Loading
PDBj
English日本語简体中文繁體中文한국어
✖
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
3NZS
DownloadVisualize
BU of 3nzs by Molmil
Structure-based Optimization of Pyrazolo -Pyrimidine and -Pyridine Inhibitors of PI3-Kinase
Descriptor: 6-(1,1-dioxidothiomorpholin-4-yl)-N-(3-methoxyphenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Authors:Murray, J.M, Wiesmann, C.
Deposit date:2010-07-16
Release date:2010-12-29
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structure-based optimization of pyrazolo-pyrimidine and -pyridine inhibitors of PI3-kinase.
Bioorg.Med.Chem.Lett., 20, 2010
3R7Q
DownloadVisualize
BU of 3r7q by Molmil
Structure-based design of thienobenzoxepin inhibitors of PI3- kinase
Descriptor: N-(2-chlorophenyl)-N-methyl-4H-thieno[3,2-c]chromene-2-carboxamide, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Authors:Murray, J.M, Wiesmann, C.
Deposit date:2011-03-22
Release date:2011-08-03
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure-based design of thienobenzoxepin inhibitors of PI3-kinase.
Bioorg.Med.Chem.Lett., 21, 2011
3R7R
DownloadVisualize
BU of 3r7r by Molmil
Structure-based design of thienobenzoxepin inhibitors of PI3-Kinase
Descriptor: 8-(acetylamino)-N-(2-chlorophenyl)-N-methyl-4,5-dihydrothieno[3,2-d][1]benzoxepine-2-carboxamide, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Authors:Murray, J.M, Wiesmann, C.
Deposit date:2011-03-22
Release date:2011-08-03
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure-based design of thienobenzoxepin inhibitors of PI3-kinase.
Bioorg.Med.Chem.Lett., 21, 2011
3P9W
DownloadVisualize
BU of 3p9w by Molmil
Crystal structure of an engineered human autonomous VH Domain in complex with VEGF
Descriptor: Vascular endothelial growth factor A, human VEGF
Authors:Ma, X, Wiesmann, C.
Deposit date:2010-10-18
Release date:2012-04-18
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Design of Synthetic Autonomous VH Domain Libraries and Structural Analysis of a VH Domain Bound to Vascular Endothelial Growth Factor.
J.Mol.Biol., 425, 2013
4O0T
DownloadVisualize
BU of 4o0t by Molmil
Back pocket flexibility provides group-II PAK selectivity for type 1 kinase inhibitors
Descriptor: 1-({1-(2-aminopyrimidin-4-yl)-2-[(2-methoxyethyl)amino]-1H-benzimidazol-6-yl}ethynyl)cyclohexanol, Serine/threonine-protein kinase PAK 1
Authors:Oh, A, Tam, C, Wang, W.
Deposit date:2013-12-14
Release date:2014-02-12
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Back Pocket Flexibility Provides Group II p21-Activated Kinase (PAK) Selectivity for Type I 1/2 Kinase Inhibitors.
J.Med.Chem., 57, 2014
<123

 

219140

PDB entries from 2024-05-01

PDB statisticsPDBj update infoContact PDBjnumon