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6V0M
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BU of 6v0m by Molmil
Sterile alpha-motif from apoptosis signal-regulating kinase 3
Descriptor: Mitogen-activated protein kinase kinase kinase 15
Authors:Trevelyan, S.J, Mace, P.D.
Deposit date:2019-11-18
Release date:2020-04-01
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure-based mechanism of preferential complex formation by apoptosis signal-regulating kinases.
Sci.Signal., 13, 2020
6VHD
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BU of 6vhd by Molmil
FphF, Staphylococcus aureus fluorophosphonate-binding serine hydrolases F, KT129 bound
Descriptor: (2~{R})-2-phenylpiperidine-1-carbaldehyde, Esterase family protein
Authors:Fellner, M, Mace, P.D.
Deposit date:2020-01-09
Release date:2020-09-16
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Structural Basis for the Inhibitor and Substrate Specificity of the Unique Fph Serine Hydrolases of Staphylococcus aureus .
Acs Infect Dis., 6, 2020
6VHE
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BU of 6vhe by Molmil
FphF, Staphylococcus aureus fluorophosphonate-binding serine hydrolases F, KT130 bound
Descriptor: (2~{R})-2-phenylpiperidine-1-carbaldehyde, Esterase family protein
Authors:Fellner, M, Mace, P.D.
Deposit date:2020-01-09
Release date:2020-09-16
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Structural Basis for the Inhibitor and Substrate Specificity of the Unique Fph Serine Hydrolases of Staphylococcus aureus .
Acs Infect Dis., 6, 2020
6WCX
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BU of 6wcx by Molmil
FphF, Staphylococcus aureus fluorophosphonate-binding serine hydrolases F, substrate bound
Descriptor: Esterase family protein, HEPTAN-1-OL
Authors:Fellner, M, Mace, P.D.
Deposit date:2020-03-31
Release date:2020-09-16
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Structural Basis for the Inhibitor and Substrate Specificity of the Unique Fph Serine Hydrolases of Staphylococcus aureus .
Acs Infect Dis., 6, 2020
6WHB
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BU of 6whb by Molmil
MEKK1 TOG domain (548-867)
Descriptor: ACETATE ION, GLYCEROL, Mitogen-activated protein kinase kinase kinase 1
Authors:Filipcik, P, Mace, P.D.
Deposit date:2020-04-07
Release date:2020-08-26
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.90032053 Å)
Cite:A cryptic tubulin-binding domain links MEKK1 to curved tubulin protomers.
Proc.Natl.Acad.Sci.USA, 117, 2020
6CGA
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BU of 6cga by Molmil
Structure of the PR-DUB complex
Descriptor: Polycomb protein Asx, Ubiquitin carboxyl-terminal hydrolase calypso
Authors:Foglizzo, M, Middleton, A.J, Day, C.L, Mace, P.D.
Deposit date:2018-02-19
Release date:2018-10-03
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:A bidentate Polycomb Repressive-Deubiquitinase complex is required for efficient activity on nucleosomes.
Nat Commun, 9, 2018
6DC0
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BU of 6dc0 by Molmil
Tribbles (TRIB1) pseudokinase fused to CCAAT-enhancer binding protein (C/EBPalpha) degron
Descriptor: Tribbles homolog 1,CCAAT/enhancer-binding protein alpha
Authors:Jamieson, S.A, Brewster, J.L, Mace, P.D.
Deposit date:2018-05-03
Release date:2018-10-10
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Substrate binding allosterically relieves autoinhibition of the pseudokinase TRIB1.
Sci Signal, 11, 2018
7QHA
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BU of 7qha by Molmil
Cryo-EM structure of the Tripartite ATP-independent Periplasmic (TRAP) transporter SiaQM from Photobacterium profundum in amphipol
Descriptor: Megabody c7HopQ, Putative TRAP-type C4-dicarboxylate transport system, large permease component, ...
Authors:North, R.A, Davies, J.S, Morado, D, Dobson, R.C.J.
Deposit date:2021-12-11
Release date:2022-12-21
Last modified:2023-03-22
Method:ELECTRON MICROSCOPY (2.97 Å)
Cite:Structure and mechanism of a tripartite ATP-independent periplasmic TRAP transporter.
Nat Commun, 14, 2023
8B01
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BU of 8b01 by Molmil
Cryo-EM structure of the Tripartite ATP-independent Periplasmic (TRAP) transporter SiaQM from Photobacterium profundum in a nanodisc
Descriptor: DECANE, DOCOSANE, HEXANE, ...
Authors:Davies, J.S, North, R.A, Dobson, R.C.J.
Deposit date:2022-09-06
Release date:2023-03-15
Method:ELECTRON MICROSCOPY (3.03 Å)
Cite:Structure and mechanism of a tripartite ATP-independent periplasmic TRAP transporter.
