4G5J
 
 | | Crystal structure of EGFR kinase in complex with BIBW2992 | | 分子名称: | (2E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3S)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide, Epidermal growth factor receptor, N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3S)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide | | 著者 | Solca, F, Dahl, G, Zoephel, A, Bader, G, Sanderson, M, Klein, C, Kraemer, O, Himmelsbach, F, Haaksma, E, Adolf, G.R. | | 登録日 | 2012-07-18 | | 公開日 | 2012-08-29 | | 最終更新日 | 2012-10-31 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Target Binding Properties and Cellular Activity of Afatinib (BIBW 2992), an Irreversible ErbB Family Blocker.
J.Pharmacol.Exp.Ther., 343, 2012
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4G5P
 | | Crystal structure of EGFR kinase T790M in complex with BIBW2992 | | 分子名称: | Epidermal growth factor receptor, N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3S)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide | | 著者 | Solca, F, Dahl, G, Zoephel, A, Bader, G, Sanderson, M, Klein, C, Kraemer, O, Himmelsbach, F, Haaksma, E, Adolf, G.R. | | 登録日 | 2012-07-18 | | 公開日 | 2012-08-29 | | 最終更新日 | 2012-10-31 | | 実験手法 | X-RAY DIFFRACTION (3.17 Å) | | 主引用文献 | Target Binding Properties and Cellular Activity of Afatinib (BIBW 2992), an Irreversible ErbB Family Blocker.
J.Pharmacol.Exp.Ther., 343, 2012
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5MR4
 | | Ligand-receptor complex. | | 分子名称: | DI(HYDROXYETHYL)ETHER, FORMIC ACID, GDNF family receptor alpha-2, ... | | 著者 | Sandmark, J, Oster, L, Aagaard, A, Roth, R.G, Dahl, G. | | 登録日 | 2016-12-21 | | 公開日 | 2018-01-17 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structure and biophysical characterization of the human full-length neurturin-GFRa2 complex: A role for heparan sulfate in signaling.
J. Biol. Chem., 293, 2018
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5MR9
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5MR5
 | | Ligand-receptor complex. | | 分子名称: | GDNF family receptor alpha-2, GLYCEROL, Neurturin, ... | | 著者 | Sandmark, J, Oster, L, Aagaard, A, Roth, R, Dahl, G. | | 登録日 | 2016-12-21 | | 公開日 | 2018-01-17 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structure and biophysical characterization of the human full-length neurturin-GFRa2 complex: A role for heparan sulfate in signaling.
J. Biol. Chem., 293, 2018
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6GY0
 | | mPI3Kd IN COMPLEX WITH AZ3 | | 分子名称: | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, ~{N}-[4-methyl-5-(1-oxidanylidene-7-sulfamoyl-isoindol-5-yl)-1,3-thiazol-2-yl]ethanamide | | 著者 | Petersen, J. | | 登録日 | 2018-06-27 | | 公開日 | 2019-02-06 | | 最終更新日 | 2019-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | A class of highly selective inhibitors bind to an active state of PI3K gamma.
Nat.Chem.Biol., 15, 2019
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6GL7
 | | Neurturin-GFRa2-RET extracellular complex | | 分子名称: | GDNF family receptor alpha-2, Neurturin, Proto-oncogene tyrosine-protein kinase receptor Ret | | 著者 | Bigalke, J.M, Aibara, S, Sandmark, J, Amunts, A. | | 登録日 | 2018-05-23 | | 公開日 | 2019-08-14 | | 最終更新日 | 2019-12-18 | | 実験手法 | ELECTRON MICROSCOPY (6.3 Å) | | 主引用文献 | Cryo-EM structure of the activated RET signaling complex reveals the importance of its cysteine-rich domain.
Sci Adv, 5, 2019
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5NMZ
 | | human Neurturin (97-197) | | 分子名称: | GLYCEROL, Neurturin | | 著者 | Bigalke, J.M, Sandmark, J, Roth, R. | | 登録日 | 2017-04-07 | | 公開日 | 2018-02-14 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structure and biophysical characterization of the human full-length neurturin-GFRa2 complex: A role for heparan sulfate in signaling.
J. Biol. Chem., 293, 2018
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