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3RLD
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BU of 3rld by Molmil
Crystal structure of the Y7I mutant of human carbonic anhydrase II
分子名称: Carbonic anhydrase 2, SULFATE ION, ZINC ION
著者Avvaru, B.S, Mikulski, R, McKenna, R.
登録日2011-04-19
公開日2012-02-08
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Kinetic and crystallographic studies of the role of tyrosine 7 in the active site of human carbonic anhydrase II.
Arch.Biochem.Biophys., 506, 2011
3RG4
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BU of 3rg4 by Molmil
Crystal structure of the W5F mutant of human carbonic anhydrase II
分子名称: Carbonic anhydrase 2, ZINC ION
著者Domsic, J.F, Robbins, A.H, McKenna, R.
登録日2011-04-07
公開日2012-02-22
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structure and catalysis by carbonic anhydrase II: role of active-site tryptophan 5.
Arch.Biochem.Biophys., 516, 2011
3RGE
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BU of 3rge by Molmil
Crystal structure of the W5H mutant of human carbonic anhydrase II
分子名称: Carbonic anhydrase 2, ZINC ION
著者Domsic, J.F, Robbins, A.H, McKenna, R.
登録日2011-04-08
公開日2012-02-22
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.096 Å)
主引用文献Structure and catalysis by carbonic anhydrase II: role of active-site tryptophan 5.
Arch.Biochem.Biophys., 516, 2011
3TMJ
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BU of 3tmj by Molmil
Joint X-ray/neutron structure of human carbonic anhydrase II at pH 7.8
分子名称: Carbonic anhydrase 2, ZINC ION
著者Fisher, Z.
登録日2011-08-31
公開日2011-11-09
最終更新日2023-09-13
実験手法NEUTRON DIFFRACTION (2 Å), X-RAY DIFFRACTION
主引用文献Neutron Structure of Human Carbonic Anhydrase II: A Hydrogen-Bonded Water Network "Switch" Is Observed between pH 7.8 and 10.0.
Biochemistry, 50, 2011
1PM9
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BU of 1pm9 by Molmil
CRYSTAL STRUCTURE OF HUMAN MNSOD H30N, Y166F MUTANT
分子名称: MANGANESE (III) ION, Superoxide dismutase [Mn], mitochondrial
著者Fan, L, Tainer, J.A.
登録日2003-06-10
公開日2003-12-16
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Amino acid substitution at the dimeric interface of human manganese superoxide dismutase
J.Biol.Chem., 279, 2004
1PL4
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BU of 1pl4 by Molmil
Crystal Structure of human MnSOD Y166F mutant
分子名称: MANGANESE (II) ION, Superoxide dismutase [Mn], mitochondrial
著者Fan, L, Tainer, J.A.
登録日2003-06-06
公開日2003-12-16
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.47 Å)
主引用文献Amino acid substitution at the dimeric interface of human manganese superoxide dismutase
J.Biol.Chem., 279, 2004
1QNM
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BU of 1qnm by Molmil
HUMAN MANGANESE SUPEROXIDE DISMUTASE MUTANT Q143N
分子名称: MANGANESE (II) ION, MANGANESE SUPEROXIDE DISMUTASE
著者Guan, Y, Tainer, J.A.
登録日1997-07-03
公開日1998-01-07
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Probing the active site of human manganese superoxide dismutase: the role of glutamine 143.
Biochemistry, 37, 1998
3KKX
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BU of 3kkx by Molmil
Neutron structure of human carbonic anhydrase II
分子名称: Carbonic anhydrase 2, ZINC ION
著者Fisher, S.Z, Langan, P.A.
登録日2009-11-06
公開日2010-01-12
最終更新日2023-09-06
実験手法NEUTRON DIFFRACTION (2 Å)
主引用文献Neutron structure of human carbonic anhydrase II: implications for proton transfer.
Biochemistry, 49, 2010
3KOK
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BU of 3kok by Molmil
Crystal structure of cobalt (II) human carbonic anhydrase II at pH 8.5
分子名称: COBALT (II) ION, Carbonic anhydrase 2
著者Avvaru, B.S.
