7SEB
 
 | | Crystal structure of human Fibrillarin in complex with compound 2 from single soak | | Descriptor: | 6-(trifluoromethyl)pyrimidin-4-amine, FORMIC ACID, rRNA 2'-O-methyltransferase fibrillarin | | Authors: | Shi, Y, El-Deeb, I.M, Masic, V, Hartley-Tassell, L, Maggioni, A, von Itzstein, M, Ve, T. | | Deposit date: | 2021-09-30 | | Release date: | 2022-02-09 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.81 Å) | | Cite: | Discovery of Cofactor Competitive Inhibitors against the Human Methyltransferase Fibrillarin.
Pharmaceuticals, 15, 2021
|
|
7SE8
 | | Crystal structure of human Fibrillarin in complex with fragment 1 from cocktail soak | | Descriptor: | (5S)-3-methyl-7-(trifluoromethyl)pyrrolo[1,2-a]pyrazin-1(2H)-one, DIMETHYL SULFOXIDE, FORMIC ACID, ... | | Authors: | Shi, Y, El-Deeb, I.M, Masic, V, Hartley-Tassell, L, Maggioni, A, von Itzstein, M, Ve, T. | | Deposit date: | 2021-09-30 | | Release date: | 2022-02-09 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Discovery of Cofactor Competitive Inhibitors against the Human Methyltransferase Fibrillarin.
Pharmaceuticals, 15, 2021
|
|
7SE6
 | | Crystal structure of human Fibrillarin in ligand-free state | | Descriptor: | FORMIC ACID, rRNA 2'-O-methyltransferase fibrillarin | | Authors: | Shi, Y, El-Deeb, I.M, Masic, V, Hartley-Tassell, L, Maggioni, A, von Itzstein, M, Ve, T. | | Deposit date: | 2021-09-30 | | Release date: | 2022-02-09 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | Discovery of Cofactor Competitive Inhibitors against the Human Methyltransferase Fibrillarin.
Pharmaceuticals, 15, 2021
|
|
7SE9
 | | Crystal structure of human Fibrillarin in complex with compound 1 from single soak | | Descriptor: | (5S)-3-methyl-7-(trifluoromethyl)pyrrolo[1,2-a]pyrazin-1(2H)-one, DIMETHYL SULFOXIDE, FORMIC ACID, ... | | Authors: | Shi, Y, El-Deeb, I.M, Masic, V, Hartley-Tassell, L, Maggioni, A, von Itzstein, M, Ve, T. | | Deposit date: | 2021-09-30 | | Release date: | 2022-02-09 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Discovery of Cofactor Competitive Inhibitors against the Human Methyltransferase Fibrillarin.
Pharmaceuticals, 15, 2021
|
|
3O9K
 | | Influenza NA in complex with compound 6 | | Descriptor: | 5-acetamido-2,6-anhydro-3,5-dideoxy-3-[(2E)-3-(4-methylphenyl)prop-2-en-1-yl]-D-glycero-D-galacto-non-2-enonic acid, Neuraminidase | | Authors: | Russell, R.J, Kerry, P.S. | | Deposit date: | 2010-08-04 | | Release date: | 2010-12-15 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.4945 Å) | | Cite: | Novel sialic acid derivatives lock open the 150-loop of an influenza A virus group-1 sialidase.
Nat Commun, 1, 2010
|
|
3O9J
 | | Influenza NA in complex with compound 5 | | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose, 5-acetamido-2,6-anhydro-3,5-dideoxy-3-prop-2-en-1-yl-D-glycero-D-galacto-non-2-enonic acid, CALCIUM ION, ... | | Authors: | Russell, R.J, Kerry, P.S. | | Deposit date: | 2010-08-04 | | Release date: | 2010-12-15 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.0002 Å) | | Cite: | Novel sialic acid derivatives lock open the 150-loop of an influenza A virus group-1 sialidase.
