5NHL
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![BU of 5nhl by Molmil](/molmil-images/mine/5nhl) | Human Erk2 with an Erk1/2 inhibitor | Descriptor: | (6~{R})-5-(2-methoxyethyl)-6-methyl-2-[5-methyl-2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]-6,7-dihydro-1~{H}-pyrrolo[3,2-c]pyridin-4-one, Mitogen-activated protein kinase 1, SULFATE ION | Authors: | Debreczeni, J.E, Ward, R.A, Bethel, P, Cook, C, Davies, E, Eckersley, K, Fairley, G, Feron, L, Flemington, V, Graham, M.A, Greenwood, R, Hopcroft, P, Howard, T.D, Hudson, J, James, M, Jones, C.D, Jones, C.R, Lamont, S, Lewis, R, Lindsay, N, Roberts, K, Simpson, I, StGallay, S, Swallow, S, Tonge, M. | Deposit date: | 2017-03-21 | Release date: | 2017-04-19 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point. J. Med. Chem., 60, 2017
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5NHH
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![BU of 5nhh by Molmil](/molmil-images/mine/5nhh) | Human Erk2 with an Erk1/2 inhibitor | Descriptor: | 5-(2-methoxyethyl)-2-[2-(oxan-4-ylamino)pyrimidin-4-yl]-6,7-dihydro-1~{H}-pyrrolo[3,2-c]pyridin-4-one, Mitogen-activated protein kinase 1, SULFATE ION | Authors: | Debreczeni, J.E, Ward, R.A, Bethel, P, Cook, C, Davies, E, Eckersley, K, Fairley, G, Feron, L, Flemington, V, Graham, M.A, Greenwood, R, Hopcroft, P, Howard, T.D, Hudson, J, James, M, Jones, C.D, Jones, C.R, Lamont, S, Lewis, R, Lindsay, N, Roberts, K, Simpson, I, StGallay, S, Swallow, S, Tonge, M. | Deposit date: | 2017-03-21 | Release date: | 2017-04-19 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point. J. Med. Chem., 60, 2017
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5NHO
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![BU of 5nho by Molmil](/molmil-images/mine/5nho) | Human Erk2 with an Erk1/2 inhibitor | Descriptor: | (6~{S})-5-(2-methoxyethyl)-6-methyl-2-[5-methyl-2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]-6,7-dihydro-1~{H}-pyrrolo[3,2-c]pyridin-4-one, Mitogen-activated protein kinase 1, SULFATE ION | Authors: | Debreczeni, J.E, Ward, R.A, Bethel, P, Cook, C, Davies, E, Eckersley, K, Fairley, G, Feron, L, Flemington, V, Graham, M.A, Greenwood, R, Hopcroft, P, Howard, T.D, Hudson, J, James, M, Jones, C.D, Jones, C.R, Lamont, S, Lewis, R, Lindsay, N, Roberts, K, Simpson, I, StGallay, S, Swallow, S, Tonge, M. | Deposit date: | 2017-03-22 | Release date: | 2017-04-19 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.24 Å) | Cite: | Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point. J. Med. Chem., 60, 2017
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5NHV
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![BU of 5nhv by Molmil](/molmil-images/mine/5nhv) | Human Erk2 with an Erk1/2 inhibitor | Descriptor: | 7-[2-(oxan-4-ylamino)pyrimidin-4-yl]-3,4-dihydro-2~{H}-pyrrolo[1,2-a]pyrazin-1-one, Mitogen-activated protein kinase 1, SULFATE ION | Authors: | Debreczeni, J.E, Ward, R.A, Bethel, P, Cook, C, Davies, E, Eckersley, K, Fairley, G, Feron, L, Flemington, V, Graham, M.A, Greenwood, R, Hopcroft, P, Howard, T.D, Hudson, J, James, M, Jones, C.D, Jones, C.R, Lamont, S, Lewis, R, Lindsay, N, Roberts, K, Simpson, I, StGallay, S, Swallow, S, Tonge, M. | Deposit date: | 2017-03-22 | Release date: | 2017-04-19 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point. J. Med. Chem., 60, 2017
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5NGU
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![BU of 5ngu by Molmil](/molmil-images/mine/5ngu) | Human Erk2 with an Erk1/2 inhibitor | Descriptor: | 2-[2-[[4-(4-methylpiperazin-1-yl)phenyl]amino]pyrimidin-4-yl]-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one, Mitogen-activated protein kinase 1, SULFATE ION | Authors: | Debreczeni, J.E, Ward, R.A, Bethel, P, Cook, C, Davies, E, Eckersley, K, Fairley, G, Feron, L, Flemington, V, Graham, M.A, Greenwood, R, Hopcroft, P, Howard, T.D, Hudson, J, James, M, Jones, C.D, Jones, C.R, Lamont, S, Lewis, R, Lindsay, N, Roberts, K, Simpson, I, StGallay, S, Swallow, S, Tonge, M. | Deposit date: | 2017-03-20 | Release date: | 2017-04-19 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.74 Å) | Cite: | Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point. J. Med. Chem., 60, 2017
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4ZZO
