7WC7
 
 | | Crystal structure of serotonin 2A receptor in complex with lisuride | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 5-hydroxytryptamine receptor 2A,5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, CHOLESTEROL, ... | | 著者 | Cao, D, Yu, J, Wang, H, Luo, Z, Liu, X, He, L, Qi, J, Fan, L, Tang, L, Chen, Z, Li, J, Cheng, J, Wang, S. | | 登録日 | 2021-12-18 | | 公開日 | 2022-01-26 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structure-based discovery of nonhallucinogenic psychedelic analogs.
Science, 375, 2022
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7WC9
 | | Crystal structure of serotonin 2A receptor in complex with non-hallucinogenic psychedelic analog | | 分子名称: | (10~{R},15~{S})-12-[3-(2-methoxyphenyl)propyl]-4-methyl-1,4,12-triazatetracyclo[7.6.1.0^{5,16}.0^{10,15}]hexadeca-5(16),6,8-triene, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 5-hydroxytryptamine receptor 2A,5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, ... | | 著者 | Cao, D, Yu, J, Wang, H, Luo, Z, Liu, X, He, L, Qi, J, Fan, L, Tang, L, Chen, Z, Li, J, Cheng, J, Wang, S. | | 登録日 | 2021-12-18 | | 公開日 | 2022-01-26 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structure-based discovery of nonhallucinogenic psychedelic analogs.
Science, 375, 2022
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7WC4
 | | Crystal structure of serotonin 2A receptor in complex with serotonin | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 5-hydroxytryptamine receptor 2A,5-hydroxytryptamine receptor 2A,5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, CHOLESTEROL, ... | | 著者 | Cao, D, Yu, J, Wang, H, Luo, Z, Liu, X, He, L, Qi, J, Fan, L, Tang, L, Chen, Z, Li, J, Cheng, J, Wang, S. | | 登録日 | 2021-12-18 | | 公開日 | 2022-01-26 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structure-based discovery of nonhallucinogenic psychedelic analogs.
Science, 375, 2022
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7WC5
 | | Crystal structure of serotonin 2A receptor in complex with psilocin | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 3-[2-(dimethylamino)ethyl]-1~{H}-indol-4-ol, 5-hydroxytryptamine receptor 2A, ... | | 著者 | Cao, D, Yu, J, Wang, H, Luo, Z, Liu, X, He, L, Qi, J, Fan, L, Tang, L, Chen, Z, Li, J, Cheng, J, Wang, S. | | 登録日 | 2021-12-18 | | 公開日 | 2022-01-26 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structure-based discovery of nonhallucinogenic psychedelic analogs.
Science, 375, 2022
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8I9T
 | | Cryo-EM structure of a Chaetomium thermophilum pre-60S ribosomal subunit - State Dbp10-1 | | 分子名称: | 60S ribosomal protein L12-like protein, 60S ribosomal protein L13, 60S ribosomal protein L14-like protein, ... | | 著者 | Lau, B, Huang, Z, Beckmann, R, Hurt, E, Cheng, J. | | 登録日 | 2023-02-07 | | 公開日 | 2023-05-17 | | 最終更新日 | 2023-07-19 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.
Embo Rep., 24, 2023
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8IA0
 | | Cryo-EM structure of a Chaetomium thermophilum pre-60S ribosomal subunit - State Puf6 | | 分子名称: | 60S ribosomal protein L12-like protein, 60S ribosomal protein L13, 60S ribosomal protein L14-like protein, ... | | 著者 | Lau, B, Huang, Z, Beckmann, R, Hurt, E, Cheng, J. | | 登録日 | 2023-02-07 | | 公開日 | 2023-05-17 | | 最終更新日 | 2023-07-19 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.
