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Crystal structure of 6-phosphogluconolactonase from Leishmania guyanensis
分子名称:	6-phosphogluconolactonase, PHOSPHATE ION
著者	Arakaki, T.L, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
登録日	2008-04-10
公開日	2008-04-22
最終更新日	2023-08-30
実験手法	X-RAY DIFFRACTION (1.7 Å)
主引用文献	Optimal description of a protein structure in terms of multiple groups undergoing TLS motion. Acta Crystallogr.,Sect.D, 62, 2006

4YWN

Crystal structure of NADH-FMN oxidoreductase from Mycobacterium avium
分子名称:	CITRATE ANION, NADH-fmn oxidoreductase
著者	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日	2015-03-20
公開日	2015-04-01
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Crystal structure of NADH-FMN oxidoreductase from Mycobacterium avium To be Published

4TZR

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1561
分子名称:	1-{4-amino-3-[2-(cyclopropyloxy)quinolin-6-yl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-2-methylpropan-2-ol, Calmodulin-domain protein kinase 1
著者	Merritt, E.A.
登録日	2014-07-10
公開日	2014-08-27
最終更新日	2023-12-27
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis. J. Med. Chem., 59, 2016

3BJE

Crystal structure of Trypanosoma brucei nucleoside phosphorylase shows uridine phosphorylase activity
分子名称:	1-O-phosphono-alpha-D-ribofuranose, CALCIUM ION, Nucleoside phosphorylase, ...
著者	Larson, E.T, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
登録日	2007-12-03
公開日	2007-12-18
最終更新日	2024-02-21
実験手法	X-RAY DIFFRACTION (1.44 Å)
主引用文献	The Crystal Structure and Activity of a Putative Trypanosomal Nucleoside Phosphorylase Reveal It to be a Homodimeric Uridine Phosphorylase J.Mol.Biol., 396, 2010

3HZR

Tryptophanyl-tRNA synthetase homolog from Entamoeba histolytica
分子名称:	Tryptophanyl-tRNA synthetase
著者	Arakaki, T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
登録日	2009-06-24
公開日	2009-07-28
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (3 Å)
主引用文献	Crystal structures of three protozoan homologs of tryptophanyl-tRNA synthetase. Mol.Biochem.Parasitol., 177, 2011

3I05

Tryptophanyl-tRNA synthetase from Trypanosoma brucei
分子名称:	Tryptophanyl-tRNA synthetase
著者	Arakaki, T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
登録日	2009-06-24
公開日	2009-07-28
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2.8 Å)
主引用文献	Crystal structures of three protozoan homologs of tryptophanyl-tRNA synthetase. Mol.Biochem.Parasitol., 177, 2011

3HV0

Tryptophanyl-tRNA synthetase from Cryptosporidium parvum
分子名称:	TRYPTOPHAN, Tryptophanyl-tRNA synthetase
著者	Arakaki, T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
登録日	2009-06-15
公開日	2009-06-30
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2.42 Å)
主引用文献	Crystal structures of three protozoan homologs of tryptophanyl-tRNA synthetase. Mol.Biochem.Parasitol., 177, 2011

3OCE

Crystal structure of fumarate lyase:delta crystallin from Brucella melitensis bound to cobalt
分子名称:	1,2-ETHANEDIOL, CHLORIDE ION, COBALT (II) ION, ...
著者	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日	2010-08-09
公開日	2010-08-18
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2.58 Å)
主引用文献	Crystal structure of fumarate lyase:delta crystallin from Brucella melitensis bound to cobalt To be Published

3OCF

Crystal structure of fumarate lyase:delta crystallin from Brucella melitensis in native form
分子名称:	1,2-ETHANEDIOL, CHLORIDE ION, Fumarate lyase:Delta crystallin
著者	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日	2010-08-09
公開日	2010-08-18
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2.1 Å)
主引用文献	Crystal structure of fumarate lyase:delta crystallin from Brucella melitensis in native form To be Published

3I7F

Aspartyl tRNA synthetase from Entamoeba histolytica
分子名称:	Aspartyl-tRNA synthetase
著者	Arakaki, T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
登録日	2009-07-08
公開日	2009-07-21
最終更新日	2024-02-21
実験手法	X-RAY DIFFRACTION (2.8 Å)
主引用文献	Crystal structure of the aspartyl-tRNA synthetase from Entamoeba histolytica. Mol.Biochem.Parasitol., 169, 2010

4JNQ

Crystal structure of a thioredoxin reductase from Brucella melitensis
分子名称:	DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, SODIUM ION, Thioredoxin reductase
著者	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日	2013-03-15
公開日	2013-04-03
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Crystal structure of a thioredoxin reductase from Brucella melitensis To be Published

7TNH

Crystal structure of CSF1R kinase domain in complex with DP-6233
分子名称:	2,2-dimethyl-N-[(6-methyl-5-{[2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl]oxy}pyridin-2-yl)carbamoyl]propanamide, CHLORIDE ION, Macrophage colony-stimulating factor 1 receptor,Fibroblast growth factor receptor 1 chimera, ...
著者	Edwards, T.E, Arakaki, T.L, Chun, L, Flynn, D.L.
登録日	2022-01-21
公開日	2022-08-24
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (2.7 Å)
主引用文献	Discovery of acyl ureas as highly selective small molecule CSF1R kinase inhibitors. Bioorg.Med.Chem.Lett., 74, 2022

