7VBC
| Back track state of human RNA Polymerase I Elongation Complex | 分子名称: | DNA (5'-D(*GP*TP*AP*CP*TP*GP*TP*CP*CP*TP*CP*TP*GP*G)-3'), DNA (5'-D(P*AP*GP*GP*AP*CP*AP*GP*CP*GP*TP*GP*TP*CP*AP*GP*CP*AP*AP*TP*A)-3'), DNA-directed RNA polymerase I subunit RPA1, ... | 著者 | Zhao, D, Liu, W, Chen, K, Yang, H, Xu, Y. | 登録日 | 2021-08-31 | 公開日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3.01 Å) | 主引用文献 | Structure of the human RNA polymerase I elongation complex. Cell Discov, 7, 2021
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7VBB
| Structure of the post state human RNA Polymerase I Elongation Complex | 分子名称: | DNA (25-MER), DNA (5'-D(*CP*TP*GP*TP*CP*CP*TP*CP*TP*GP*GP*CP*GP*A)-3'), DNA-directed RNA polymerase I subunit RPA1, ... | 著者 | Zhao, D, Liu, W, Chen, K, Yang, H, Xu, Y. | 登録日 | 2021-08-31 | 公開日 | 2022-03-02 | 実験手法 | ELECTRON MICROSCOPY (2.81 Å) | 主引用文献 | Structure of the human RNA polymerase I elongation complex. Cell Discov, 7, 2021
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7YCX
| The structure of INTAC-PEC complex | 分子名称: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB1,DNA-directed RNA polymerase II subunit RPB1, ... | 著者 | Zheng, H, Jin, Q, Wang, X, Qi, Y, Liu, W, Ren, Y, Zhao, D, Chen, F.X, Cheng, J, Chen, X, Xu, Y. | 登録日 | 2022-07-02 | 公開日 | 2023-03-15 | 最終更新日 | 2023-09-27 | 実験手法 | ELECTRON MICROSCOPY (4.18 Å) | 主引用文献 | Structural basis of INTAC-regulated transcription. Protein Cell, 14, 2023
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7YKO
| Crystal structure of a novel alpha/beta hydrolase mutant from thermomonospora curvata in complex with pentane-1,5-diol | 分子名称: | Triacylglycerol lipase, pentane-1,5-diol | 著者 | Han, X, Jian, G, Bornscheuer, U.T, Wei, R, Liu, W. | 登録日 | 2022-07-23 | 公開日 | 2023-07-26 | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | 主引用文献 | Crystal structure of a novel alpha/beta hydrolase mutant from thermomonospora curvata in complex with pentane-1,5-diol To Be Published
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7YKP
| Crystal structure of a novel alpha/beta hydrolase from thermomonospora curvata with glycerol | 分子名称: | GLYCEROL, Triacylglycerol lipase | 著者 | Han, X, Jian, G, Bornscheuer, U.T, Wei, R, Liu, W. | 登録日 | 2022-07-23 | 公開日 | 2023-07-26 | 実験手法 | X-RAY DIFFRACTION (1.18 Å) | 主引用文献 | Crystal structure of a novel alpha/beta hydrolase from thermomonospora curvata with glycerol To Be Published
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7YKQ
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7YXA
| XFEL crystal structure of the human sphingosine 1 phosphate receptor 5 in complex with ONO-5430608 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[6-(2-naphthalen-1-ylethoxy)-2,3,4,5-tetrahydro-1H-3-benzazepin-3-ium-3-yl]butanoic acid, ... | 著者 | Lyapina, E, Marin, E, Gusach, A, Orekhov, P, Gerasimov, A, Luginina, A, Vakhrameev, D, Ergasheva, M, Kovaleva, M, Khusainov, G, Khorn, P, Shevtsov, M, Kovalev, K, Okhrimenko, I, Bukhdruker, S, Popov, P, Hu, H, Weierstall, U, Liu, W, Cho, Y, Gushchin, I, Rogachev, A, Bourenkov, G, Park, S, Park, G, Huyn, H.J, Park, J, Gordeliy, V, Borshchevskiy, V, Mishin, A, Cherezov, V. | 登録日 | 2022-02-15 | 公開日 | 2022-08-10 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural basis for receptor selectivity and inverse agonism in S1P 5 receptors. Nat Commun, 13, 2022
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5OVQ
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2LA8
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5Z8F
