4NJV
| Crystal structure of multidrug-resistant clinical isolate A02 HIV-1 protease in complex with ritonavir | Descriptor: | Protease, RITONAVIR | Authors: | Yedidi, R.S, Garimella, H, Chang, S.B, Kaufman, J.D, Das, D, Wingfield, P.T, Mitsuya, H. | Deposit date: | 2013-11-11 | Release date: | 2014-04-02 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | A Conserved Hydrogen-Bonding Network of P2 bis-Tetrahydrofuran-Containing HIV-1 Protease Inhibitors (PIs) with a Protease Active-Site Amino Acid Backbone Aids in Their Activity against PI-Resistant HIV. Antimicrob.Agents Chemother., 58, 2014
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4NJT
| Crystal structure of multidrug-resistant clinical isolate A02 HIV-1 protease in complex with darunavir | Descriptor: | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, Protease | Authors: | Yedidi, R.S, Garimella, H, Chang, S.B, Kaufman, J.D, Das, D, Wingfield, P.T, Ghosh, A.K, Mitsuya, H. | Deposit date: | 2013-11-11 | Release date: | 2014-04-02 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | A Conserved Hydrogen-Bonding Network of P2 bis-Tetrahydrofuran-Containing HIV-1 Protease Inhibitors (PIs) with a Protease Active-Site Amino Acid Backbone Aids in Their Activity against PI-Resistant HIV. Antimicrob.Agents Chemother., 58, 2014
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1QBZ
| THE CRYSTAL STRUCTURE OF THE SIV GP41 ECTODOMAIN AT 1.47 A | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, CHLORIDE ION, MERCURY (II) ION, ... | Authors: | Yang, Z.-N, Mueser, T.C, Kaufman, J, Stahl, S.J, Wingfield, P.T, Hyde, C.C. | Deposit date: | 1999-04-28 | Release date: | 1999-05-17 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | The crystal structure of the SIV gp41 ectodomain at 1.47 A resolution. J.Struct.Biol., 126, 1999
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1EY1
| SOLUTION STRUCTURE OF ESCHERICHIA COLI NUSB | Descriptor: | ANTITERMINATION FACTOR NUSB | Authors: | Altieri, A.S, Mazzulla, M.J, Horita, D.A, Coats, R.H, Wingfield, P.T, Byrd, R.A. | Deposit date: | 2000-05-05 | Release date: | 2000-06-14 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | The structure of the transcriptional antiterminator NusB from Escherichia coli. Nat.Struct.Biol., 7, 2000
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6I1B
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7I1B
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4TRX
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3TRX
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2JR0
| Solution structure of NusB from Aquifex Aeolicus | Descriptor: | N utilization substance protein B homolog | Authors: | Das, R, Loss, S, Li, J, Tarasov, S, Wingfield, P, Waugh, D.S, Byrd, R.A, Altieri, A.S. | Deposit date: | 2007-06-18 | Release date: | 2008-02-19 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | Structural biophysics of the NusB:NusE antitermination complex. J.Mol.Biol., 376, 2008
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8VJN
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8VJO
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2EZQ
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2EZP
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2EZS
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2EZO
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2EZR
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7U0F
| HIV-1 Rev in complex with tubulin | Descriptor: | Protein Rev, Tubulin alpha-1A chain, Tubulin beta chain | Authors: | Eren, E. | Deposit date: | 2022-02-18 | Release date: | 2023-08-23 | Last modified: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (3.53 Å) | Cite: | Structural basis of microtubule depolymerization by the kinesin-like activity of HIV-1 Rev. Structure, 31, 2023
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5V4Y
| X-ray crystal structure of wild type HIV-1 protease in complex with GRL-09510 | Descriptor: | (3S,3aR,5R,7aS,8S)-hexahydro-4H-3,5-methanofuro[2,3-b]pyran-8-yl [(2S,3R)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}-1-phenylbutan-2-yl]carbamate, Protease | Authors: | Yedidi, R.S, Delino, N.S, Das, D, Kaufman, J.D, Wingfield, P.T, Ghosh, A.K, Mitsuya, H. | Deposit date: | 2017-03-11 | Release date: | 2017-09-13 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | GRL-09510, a Unique P2-Crown-Tetrahydrofuranylurethane -Containing HIV-1 Protease Inhibitor, Maintains Its Favorable Antiviral Activity against Highly-Drug-Resistant HIV-1 Variants in vitro. Sci Rep, 7, 2017
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1QA5
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1QA4
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1QCE
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2NVH
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7M18
| HeLa-tubulin in complex with cryptophycin 1 | Descriptor: | Cryptophycin 1, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Eren, E. | Deposit date: | 2021-03-12 | Release date: | 2021-09-08 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.38 Å) | Cite: | Conformational changes in tubulin upon binding cryptophycin-52 reveal its mechanism of action. J.Biol.Chem., 297, 2021
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7M20
| 18-mer HeLa-tubulin rings in complex with Cryptophycin 1 | Descriptor: | Cryptophycin 1, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Eren, E. | Deposit date: | 2021-03-15 | Release date: | 2021-09-08 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.84 Å) | Cite: | Conformational changes in tubulin upon binding cryptophycin-52 reveal its mechanism of action. J.Biol.Chem., 297, 2021
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7LXB
| HeLa-tubulin in complex with cryptophycin 52 | Descriptor: | Cryptophycin 52, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Eren, E. | Deposit date: | 2021-03-03 | Release date: | 2021-09-08 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.26 Å) | Cite: | Conformational changes in tubulin upon binding cryptophycin-52 reveal its mechanism of action. J.Biol.Chem., 297, 2021
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