5HFZ
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![BU of 5hfz by Molmil](/molmil-images/mine/5hfz) | Mmi1 YTH domain | Descriptor: | YTH domain-containing protein mmi1 | Authors: | Chatterjee, D, Goldgur, Y, Shuman, S. | Deposit date: | 2016-01-07 | Release date: | 2016-02-10 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Transcription of lncRNA prt, clustered prt RNA sites for Mmi1 binding, and RNA polymerase II CTD phospho-sites govern the repression of pho1 gene expression under phosphate-replete conditions in fission yeast. Rna, 22, 2016
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5H8A
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![BU of 5h8a by Molmil](/molmil-images/mine/5h8a) | Mmi1 YTH domain | Descriptor: | YTH domain-containing protein mmi1 | Authors: | Chatterjee, D, Goldgur, Y, Shuman, S. | Deposit date: | 2015-12-23 | Release date: | 2016-01-13 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.751 Å) | Cite: | Transcription of lncRNA prt, clustered prt RNA sites for Mmi1 binding, and RNA polymerase II CTD phospho-sites govern the repression of pho1 gene expression under phosphate-replete conditions in fission yeast. Rna, 22, 2016
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6SGP
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![BU of 6sgp by Molmil](/molmil-images/mine/6sgp) | X-ray structure of human glutamate carboxypeptidase II (GCPII) - the E424M inactive mutant, in complex with a sulfamide inhibitor GluGlu | Descriptor: | (2~{S})-2-[[(2~{S})-1,5-bis(oxidanyl)-1,5-bis(oxidanylidene)pentan-2-yl]sulfamoylamino]pentanedioic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Barinka, C, Shukla, S, Motlova, L. | Deposit date: | 2019-08-05 | Release date: | 2020-08-26 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Structural, Biochemical, and Computational Characterization of Sulfamides as Bimetallic Peptidase Inhibitors. J.Chem.Inf.Model., 2024
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6VT4
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![BU of 6vt4 by Molmil](/molmil-images/mine/6vt4) | Naegleria gruberi RNA ligase R149A mutant apo | Descriptor: | RNA Ligase | Authors: | Unciuleac, M.C, Goldgur, Y, Shuman, S. | Deposit date: | 2020-02-12 | Release date: | 2020-04-08 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.16 Å) | Cite: | Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation. Nucleic Acids Res., 48, 2020
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6VTE
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![BU of 6vte by Molmil](/molmil-images/mine/6vte) | Naegleria gruberi RNA Ligase K170M mutant with AMP and Mn | Descriptor: | ADENOSINE MONOPHOSPHATE, MANGANESE (II) ION, RNA ligase | Authors: | Unciuleac, M.C, Goldgur, Y, Shuman, S. | Deposit date: | 2020-02-12 | Release date: | 2020-04-08 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation. Nucleic Acids Res., 48, 2020
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6VT8
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![BU of 6vt8 by Molmil](/molmil-images/mine/6vt8) | Naegleria gruberi RNA ligase E312A mutant with AMP and Mn | Descriptor: | ADENOSINE MONOPHOSPHATE, MANGANESE (II) ION, RNA Ligase | Authors: | Unciuleac, M.C, Goldgur, Y, Shuman, S. | Deposit date: | 2020-02-12 | Release date: | 2020-04-08 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.998 Å) | Cite: | Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation. Nucleic Acids Res., 48, 2020
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6VT3
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![BU of 6vt3 by Molmil](/molmil-images/mine/6vt3) | Naegleria gruberi RNA ligase K326A mutant apo | Descriptor: | RNA Ligase | Authors: | Unciuleac, M.C, Goldgur, Y, Shuman, S. | Deposit date: | 2020-02-12 | Release date: | 2020-04-08 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.844 Å) | Cite: | Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation. Nucleic Acids Res., 48, 2020
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6VTD
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![BU of 6vtd by Molmil](/molmil-images/mine/6vtd) | Naegleria gruberi RNA ligase R149A mutant with ATP and Mn | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, RNA Ligase | Authors: | Unciuleac, M.C, Goldgur, Y, Shuman, S. | Deposit date: | 2020-02-12 | Release date: | 2020-04-08 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation. Nucleic Acids Res., 48, 2020
