{3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}-4-(trifluoromethyl)benzenesulfonamide, SULFATE ION, Serine/threonine-protein kinase B-raf | 著者 | zhang, Y, zhang, c, wang, w. | 登録日 | 2015-01-26 | 公開日 | 2015-10-28 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | RAF inhibitors that evade paradoxical MAPK pathway activation. Nature, 526, 2015
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4XV1
| B-Raf Kinase V600E oncogenic mutant in complex with PLX7904 | 分子名称: | N'-(3-{[5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)-N-ethyl-N-methylsulfuric diamide, Serine/threonine-protein kinase B-raf | 著者 | Zhang, Y, Zhang, C. | 登録日 | 2015-01-26 | 公開日 | 2015-10-28 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | 主引用文献 | RAF inhibitors that evade paradoxical MAPK pathway activation. Nature, 526, 2015
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6WXK
| PHF23 PHD Domain Apo | 分子名称: | PHD finger protein 23, ZINC ION | 著者 | Vann, K.R, Zhang, J, Zhang, Y, Kutateladze, T. | 登録日 | 2020-05-11 | 公開日 | 2020-07-15 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion. Nat Commun, 11, 2020
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8AEY
| 3 A CRYO-EM STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS FERRITIN FROM TIMEPIX3 detector | 分子名称: | Ferritin BfrB | 著者 | Zhang, Y, van Schayck, J.P, Knoops, K, Peters, P.J, Ravelli, R.B.G. | 登録日 | 2022-07-14 | 公開日 | 2023-01-18 | 最終更新日 | 2023-03-01 | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | 主引用文献 | Integration of an Event-driven Timepix3 Hybrid Pixel Detector into a Cryo-EM Workflow Microsc Microanal, 2023
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4XVC
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1AOG
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7Q83
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5WTA
| Crystal Structure of Staphylococcus aureus SdrE apo form | 分子名称: | Serine-aspartate repeat-containing protein E | 著者 | Wu, M, Zhang, Y, Hang, T, Wang, C, Yang, Y, Zang, J, Zhang, M, Zhang, X. | 登録日 | 2016-12-10 | 公開日 | 2017-07-19 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Staphylococcus aureus SdrE captures complement factor H's C-terminus via a novel 'close, dock, lock and latch' mechanism for complement evasion Biochem. J., 474, 2017
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3CIV
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1FTA
| FRUCTOSE-1,6-BISPHOSPHATASE(D-FRUCTOSE-1,6-BISPHOSPHATE, 1-PHOSPHOHYDROLASE) (E.C.3.1.3.11) COMPLEXED WITH THE ALLOSTERIC INHIBITOR AMP | 分子名称: | ADENOSINE MONOPHOSPHATE, FRUCTOSE-1,6-BISPHOSPHATASE | 著者 | Zhang, Y, Liang, J.-Y, Huang, S, Lipscomb, W.N. | 登録日 | 1993-09-27 | 公開日 | 1995-11-14 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | The allosteric site of human liver fructose-1,6-bisphosphatase. Analysis of six AMP site mutants based on the crystal structure. J.Biol.Chem., 269, 1994
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5LQ6
| Salmonella effector SpvD - R161 variant | 分子名称: | SODIUM ION, Virulence protein vsdE | 著者 | Zhang, Y, Grabe, G.J, Rolhion, N, Yang, Y, Holden, D.W, Hare, S.A. | 登録日 | 2016-08-16 | 公開日 | 2016-11-02 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | 主引用文献 | The Salmonella Effector SpvD Is a Cysteine Hydrolase with a Serovar-specific Polymorphism Influencing Catalytic Activity, Suppression of Immune Responses, and Bacterial Virulence. J. Biol. Chem., 291, 2016
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5WMG
| N-terminal bromodomain of BRD4 in complex with OTX-015 | 分子名称: | 1,2-ETHANEDIOL, 4-{6-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(1S)-1-(pyridin-2-yl)ethyl]-1H-pyrrolo[3,2-b]pyridin-3-yl}benzoic acid, Bromodomain-containing protein 4 | 著者 | Zhang, Y. | 登録日 | 2017-07-28 | 公開日 | 2018-08-01 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.19 Å) | 主引用文献 | BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor. Cancer Discov, 8, 2018
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5WMD
| N-terminal bromodomain of BRD4 in complex with OTX-015 | 分子名称: | 2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-N-(4-hydroxyphenyl)acetamide, Bromodomain-containing protein 4 | 著者 | Zhang, Y. | 登録日 | 2017-07-28 | 公開日 | 2018-08-01 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.27 Å) | 主引用文献 | BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor. Cancer Discov, 8, 2018
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5WMA
| N-terminal bromodomain of BRD4 in complex with PLX5981 | 分子名称: | 1,2-ETHANEDIOL, 5-(3,5-dimethyl-1,2-oxazol-4-yl)-1H-pyrrolo[2,3-b]pyridine, Bromodomain-containing protein 4 | 著者 | Zhang, Y. | 登録日 | 2017-07-28 | 公開日 | 2018-08-01 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.401 Å) | 主引用文献 | BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor. Cancer Discov, 8, 2018
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6URG
| Cryo-EM structure of human CPSF160-WDR33-CPSF30-CPSF100 PIM complex | 分子名称: | Cleavage and polyadenylation specificity factor subunit 1, Cleavage and polyadenylation specificity factor subunit 2, Cleavage and polyadenylation specificity factor subunit 4, ... | 著者 | Sun, Y, Zhang, Y, Walz, T, Tong, L. | 登録日 | 2019-10-23 | 公開日 | 2019-11-27 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural Insights into the Human Pre-mRNA 3'-End Processing Machinery. Mol.Cell, 77, 2020
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6E83
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6URO
| Cryo-EM structure of human CPSF160-WDR33-CPSF30-PAS RNA-CstF77 complex | 分子名称: | Cleavage and polyadenylation specificity factor subunit 1, Cleavage and polyadenylation specificity factor subunit 4, Cleavage stimulation factor subunit 3, ... | 著者 | Sun, Y, Zhang, Y, Walz, T, Tong, L. | 登録日 | 2019-10-23 | 公開日 | 2019-11-27 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural Insights into the Human Pre-mRNA 3'-End Processing Machinery. Mol.Cell, 77, 2020
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6P79
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6E86
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