2MMW

LASSO PEPTIDE BASED INTEGRIN INHIBITOR: MICROCIN J25 VARIANT WITH RGD SUBSTITUTION of GLY12-ILE13-GLY14

Summary for 2MMW

• Entry DOI: 10.2210/pdb2mmw/pdb
• NMR Information: BMRB: 21000
• Descriptor: Microcin J25 (1 entity in total)
• Functional Keywords: lasso peptide, microcin j25, epitope grafting, peptide scaffold, integrin inhibitor, angiogenesis, antimicrobial protein, cell adhesion inhibitor, antibiotic
• Biological source: Escherichia coli
• Cellular location: Secreted: Q9X2V7
• Total number of polymer chains: 1
• Total formula weight: 2228.42

Authors

Knappe, T.A.,Linne, U.,Xie, X.,Marahiel, M.A. (deposition date: 2014-03-20, release date: 2014-05-14, Last modification date: 2024-10-30)

• Primary citation: Knappe, T.A.,Manzenrieder, F.,Mas-Moruno, C.,Linne, U.,Sasse, F.,Kessler, H.,Xie, X.,Marahiel, M.A.; Introducing lasso peptides as molecular scaffolds for drug design: engineering of an integrin antagonist.; Angew.Chem.Int.Ed.Engl., 50:8714-8717, 2011; PubMed: 21812076; DOI: 10.1002/anie.201102190

Experimental method

SOLUTION NMR