3HHJ

Crystal structure of mutator mutT from Bartonella henselae
分子名称:	MAGNESIUM ION, Mutator mutT protein
著者	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日	2009-05-15
公開日	2009-05-26
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2.1 Å)
主引用文献	Structure of a Nudix hydrolase (MutT) in the Mg(2+)-bound state from Bartonella henselae, the bacterium responsible for cat scratch fever. Acta Crystallogr.,Sect.F, 67, 2011

4WG3

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1610
分子名称:	3-(7-ethoxynaphthalen-2-yl)-1-(2-methylpropyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1
著者	Merritt, E.A.
登録日	2014-09-17
公開日	2014-10-15
最終更新日	2023-12-27
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1610 to be published

4WG5

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1647
分子名称:	5-amino-3-[7-(cyclobutyloxy)quinolin-3-yl]-1-cyclohexyl-1H-pyrazole-4-carboxamide, Calmodulin-domain protein kinase 1
著者	Merritt, E.A.
登録日	2014-09-17
公開日	2014-10-15
最終更新日	2023-12-27
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1647 to be published

4WG4

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1613
分子名称:	3-(7-ethoxynaphthalen-2-yl)-1-(piperidin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1
著者	Merritt, E.A.
登録日	2014-09-17
公開日	2014-10-15
最終更新日	2023-12-27
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1613 to be published

4YJN

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1639
分子名称:	5-amino-1-tert-butyl-3-[2-(cyclobutyloxy)quinolin-6-yl]-1H-pyrazole-4-carboxamide, Calmodulin-domain protein kinase 1
著者	Merritt, E.A.
登録日	2015-03-03
公開日	2015-11-25
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (2.6 Å)
主引用文献	SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1. Acs Med.Chem.Lett., 6, 2015

4YSJ

Calcium-Dependent Protein Kinase from Eimeria tenella in complex with ADP
分子名称:	ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Calmodulin-like domain protein kinase, ...
著者	Merritt, E.A.
登録日	2015-03-17
公開日	2016-04-06
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (2.7 Å)
主引用文献	CDPK is a druggable target in the apicomplexan parasite Eimeria to be published

3I7B

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with bumped kinase inhibitor NM-PP1
分子名称:	1,2-ETHANEDIOL, 1-(1-methylethyl)-3-(naphthalen-1-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1, ...
著者	Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
登録日	2009-07-08
公開日	2010-02-09
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (1.988 Å)
主引用文献	Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors. Nat.Struct.Mol.Biol., 17, 2010

3I7C

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with bumped kinase inhibitor NA-PP2
分子名称:	1-tert-butyl-3-naphthalen-2-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1
著者	Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
登録日	2009-07-08
公開日	2010-02-09
最終更新日	2023-11-22
実験手法	X-RAY DIFFRACTION (1.98 Å)
主引用文献	Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors. Nat.Struct.Mol.Biol., 17, 2010

3I79

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1)
分子名称:	1,2-ETHANEDIOL, Calmodulin-domain protein kinase 1
著者	Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
登録日	2009-07-08
公開日	2009-08-11
最終更新日	2024-02-21
実験手法	X-RAY DIFFRACTION (2.04 Å)
主引用文献	Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors. Nat.Struct.Mol.Biol., 17, 2010

3LC0

Histidyl-tRNA synthetase from Trypanosoma cruzi (Histidine complex)
分子名称:	HISTIDINE, Histidyl-tRNA synthetase
著者	Merritt, E.A, Larson, E.T, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
登録日	2010-01-08
公開日	2010-01-19
最終更新日	2024-02-21
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Crystal Structures of Trypanosomal Histidyl-tRNA Synthetase Illuminate Differences between Eukaryotic and Prokaryotic Homologs. J.Mol.Biol., 397, 2010

4MX9

CDPK1 from Neospora caninum in complex with inhibitor UW1294
分子名称:	3-(6-ethoxynaphthalen-2-yl)-1-[(1-methylpiperidin-4-yl)methyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-like domain protein kinase isoenzyme gamma, related
著者	Merritt, E.A.
登録日	2013-09-26
公開日	2013-10-09
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (3.1 Å)
主引用文献	Neospora caninum Calcium-Dependent Protein Kinase 1 Is an Effective Drug Target for Neosporosis Therapy. Plos One, 9, 2014

4ONA

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1517
分子名称:	5-amino-1-tert-butyl-3-(7-ethoxyquinolin-3-yl)-1H-pyrazole-4-carboxamide, Calmodulin-domain protein kinase 1
著者	Merritt, E.A.
登録日	2014-01-28
公開日	2014-03-19
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (2.4 Å)
主引用文献	Potent and selective inhibitors of CDPK1 from T. gondii and C. parvum based on a 5-aminopyrazole-4-carboxamide scaffold. ACS Med Chem Lett, 5, 2014

4PJT

Structure of PARP1 catalytic domain bound to inhibitor BMN 673
分子名称:	(8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-3-one, GLYCEROL, Poly [ADP-ribose] polymerase 1, ...
著者	Aoyagi-Scharber, M, Gardberg, A.S, Arakaki, T.L.
登録日	2014-05-12
公開日	2014-09-24
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (2.35 Å)
主引用文献	Structural basis for the inhibition of poly(ADP-ribose) polymerases 1 and 2 by BMN 673, a potent inhibitor derived from dihydropyridophthalazinone. Acta Crystallogr.,Sect.F, 70, 2014

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