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![BU of 4zzo by Molmil](/molmil-images/mine/4zzo) | Human ERK2 in complex with an irreversible inhibitor | Descriptor: | MITOGEN-ACTIVATED PROTEIN KINASE 1, N-[2-[[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]amino]phenyl]propanamide, SULFATE ION | Authors: | Ward, R.A, Colclough, N, Challinor, M, Debreczeni, J.E, Eckersley, K, Fairley, G, Feron, L, Flemington, V, Graham, M.A, Greenwood, R, Hopcroft, P, Howard, T.D, James, M, Jones, C.D, Jones, C.R, Renshaw, J, Roberts, K, Snow, L, Tonge, M, Yeung, K. | Deposit date: | 2015-04-10 | Release date: | 2015-05-27 | Last modified: | 2015-08-26 | Method: | X-RAY DIFFRACTION (1.63 Å) | Cite: | Structure-Guided Design of Highly Selective and Potent Covalent Inhibitors of Erk1/2. J.Med.Chem., 58, 2015
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8FFR
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![BU of 8ffr by Molmil](/molmil-images/mine/8ffr) | Revised structure of the rabies virus nucleoprotein-RNA complex | Descriptor: | Nucleoprotein, PHOSPHATE ION, RNA (99-MER) | Authors: | Leyrat, C, Bourhis, J.M, Albertini, A.A.V, Wernimont, A.K, Muziol, T, Ravelli, R.B.G, Weissenhorn, W, Ruigrok, R.W.H, Jamin, M. | Deposit date: | 2022-12-09 | Release date: | 2023-01-11 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.49 Å) | Cite: | Structure and Dynamics of the Unassembled Nucleoprotein of Rabies Virus in Complex with Its Phosphoprotein Chaperone Module. Viruses, 14, 2022
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4HEO
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![BU of 4heo by Molmil](/molmil-images/mine/4heo) | |
2WFH
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![BU of 2wfh by Molmil](/molmil-images/mine/2wfh) | The Human Slit 2 Dimerization Domain D4 | Descriptor: | SLIT HOMOLOG 2 PROTEIN C-PRODUCT, SULFATE ION | Authors: | Seiradake, E, von Philipsborn, A.C, Henry, M, Fritz, M, Lortat-Jacob, H, Jamin, M, Hemrika, W, Bastmeyer, M, Cusack, S, McCarthy, A.A. | Deposit date: | 2009-04-06 | Release date: | 2009-04-21 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure and functional relevance of the Slit2 homodimerization domain. EMBO Rep., 10, 2009
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3PMK
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![BU of 3pmk by Molmil](/molmil-images/mine/3pmk) | Crystal structure of the Vesicular Stomatitis Virus RNA free nucleoprotein/phosphoprotein complex | Descriptor: | Nucleocapsid protein, Phosphoprotein | Authors: | Leyrat, C, Yabukarski, F, Tarbouriech, N, Ruigrok, R.W.H, Jamin, M. | Deposit date: | 2010-11-17 | Release date: | 2011-10-05 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.03 Å) | Cite: | Structure of the Vesicular Stomatitis Virus N0-P Complex Plos Pathog., 7, 2011
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2XD5
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![BU of 2xd5 by Molmil](/molmil-images/mine/2xd5) | Structural insights into the catalytic mechanism and the role of Streptococcus pneumoniae PBP1b | Descriptor: | CHLORIDE ION, N-BENZOYL-D-ALANINE, PENICILLIN-BINDING PROTEIN 1B, ... | Authors: | Macheboeuf, P, Lemaire, D, Jamin, M, Dideberg, O, Dessen, A. | Deposit date: | 2010-04-29 | Release date: | 2010-05-26 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural Insights Into the Catalytic Mechanism and the Role of Streptococcus Pneumoniae Pbp1B To be Published
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2K47
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![BU of 2k47 by Molmil](/molmil-images/mine/2k47) | Solution structure of the C-terminal N-RNA binding domain of the Vesicular Stomatitis Virus Phosphoprotein | Descriptor: | Phosphoprotein | Authors: | Ribeiro, E.A, Favier, A, Gerard, F.C, Leyrat, C, Brutscher, B, Blondel, D, Ruigrok, R.W, Blackledge, M, Jamin, M. | Deposit date: | 2008-05-28 | Release date: | 2008-09-09 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution Structure of the C-Terminal Nucleoprotein-RNA Binding Domain of the Vesicular Stomatitis Virus Phosphoprotein. J.Mol.Biol., 2008
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4GJW
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![BU of 4gjw by Molmil](/molmil-images/mine/4gjw) | |
4CO6
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![BU of 4co6 by Molmil](/molmil-images/mine/4co6) | Crystal structure of the Nipah virus RNA free nucleoprotein- phosphoprotein complex | Descriptor: | BROMIDE ION, CHLORIDE ION, NUCLEOPROTEIN, ... | Authors: | Yabukarksi, F, Lawrence, P, Tarbouriech, N, Bourhis, J.M, Jensen, M.R, Ruigrok, R.W.H, Blackledge, M, Volchkov, V, Jamin, M. | Deposit date: | 2014-01-27 | Release date: | 2014-08-13 | Last modified: | 2014-09-17 | Method: | X-RAY DIFFRACTION (2.498 Å) | Cite: | Structure of Nipah Virus Unassembled Nucleoprotein in Complex with its Viral Chaperone. Nat.Struct.Mol.Biol., 21, 2014