Nat Commun, 14, 2023
8THI
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BU of 8thi by Molmil
Cryo-EM structure of the Tripartite ATP-independent Periplasmic (TRAP) transporter SiaQM from Haemophilus influenzae (parallel dimer)
Descriptor: (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, SODIUM ION, Sialic acid TRAP transporter permease protein SiaT
Authors:Davies, J.S, Currie, M.C, Dobson, R.C.J, North, R.A.
Deposit date:2023-07-16
Release date:2023-11-22
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (3.36 Å)
Cite:Structural and biophysical analysis of a Haemophilus influenzae tripartite ATP-independent periplasmic (TRAP) transporter.
Elife, 12, 2024
8THJ
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BU of 8thj by Molmil
Cryo-EM structure of the Tripartite ATP-independent Periplasmic (TRAP) transporter SiaQM from Haemophilus influenzae (antiparallel dimer)
Descriptor: (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, PHOSPHATIDYLETHANOLAMINE, SODIUM ION, ...
Authors:Davies, J.S, Currie, M.C, Dobson, R.C.J, North, R.A.
Deposit date:2023-07-16
Release date:2023-11-22
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (2.99 Å)
Cite:Structural and biophysical analysis of a Haemophilus influenzae tripartite ATP-independent periplasmic (TRAP) transporter.
Elife, 12, 2024
7T3E
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BU of 7t3e by Molmil
Structure of the sialic acid bound Tripartite ATP-independent Periplasmic (TRAP) periplasmic component SiaP from Photobacterium profundum
Descriptor: N-acetyl-beta-neuraminic acid, SULFATE ION, TRAP-type C4-dicarboxylate transport system, ...
Authors:Davies, J.S, Currie, M.J, North, R.A, Dobson, R.C.J.
Deposit date:2021-12-07
Release date:2022-12-14
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.04 Å)
Cite:Structure and mechanism of a tripartite ATP-independent periplasmic TRAP transporter.
Nat Commun, 14, 2023
5VNZ
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BU of 5vnz by Molmil
Structure of a TRAF6-Ubc13~Ub complex
Descriptor: TNF receptor-associated factor 6, Ubiquitin, Ubiquitin-conjugating enzyme E2 N, ...
Authors:Middleton, A.J, Day, C.L.
Deposit date:2017-05-01
Release date:2017-12-06
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.41 Å)
Cite:The activity of TRAF RING homo- and heterodimers is regulated by zinc finger 1.
Nat Commun, 8, 2017
5V62
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BU of 5v62 by Molmil
Phospho-ERK2 bound to bivalent inhibitor SBP3
Descriptor: 5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE, GLYCEROL, Mitogen-activated protein kinase 1, ...
Authors:Lechtenberg, B.C, Riedl, S.J.
Deposit date:2017-03-15
Release date:2017-07-26
Last modified:2024-07-10
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-Guided Strategy for the Development of Potent Bivalent ERK Inhibitors.
ACS Med Chem Lett, 8, 2017
5VO0
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BU of 5vo0 by Molmil
Structure of a TRAF6-Ubc13~Ub complex
Descriptor: POTASSIUM ION, TNF receptor-associated factor 6, Ubiquitin, ...
Authors:Middleton, A.J, Day, C.L.
Deposit date:2017-05-01
Release date:2017-12-06
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:The activity of TRAF RING homo- and heterodimers is regulated by zinc finger 1.
Nat Commun, 8, 2017
5V61
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BU of 5v61 by Molmil
Phospho-ERK2 bound to bivalent inhibitor SBP2
Descriptor: 2-oxo-6,9,12,15-tetraoxa-3-azaoctadecan-18-oic acid, 5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE, GLYCEROL, ...
Authors:Lechtenberg, B.C, Riedl, S.J.
Deposit date:2017-03-15
Release date:2017-07-26
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure-Guided Strategy for the Development of Potent Bivalent ERK Inhibitors.
ACS Med Chem Lett, 8, 2017
5V60
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BU of 5v60 by Molmil
Phospho-ERK2 bound to AMP-PCP
Descriptor: GLYCEROL, MAGNESIUM ION, Mitogen-activated protein kinase 1, ...
Authors:Lechtenberg, B.C, Riedl, S.J.
Deposit date:2017-03-15
Release date:2017-07-26
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Structure-Guided Strategy for the Development of Potent Bivalent ERK Inhibitors.
ACS Med Chem Lett, 8, 2017
7L3L
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BU of 7l3l by Molmil
Structure of TRAF5 and TRAF6 RING Hetero dimer
Descriptor: TNF receptor-associated factor 5, TNF receptor-associated factor 6, ZINC ION
Authors:Das, A, Middleton, A.J, Padala, P, Day, C.L.
Deposit date:2020-12-17
Release date:2021-02-17
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The structure and ubiquitin binding properties of TRAF RING heterodimers.
J.Mol.Biol., 2021
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