6SR7
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![BU of 6sr7 by Molmil](/molmil-images/mine/6sr7) | Structure of the U1A variant A1-98 Y31H/Q36R/K98W | Descriptor: | SULFATE ION, U1 small nuclear ribonucleoprotein A | Authors: | Rosenbach, H, Span, I. | Deposit date: | 2019-09-05 | Release date: | 2020-05-13 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Expanding crystallization tools for nucleic acid complexes using U1A protein variants. J.Struct.Biol., 210, 2020
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6SQV
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![BU of 6sqv by Molmil](/molmil-images/mine/6sqv) | Structure of the U1A variant A1-98 Y31H/Q36R/R70W | Descriptor: | SULFATE ION, U1 small nuclear ribonucleoprotein A | Authors: | Rosenbach, H, Span, I. | Deposit date: | 2019-09-04 | Release date: | 2020-05-13 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Expanding crystallization tools for nucleic acid complexes using U1A protein variants. J.Struct.Biol., 210, 2020
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6SQN
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6SQT
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6SQQ
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2JDF
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![BU of 2jdf by Molmil](/molmil-images/mine/2jdf) | Human gamma-B crystallin | Descriptor: | GAMMA CRYSTALLIN B | Authors: | Ebersbach, H, Fiedler, E, Scheuermann, T, Fiedler, M, Stubbs, M.T, Reimann, C, Proetzel, G, Rudolph, R, Fiedler, U. | Deposit date: | 2007-01-08 | Release date: | 2007-07-24 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Affilin-Novel Binding Molecules Based on Human Gamma-B-Crystallin, an All Beta-Sheet Protein. J.Mol.Biol., 372, 2007
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2JDG
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![BU of 2jdg by Molmil](/molmil-images/mine/2jdg) | Affilin based on HUMAN GAMMA-B CRYSTALLIN | Descriptor: | GAMMA CRYSTALLIN B | Authors: | Ebersbach, H, Fiedler, E, Scheuermann, T, Fiedler, M, Stubbs, M.T, Reimann, C, Proetzel, G, Rudolph, R, Fiedler, U. | Deposit date: | 2007-01-08 | Release date: | 2007-07-24 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Affilin-Novel Binding Molecules Based on Human Gamma-B-Crystallin, an All Beta-Sheet Protein. J.Mol.Biol., 372, 2007
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1ODO
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![BU of 1odo by Molmil](/molmil-images/mine/1odo) | 1.85 A structure of CYP154A1 from Streptomyces coelicolor A3(2) | Descriptor: | 4-PHENYL-1H-IMIDAZOLE, PROTOPORPHYRIN IX CONTAINING FE, PUTATIVE CYTOCHROME P450 154A1 | Authors: | Podust, L.M, Kim, Y, Arase, M, Bach, H, Sherman, D.H, Lamb, D.C, Kelly, S.L, Waterman, M.R. | Deposit date: | 2003-02-19 | Release date: | 2004-01-02 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Comparison of the 1.85 A Structure of Cyp154A1 from Streptomyces Coelicolor A3(2) with the Closely Related Cyp154C1 and Cyps from Antibiotic Biosynthetic Pathways. Protein Sci., 13, 2004
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1GWI
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![BU of 1gwi by Molmil](/molmil-images/mine/1gwi) | The 1.92 A structure of Streptomyces coelicolor A3(2) CYP154C1: A new monooxygenase that functionalizes macrolide ring systems | Descriptor: | CYTOCHROME P450 154C1, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION | Authors: | Podust, L.M, Kim, Y, Arase, M, Neely, B.A, Beck, B.J, Bach, H, Sherman, D.H, Lamb, D.C, Kelly, S.L, Waterman, M.R. | Deposit date: | 2002-03-15 | Release date: | 2003-01-29 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | The 1.92 A Structure of Streptomyces Coelicolor A3(2) Cyp154C1: A New Monooxygenase that Functionalizes Macrolide Ring Systems J.Biol.Chem., 278, 2003
