4FV0
 
 | |
2MLJ
 | |
2MFV
 | |
4FV3
 | |
2MMW
 | |
4FV6
 | | Crystal Structure of the ERK2 complexed with E57 | | 分子名称: | 1,2-ETHANEDIOL, Mitogen-activated protein kinase 1, N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-4-(2-{[(2S)-1-hydroxybutan-2-yl]amino}-5-methylpyrimidin-4-yl)-1H-pyrrole-2-carboxamide, ... | | 著者 | Kang, Y.N, Stuckey, J.A, Xie, X. | | 登録日 | 2012-06-29 | | 公開日 | 2012-08-29 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal Structure of the ERK2 complexed with E57
TO BE PUBLISHED
|
|
4FV7
 | |
4FUX
 | |
4G6O
 | | Crystal Structure of the ERK2 | | 分子名称: | 1,2-ETHANEDIOL, 4-{4-[4-(aminomethyl)-3-(trifluoromethyl)phenyl]-1H-pyrazol-5-yl}-N-(2,3-dihydro-1-benzofuran-5-ylmethyl)-1H-pyrrole-2-carboxamide, Mitogen-activated protein kinase 1, ... | | 著者 | Kang, Y.N, Stuckey, J.A, Xie, X. | | 登録日 | 2012-07-19 | | 公開日 | 2012-09-19 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal Structure of the ERK2 complexed with E28
to be published
|
|
2MMT
 | | Lasso peptide-based integrin inhibitor: Microcin J25 variant with RGDF substitution of Gly12-Ile13-Gly14-Thr15 | | 分子名称: | Microcin J25 RGDF mutant | | 著者 | Hegemann, J.D, Zimmermann, M, Knappe, T.A, Xie, X, Marahiel, M.A. | | 登録日 | 2014-03-18 | | 公開日 | 2014-07-02 | | 最終更新日 | 2014-07-23 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Rational improvement of the affinity and selectivity of integrin binding of grafted lasso peptides.
J.Med.Chem., 57, 2014
|
|
4FUY
 | |
4FV9
 | | Crystal Structure of the ERK2 complexed with E71 | | 分子名称: | 1,2-ETHANEDIOL, 3-[4-(2,3-difluorophenyl)-1,2-oxazol-5-yl]-5-(pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine, Mitogen-activated protein kinase 1, ... | | 著者 | Kang, Y.N, Stuckey, J.A, Xie, X. | | 登録日 | 2012-06-29 | | 公開日 | 2012-08-29 | | 最終更新日 | 2014-09-24 | | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | | 主引用文献 | Crystal Structure of the ERK2 complexed with E71
TO BE PUBLISHED
|
|
4G6N
 | | Crystal Structure of the ERK2 | | 分子名称: | 3-(4-chlorophenyl)-4,5,6,7-tetrahydro-1H-indazole, Mitogen-activated protein kinase 1, SULFATE ION | | 著者 | Kang, Y.N, Stuckey, J.A, Xie, X. | | 登録日 | 2012-07-19 | | 公開日 | 2012-09-19 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal Structure of the ERK2 complexed with EK0
to be published
|
|
4FV1
 | |
2LX6
 | |
4FV4
 | | Crystal Structure of the ERK2 complexed with EK7 | | 分子名称: | 9-(dimethylamino)-2-[(3-hydroxyphenyl)amino]-5,6-dihydrothieno[3,4-h]quinazoline-7-carbonitrile, GLYCEROL, Mitogen-activated protein kinase 1, ... | | 著者 | Kang, Y.N, Stuckey, J.A, Xie, X. | | 登録日 | 2012-06-29 | | 公開日 | 2012-08-29 | | 最終更新日 | 2014-09-24 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal Structure of the ERK2 complexed with EK7
TO BE PUBLISHED
|
|
5DRB
 | | Crystal structure of WNK1 in complex with WNK463 | | 分子名称: | N-tert-butyl-1-(1-{5-[5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl]pyridin-2-yl}piperidin-4-yl)-1H-imidazole-5-carboxamide, Serine/threonine-protein kinase WNK1 | | 著者 | Kohls, D, Xie, X. | | 登録日 | 2015-09-15 | | 公開日 | 2016-09-07 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Small-molecule WNK inhibition regulates cardiovascular and renal function.
