1C9B
 
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5F5R
 | | TRAP1N-ADPNP | | Descriptor: | Heat shock protein 75 kDa, mitochondrial, MAGNESIUM ION, ... | | Authors: | Tsai, F.T.F, Lee, S, Sung, N, Lee, J, Chang, C, Joachimiak, A. | | Deposit date: | 2015-12-04 | | Release date: | 2016-03-02 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Mitochondrial Hsp90 is a ligand-activated molecular chaperone coupling ATP binding to dimer closure through a coiled-coil intermediate.
Proc.Natl.Acad.Sci.USA, 113, 2016
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3M6C
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6NZ6
 | | YcjX-GDP (type II) | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, YcjX Stress Protein | | Authors: | Tsai, J, Sung, N, Lee, J, Chang, C, Lee, S, Tsai, F.T. | | Deposit date: | 2019-02-12 | | Release date: | 2019-09-18 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Crystal Structure of the YcjX Stress Protein Reveals a Ras-Like GTP-Binding Protein.
J.Mol.Biol., 431, 2019
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6NZ5
 | | YcjX-GDPCP | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, YcjX Stress Protein | | Authors: | Lee, S, Tsai, J, Tsai, F.T, Sung, N, Lee, J, Chang, C. | | Deposit date: | 2019-02-12 | | Release date: | 2019-09-18 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.233 Å) | | Cite: | Crystal Structure of the YcjX Stress Protein Reveals a Ras-Like GTP-Binding Protein.
J.Mol.Biol., 431, 2019
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6NZ4
 | | YcjX-GDP (type I) | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, YcjX Stress Protein | | Authors: | Lee, S, Tsai, J, Tsai, F.T. | | Deposit date: | 2019-02-12 | | Release date: | 2019-09-18 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.92 Å) | | Cite: | Crystal Structure of the YcjX Stress Protein Reveals a Ras-Like GTP-Binding Protein.
J.Mol.Biol., 431, 2019
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4FCV
 | | Crystal structure of the C-terminal domain of ClpB | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Chaperone protein ClpB | | Authors: | Biter, A.B, Lee, S, Sung, N, Tsai, F.T.F. | | Deposit date: | 2012-05-25 | | Release date: | 2012-07-18 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Structural basis for intersubunit signaling in a protein disaggregating machine.
Proc.Natl.Acad.Sci.USA, 109, 2012
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4FD2
 | | Crystal structure of the C-terminal domain of ClpB | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Chaperone protein ClpB | | Authors: | Biter, A.B, Lee, S, Sung, N, Tsai, F.T.F. | | Deposit date: | 2012-05-25 | | Release date: | 2012-07-18 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structural basis for intersubunit signaling in a protein disaggregating machine.
Proc.Natl.Acad.Sci.USA, 109, 2012
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4FCT
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4FCW
 | | Crystal structure of the C-terminal domain of ClpB | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Chaperone protein ClpB | | Authors: | Biter, A.B, Lee, S, Sung, N, Tsai, F.T.F. | | Deposit date: | 2012-05-25 | | Release date: | 2012-07-18 | | Last modified: | 2018-04-18 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Structural basis for intersubunit signaling in a protein disaggregating machine.
Proc.Natl.Acad.Sci.USA, 109, 2012
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5HPH
 | | Structure of TRAP1 fragment | | Descriptor: | GLYCEROL, Heat shock protein 75 kDa, mitochondrial, ... | | Authors: | Sung, N, Chang, C, Lee, S, Tsai, F.T.F. | | Deposit date: | 2016-01-20 | | Release date: | 2016-08-10 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.429 Å) | | Cite: | 2.4 angstrom resolution crystal structure of human TRAP1NM, the Hsp90 paralog in the mitochondrial matrix.
Acta Crystallogr D Struct Biol, 72, 2016
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5F3K
 | | X-Ray Crystallographic Structure of hTrap1 N-terminal Domain-apo | | Descriptor: | Heat shock protein 75 kDa, mitochondrial | | Authors: | Sung, N, Lee, J, Kim, J, Chang, C, Joachimiak, A, Lee, S, Tsai, F.T.F. | | Deposit date: | 2015-12-02 | | Release date: | 2016-03-02 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.82 Å) | | Cite: | Mitochondrial Hsp90 is a ligand-activated molecular chaperone coupling ATP binding to dimer closure through a coiled-coil intermediate.
