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MLL1 SET N3861I/Q3867L bound to inhibitor 12 (TC-5140)
Descriptor:	5'-{[(3S)-3-amino-3-carboxypropyl]({1-[(3-chlorophenyl)methyl]azetidin-3-yl}methyl)amino}-5'-deoxyadenosine, Histone-lysine N-methyltransferase, ZINC ION
Authors:	Petrunak, E.M, Stuckey, J.A.
Deposit date:	2019-09-09
Release date:	2020-07-01
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Discovery of Potent Small-Molecule Inhibitors of MLL Methyltransferase. Acs Med.Chem.Lett., 11, 2020

DCN1 bound to DI-591
Descriptor:	DCN1-like protein 1, N-[(1S)-1-cyclohexyl-2-{[3-(morpholin-4-yl)propanoyl]amino}ethyl]-N~2~-propanoyl-3-[6-(propan-2-yl)-1,3-benzothiazol-2-yl]-L-alaninamide
Authors:	Stuckey, J.
Deposit date:	2017-01-04
Release date:	2017-11-01
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (2.58 Å)
Cite:	A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylation. Nat Commun, 8, 2017