7ZZW
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![BU of 7zzw by Molmil](/molmil-images/mine/7zzw) | Ligand binding to HDAC2 | Descriptor: | 1,2-ETHANEDIOL, 2-(cyclohexylazaniumyl)ethanesulfonate, CALCIUM ION, ... | Authors: | Cleasby, A, Tisi, D. | Deposit date: | 2022-05-26 | Release date: | 2022-09-21 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
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8A0B
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![BU of 8a0b by Molmil](/molmil-images/mine/8a0b) | Inhibitor binding to HDAC2 | Descriptor: | 1,2-ETHANEDIOL, 1,3-dihydroisoindol-2-yl-[(2R,4S)-4-phenylpyrrolidin-1-ium-2-yl]methanone, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ... | Authors: | Cleasby, A, Tisi, D. | Deposit date: | 2022-05-27 | Release date: | 2022-09-21 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.746 Å) | Cite: | Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
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7ZZS
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![BU of 7zzs by Molmil](/molmil-images/mine/7zzs) | HDAC2 complexed with an inhibitory ligand | Descriptor: | (5~{S})-5-(4-chlorophenyl)pyrrolidin-2-one, 1,2-ETHANEDIOL, 2-(cyclohexylazaniumyl)ethanesulfonate, ... | Authors: | Cleasby, A, Tisi, D. | Deposit date: | 2022-05-26 | Release date: | 2022-09-21 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
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7ZZU
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![BU of 7zzu by Molmil](/molmil-images/mine/7zzu) | Inhibitory Ligand binding to HDAC2 | Descriptor: | 1,2-ETHANEDIOL, 2-[4-[(2~{R},4~{S})-4-phenylpyrrolidin-2-yl]carbonylpiperazin-1-yl]pyridine-3-carbonitrile, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ... | Authors: | Cleasby, A, Tisi, D. | Deposit date: | 2022-05-26 | Release date: | 2022-09-21 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
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8JJS
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![BU of 8jjs by Molmil](/molmil-images/mine/8jjs) | Human K-Ras G12D (GDP-bound) in complex with cyclic peptide inhibitor AP10343 | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, MAA-ILE-SAR-SAR-7T2-SAR-IAE-LEU-MEA-MLE-7TK, ... | Authors: | Irie, M, Fukami, T.A, Tanada, M, Ohta, A, Torizawa, T. | Deposit date: | 2023-05-31 | Release date: | 2023-07-26 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.534 Å) | Cite: | Development of Orally Bioavailable Peptides Targeting an Intracellular Protein: From a Hit to a Clinical KRAS Inhibitor. J.Am.Chem.Soc., 145, 2023
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5WPH
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![BU of 5wph by Molmil](/molmil-images/mine/5wph) | Crystal structure of ArsN, N-acetyltransferase with substrate AST from Pseudomonas putida KT2440 | Descriptor: | (2S)-2-amino-4-[hydroxy(methyl)arsoryl]butanoic acid, Phosphinothricin N-acetyltransferase, SODIUM ION | Authors: | Venkadesh, S, Dheeman, D.S, Yoshinaga, M, Kandavelu, P, Rosen, B.P. | Deposit date: | 2017-08-04 | Release date: | 2018-10-10 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.19 Å) | Cite: | Arsinothricin, an arsenic-containing non-proteinogenic amino acid analog of glutamate, is a broad-spectrum antibiotic. Commun Biol, 2, 2019
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6M7G
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![BU of 6m7g by Molmil](/molmil-images/mine/6m7g) | Crystal structure of ArsN, N-acetyltransferase with substrate phosphinothricin from Pseudomonas putida KT2440 | Descriptor: | PHOSPHINOTHRICIN, Phosphinothricin N-acetyltransferase | Authors: | Venkadesh, S, Dheeman, D.S, Yoshinaga, M, Kandavelu, P, Rosen, B.P. | Deposit date: | 2018-08-20 | Release date: | 2019-04-24 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.657 Å) | Cite: | Arsinothricin, an arsenic-containing non-proteinogenic amino acid analog of glutamate, is a broad-spectrum antibiotic. Commun Biol, 2, 2019
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2ZXT