Embo Rep., 24, 2023
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8I9Y
 | | Cryo-EM structure of a Chaetomium thermophilum pre-60S ribosomal subunit - Ytm1-2 | | 分子名称: | 60S ribosomal protein L12-like protein, 60S ribosomal protein L13, 60S ribosomal protein L14-like protein, ... | | 著者 | Lau, B, Huang, Z, Beckmann, R, Hurt, E, Cheng, J. | | 登録日 | 2023-02-07 | | 公開日 | 2023-05-17 | | 最終更新日 | 2023-07-19 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.
Embo Rep., 24, 2023
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8I9W
 | | Cryo-EM structure of a Chaetomium thermophilum pre-60S ribosomal subunit - Dbp10-3 | | 分子名称: | 60S ribosomal protein L12-like protein, 60S ribosomal protein L13, 60S ribosomal protein L14-like protein, ... | | 著者 | Lau, B, Huang, Z, Beckmann, R, Hurt, E, Cheng, J. | | 登録日 | 2023-02-07 | | 公開日 | 2023-05-17 | | 最終更新日 | 2023-07-19 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.
Embo Rep., 24, 2023
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8I9R
 | | Cryo-EM structure of a Chaetomium thermophilum pre-60S ribosomal subunit - State 5S RNP | | 分子名称: | 60S ribosomal protein L13, 60S ribosomal protein L14-like protein, 60S ribosomal protein L16-like protein, ... | | 著者 | Lau, B, Huang, Z, Beckmann, R, Hurt, E, Cheng, J. | | 登録日 | 2023-02-07 | | 公開日 | 2023-05-17 | | 最終更新日 | 2023-07-19 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.
Embo Rep., 24, 2023
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8I9Z
 | | Cryo-EM structure of a Chaetomium thermophilum pre-60S ribosomal subunit - State Spb4 | | 分子名称: | 60S ribosomal protein L12-like protein, 60S ribosomal protein L13, 60S ribosomal protein L14-like protein, ... | | 著者 | Lau, B, Huang, Z, Beckmann, R, Hurt, E, Cheng, J. | | 登録日 | 2023-02-07 | | 公開日 | 2023-05-17 | | 最終更新日 | 2023-07-19 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.
Embo Rep., 24, 2023
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8I9V
 | | Cryo-EM structure of a Chaetomium thermophilum pre-60S ribosomal subunit - State Dbp10-2 | | 分子名称: | 60S ribosomal protein L12-like protein, 60S ribosomal protein L13, 60S ribosomal protein L14-like protein, ... | | 著者 | Lau, B, Huang, Z, Beckmann, R, Hurt, E, Cheng, J. | | 登録日 | 2023-02-07 | | 公開日 | 2023-05-17 | | 最終更新日 | 2023-07-19 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.
Embo Rep., 24, 2023
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8I9P
 | | Cryo-EM structure of a Chaetomium thermophilum pre-60S ribosomal subunit - State Mak16 | | 分子名称: | 60S ribosomal protein L13, 60S ribosomal protein L14-like protein, 60S ribosomal protein L16-like protein, ... | | 著者 | Lau, B, Huang, Z, Beckmann, R, Hurt, E, Cheng, J. | | 登録日 | 2023-02-07 | | 公開日 | 2023-05-17 | | 最終更新日 | 2023-07-19 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.
Embo Rep., 24, 2023
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8I9X
 | | Cryo-EM structure of a Chaetomium thermophilum pre-60S ribosomal subunit - Ytm1-1 | | 分子名称: | 60S ribosomal protein L12-like protein, 60S ribosomal protein L13, 60S ribosomal protein L14-like protein, ... | | 著者 | Lau, B, Huang, Z, Beckmann, R, Hurt, E, Cheng, J. | | 登録日 | 2023-02-07 | | 公開日 | 2023-05-17 | | 最終更新日 | 2023-07-19 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.