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6VT5
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![BU of 6vt5 by Molmil](/molmil-images/mine/6vt5) | |
6VTF
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![BU of 6vtf by Molmil](/molmil-images/mine/6vtf) | Naegleria gruberi RNA ligase with PPi | Descriptor: | PYROPHOSPHATE 2-, RNA ligase | Authors: | Unciuleac, M.C, Goldgur, Y, Shuman, S. | Deposit date: | 2020-02-12 | Release date: | 2020-04-08 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.71 Å) | Cite: | Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation. Nucleic Acids Res., 48, 2020
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6VT6
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![BU of 6vt6 by Molmil](/molmil-images/mine/6vt6) | Naegleria gruberi RNA ligase K170A mutant with ATP and Mn | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, RNA Ligase | Authors: | Unciuleac, M.C, Goldgur, Y, Shuman, S. | Deposit date: | 2020-02-12 | Release date: | 2020-04-08 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.969 Å) | Cite: | Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation. Nucleic Acids Res., 48, 2020
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6VTG
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![BU of 6vtg by Molmil](/molmil-images/mine/6vtg) | Naegleria gruberi RNA ligase E227A mutant apo | Descriptor: | RNA ligase | Authors: | Unciuleac, M.C, Goldgur, Y, Shuman, S. | Deposit date: | 2020-02-12 | Release date: | 2020-04-08 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation. Nucleic Acids Res., 48, 2020
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6VT9
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![BU of 6vt9 by Molmil](/molmil-images/mine/6vt9) | Naegleria gruberi RNA ligase E227A mutant with ATP and Mn | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, RNA ligase | Authors: | Unciuleac, M.C, Goldgur, Y, Shuman, S. | Deposit date: | 2020-02-12 | Release date: | 2020-04-08 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation. Nucleic Acids Res., 48, 2020
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2LJ6
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![BU of 2lj6 by Molmil](/molmil-images/mine/2lj6) | |
1VS0
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![BU of 1vs0 by Molmil](/molmil-images/mine/1vs0) | Crystal Structure of the Ligase Domain from M. tuberculosis LigD at 2.4A | Descriptor: | CHLORIDE ION, MAGNESIUM ION, Putative DNA ligase-like protein Rv0938/MT0965, ... | Authors: | Akey, D, Martins, A, Aniukwu, J, Glickman, M.S, Shuman, S, Berger, J.M, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2006-01-27 | Release date: | 2006-02-28 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal Structure and Nonhomologous End-joining Function of the Ligase Component of Mycobacterium DNA Ligase D. J.Biol.Chem., 281, 2006
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4YKL
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![BU of 4ykl by Molmil](/molmil-images/mine/4ykl) | Hnt3 in complex with DNA and guanosine | Descriptor: | Aprataxin-like protein, CHLORIDE ION, DNA (5'-D(*GP*AP*AP*TP*CP*AP*TP*AP*AP*C)-3'), ... | Authors: | Jacewicz, A, Chauleau, M, Shuman, S. | Deposit date: | 2015-03-04 | Release date: | 2015-06-03 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | DNA3'pp5'G de-capping activity of aprataxin: effect of cap nucleoside analogs and structural basis for guanosine recognition. Nucleic Acids Res., 43, 2015
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2IA5
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![BU of 2ia5 by Molmil](/molmil-images/mine/2ia5) | T4 polynucleotide kinase/phosphatase with bound sulfate and magnesium. | Descriptor: | ARSENIC, MAGNESIUM ION, Polynucleotide kinase, ... | Authors: | Zhu, H, Smith, P.C, Wang, L.K, Lima, C.D, Shuman, S. | Deposit date: | 2006-09-07 | Release date: | 2007-06-05 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structure-function analysis of the 3' phosphatase component of T4 polynucleotide kinase/phosphatase. Virology, 366, 2007
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1Z3C