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8B8V
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8BJW
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![BU of 8bjw by Molmil](/molmil-images/mine/8bjw) | |
3L32
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![BU of 3l32 by Molmil](/molmil-images/mine/3l32) | |
3T4R
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![BU of 3t4r by Molmil](/molmil-images/mine/3t4r) | |
2JLN
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![BU of 2jln by Molmil](/molmil-images/mine/2jln) | Structure of Mhp1, a nucleobase-cation-symport-1 family transporter | Descriptor: | MERCURY (II) ION, MHP1, SODIUM ION | Authors: | Weyand, S, Shimamura, T, Yajima, S, Suzuki, S, Mirza, O, Krusong, K, Carpenter, E.P, Rutherford, N.G, Hadden, J.M, O'Reilly, J, Ma, P, Saidijam, M, Patching, S.G, Hope, R.J, Norbertczak, H.T, Roach, P.C.J, Iwata, S, Henderson, P.J.F, Cameron, A.D. | Deposit date: | 2008-09-11 | Release date: | 2008-10-28 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Structure and Molecular Mechanism of a Nucleobase-Cation-Symport-1 Family Transporter. Science, 322, 2008
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6GOX
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![BU of 6gox by Molmil](/molmil-images/mine/6gox) | SecA | Descriptor: | Protein translocase subunit SecA | Authors: | White, S.A, Huber, D. | Deposit date: | 2018-06-04 | Release date: | 2019-06-19 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | The C-terminal tail of the bacterial translocation ATPase SecA modulates its activity. Elife, 8, 2019
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4SGB
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![BU of 4sgb by Molmil](/molmil-images/mine/4sgb) | |
3LMW
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![BU of 3lmw by Molmil](/molmil-images/mine/3lmw) | Crystal structure of iota-carrageenase family GH82 from A. fortis in absence of chloride ions | Descriptor: | CALCIUM ION, Iota-carrageenase, CgiA, ... | Authors: | Rebuffet, E, Barbeyron, T, Jeudy, A, Czjzek, M, Michel, G. | Deposit date: | 2010-02-01 | Release date: | 2010-08-18 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Identification of catalytic residues and mechanistic analysis of family GH82 iota-carrageenases Biochemistry, 49, 2010
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5OCQ
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![BU of 5ocq by Molmil](/molmil-images/mine/5ocq) | Crystal structure of the complex of the kappa-carrageenase from Pseudoalteromonas carrageenovora with an oligotetrasaccharide of kappa-carrageenan | Descriptor: | 3,6-anhydro-D-galactose, 4-O-sulfo-beta-D-galactopyranose, CITRIC ACID, ... | Authors: | Czjzek, M, Leroux, C, Bernard, T, Matard-Mann, M, Jeudy, A, Michel, G. | Deposit date: | 2017-07-03 | Release date: | 2017-10-18 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural insights into marine carbohydrate degradation by family GH16 kappa-carrageenases. J. Biol. Chem., 292, 2017
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5OPQ
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![BU of 5opq by Molmil](/molmil-images/mine/5opq) | A 3,6-anhydro-D-galactosidase produced by Zobellia galactanivorans. This is an exo-lytic enzyme that hydrolyzes terminal 3,6-anhydro-D-galactose from the non-reducing end of carrageenan oligosaccharides. | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3,6-anhydro-D-galactosidase, ... | Authors: | Ficko-Blean, E, Michel, G, Czjzek, M. | Deposit date: | 2017-08-10 | Release date: | 2017-11-29 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Carrageenan catabolism is encoded by a complex regulon in marine heterotrophic bacteria. Nat Commun, 8, 2017
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5OCR
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![BU of 5ocr by Molmil](/molmil-images/mine/5ocr) | Crystal structure of the kappa-carrageenase zobellia_236 from Zobellia galactanivorans | Descriptor: | GLYCEROL, Kappa-carrageenase, MAGNESIUM ION | Authors: | Czjzek, M, Matard-Mann, M, Michel, G, Jeudy, A, Larocque, R. | Deposit date: | 2017-07-03 | Release date: | 2017-10-18 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.66 Å) | Cite: | Structural insights into marine carbohydrate degradation by family GH16 kappa-carrageenases. J. Biol. Chem., 292, 2017
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