Embo Rep., 24, 2023
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7VOE
 | | Crystal structure of 5-HT2AR in complex with aripiprazole | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, 7-[4-[4-[2,3-bis(chloranyl)phenyl]piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one, ... | | 著者 | Chen, Z, Fan, L, Wang, H, Yu, J, Lu, D, Qi, J, Nie, F, Luo, Z, Liu, Z, Cheng, J, Wang, S. | | 登録日 | 2021-10-13 | | 公開日 | 2021-12-22 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structure-based design of a novel third-generation antipsychotic drug lead with potential antidepressant properties.
Nat.Neurosci., 25, 2022
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7VOD
 | | Crystal structure of 5-HT2AR in complex with cariprazine | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 3-[4-[2-[4-[2,3-bis(chloranyl)phenyl]piperazin-1-yl]ethyl]cyclohexyl]-1,1-dimethyl-urea, 5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, ... | | 著者 | Chen, Z, Fan, L, Wang, H, Yu, J, Lu, D, Qi, J, Nie, F, Luo, Z, Liu, Z, Cheng, J, Wang, S. | | 登録日 | 2021-10-13 | | 公開日 | 2021-12-22 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Structure-based design of a novel third-generation antipsychotic drug lead with potential antidepressant properties.
Nat.Neurosci., 25, 2022
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7Y1A
 | | Lateral hexamer | | 分子名称: | B-phycoerythrin beta chain, LRH, PHYCOERYTHROBILIN, ... | | 著者 | You, X, Zhang, X, Cheng, J, Xiao, Y.N, Sun, S, Sui, S.F. | | 登録日 | 2022-06-07 | | 公開日 | 2023-01-18 | | 最終更新日 | 2023-04-19 | | 実験手法 | ELECTRON MICROSCOPY (6.3 Å) | | 主引用文献 | In situ structure of the red algal phycobilisome-PSII-PSI-LHC megacomplex.
Nature, 616, 2023
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7Y4L
 | | PBS of PBS-PSII-PSI-LHCs from Porphyridium purpureum. | | 分子名称: | Allophycocyanin alpha subunit, Allophycocyanin beta 18 subunit, Allophycocyanin beta subunit, ... | | 著者 | You, X, Zhang, X, Cheng, J, Xiao, Y.N, Sun, S, Sui, S.F. | | 登録日 | 2022-06-15 | | 公開日 | 2023-01-18 | | 最終更新日 | 2023-04-19 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | In situ structure of the red algal phycobilisome-PSII-PSI-LHC megacomplex.
Nature, 616, 2023
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7Y5E
 | | In situ single-PBS-PSII-PSI-LHCs megacomplex. | | 分子名称: | (1R,2S)-4-{(1E,3E,5E,7E,9E,11E,13E,15E,17E)-18-[(4S)-4-hydroxy-2,6,6-trimethylcyclohex-1-en-1-yl]-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaen-1-yl}-2,5,5-trimethylcyclohex-3-en-1-ol, (2S)-2,3-dihydroxypropyl octadecanoate, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, ... | | 著者 | You, X, Zhang, X, Cheng, J, Xiao, Y.N, Sui, S.F. | | 登録日 | 2022-06-17 | | 公開日 | 2023-02-01 | | 最終更新日 | 2023-04-26 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | In situ structure of the red algal phycobilisome-PSII-PSI-LHC megacomplex.
Nature, 616, 2023
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7Y7A
 | | In situ double-PBS-PSII-PSI-LHCs megacomplex from Porphyridium purpureum. | | 分子名称: | (1R,2S)-4-{(1E,3E,5E,7E,9E,11E,13E,15E,17E)-18-[(4S)-4-hydroxy-2,6,6-trimethylcyclohex-1-en-1-yl]-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaen-1-yl}-2,5,5-trimethylcyclohex-3-en-1-ol, (2S)-2,3-dihydroxypropyl octadecanoate, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, ... | | 著者 | You, X, Zhang, X, Cheng, J, Xiao, Y.N, Sun, S, Sui, S.F. | | 登録日 | 2022-06-22 | | 公開日 | 2023-02-08 | | 最終更新日 | 2023-04-19 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | In situ structure of the red algal phycobilisome-PSII-PSI-LHC megacomplex.