登録日2009-11-13
公開日2010-08-25
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Comparison of solution and crystal properties of Co(II)-substituted human carbonic anhydrase II.
Arch.Biochem.Biophys., 502, 2010
3KOI
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Crystal structure of cobalt (III) human carbonic anhydrase II at pH 6.0
分子名称: COBALT (III) ION, Carbonic anhydrase 2
著者Avvaru, B.S.
登録日2009-11-13
公開日2010-08-25
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.64 Å)
主引用文献Comparison of solution and crystal properties of Co(II)-substituted human carbonic anhydrase II.
Arch.Biochem.Biophys., 502, 2010
3KON
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BU of 3kon by Molmil
Crystal structure of cobalt (II) human carbonic anhydrase II at pH 11.0
分子名称: COBALT (II) ION, Carbonic anhydrase 2
著者Avvaru, B.S.
登録日2009-11-13
公開日2010-08-25
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Comparison of solution and crystal properties of Co(II)-substituted human carbonic anhydrase II.
Arch.Biochem.Biophys., 502, 2010
3KS3
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BU of 3ks3 by Molmil
High resolution structure of Human Carbonic Anhydrase II at 0.9 A
分子名称: Carbonic anhydrase 2, GLYCEROL, ZINC ION
著者Avvaru, B.S.
登録日2009-11-20
公開日2010-01-26
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (0.9 Å)
主引用文献A short, strong hydrogen bond in the active site of human carbonic anhydrase II.
Biochemistry, 49, 2010
3MNH
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BU of 3mnh by Molmil
Human Carbonic Anhydrase II Mutant K170A
分子名称: Carbonic anhydrase 2, SODIUM ION, ZINC ION
著者Domsic, J.F, McKenna, R.
登録日2010-04-21
公開日2010-07-14
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structural and kinetic study of the extended active site for proton transfer in human carbonic anhydrase II.
Biochemistry, 49, 2010
3MNI
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BU of 3mni by Molmil
Human Carbonic Anhydrase II Mutant K170D
分子名称: Carbonic anhydrase 2, SODIUM ION, ZINC ION
著者Domsic, J.F, McKenna, R.
登録日2010-04-21
公開日2010-07-14
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structural and kinetic study of the extended active site for proton transfer in human carbonic anhydrase II.
Biochemistry, 49, 2010
3MNJ
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BU of 3mnj by Molmil
Human Carbonic Anhydrase II Mutant K170E
分子名称: Carbonic anhydrase 2, SODIUM ION, ZINC ION
著者Domsic, J.F, McKenna, R.
登録日2010-04-21
公開日2010-07-14
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structural and kinetic study of the extended active site for proton transfer in human carbonic anhydrase II.
Biochemistry, 49, 2010
3MNK
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BU of 3mnk by Molmil
Human Carbonic Anhydrase II Mutant K170H
分子名称: Carbonic anhydrase 2, SODIUM ION, ZINC ION
著者Domsic, J.F, McKenna, R.
登録日2010-04-21
公開日2010-07-14
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structural and kinetic study of the extended active site for proton transfer in human carbonic anhydrase II.
Biochemistry, 49, 2010
3CAJ
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BU of 3caj by Molmil
Crystal structure of the human carbonic anhydrase II in complex with ethoxzolamide
分子名称: 6-ethoxy-1,3-benzothiazole-2-sulfonamide, CHLORIDE ION, Carbonic anhydrase 2, ...
著者Di Fiore, A, De Simone, G.
登録日2008-02-20
公開日2008-04-08
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors
Bioorg.Med.Chem.Lett., 18, 2008
4E5Q
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BU of 4e5q by Molmil
Human Carbonic Anhydrase II in complex with cyanate
分子名称: Carbonic anhydrase 2, ZINC ION, cyanic acid
著者West, D, McKenna, R.
登録日2012-03-14
公開日2013-03-27
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.7024 Å)
主引用文献Human carbonic anhydrase II-cyanate inhibitor complex: putting the debate to rest.
