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4E5K
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BU of 4e5k by Molmil
Thermostable phosphite dehydrogenase in complex with NAD and sulfite
Descriptor: NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Phosphite dehydrogenase (thermostable variant), SULFITE ION
Authors:Zou, Y, Zhang, H, Nair, S.K.
Deposit date:2012-03-14
Release date:2012-05-30
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structures of phosphite dehydrogenase provide insights into nicotinamide cofactor regeneration.
Biochemistry, 51, 2012
4YAR
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BU of 4yar by Molmil
2-Hydroxyethylphosphonate dioxygenase (HEPD) E176H
Descriptor: 2-hydroxyethylphosphonate dioxygenase, ACETATE ION, CADMIUM ION, ...
Authors:Chekan, J.R, Nair, S.K.
Deposit date:2015-02-17
Release date:2015-03-04
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:A Common Late-Stage Intermediate in Catalysis by 2-Hydroxyethyl-phosphonate Dioxygenase and Methylphosphonate Synthase.
J.Am.Chem.Soc., 137, 2015
4ZOQ
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BU of 4zoq by Molmil
Crystal Structure of a Lanthipeptide Protease
Descriptor: Intracellular serine protease
Authors:Dong, S.H, Nair, S.K.
Deposit date:2015-05-06
Release date:2016-03-23
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Applications of the class II lanthipeptide protease LicP for sequence-specific, traceless peptide bond cleavage.
Chem Sci, 6, 2015
4QED
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BU of 4qed by Molmil
ElxO Y152F with NADPH Bound
Descriptor: ElxO, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFATE ION
Authors:Garg, N, Nair, S.K.
Deposit date:2014-05-15
Release date:2014-07-02
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Substrate Specificity of the Lanthipeptide Peptidase ElxP and the Oxidoreductase ElxO.
Acs Chem.Biol., 9, 2014
5WA3
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BU of 5wa3 by Molmil
Pyridine synthase, TbtD, from thiomuracin biosynthesis
Descriptor: Pyridine synthase TbtD
Authors:Cogan, D.P, Nair, S.K.
Deposit date:2017-06-24
Release date:2017-11-22
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural insights into enzymatic [4+2] aza-cycloaddition in thiopeptide antibiotic biosynthesis.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
6M7Y
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BU of 6m7y by Molmil
Dehydratase, NisB, bound to a non-eliminable substrate analog
Descriptor: Lantibiotic, Nisin biosynthesis protein NisB
Authors:Cogan, D.P, Nair, S.K.
Deposit date:2018-08-21
Release date:2019-08-14
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.794 Å)
Cite:Characterization of glutamyl-tRNA-dependent dehydratases using nonreactive substrate mimics.
Proc.Natl.Acad.Sci.USA, 116, 2019
8HI8
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BU of 8hi8 by Molmil
Crystal structure of a holoenzyme TglHI with three Fe ions for Pseudomonas syringae Peptidyl (S) 2-mercaptoglycine biosynthesis
Descriptor: DUF692 family protein, FE (III) ION, RiPP Recognition Protein
Authors:Cheng, W, Zheng, Y.H, Fu, X.L.
Deposit date:2022-11-18
Release date:2023-08-23
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.49 Å)
Cite:Structures of the holoenzyme TglHI required for 3-thiaglutamate biosynthesis.
Structure, 31, 2023
8HCI
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BU of 8hci by Molmil
Crystal structure of a holoenzyme Fe-free TglHI for Pseudomonas syringae Peptidyl (S) 2-mercaptoglycine biosynthesis
Descriptor: DUF692 family protein, RiPP Recognition protein
Authors:Cheng, W, Zheng, Y.H, Fu, X.L.
Deposit date:2022-11-01
Release date:2023-08-23
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.399 Å)
Cite:Structures of the holoenzyme TglHI required for 3-thiaglutamate biosynthesis.
Structure, 31, 2023
8HI7
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BU of 8hi7 by Molmil
Crystal structure of a holoenzyme TglHI with two Fe irons for Pseudomonas syringae Peptidyl (S) 2-mercaptoglycine biosynthesis
Descriptor: DUF692 family protein, FE (III) ION, RiPP Recognition protein
Authors:Cheng, W, Zheng, Y.H, Fu, X.L.
