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Discovery of Functionally Selective Transforming Growth Factor beta Type II Receptor (TGF-beta RII) Inhibitors as Anti-Fibrosis Agents
Descriptor:	5-[(3S)-5,5-dimethyloxolan-3-yl]-6-methoxy-3-(2-methoxypyridin-4-yl)pyrazolo[1,5-a]pyrimidine, TGF-beta receptor type-2
Authors:	Nishihata, J, Nomura, A, Miwa, S, Doi, S, Adachi, T.
Deposit date:	2021-01-12
Release date:	2021-06-16
Last modified:	2023-11-29
Method:	X-RAY DIFFRACTION (2.39 Å)
Cite:	Discovery of Selective Transforming Growth Factor beta Type II Receptor Inhibitors as Antifibrosis Agents. Acs Med.Chem.Lett., 12, 2021

Crystal structure of full-length CbnR complexed with the target DNA complex
Descriptor:	DNA (56-mer), LysR-type regulatory protein
Authors:	Senda, M, Giannopoulou, E, Senda, T.
Deposit date:	2020-10-12
Release date:	2021-03-10
Last modified:	2023-11-29
Method:	X-RAY DIFFRACTION (3.6 Å)
Cite:	Crystal structure of the full-length LysR-type transcription regulator CbnR in complex with promoter DNA. Febs J., 288, 2021

Crystal structure of Pim1 kinase in complex with small molecule inhibitor
Descriptor:	2-{4-[(3-aminopropyl)amino]quinazolin-2-yl}phenol, CALCIUM ION, CHLORIDE ION, ...
Authors:	Parker, L.J.
Deposit date:	2011-11-06
Release date:	2012-04-11
Last modified:	2023-11-01
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	A novel pim-1 kinase inhibitor targeting residues that bind the substrate Peptide. J.Mol.Biol., 417, 2012