Nat.Chem.Biol., 12, 2016
|
|
5TPY
 | | Crystal structure of an exonuclease resistant RNA from Zika virus | | 分子名称: | HEXANE-1,6-DIOL, MAGNESIUM ION, RNA (71-MER) | | 著者 | Akiyama, B.M, Laurence, H.M, Massey, A.R, Costantino, D.A, Xie, X, Yang, Y, Shi, P.-Y, Nix, J.C, Beckham, J.D, Kieft, J.S. | | 登録日 | 2016-10-21 | | 公開日 | 2016-12-14 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.805 Å) | | 主引用文献 | Zika virus produces noncoding RNAs using a multi-pseudoknot structure that confounds a cellular exonuclease.
Science, 354, 2016
|
|
5EP6
 | | The crystal structure of NAP1 in complex with TBK1 | | 分子名称: | 5-azacytidine-induced protein 2, GLYCEROL, Serine/threonine-protein kinase TBK1 | | 著者 | Li, F, Xie, X, Liu, J, Pan, L. | | 登録日 | 2015-11-11 | | 公開日 | 2016-09-28 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.451 Å) | | 主引用文献 | Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins.
Nat Commun, 7, 2016
|
|
5EOF
 | | Crystal structure of OPTN NTD and TBK1 CTD complex | | 分子名称: | Optineurin, Serine/threonine-protein kinase TBK1 | | 著者 | Li, F, Xie, X, Liu, J, Pan, L. | | 登録日 | 2015-11-10 | | 公開日 | 2016-09-28 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins.
Nat Commun, 7, 2016
|
|
4NAG
 | | Xanthomonins I III are a New Class of Lasso Peptides Featuringa Seven-Membered Macrolactam Ring | | 分子名称: | HEXANE-1,6-DIOL, Xanthomonin I | | 著者 | Hegemann, J.D, Zimmermann, M, Zhu, S, Steuber, H, Harms, K, Xie, X, Marahiel, M.A. | | 登録日 | 2013-10-22 | | 公開日 | 2014-04-30 | | 最終更新日 | 2014-05-21 | | 実験手法 | X-RAY DIFFRACTION (0.81 Å) | | 主引用文献 | Xanthomonins I-III: A New Class of Lasso Peptides with a Seven-Residue Macrolactam Ring.
Angew.Chem.Int.Ed.Engl., 53, 2014
|
|
4OPI
 | | Constructing tailored isoprenoid products by structure-guided modification of geranylgeranyl reductase. | | 分子名称: | Conserved Archaeal protein, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, GERANYLGERANYL DIPHOSPHATE | | 著者 | McAndrew, R.P, Kung, Y, Xie, X, Liu, C, Pereira, J.H, Keasling, J.D, Adams, P.D. | | 登録日 | 2014-02-05 | | 公開日 | 2014-07-09 | | 最終更新日 | 2014-07-23 | | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | | 主引用文献 | Constructing tailored isoprenoid products by structure-guided modification of geranylgeranyl reductase.
Structure, 22, 2014
|
|
4OPT
 | | Constructing tailored isoprenoid products by structure-guided modification of geranylgeranyl reductase | | 分子名称: | Conserved Archaeal protein, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, GERANYLGERANYL DIPHOSPHATE, ... | | 著者 | McAndrew, R.P, Kung, Y, Xie, X, Liu, C, Pereira, J.H, Keasling, J.D, Adams, P.D. | | 登録日 | 2014-02-06 | | 公開日 | 2014-07-09 | | 最終更新日 | 2014-07-23 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Constructing tailored isoprenoid products by structure-guided modification of geranylgeranyl reductase.
Structure, 22, 2014
|
|
4OPC
 | | Constructing tailored isoprenoid products by structure-guided modification of geranylgeranyl reductase. | | 分子名称: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, Conserved Archaeal protein, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE | | 著者 | McAndrew, R.P, Kung, Y, Xie, X, Liu, C, Pereira, J.H, Keasling, J.D, Adams, P.D. | | 登録日 | 2014-02-05 | | 公開日 | 2014-07-09 | | 最終更新日 | 2014-07-23 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Constructing tailored isoprenoid products by structure-guided modification of geranylgeranyl reductase.
Structure, 22, 2014
|
|
4OPU
 | | Constructing tailored isoprenoid products by structure-guided modification of geranylgeranyl reductase | | 分子名称: | Conserved Archaeal protein, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, GERANYLGERANYL DIPHOSPHATE | | 著者 | McAndrew, R.P, Kung, Y, Xie, X, Liu, C, Pereira, J.H, Keasling, J.D, Adams, P.D. | | 登録日 | 2014-02-06 | | 公開日 | 2014-07-09 | | 最終更新日 | 2014-07-23 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Constructing tailored isoprenoid products by structure-guided modification of geranylgeranyl reductase.
Structure, 22, 2014
|
|