Deposit date:2022-11-18
Release date:2023-08-23
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Structures of the holoenzyme TglHI required for 3-thiaglutamate biosynthesis.
Structure, 31, 2023
6MPZ
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BU of 6mpz by Molmil
Crystal structure of a double glycine motif protease from AMS/PCAT transporter in complex with the leader peptide
Descriptor: 3,6,9,12,15,18-HEXAOXAICOSANE, Double Glycine Motif Protease domain from AMS/PCAT Transporter, peptide aldehyde inhibitor 1 based on the ProcA2.8 leader peptide
Authors:Dong, S.-H, Nair, S.K.
Deposit date:2018-10-09
Release date:2019-02-06
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Insights into AMS/PCAT transporters from biochemical and structural characterization of a double Glycine motif protease.
Elife, 8, 2019
7MSK
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BU of 7msk by Molmil
ThuS glycosin S-glycosyltransferase
Descriptor: Glyco_trans_2-like domain-containing protein, MAGNESIUM ION, URIDINE-5'-DIPHOSPHATE-2-DEOXY-2-FLUORO-ALPHA-D-GLUCOSE
Authors:Garg, N, Nair, S.K.
Deposit date:2021-05-11
Release date:2022-04-13
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Structural and mechanistic investigations of protein S-glycosyltransferases.
Cell Chem Biol, 28, 2021
7MSN
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BU of 7msn by Molmil
SunS glycosin S-glycosyltransferase
Descriptor: SPbeta prophage-derived glycosyltransferase SunS, URIDINE-5'-DIPHOSPHATE-GLUCOSE
Authors:Garg, N, Nair, S.K.
Deposit date:2021-05-11
Release date:2022-04-13
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural and mechanistic investigations of protein S-glycosyltransferases.
Cell Chem Biol, 28, 2021
7MSP
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BU of 7msp by Molmil
SunS glycosin S-glycosyltransferase
Descriptor: MAGNESIUM ION, SPbeta prophage-derived glycosyltransferase SunS, URIDINE-5'-DIPHOSPHATE-GLUCOSE
Authors:Garg, N, Nair, S.K.
Deposit date:2021-05-11
Release date:2022-04-13
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and mechanistic investigations of protein S-glycosyltransferases.
Cell Chem Biol, 28, 2021
7RTY
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BU of 7rty by Molmil
Crystal Structure of PsfC from Pseudomonas syringae PB-5123
Descriptor: FE (II) ION, PsfC
Authors:Ongpipattanakul, C, Nair, S.K.
Deposit date:2021-08-16
Release date:2021-09-15
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.963 Å)
Cite:Biosynthesis of fosfomycin in pseudomonads reveals an unexpected enzymatic activity in the metallohydrolase superfamily.
Proc.Natl.Acad.Sci.USA, 118, 2021
6WQ1
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BU of 6wq1 by Molmil
Eukaryotic LanCL2 protein
Descriptor: LanC-like protein 2, ZINC ION
Authors:Nair, S.K, Garg, N.
Deposit date:2020-04-28
Release date:2021-05-05
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.295 Å)
Cite:LanCLs add glutathione to dehydroamino acids generated at phosphorylated sites in the proteome.
Cell, 184, 2021
8CWX
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BU of 8cwx by Molmil
NMR structure of a Stapled Lanthipeptide Natural Product
Descriptor: Lanthipeptide Natural Product mSmoAc
Authors:Pei, Z, Zhu, L, Nair, S.K.
Deposit date:2022-05-19
Release date:2022-10-12
Last modified:2024-07-10
Method:SOLUTION NMR
Cite:Class V Lanthipeptide Cyclase Directs the Biosynthesis of a Stapled Peptide Natural Product.
J.Am.Chem.Soc., 144, 2022
8CZK
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BU of 8czk by Molmil
Human LanCL1 bound to GSH and Dhb-Erk peptide
Descriptor: Deb-Erk peptide, GLUTATHIONE, Glutathione S-transferase LANCL1, ...
Authors:Ongpipattanakul, C, Nair, S.K.
Deposit date:2022-05-24
Release date:2023-01-25
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:The mechanism of thia-Michael addition catalyzed by LanC enzymes.
