7AHO
| RUVBL1-RUVBL2 heterohexameric ring after binding of RNA helicase DHX34 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, RuvB-like 1, RuvB-like 2 | Authors: | Lopez-Perrote, A, Rodriguez, C.F, Llorca, O. | Deposit date: | 2020-09-25 | Release date: | 2020-11-25 | Method: | ELECTRON MICROSCOPY (4.18 Å) | Cite: | Regulation of RUVBL1-RUVBL2 AAA-ATPases by the nonsense-mediated mRNA decay factor DHX34, as evidenced by Cryo-EM. Elife, 9, 2020
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9EMA
| RUVBL1/2 in complex with ATP and CB-6644 inhibitor | Descriptor: | 5-chloranyl-2-ethoxy-4-fluoranyl-~{N}-[4-[[3-(methoxymethyl)-1-oxidanylidene-6,7-dihydro-5~{H}-pyrazolo[1,2-a][1,2]benzodiazepin-2-yl]amino]-2,2-dimethyl-4-oxidanylidene-butyl]benzamide, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Lopez-Perrote, A, Llorca, O, Garcia-Martin, C. | Deposit date: | 2024-03-07 | Release date: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (2.4 Å) | Cite: | Mechanism of allosteric inhibition of RUVBL1-RUVBL2 by the small-molecule CB-6644 Cell Rep Phys Sci, 2024
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9EMC
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7P6X
| Cryo-Em structure of the hexameric RUVBL1-RUVBL2 in complex with ZNHIT2 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, RuvB-like 1, RuvB-like 2 | Authors: | Llorca, O, Serna, M, Fernandez-Leiro, R. | Deposit date: | 2021-07-18 | Release date: | 2021-12-15 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | CryoEM of RUVBL1-RUVBL2-ZNHIT2, a complex that interacts with pre-mRNA-processing-splicing factor 8. Nucleic Acids Res., 50, 2022
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