6XH3
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7REX
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3Q50
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1R5T
| The Crystal Structure of Cytidine Deaminase CDD1, an Orphan C to U editase from Yeast | Descriptor: | Cytidine deaminase, ZINC ION | Authors: | Xie, K, Sowden, M.P, Dance, G.S.C, Torelli, A.T, Smith, H.C, Wedekind, J.E. | Deposit date: | 2003-10-13 | Release date: | 2004-05-25 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The structure of a yeast RNA-editing deaminase provides insight into the fold and function of activation-induced deaminase and APOBEC-1. Proc.Natl.Acad.Sci.Usa, 101, 2004
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7LHX
| Human U1A protein with F37M and F77M mutations for improved phasing | Descriptor: | ACETATE ION, BETA-MERCAPTOETHANOL, SODIUM ION, ... | Authors: | Jenkins, J.L, Lippa, G.M, Wedekind, J.E. | Deposit date: | 2021-01-26 | Release date: | 2021-03-17 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Affinity and Structural Analysis of the U1A RNA Recognition Motif with Engineered Methionines to Improve Experimental Phasing Crystals, 11, 2021
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6CMN
| Co-Crystal Structure of HIV-1 TAR Bound to Lab-Evolved RRM TBP6.7 | Descriptor: | TAR-Binding Protein 6.7, Trans-Activation Response RNA Element | Authors: | Belashov, I.A, Wedekind, J.E. | Deposit date: | 2018-03-05 | Release date: | 2018-06-06 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.796 Å) | Cite: | Structure of HIV TAR in complex with a Lab-Evolved RRM provides insight into duplex RNA recognition and synthesis of a constrained peptide that impairs transcription. Nucleic Acids Res., 46, 2018
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2P7F
| The Novel Use of a 2',5'-Phosphodiester Linkage as a Reaction Intermediate at the Active Site of a Small Ribozyme | Descriptor: | COBALT HEXAMMINE(III), Loop A ribozyme strand, Loop B S-turn strand, ... | Authors: | Torelli, A.T, Krucinska, J, Wedekind, J.E. | Deposit date: | 2007-03-20 | Release date: | 2007-05-22 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | A comparison of vanadate to a 2'-5' linkage at the active site of a small ribozyme suggests a role for water in transition-state stabilization Rna, 13, 2007
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2P7E
| Vanadate at the Active Site of a Small Ribozyme Suggests a Role for Water in Transition-State Stabilization | Descriptor: | 3' substrate strand, octameric fragment, 5' substrate strand, ... | Authors: | Torelli, A.T, Krucinska, J, Wedekind, J.E. | Deposit date: | 2007-03-20 | Release date: | 2007-05-22 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | A comparison of vanadate to a 2'-5' linkage at the active site of a small ribozyme suggests a role for water in transition-state stabilization Rna, 13, 2007
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2P7D
| A Minimal, 'Hinged' Hairpin Ribozyme Construct Solved with Mimics of the Product Strands at 2.25 Angstroms Resolution | Descriptor: | 3' substrate strand, octameric fragment, 5' substrate strand, ... | Authors: | Torelli, A.T, Krucinska, J, Wedekind, J.E. | Deposit date: | 2007-03-20 | Release date: | 2007-05-22 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | A comparison of vanadate to a 2'-5' linkage at the active site of a small ribozyme suggests a role for water in transition-state stabilization Rna, 13, 2007
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2FGP