| Solution structure for the unique dimeric 4:2 complex of a platinum(II)-based tripod bound to a hybrid-1 human telomeric G-quadruplex | 分子名称: | 4-[1-(2,5,8-triazonia-1$l^4-platinabicyclo[3.3.0]octan-1-yl)pyridin-1-ium-4-yl]-N,N-bis[4-[1-(2,5,8-triazonia-1$l^4-platinabicyclo[3.3.0]octan-1-yl)pyridin-1-ium-4-yl]phenyl]aniline, G-quadruplex DNA (26-MER) | 著者 | Liu, W.T, Zhong, Y.F, Liu, L.Y, Zeng, W.J, Wang, F.Y, Yang, D.Z, Mao, Z.W. | 登録日 | 2018-01-31 | 公開日 | 2018-09-19 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structures of multiple G-quadruplex complexes induced by a platinum(II)-based tripod reveal dynamic binding Nat Commun, 9, 2018
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5Z80
| Solution structure for the 1:1 complex of a platinum(II)-based tripod bound to a hybrid-1 human telomeric G-quadruplex | 分子名称: | 4-[1-(2,5,8-triazonia-1$l^4-platinabicyclo[3.3.0]octan-1-yl)pyridin-1-ium-4-yl]-N,N-bis[4-[1-(2,5,8-triazonia-1$l^4-platinabicyclo[3.3.0]octan-1-yl)pyridin-1-ium-4-yl]phenyl]aniline, G-quadruplex DNA (26-MER) | 著者 | Liu, W.T, Zhong, Y.F, Liu, L.Y, Zeng, W.J, Wang, F.Y, Yang, D.Z, Mao, Z.W. | 登録日 | 2018-01-30 | 公開日 | 2018-09-19 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structures of multiple G-quadruplex complexes induced by a platinum(II)-based tripod reveal dynamic binding Nat Commun, 9, 2018
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7DWA
| Structure of a novel beta-mannanase BaMan113A with mannotriose, N236Y mutation | 分子名称: | Endo-beta-1,4-mannanase, beta-D-mannopyranose-(1-4)-beta-D-mannopyranose-(1-4)-alpha-D-mannopyranose | 著者 | Liu, W.T, Liu, W.D, Zheng, Y.Y. | 登録日 | 2021-01-15 | 公開日 | 2021-06-02 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | Functional and structural investigation of a novel beta-mannanase BaMan113A from Bacillus sp. N16-5. Int.J.Biol.Macromol., 182, 2021
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7DW8
| Structure of a novel beta-mannanase BaMan113A with mannobiose, N236Y mutation. | 分子名称: | Endo-beta-1,4-mannanase, beta-D-mannopyranose-(1-4)-beta-D-mannopyranose | 著者 | Liu, W.T, Liu, W.D, Zheng, Y.Y. | 登録日 | 2021-01-15 | 公開日 | 2021-06-02 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Functional and structural investigation of a novel beta-mannanase BaMan113A from Bacillus sp. N16-5. Int.J.Biol.Macromol., 182, 2021
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7DVZ
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3WB9
| Crystal Structures of meso-diaminopimelate dehydrogenase from Symbiobacterium thermophilum | 分子名称: | Diaminopimelate dehydrogenase, GLYCEROL | 著者 | Liu, W.D, Li, Z, Huang, C.H, Guo, R.T, Wu, Q.Q, Zhu, D.M. | 登録日 | 2013-05-14 | 公開日 | 2014-03-26 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Structural and mutational studies on the unusual substrate specificity of meso-diaminopimelate dehydrogenase from Symbiobacterium thermophilum. Chembiochem, 15, 2014
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3WBF
| Crystal Structure of meso-diaminopimelate dehydrogenase from Symbiobacterium thermophilum co-crystallized with NADP+ and DAP | 分子名称: | 2,6-DIAMINOPIMELIC ACID, Diaminopimelate dehydrogenase, GLYCEROL, ... | 著者 | Liu, W.D, Li, Z, Huang, C.H, Guo, R.T, Wu, Q.Q, Zhu, D.M. | 登録日 | 2013-05-15 | 公開日 | 2014-03-26 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | 主引用文献 | Structural and mutational studies on the unusual substrate specificity of meso-diaminopimelate dehydrogenase from Symbiobacterium thermophilum. Chembiochem, 15, 2014
