3NZS

Structure-based Optimization of Pyrazolo -Pyrimidine and -Pyridine Inhibitors of PI3-Kinase

Summary for 3NZS

• Entry DOI: 10.2210/pdb3nzs/pdb
• Related: 3NZU
• Descriptor: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, 6-(1,1-dioxidothiomorpholin-4-yl)-N-(3-methoxyphenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine (2 entities in total)
• Functional Keywords: kinase p110, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 109770.06

Authors

Murray, J.M.,Wiesmann, C. (deposition date: 2010-07-16, release date: 2010-12-29, Last modification date: 2024-02-21)

• Primary citation: Staben, S.T.,Heffron, T.P.,Sutherlin, D.P.,Bhat, S.R.,Castanedo, G.M.,Chuckowree, I.S.,Dotson, J.,Folkes, A.J.,Friedman, L.S.,Lee, L.,Lesnick, J.,Lewis, C.,Murray, J.M.,Nonomiya, J.,Olivero, A.G.,Plise, E.,Pang, J.,Prior, W.W.,Salphati, L.,Rouge, L.,Sampath, D.,Tsui, V.,Wan, N.C.,Wang, S.,Wiesmann, C.,Wu, P.,Zhu, B.Y.; Structure-based optimization of pyrazolo-pyrimidine and -pyridine inhibitors of PI3-kinase.; Bioorg.Med.Chem.Lett., 20:6048-6051, 2010; PubMed: 20822905; DOI: 10.1016/j.bmcl.2010.08.067

Experimental method

X-RAY DIFFRACTION (2.75 Å)