| Crystal structure of a minimal, all RNA hairpin ribozyme with modifications (g8dap, u39c) at ph 8.6 | Descriptor: | 5'-R(*CP*GP*GP*UP*GP*AP*(N6G)P*AP*AP*GP*GP*G)-3', 5'-R(*GP*GP*CP*AP*GP*AP*GP*AP*AP*AP*CP*AP*CP*AP*CP*GP*A)-3', 5'-R(*UP*CP*CP*CP*AP*GP*UP*CP*CP*AP*CP*CP*G)-3', ... | Authors: | Salter, J.D, Wedekind, J.E. | Deposit date: | 2005-12-22 | Release date: | 2006-02-14 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Water in the Active Site of an All-RNA Hairpin Ribozyme and Effects of Gua8 Base Variants on the Geometry of Phosphoryl Transfer. Biochemistry, 45, 2006
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1U7H
| Structure and a Proposed Mechanism for Ornithine Cyclodeaminase from Pseudomonas putida | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SODIUM ION, ... | Authors: | Alam, S, Goodman, J.L, Wang, S, Ruzicka, F.J, Frey, P.A, Wedekind, J.E. | Deposit date: | 2004-08-03 | Release date: | 2004-11-09 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Ornithine Cyclodeaminase: Structure, Mechanism of Action, and Implications for
the u-Crystallin Family; Biochemistry, 43, 2004
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1T2Q
| The Crystal Structure of an NNA7 Fab that recognizes an N-type blood group antigen | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Fab NNA7 Heavy Chain, Fab NNA7 Light Chain, ... | Authors: | Xie, K, Song, S.C, Spitalnik, S.L, Wedekind, J.E. | Deposit date: | 2004-04-22 | Release date: | 2005-06-07 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Crystal Structure and Mutational Analysis of an Antibody that Recognizes an N-type Blood Group Antigen To be Published
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1ONE
| YEAST ENOLASE COMPLEXED WITH AN EQUILIBRIUM MIXTURE OF 2'-PHOSPHOGLYCEATE AND PHOSPHOENOLPYRUVATE | Descriptor: | 2-PHOSPHOGLYCERIC ACID, ENOLASE, MAGNESIUM ION, ... | Authors: | Larsen, T.M, Wedekind, J.E, Rayment, I, Reed, G.H. | Deposit date: | 1995-12-05 | Release date: | 1997-01-11 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | A carboxylate oxygen of the substrate bridges the magnesium ions at the active site of enolase: structure of the yeast enzyme complexed with the equilibrium mixture of 2-phosphoglycerate and phosphoenolpyruvate at 1.8 A resolution. Biochemistry, 35, 1996
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3CQS
| A 3'-OH, 2',5'-phosphodiester substitution in the hairpin ribozyme active site reveals similarities with protein ribonucleases | Descriptor: | 13-mer substrate strand with 3'-OH, 2',5'-phosphodiester covalently linking 5th and 6th nucleotides, 19-mer ribozyme strand, ... | Authors: | Torelli, A.T, Spitale, R.C, Krucinska, J, Wedekind, J.E. | Deposit date: | 2008-04-03 | Release date: | 2008-05-20 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Shared traits on the reaction coordinates of ribonuclease and an RNA enzyme Biochem.Biophys.Res.Commun., 371, 2008
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3CR1
| crystal structure of a minimal, mutant, all-RNA hairpin ribozyme (A38C, A-1OMA) grown from MgCl2 | Descriptor: | MAGNESIUM ION, RNA (5'-R(*UP*CP*CP*CP*(A2M)P*GP*UP*CP*CP*AP*CP*CP*G)-3'), RNA (5'-R(*UP*CP*GP*UP*GP*GP*UP*CP*CP*AP*UP*UP*AP*CP*CP*UP*GP*CP*C)-3'), ... | Authors: | Salter, J.D, Wedekind, J.E. | Deposit date: | 2008-04-04 | Release date: | 2008-08-26 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structural effects of nucleobase variations at key active site residue Ade38 in the hairpin ribozyme. Rna, 14, 2008
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4JF2
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2D03
| Crystal structure of the G91S mutant of the NNA7 Fab | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | Authors: | Xie, K, Song, S.C, Spitalnik, S.L, Wedekind, J.E. | Deposit date: | 2005-07-23 | Release date: | 2006-01-24 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Crystallographic analysis of the NNA7 Fab and proposal for the mode of human blood-group recognition. Acta Crystallogr.,Sect.D, 61, 2005
