1BSC
 
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1AB7
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1B21
 | | DELETION OF A BURIED SALT BRIDGE IN BARNASE | | 分子名称: | PROTEIN (BARNASE), ZINC ION | | 著者 | Vaughan, C.K, Harryson, P, Buckle, A.M, Oliveberg, M, Fersht, A.R. | | 登録日 | 1998-12-03 | | 公開日 | 1998-12-09 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | A structural double-mutant cycle: estimating the strength of a buried salt bridge in barnase.
Acta Crystallogr.,Sect.D, 58, 2002
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1B20
 | | DELETION OF A BURIED SALT-BRIDGE IN BARNASE | | 分子名称: | PROTEIN (BARNASE), ZINC ION | | 著者 | Vaughan, C.K, Harryson, P, Buckle, A.M, Oliveberg, M, Fersht, A.R. | | 登録日 | 1998-12-03 | | 公開日 | 1998-12-09 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | A structural double-mutant cycle: estimating the strength of a buried salt bridge in barnase.
Acta Crystallogr.,Sect.D, 58, 2002
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1B2Z
 | | DELETION OF A BURIED SALT BRIDGE IN BARNASE | | 分子名称: | PROTEIN (BARNASE), ZINC ION | | 著者 | Vaughan, C.K, Harryson, P, Buckle, A.M, Oliveberg, M, Fersht, A.R. | | 登録日 | 1998-12-03 | | 公開日 | 1998-12-09 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | | 主引用文献 | A structural double-mutant cycle: estimating the strength of a buried salt bridge in barnase.
Acta Crystallogr.,Sect.D, 58, 2002
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1B2X
 | | BARNASE WILDTYPE STRUCTURE AT PH 7.5 FROM A CRYO_COOLED CRYSTAL AT 100K | | 分子名称: | PROTEIN (BARNASE), ZINC ION | | 著者 | Harrison, P, Vaughan, C.K, Buckle, A.M, Fersht, A.R. | | 登録日 | 1998-12-03 | | 公開日 | 1998-12-09 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | A structural double-mutant cycle: estimating the strength of a buried salt bridge in barnase.
Acta Crystallogr.,Sect.D, 58, 2002
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1BNF
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1BNE
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1BNG
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1BRN
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1BTB
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1BTA
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1BNI
 | | BARNASE WILDTYPE STRUCTURE AT PH 6.0 | | 分子名称: | BARNASE | | 著者 | Cameron, A, Henrick, K, Fersht, A.R, Dodson, G, Buckle, A.M. | | 登録日 | 1995-05-17 | | 公開日 | 1995-09-15 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal structural analysis of mutations in the hydrophobic cores of barnase.
J.Mol.Biol., 234, 1993
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1BNJ
 | | BARNASE WILDTYPE STRUCTURE AT PH 9.0 | | 分子名称: | BARNASE | | 著者 | Cameron, A, Henrick, K, Fersht, A.R, Dodson, G, Buckle, A.M. | | 登録日 | 1995-05-17 | | 公開日 | 1995-09-15 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal structural analysis of mutations in the hydrophobic cores of barnase.
J.Mol.Biol., 234, 1993
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1COA
 | | THE EFFECT OF CAVITY CREATING MUTATIONS IN THE HYDROPHOBIC CORE OF CHYMOTRYPSIN INHIBITOR 2 | | 分子名称: | CHYMOTRYPSIN INHIBITOR 2 | | 著者 | Jackson, S.E, Moracci, M, Elmasry, N, Johnson, C.M, Fersht, A.R. | | 登録日 | 1993-05-14 | | 公開日 | 1994-01-31 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Effect of cavity-creating mutations in the hydrophobic core of chymotrypsin inhibitor 2.
Biochemistry, 32, 1993
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5NP0
 | | Closed dimer of human ATM (Ataxia telangiectasia mutated) | | 分子名称: | Serine-protein kinase ATM | | 著者 | Baretic, D, Pollard, H.K, Fisher, D.I, Johnson, C.M, Santhanam, B, Truman, C.M, Kouba, T, Fersht, A.R, Phillips, C, Williams, R.L. | | 登録日 | 2017-04-13 | | 公開日 | 2017-05-17 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (5.7 Å) | | 主引用文献 | Structures of closed and open conformations of dimeric human ATM.
Sci Adv, 3, 2017
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5NP1
 | | Open protomer of human ATM (Ataxia telangiectasia mutated) | | 分子名称: | Serine-protein kinase ATM | | 著者 | Baretic, D, Pollard, H.K, Fisher, D.I, Johnson, C.M, Santhanam, B, Truman, C.M, Kouba, T, Fersht, A.R, Phillips, C, Williams, R.L. | | 登録日 | 2017-04-13 | | 公開日 | 2017-05-17 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (5.7 Å) | | 主引用文献 | Structures of closed and open conformations of dimeric human ATM.