Proc.Natl.Acad.Sci.USA, 113, 2016
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8FDS
 | | Ankyrin domain of SKD3 isoform 2 | | Descriptor: | Caseinolytic peptidase B protein homolog, FORMIC ACID | | Authors: | Lee, S, Tsai, F.T.F, Chang, C. | | Deposit date: | 2022-12-04 | | Release date: | 2023-04-19 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Structural basis of impaired disaggregase function in the oxidation-sensitive SKD3 mutant causing 3-methylglutaconic aciduria.
Nat Commun, 14, 2023
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7TFM
 | | Atomic Structure of the Leishmania spp. Hsp100 N-Domain | | Descriptor: | ATP-dependent Clp protease subunit, heat shock protein 100 (HSP100), GLYCEROL | | Authors: | Mercado, J.M, Lee, S, Chang, C, Sung, N, Soong, L, Catic, A, Tsai, F.T.F. | | Deposit date: | 2022-01-06 | | Release date: | 2022-02-16 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.055 Å) | | Cite: | Atomic structure of the Leishmania spp. Hsp100 N-domain.
Proteins, 90, 2022
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8DEH
 | | Ankyrin domain of SKD3 | | Descriptor: | Caseinolytic peptidase B protein homolog | | Authors: | Lee, S, Tsai, F.T.F. | | Deposit date: | 2022-06-20 | | Release date: | 2023-04-19 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.815 Å) | | Cite: | Structural basis of impaired disaggregase function in the oxidation-sensitive SKD3 mutant causing 3-methylglutaconic aciduria.
Nat Commun, 14, 2023
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6N8V
 | | Hsp104DWB open conformation | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein 104 | | Authors: | Lee, S, Rho, S.H, Lee, J, Sung, N, Liu, J, Tsai, F.T.F. | | Deposit date: | 2018-11-30 | | Release date: | 2019-01-02 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (9.3 Å) | | Cite: | Cryo-EM Structures of the Hsp104 Protein Disaggregase Captured in the ATP Conformation.
Cell Rep, 26, 2019
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6N8Z
 | | HSP104DWB extended conformation | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein 104 | | Authors: | Lee, S, Rho, S.H, Lee, J, Sung, N, Liu, J, Tsai, F.T.F. | | Deposit date: | 2018-11-30 | | Release date: | 2019-01-02 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (9.3 Å) | | Cite: | Cryo-EM Structures of the Hsp104 Protein Disaggregase Captured in the ATP Conformation.
Cell Rep, 26, 2019
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6N8T
 | | Hsp104DWB closed conformation | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein 104 | | Authors: | Lee, S, Rho, S.H, Lee, J, Sung, N, Liu, J, Tsai, F.T.F. | | Deposit date: | 2018-11-30 | | Release date: | 2019-01-02 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (7.7 Å) | | Cite: | Cryo-EM Structures of the Hsp104 Protein Disaggregase Captured in the ATP Conformation.
Cell Rep, 26, 2019
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1QVR
 | | Crystal Structure Analysis of ClpB | | Descriptor: | ClpB protein, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, PLATINUM (II) ION | | Authors: | Lee, S, Sowa, M.E, Watanabe, Y, Sigler, P.B, Chiu, W, Yoshida, M, Tsai, F.T.F. | | Deposit date: | 2003-08-28 | | Release date: | 2003-10-21 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | The Structure of ClpB: A Molecular Chaperone that Rescues Proteins from an Aggregated State
Cell(Cambridge,Mass.), 115, 2003
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1AJ6
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5WBW
 | | Yeast Hsp104 fragment 1-360 | | Descriptor: | Heat shock protein 104 | | Authors: | Lee, S. | | Deposit date: | 2017-06-29 | | Release date: | 2018-01-03 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural determinants for protein unfolding and translocation by the Hsp104 protein disaggregase.
Biosci. Rep., 37, 2017
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6AMN
 | | Crystal Structure of Hsp104 N Domain | | Descriptor: | Heat shock protein 104 | | Authors: | Lee, S. | | Deposit date: | 2017-08-10 | | Release date: | 2017-11-29 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.816 Å) | | Cite: | Overlapping and Specific Functions of the Hsp104 N Domain Define Its Role in Protein Disaggregation.
Sci Rep, 7, 2017
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