Nature, 616, 2023
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8JNL
 | | Psb34 from red algal Porphyridium purpureum. | | 分子名称: | Psb34 | | 著者 | You, X, Zhang, X, Cheng, J, Xiao, Y.N, Sun, S, Sui, S.F. | | 登録日 | 2023-06-06 | | 公開日 | 2023-08-02 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structure of lateral hexamer of PBS-PSII-PSI-LHCs megacomplex at 6.3 Angstroms resolution.
To Be Published
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8JNN
 | | linker protein LPP1 from red algal Porphyridium purpureum. | | 分子名称: | LPP1 | | 著者 | You, X, Zhang, X, Cheng, J, Xiao, Y.N, Sun, S, Sui, S.F. | | 登録日 | 2023-06-06 | | 公開日 | 2023-08-02 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structure of lateral hexamer of PBS-PSII-PSI-LHCs megacomplex at 6.3 Angstroms resolution.
To Be Published
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8JNG
 | | Methanesulfonate monooxygenase ferredoxin subunit of PBS-PSII-PSI-LHCs from Porphyridium purpureum. | | 分子名称: | FE2/S2 (INORGANIC) CLUSTER, Methanesulfonate monooxygenase ferredoxin subunit | | 著者 | You, X, Zhang, X, Cheng, J, Xiao, Y.N, Sun, S, Sui, S.F. | | 登録日 | 2023-06-06 | | 公開日 | 2023-08-02 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structure of lateral hexamer of PBS-PSII-PSI-LHCs megacomplex at 6.3 Angstroms resolution.
To Be Published
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8JNM
 | | PsbW from red algal Porphyridium purpureum. | | 分子名称: | PsbW | | 著者 | You, X, Zhang, X, Cheng, J, Xiao, Y.N, Sun, S, Sui, S.F. | | 登録日 | 2023-06-06 | | 公開日 | 2023-08-02 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structure of lateral hexamer of PBS-PSII-PSI-LHCs megacomplex at 6.3 Angstroms resolution.
To Be Published
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6BQG
 | | Crystal structure of 5-HT2C in complex with ergotamine | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 5-hydroxytryptamine receptor 2C,Soluble cytochrome b562, Ergotamine | | 著者 | Peng, Y, McCorvy, J.D, Harpsoe, K, Lansu, K, Yuan, S, Popov, P, Qu, L, Pu, M, Che, T, Nikolajse, L.F, Huang, X.P, Wu, Y, Shen, L, Bjorn-Yoshimoto, W.E, Ding, K, Wacker, D, Han, G.W, Cheng, J, Katritch, V, Jensen, A.A, Hanson, M.A, Zhao, S, Gloriam, D.E, Roth, B.L, Stevens, R.C, Liu, Z. | | 登録日 | 2017-11-27 | | 公開日 | 2018-02-14 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | 5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.
Cell, 172, 2018
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6BQH
 | | Crystal structure of 5-HT2C in complex with ritanserin | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 5-hydroxytryptamine receptor 2C,Soluble cytochrome b562, 6-(2-{4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl}ethyl)-7-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one, ... | | 著者 | Peng, Y, McCorvy, J.D, Harpsoe, K, Lansu, K, Yuan, S, Popov, P, Qu, L, Pu, M, Che, T, Nikolajse, L.F, Huang, X.P, Wu, Y, Shen, L, Bjorn-Yoshimoto, W.E, Ding, K, Wacker, D, Han, G.W, Cheng, J, Katritch, V, Jensen, A.A, Hanson, M.A, Zhao, S, Gloriam, D.E, Roth, B.L, Stevens, R.C, Liu, Z. | | 登録日 | 2017-11-27 | | 公開日 | 2018-02-14 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | 5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.
Cell, 172, 2018
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