Sci Adv, 3, 2017
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5O1D
 | | p53 cancer mutant Y220C in complex with compound MB481 | | 分子名称: | 3-iodanyl-2-oxidanyl-5-propoxy-4-pyrrol-1-yl-benzoic acid, Cellular tumor antigen p53, GLYCEROL, ... | | 著者 | Joerger, A.C, Bauer, M.R, Baud, M.G.J, Fersht, A.R. | | 登録日 | 2017-05-18 | | 公開日 | 2018-05-09 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.36 Å) | | 主引用文献 | Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines.
Eur J Med Chem, 152, 2018
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5O1C
 | | p53 cancer mutant Y220C in complex with compound MB184 | | 分子名称: | 5-(4-fluorophenyl)-3-iodanyl-2-oxidanyl-4-pyrrol-1-yl-benzoic acid, Cellular tumor antigen p53, ZINC ION | | 著者 | Joerger, A.C, Baud, M.G.J, Bauer, M.R, Fersht, A.R. | | 登録日 | 2017-05-18 | | 公開日 | 2018-05-09 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.32 Å) | | 主引用文献 | Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines.
Eur J Med Chem, 152, 2018
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5O1I
 | | p53 cancer mutant Y220C in complex with compound MB710 | | 分子名称: | 1,2-ETHANEDIOL, 2-(diethylamino)-6-iodanyl-5-oxidanyl-7-pyrrol-1-yl-1,3-benzothiazole-4-carboxylic acid, Cellular tumor antigen p53, ... | | 著者 | Joerger, A.C, Baud, M.G.J, Bauer, M.R, Fersht, A.R. | | 登録日 | 2017-05-18 | | 公開日 | 2018-05-09 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines.
Eur J Med Chem, 152, 2018
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5O1F
 | | p53 cancer mutant Y220C in complex with compound MB582 | | 分子名称: | 5-butoxy-3-iodanyl-2-oxidanyl-4-pyrrol-1-yl-benzoic acid, Cellular tumor antigen p53, ZINC ION | | 著者 | Joerger, A.C, Bauer, M.R, Baud, M.G.J, Fersht, A.R. | | 登録日 | 2017-05-18 | | 公開日 | 2018-05-09 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | | 主引用文献 | Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines.
Eur J Med Chem, 152, 2018
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5O1E
 | | p53 cancer mutant Y220C im complex with compound MB577 | | 分子名称: | 3-iodanyl-2-oxidanyl-5-prop-2-enoxy-4-pyrrol-1-yl-benzoic acid, Cellular tumor antigen p53, GLYCEROL, ... | | 著者 | Joerger, A.C, Baud, M.G.J, Bauer, M.R, Fersht, A.R. | | 登録日 | 2017-05-18 | | 公開日 | 2018-05-09 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines.
Eur J Med Chem, 152, 2018
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5O1A
 | | p53 cancer mutant Y220C in complex with compound MB240 | | 分子名称: | Cellular tumor antigen p53, GLYCEROL, ZINC ION, ... | | 著者 | Joerger, A.C, Bauer, M.R, Baud, M.G.J, Fersht, A.R. | | 登録日 | 2017-05-18 | | 公開日 | 2018-05-09 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.44 Å) | | 主引用文献 | Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines.
Eur J Med Chem, 152, 2018
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5O1H
 | | p53 cancer mutant Y220C in complex with compound MB539 | | 分子名称: | 3-iodanyl-2-oxidanyl-5-propylsulfanyl-4-pyrrol-1-yl-benzoic acid, Cellular tumor antigen p53, GLYCEROL, ... | | 著者 | Joerger, A.C, Bauer, M.R, Baud, M.G.J, Fersht, A.R. | | 登録日 | 2017-05-18 | | 公開日 | 2018-05-09 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.32 Å) | | 主引用文献 | Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines.
Eur J Med Chem, 152, 2018
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5O1B
 | | p53 cancer mutant Y220C in complex with compound MB84 | | 分子名称: | 6-(hydroxymethyl)-2,4-bis(iodanyl)-3-pyrrol-1-yl-phenol, Cellular tumor antigen p53, GLYCEROL, ... | | 著者 | Joerger, A.C, Bauer, M.R, Baud, M.G.J, Fersht, A.R. | | 登録日 | 2017-05-18 | | 公開日 | 2018-05-09 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | | 主引用文献 | Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines.
Eur J Med Chem, 152, 2018
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