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2D2L
| Crystal Structure of a minimal, all-RNA hairpin ribozyme with a propyl linker (C3) at position U39 | Descriptor: | 5'-R(*CP*GP*GP*UP*GP*AP*GP*AP*AP*GP*GP*G)-3', 5'-R(*GP*GP*CP*AP*GP*AP*GP*AP*AP*AP*CP*AP*CP*AP*CP*GP*A)-3', 5'-R(*UP*CP*CP*CP*(A2M)P*GP*UP*CP*CP*AP*CP*CP*G)-3', ... | Authors: | Alam, S, Grum-Tokars, V, Krucinska, J, Kundracik, M.L, Wedekind, J.E. | Deposit date: | 2005-09-11 | Release date: | 2005-11-01 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Conformational heterogeneity at position U37 of an all-RNA hairpin ribozyme with implications for metal binding and the catalytic structure of the S-turn Biochemistry, 44, 2005
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2BCY
| Crystal Structure of a minimal, mutant all-RNA hairpin ribozyme (U39C, G8MTU) | Descriptor: | 5'-R(*CP*GP*GP*UP*GP*AP*(MTU)P*AP*AP*GP*GP*G)-3', 5'-R(*GP*GP*CP*AP*GP*AP*GP*AP*AP*AP*CP*AP*CP*AP*CP*GP*A)-3', 5'-R(*UP*CP*CP*CP*AP*GP*UP*CP*CP*AP*CP*CP*G)-3', ... | Authors: | Salter, J.D, Wedekind, J.E. | Deposit date: | 2005-10-19 | Release date: | 2006-02-14 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Water in the Active Site of an All-RNA Hairpin Ribozyme and Effects of Gua8 Base Variants on the Geometry of Phosphoryl Transfer. Biochemistry, 45, 2006
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2BCZ
| Crystal Structure of a minimal, mutant all-RNA hairpin ribozyme (U39C, G8I, 2'deoxy A-1) | Descriptor: | 5'-R(*CP*GP*GP*UP*GP*AP*IP*AP*AP*GP*GP*G)-3', 5'-R(*GP*GP*CP*AP*GP*AP*GP*AP*AP*AP*CP*AP*CP*AP*CP*GP*A)-3', 5'-R(*UP*CP*CP*CP*(DA)P*GP*UP*CP*CP*AP*CP*CP*G)-3'), ... | Authors: | Salter, J.D, Wedekind, J.E. | Deposit date: | 2005-10-19 | Release date: | 2006-02-14 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Water in the Active Site of an All-RNA Hairpin Ribozyme and Effects of Gua8 Base Variants on the Geometry of Phosphoryl Transfer. Biochemistry, 45, 2006
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2D2K
| Crystal Structure of a minimal, native (U39) all-RNA hairpin ribozyme | Descriptor: | 5'-R(*CP*GP*GP*UP*GP*AP*GP*AP*AP*GP*GP*G)-3', 5'-R(*GP*GP*CP*AP*GP*AP*GP*AP*AP*AP*CP*AP*CP*AP*CP*GP*A)-3', 5'-R(*UP*CP*CP*CP*(A2M)P*GP*UP*CP*CP*AP*CP*CP*G)-3', ... | Authors: | Alam, S, Grum-Tokars, V, Krucinska, J, Kundracik, M.L, Wedekind, J.E. | Deposit date: | 2005-09-11 | Release date: | 2005-11-01 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Conformational heterogeneity at position U37 of an all-RNA hairpin ribozyme with implications for metal binding and the catalytic structure of the S-turn Biochemistry, 44, 2005
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6XH2
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1X9C
| An all-RNA Hairpin Ribozyme with mutation U39C | Descriptor: | 5'-R(*CP*GP*GP*UP*GP*AP*GP*AP*AP*GP*GP*G)-3', 5'-R(*GP*GP*CP*AP*GP*AP*GP*AP*AP*AP*CP*AP*CP*AP*CP*GP*A)-3', 5'-R(*UP*CP*CP*CP*(A2M)P*GP*UP*CP*CP*AP*CP*CP*G)-3', ... | Authors: | Alam, S, Grum-Tokars, V, Krucinska, J, Kundracik, M.L, Wedekind, J.E. | Deposit date: | 2004-08-20 | Release date: | 2005-11-22 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.19 Å) | Cite: | Conformational Heterogeneity at Position U37 of an All-RNA Hairpin Ribozyme with Implications for Metal Binding and the Catalytic Structure of the S-Turn. Biochemistry, 44, 2005
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6XKN
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6XKO
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