Nat Commun, 1, 2010
|
|
8F73
 | |
3SIT
 | |
3SIS
 | |
2I2S
 | | Crystal Structure of the porcine CRW-8 rotavirus VP8* carbohydrate-recognising domain | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-O-methyl-5-N-acetyl-alpha-D-neuraminic acid, GLYCEROL, ... | | Authors: | Blanchard, H. | | Deposit date: | 2006-08-16 | | Release date: | 2007-04-03 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Insight into Host Cell Carbohydrate-recognition by Human and Porcine Rotavirus from Crystal Structures of the Virion Spike Associated Carbohydrate-binding Domain (VP8*)
J.Mol.Biol., 367, 2007
|
|
3I27
 | | Structure of bovine torovirus Hemagglutinin-Esterase in complex with receptor | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin-esterase, ... | | Authors: | Zeng, Q.H, Huizinga, E.G. | | Deposit date: | 2009-06-29 | | Release date: | 2009-09-15 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural basis for ligand and substrate recognition by torovirus hemagglutinin esterases
Proc.Natl.Acad.Sci.USA, 106, 2009
|
|
3I26
 | | Structure of bovine torovirus Hemagglutinin-Esterase | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin-esterase, ... | | Authors: | Zeng, Q.H, Huizinga, E.G. | | Deposit date: | 2009-06-29 | | Release date: | 2009-09-15 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural basis for ligand and substrate recognition by torovirus hemagglutinin esterases
Proc.Natl.Acad.Sci.USA, 106, 2009
|
|
3I1L
 | |
3I1K
 | | Structure of porcine torovirus Hemagglutinin-Esterase | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETIC ACID, Hemagglutinin-esterase protein | | Authors: | Zeng, Q.H, Huizinga, E.G. | | Deposit date: | 2009-06-26 | | Release date: | 2009-09-15 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural basis for ligand and substrate recognition by torovirus hemagglutinin esterases
Proc.Natl.Acad.Sci.USA, 106, 2009
|
|
2P3I
 | | Crystal structure of Rhesus Rotavirus VP8* at 295K | | Descriptor: | 2-O-methyl-5-N-acetyl-alpha-D-neuraminic acid, SULFATE ION, VP4 | | Authors: | Blanchard, H. | | Deposit date: | 2007-03-09 | | Release date: | 2008-03-11 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Effects on sialic acid recognition of amino acid mutations in the carbohydrate-binding cleft of the rotavirus spike protein
Glycobiology, 19, 2009
|
|
2P3K
 | | Crystal structure of Rhesus rotavirus VP8* at 100K | | Descriptor: | 2-O-methyl-5-N-acetyl-alpha-D-neuraminic acid, GLYCEROL, SULFATE ION, ... | | Authors: | Blanchard, H. | | Deposit date: | 2007-03-09 | | Release date: | 2008-03-11 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.56 Å) | | Cite: | Effects on sialic acid recognition of amino acid mutations in the carbohydrate-binding cleft of the rotavirus spike protein
Glycobiology, 19, 2009
|
|
2P3J
 | |
1NNC
 | |
5BWI
 | |
4D8S
 | | Influenza NA in complex with antiviral compound | | Descriptor: | CALCIUM ION, Neuraminidase, pentan-3-yl 2-acetamido-2,4-dideoxy-alpha-L-threo-hex-4-enopyranosiduronic acid | | Authors: | Kerry, P.S, Russell, R.J.M.R. | | Deposit date: | 2012-01-11 | | Release date: | 2013-02-13 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.398 Å) | | Cite: | Exploring the interactions of unsaturated glucuronides with influenza virus sialidase.
J.Med.Chem., 55, 2012
|
|
5CAZ
 | | Crystallographic structure of apo human rotavirus K8 VP8* | | Descriptor: | GLYCEROL, ISOPROPYL ALCOHOL, Outer capsid protein VP4, ... | | Authors: | Yu, X, Blanchard, H. | | Deposit date: | 2015-06-30 | | Release date: | 2016-06-08 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Substantial Receptor-induced Structural Rearrangement of Rotavirus VP8*: Potential Implications for Cross-Species Infection.
Chembiochem, 16, 2015
|
|
5CB7
 | |
5CA6
 | |
7XVR
 | |
7XVV
 | |