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![BU of 1z3c by Molmil](/molmil-images/mine/1z3c) | Encephalitozooan cuniculi mRNA Cap (Guanine-N7) Methyltransferasein complexed with AzoAdoMet | Descriptor: | S-5'-AZAMETHIONINE-5'-DEOXYADENOSINE, mRNA CAPPING ENZYME | Authors: | Hausmann, S, Zhang, S, Fabrega, C, Schneller, S.W, Lima, C.D, Shuman, S. | Deposit date: | 2005-03-11 | Release date: | 2005-03-22 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Encephalitozoon cuniculi mRNA cap (guanine N-7) methyltransferase: methyl acceptor specificity, inhibition BY S-adenosylmethionine analogs, and structure-guided mutational analysis. J.Biol.Chem., 280, 2005
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1N82
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![BU of 1n82 by Molmil](/molmil-images/mine/1n82) | The high-resolution crystal structure of IXT6, a thermophilic, intracellular xylanase from G. stearothermophilus | Descriptor: | GLYCEROL, SODIUM ION, intra-cellular xylanase | Authors: | Solomon, V, Teplitsky, A, Golan, G, Gilboa, R, Reiland, V, Shulami, S, Moryles, S, Zolotnitsky, G, Shoham, Y, Shoham, G. | Deposit date: | 2002-11-19 | Release date: | 2003-11-25 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | The high-resolution crystal structure of IXT6,
a thermophilic, intracellular xylanase from G. stearothermophilus To be Published
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8TKB
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![BU of 8tkb by Molmil](/molmil-images/mine/8tkb) | |
1RI1
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![BU of 1ri1 by Molmil](/molmil-images/mine/1ri1) | Structure and mechanism of mRNA cap (guanine N-7) methyltransferase | Descriptor: | 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, S-ADENOSYL-L-HOMOCYSTEINE, mRNA CAPPING ENZYME | Authors: | Fabrega, C, Hausmann, S, Shen, V, Shuman, S, Lima, C.D. | Deposit date: | 2003-11-16 | Release date: | 2004-02-03 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure and mechanism of mRNA cap (Guanine-n7) methyltransferase Mol.Cell, 13, 2004
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1RI5
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![BU of 1ri5 by Molmil](/molmil-images/mine/1ri5) | Structure and mechanism of mRNA cap (guanine N-7) methyltransferase | Descriptor: | mRNA CAPPING ENZYME | Authors: | Fabrega, C, Hausmann, S, Shen, V, Shuman, S, Lima, C.D, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2003-11-16 | Release date: | 2004-02-03 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure and mechanism of mRNA cap (Guanine-n7) methyltransferase Mol.Cell, 13, 2004
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1RI4
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![BU of 1ri4 by Molmil](/molmil-images/mine/1ri4) | Structure and mechanism of mRNA cap (guanine N-7) methyltransferase | Descriptor: | S-ADENOSYLMETHIONINE, mRNA CAPPING ENZYME | Authors: | Fabrega, C, Hausmann, S, Shen, V, Shuman, S, Lima, C.D. | Deposit date: | 2003-11-16 | Release date: | 2004-02-03 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure and mechanism of mRNA cap (Guanine-n7) methyltransferase Mol.Cell, 13, 2004
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1RI2
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![BU of 1ri2 by Molmil](/molmil-images/mine/1ri2) | Structure and mechanism of mRNA cap (guanine N-7) methyltransferase | Descriptor: | 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, mRNA CAPPING ENZYME | Authors: | Fabrega, C, Hausmann, S, Shen, V, Shuman, S, Lima, C.D. | Deposit date: | 2003-11-16 | Release date: | 2004-02-03 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structure and mechanism of mRNA cap (Guanine-n7) methyltransferase Mol.Cell, 13, 2004
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1J5D
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![BU of 1j5d by Molmil](/molmil-images/mine/1j5d) | SOLUTION STRUCTURE OF OXIDIZED PARAMAGNETIC CU(II) PLASTOCYANIN FROM SYNECHOCYSTIS PCC6803-MINIMIZED AVERAGE STRUCTURE | Descriptor: | COPPER (II) ION, PLASTOCYANIN | Authors: | Bertini, I, Ciurli, S, Dikiy, A, Fernandez, C.O, Luchinat, C, Safarov, N, Shumilin, S, Vila, A.J. | Deposit date: | 2002-04-02 | Release date: | 2002-04-10 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | The first solution structure of a paramagnetic copper(II) protein: the case of oxidized plastocyanin from the cyanobacterium Synechocystis PCC6803. J.Am.Chem.Soc., 123, 2001
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