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![BU of 2zxt by Molmil](/molmil-images/mine/2zxt) | Crystal structure of Tim40/MIA40, a disulfide relay system in mitochondria, solved as MBP fusion protein | Descriptor: | Maltose-binding periplasmic protein, LINKER, Mitochondrial intermembrane space import and assembly protein 40, ... | Authors: | Kawano, S, Momose, T, Watanabe, N, Endo, T. | Deposit date: | 2009-01-07 | Release date: | 2009-08-04 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural basis of yeast Tim40/Mia40 as an oxidative translocator in the mitochondrial intermembrane space. Proc.Natl.Acad.Sci.USA, 106, 2009
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3BOY
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![BU of 3boy by Molmil](/molmil-images/mine/3boy) | Crystal structure of the HutP antitermination complex bound to the HUT mRNA | Descriptor: | 5'-R(*UP*UP*UP*AP*GP*UP*UP*UP*UP*UP*AP*GP*UP*UP*UP*UP*UP*AP*GP*UP*UP*U)-3', HISTIDINE, Hut operon positive regulatory protein, ... | Authors: | Kumarevel, T.S, Balasundaresan, D, Jeyakanthan, J, Shinkai, A, Yokoyama, S, Kumar, P.K.R, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-12-18 | Release date: | 2008-01-15 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal Structure of HutP complexed with the 55-mer RNA To be Published
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6K84
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![BU of 6k84 by Molmil](/molmil-images/mine/6k84) | Structure of anti-prion RNA aptamer | Descriptor: | RNA (25-MER) | Authors: | Mashima, T, Lee, J.H, Hayashi, T, Nagata, T, Kinoshita, M, Katahira, M. | Deposit date: | 2019-06-11 | Release date: | 2020-04-01 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Development and structural determination of an anti-PrPCaptamer that blocks pathological conformational conversion of prion protein. Sci Rep, 10, 2020
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3A3C
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![BU of 3a3c by Molmil](/molmil-images/mine/3a3c) | Crystal structure of TIM40/MIA40 fusing MBP, C296S and C298S mutant | Descriptor: | Maltose-binding periplasmic protein, LINKER, Mitochondrial intermembrane space import and assembly protein 40, ... | Authors: | Kawano, S, Naoe, M, Momose, T, Watanabe, N, Endo, T. | Deposit date: | 2009-06-11 | Release date: | 2009-08-04 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis of yeast Tim40/Mia40 as an oxidative translocator in the mitochondrial intermembrane space. Proc.Natl.Acad.Sci.USA, 106, 2009
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5YV5
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![BU of 5yv5 by Molmil](/molmil-images/mine/5yv5) | Crystal structure of the complex of archaeal ribosomal stalk protein aP1 and archaeal ribosome recycling factor aABCE1. | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATPase RIL, Archaeal ribosomal stalk protein aP1, ... | Authors: | Imai, H, Abe, T, Miyoshi, T, Nishikawa, S, Ito, K, Uchiumi, T. | Deposit date: | 2017-11-24 | Release date: | 2018-07-18 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The ribosomal stalk protein is crucial for the action of the conserved ATPase ABCE1 Nucleic Acids Res., 46, 2018
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1VEA
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![BU of 1vea by Molmil](/molmil-images/mine/1vea) | Crystal Structure of HutP, an RNA binding antitermination protein | Descriptor: | Hut operon positive regulatory protein, N-(2-NAPHTHYL)HISTIDINAMIDE | Authors: | Kumarevel, T.S, Fujimoto, Z, Karthe, P, Oda, M, Mizuno, H, Kumar, P.K.R. | Deposit date: | 2004-03-29 | Release date: | 2004-07-20 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal Structure of Activated HutP; An RNA Binding Protein that Regulates Transcription of the hut Operon in Bacillus subtilis Structure, 12, 2004
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1WRQ
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1WPT
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![BU of 1wpt by Molmil](/molmil-images/mine/1wpt) | Crystal Structure of HutP, an RNA binding anti-termination protein | Descriptor: | Hut operon positive regulatory protein | Authors: | Kumarevel, T, Mizuno, H, Kumar, P.K.R. | Deposit date: | 2004-09-13 | Release date: | 2005-08-30 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Characterization of the metal ion binding site in the anti-terminator protein, HutP, of Bacillus subtilis Nucleic Acids Res., 33, 2005