Acta Crystallogr F Struct Biol Commun, 70, 2014
4G0C
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BU of 4g0c by Molmil
Neutron structure of acetazolamide-bound human carbonic anhydrase II reveal molecular details of drug binding.
分子名称: 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, Carbonic anhydrase 2, ZINC ION
著者Fisher, S.Z, McKenna, R, Aggarwal, M.
登録日2012-07-09
公開日2012-09-19
最終更新日2023-09-13
実験手法NEUTRON DIFFRACTION (2 Å)
主引用文献Neutron diffraction of acetazolamide-bound human carbonic anhydrase II reveals atomic details of drug binding.
J.Am.Chem.Soc., 134, 2012
4GL1
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BU of 4gl1 by Molmil
Structure of H64A/N62L/N67L Human Carbonic Anhydrase II triple mutant
分子名称: Carbonic anhydrase 2, ZINC ION
著者West, D.M.
登録日2012-08-13
公開日2013-09-04
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Hydrophobicity and low pKa impact catalytic efficiency of Human Carbonic Anhydrases
To be Published
4HEY
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BU of 4hey by Molmil
Activity Enhancers of H64A Variant of Human Carbonic Anhydrase II Possess Multiple Binding Sites within and around the Enzyme Structure
分子名称: 4-METHYLIMIDAZOLE, Carbonic anhydrase 2, ZINC ION
著者Aggarwal, M, McKenna, R.
登録日2012-10-04
公開日2013-10-23
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Structural insight into activity enhancement and inhibition of H64A carbonic anhydrase II by imidazoles.
IUCrJ, 1, 2014
4HEW
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BU of 4hew by Molmil
Activity Enhancers of H64A Variant of Human Carbonic Anhydrase II Possess Multiple Binding Sites within and around the Enzyme Structure
分子名称: 2-METHYLIMIDAZOLE, Carbonic anhydrase 2, ZINC ION
著者Aggarwal, M, McKenna, R.
登録日2012-10-04
公開日2013-10-23
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.6984 Å)
主引用文献Structural insight into activity enhancement and inhibition of H64A carbonic anhydrase II by imidazoles.
IUCrJ, 1, 2014
4HBA
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Structural and Catalytic Characterization of a Thermal and Acid Stable Variant of Human Carbonic Anhydrase II Containing an Engineered Disulfide Bond
分子名称: Carbonic anhydrase 2, GLYCEROL, ZINC ION
著者Boone, C.D, Habibzadegan, A, McKenna, R.
登録日2012-09-27
公開日2013-07-31
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (1.762 Å)
主引用文献Structural and catalytic characterization of a thermally stable and acid-stable variant of human carbonic anhydrase II containing an engineered disulfide bond.
Acta Crystallogr.,Sect.D, 69, 2013
4HF3
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Activity Enhancers of H64A Variant of Human Carbonic Anhydrase II Possess Multiple Binding Sites within and around the Enzyme Structure
分子名称: Carbonic anhydrase 2, IMIDAZOLE, ZINC ION
著者Aggarwal, M, McKenna, R.
登録日2012-10-04
公開日2013-10-23
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.1476 Å)
主引用文献Structural insight into activity enhancement and inhibition of H64A carbonic anhydrase II by imidazoles.
IUCrJ, 1, 2014
4FIK
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Human carbonic anhydrase II H64A complexed with thioxolone hydrolysis products
分子名称: 2,4-dihydroxybenzenesulfenic acid, 4,4'-disulfanediyldibenzene-1,3-diol, 4-MERCAPTOBENZENE-1,3-DIOL, ...
著者Sippel, K.H, Genis, C, Govindasamy, L, Agbandje-McKenna, M, Tripp, B.C, McKenna, R.
登録日2012-06-08
公開日2012-06-27
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Synchrotron Radiation Provides a Plausible Explanation for the Generation of a Free Radical Adduct of Thioxolone in Mutant Carbonic Anhydrase II.
J Phys Chem Lett, 1, 2010

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