Proc.Natl.Acad.Sci.USA, 120, 2023
8CZL
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BU of 8czl by Molmil
Human LanCL1 bound to methyl glutathione (MeGSH)
Descriptor: Glutathione S-transferase LANCL1, L-GAMMA-GLUTAMYL-S-METHYLCYSTEINYLGLYCINE, ZINC ION
Authors:Ongpipattanakul, C, Nair, S.K.
Deposit date:2022-05-24
Release date:2023-01-25
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:The mechanism of thia-Michael addition catalyzed by LanC enzymes.
Proc.Natl.Acad.Sci.USA, 120, 2023
8D19
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BU of 8d19 by Molmil
Human LanCL1 bound to GSH
Descriptor: GLUTATHIONE, Glutathione S-transferase LANCL1, ZINC ION
Authors:Ongpipattanakul, C, Nair, S.K.
Deposit date:2022-05-26
Release date:2023-01-25
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:The mechanism of thia-Michael addition catalyzed by LanC enzymes.
Proc.Natl.Acad.Sci.USA, 120, 2023
6B9T
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BU of 6b9t by Molmil
Crystal structure of MPnS with substrate 2-hydroxyethylphosphonate (2-HEP) and Fe(II) bound
Descriptor: (2-hydroxyethyl)phosphonic acid, FE (III) ION, FORMIC ACID, ...
Authors:Born, D.A, Drennan, C.L.
Deposit date:2017-10-11
Release date:2017-12-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural basis for methylphosphonate biosynthesis.
Science, 358, 2017
6B9S
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BU of 6b9s by Molmil
MPnS crystallized in the absence of substrate
Descriptor: FE (III) ION, Methylphosphonate synthase
Authors:Born, D.A, Drennan, C.L.
Deposit date:2017-10-11
Release date:2017-12-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.373 Å)
Cite:Structural basis for methylphosphonate biosynthesis.
Science, 358, 2017
6B9R
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BU of 6b9r by Molmil
Streptomyces albus HEPD with substrate 2-hydroxyethylphosphonate (2-HEP) and Fe(II) bound
Descriptor: (2-hydroxyethyl)phosphonic acid, FE (III) ION, GLYCEROL, ...
Authors:Born, D.A, Drennan, C.L.
Deposit date:2017-10-11
Release date:2017-12-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.802 Å)
Cite:Structural basis for methylphosphonate biosynthesis.
Science, 358, 2017
6C0Y
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BU of 6c0y by Molmil
Lysinoalanine synthase, DurN, from duramycin biosynthesis bound to duramycin
Descriptor: CYS-LYS-GLN-DAL-CYS-ALA-PHE-GLY-PRO-PHE-DBB-PHE-VAL-CYS-BH2-GLY-ASN-DBB-LYS, Lysinoalanine synthase, POTASSIUM ION
Authors:Cogan, D.P, Nair, S.K.
Deposit date:2018-01-03
Release date:2018-09-05
Last modified:2024-07-10
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Substrate-assisted enzymatic formation of lysinoalanine in duramycin.
Nat. Chem. Biol., 14, 2018
6C0G
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BU of 6c0g by Molmil
Lysinoalanine synthase, DurN, from duramycin biosynthesis
Descriptor: Lysinoalanine synthase, POTASSIUM ION
Authors:Cogan, D.P, Nair, S.K.
Deposit date:2017-12-31
Release date:2018-09-05
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.145 Å)
Cite:Substrate-assisted enzymatic formation of lysinoalanine in duramycin.
Nat. Chem. Biol., 14, 2018
6C0H
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BU of 6c0h by Molmil
Lysinoalanine synthase, DurN, from duramycin biosynthesis bound to 1-Dha6Ala
Descriptor: GLN-DAL-CYS-ALA-PHE-GLY-PRO-PHE-DBB-PHE-VAL-CYS-BH2-GLY, Lysinoalanine synthase, POTASSIUM ION
Authors:Cogan, D.P, Nair, S.K.
Deposit date:2017-12-31
Release date:2018-09-05
Last modified:2024-07-10
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Substrate-assisted enzymatic formation of lysinoalanine in duramycin.
Nat. Chem. Biol., 14, 2018

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