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1WMQ
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![BU of 1wmq by Molmil](/molmil-images/mine/1wmq) | Structure of the HutP antitermination complex bound to a single stranded region of hut mRNA | Descriptor: | 5'-R(P*UP*UP*UP*AP*GP*UP*U)-3', HISTIDINE, Hut operon positive regulatory protein, ... | Authors: | Kumarevel, T.S, Mizuno, H, Kumar, P.K.R. | Deposit date: | 2004-07-14 | Release date: | 2005-03-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural basis of HutP-mediated anti-termination and roles of the Mg2+ ion and L-histidine ligand. Nature, 434, 2005
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1WPV
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![BU of 1wpv by Molmil](/molmil-images/mine/1wpv) | Crystal Structure of Activated Binary complex of HutP, an RNA binding anti-termination protein | Descriptor: | HISTIDINE, Hut operon positive regulatory protein, MAGNESIUM ION | Authors: | Kumarevel, T.S, Mizuno, H, Kumar, P.K.R. | Deposit date: | 2004-09-14 | Release date: | 2005-03-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural basis of HutP-mediated anti-termination and roles of the Mg2+ ion and L-histidine ligand. Nature, 434, 2005
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1WPU
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1WRO
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![BU of 1wro by Molmil](/molmil-images/mine/1wro) | Metal Ion dependency of the antiterminator protein, HutP, for binding to the terminator region of hut mRNA- A structural basis | Descriptor: | BARIUM ION, HISTIDINE, Hut operon positive regulatory protein | Authors: | Kumarevel, T, Mizuno, H, Kumar, P.K.R. | Deposit date: | 2004-10-25 | Release date: | 2005-08-30 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Characterization of the metal ion binding site in the anti-terminator protein, HutP, of Bacillus subtilis Nucleic Acids Res., 33, 2005
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1WRN
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![BU of 1wrn by Molmil](/molmil-images/mine/1wrn) | Metal Ion dependency of the antiterminator protein, HutP, for binding to the terminator region of hut mRNA- A structural basis | Descriptor: | DI(HYDROXYETHYL)ETHER, HISTIDINE, Hut operon positive regulatory protein, ... | Authors: | Kumarevel, T, Mizuno, H, Kumar, P.K.R. | Deposit date: | 2004-10-25 | Release date: | 2005-08-30 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Characterization of the metal ion binding site in the anti-terminator protein, HutP, of Bacillus subtilis Nucleic Acids Res., 33, 2005
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1WPS
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2ZE4
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![BU of 2ze4 by Molmil](/molmil-images/mine/2ze4) | Crystal structure of phospholipase D from streptomyces antibioticus | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Phospholipase D | Authors: | Suzuki, A, Kakuno, K, Saito, R, Iwasaki, Y, Yamane, T, Yamane, T. | Deposit date: | 2007-12-05 | Release date: | 2007-12-25 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of phospholipase D from streptomyces antibioticus To be Published
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2ZE9
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![BU of 2ze9 by Molmil](/molmil-images/mine/2ze9) | Crystal structure of H168A mutant of phospholipase D from Streptomyces antibioticus, as a complex with phosphatidylcholine | Descriptor: | (2R)-3-(phosphonooxy)propane-1,2-diyl diheptanoate, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Phospholipase D | Authors: | Suzuki, A, Toda, H, Iwasaki, Y, Yamane, T, Yamane, T. | Deposit date: | 2007-12-06 | Release date: | 2007-12-25 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of phospholipase D from streptomyces antibioticus To be Published
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