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3WBB
| Crystal Structures of meso-diaminopimelate dehydrogenase from Symbiobacterium thermophilum | 分子名称: | Diaminopimelate dehydrogenase, GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Liu, W.D, Li, Z, Huang, C.H, Guo, R.T, Wu, Q.Q, Zhu, D.M. | 登録日 | 2013-05-14 | 公開日 | 2014-03-26 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Structural and mutational studies on the unusual substrate specificity of meso-diaminopimelate dehydrogenase from Symbiobacterium thermophilum. Chembiochem, 15, 2014
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7DVJ
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7DV7
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8I6V
| Cryo-EM structure of the polyphosphate polymerase VTC complex(Vtc4/Vtc3/Vtc1) | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, MANGANESE (II) ION, PHOSPHATE ION, ... | 著者 | Mayer, A, Wu, S, Ye, S. | 登録日 | 2023-01-29 | 公開日 | 2023-03-01 | 最終更新日 | 2023-05-31 | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | 主引用文献 | Cryo-EM structure of the polyphosphate polymerase VTC reveals coupling of polymer synthesis to membrane transit. Embo J., 42, 2023
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5O2E
| Crystal structure of NDM-1 in complex with hydrolyzed cefuroxime - new refinement | 分子名称: | (2R,5S)-5-[(carbamoyloxy)methyl]-2-[(R)-carboxy{[(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetyl]amino}methyl]-5,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, Metallo-beta-lactamase type 2, SULFATE ION, ... | 著者 | Raczynska, J.E, Shabalin, I.G, Jaskolski, M, Minor, W, Wlodawer, A. | 登録日 | 2017-05-20 | 公開日 | 2018-12-26 | 最終更新日 | 2023-02-22 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | A close look onto structural models and primary ligands of metallo-beta-lactamases. Drug Resist. Updat., 40, 2018
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5O2F
| Crystal structure of NDM-1 in complex with hydrolyzed ampicillin - new refinement | 分子名称: | (2R,4S)-2-[(R)-{[(2R)-2-amino-2-phenylacetyl]amino}(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, 1,2-ETHANEDIOL, CHLORIDE ION, ... | 著者 | Raczynska, J.E, Shabalin, I.G, Jaskolski, M, Minor, W, Wlodawer, A. | 登録日 | 2017-05-20 | 公開日 | 2018-12-26 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | A close look onto structural models and primary ligands of metallo-beta-lactamases. Drug Resist. Updat., 40, 2018
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6XLO
| Crystal structure of bRaf in complex with inhibitor | 分子名称: | 3-(2-cyanopropan-2-yl)-N-[2-fluoro-4-methyl-5-(7-methyl-8-oxo-7,8-dihydropyrido[2,3-d]pyridazin-3-yl)phenyl]benzamide, IODIDE ION, Serine/threonine-protein kinase B-raf | 著者 | Yin, J, Eigenbrot, C, Wang, W. | 登録日 | 2020-06-28 | 公開日 | 2021-05-26 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.493 Å) | 主引用文献 | Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a 5-Fluoro-4-(3 H )-quinazolinone Aryl Urea pan-RAF Kinase Inhibitor. J.Med.Chem., 64, 2021
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6XCJ
| Crystal Structure of DH650 Fab from a Rhesus Macaque in Complex with HIV-1 gp120 Core | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, DH650 Fab Heavy Chain, DH650 Fab Light Chain, ... | 著者 | Raymond, D.D, Chug, H, Harrison, S.C. | 登録日 | 2020-06-08 | 公開日 | 2020-12-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth. Science, 371, 2021
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6XRT
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