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5NHY
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![BU of 5nhy by Molmil](/molmil-images/mine/5nhy) | BAY-707 in complex with MTH1 | Descriptor: | 7,8-dihydro-8-oxoguanine triphosphatase, GLYCEROL, SULFATE ION, ... | Authors: | Ellermann, M, Eheim, A, Giese, A, Bunse, S, Nowak-Reppel, K, Neuhaus, R, Weiske, J, Quanz, M, Glasauer, A, Meyer, H, Queisser, N, Irlbacher, H, Bader, B, Rahm, F, Viklund, J, Andersson, M, Ericsson, U, Ginman, T, Forsblom, R, Lindstrom, J, Silvander, C, Tresaugues, L, Gorjanacz, M. | Deposit date: | 2017-03-22 | Release date: | 2017-07-19 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Novel Class of Potent and Cellularly Active Inhibitors Devalidates MTH1 as Broad-Spectrum Cancer Target. ACS Chem. Biol., 12, 2017
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6YM5
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![BU of 6ym5 by Molmil](/molmil-images/mine/6ym5) | Crystal structure of BAY-091 with PIP4K2A | Descriptor: | (2~{R})-2-[[3-cyano-2-[4-(2-fluoranyl-3-methyl-phenyl)phenyl]-1,7-naphthyridin-4-yl]amino]butanoic acid, PHOSPHATE ION, Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha | Authors: | Holton, S.J, Wortmann, L, Braeuer, N, Irlbacher, H, Weiske, J, Lechner, C, Meier, R, Puetter, V, Christ, C, ter Laak, T, Lienau, P, Lesche, R, Nicke, B, Bauser, M, Haegebarth, A, von Nussbaum, F, Mumberg, D, Lemos, C. | Deposit date: | 2020-04-07 | Release date: | 2021-04-14 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Discovery and Characterization of the Potent and Highly Selective 1,7-Naphthyridine-Based Inhibitors BAY-091 and BAY-297 of the Kinase PIP4K2A. J.Med.Chem., 64, 2021
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6YM3
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![BU of 6ym3 by Molmil](/molmil-images/mine/6ym3) | Crystal structure of Compound 1 with PIP4K2A | Descriptor: | (2~{R})-2-[[3-cyano-2-[4-(2-ethoxyphenyl)phenyl]-5,8-dihydro-1,7-naphthyridin-4-yl]amino]propanoic acid, PHOSPHATE ION, Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha | Authors: | Holton, S.J, Wortmann, L, Braeuer, N, Irlbacher, H, Weiske, J, Lechner, C, Meier, R, Puetter, V, Christ, C, ter Laak, T, Lienau, P, Lesche, R, Nicke, B, Bauser, M, Haegebarth, A, von Nussbaum, F, Mumberg, D, Lemos, C. | Deposit date: | 2020-04-07 | Release date: | 2021-04-14 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Discovery and Characterization of the Potent and Highly Selective 1,7-Naphthyridine-Based Inhibitors BAY-091 and BAY-297 of the Kinase PIP4K2A. J.Med.Chem., 64, 2021
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6YM4
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![BU of 6ym4 by Molmil](/molmil-images/mine/6ym4) | Crystal structure of BAY-297 with PIP4K2A | Descriptor: | (2~{R})-2-[[2-[4-(3-chloranyl-2-fluoranyl-phenyl)phenyl]-3-cyano-1,7-naphthyridin-4-yl]amino]butanamide, GLYCEROL, Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha | Authors: | Holton, S.J, Wortmann, L, Braeuer, N, Irlbacher, H, Weiske, J, Lechner, C, Meier, R, Puetter, V, Christ, C, ter Laak, T, Lienau, P, Lesche, R, Nicke, B, Bauser, M, Haegebarth, A, von Nussbaum, F, Mumberg, D, Lemos, C. | Deposit date: | 2020-04-07 | Release date: | 2021-04-14 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Discovery and Characterization of the Potent and Highly Selective 1,7-Naphthyridine-Based Inhibitors BAY-091 and BAY-297 of the Kinase PIP4K2A. J.Med.Chem., 64, 2021
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1FVG
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![BU of 1fvg by Molmil](/molmil-images/mine/1fvg) | CRYSTAL STRUCTURE OF BOVINE PEPTIDE METHIONINE SULFOXIDE REDUCTASE | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, PEPTIDE METHIONINE SULFOXIDE REDUCTASE | Authors: | Lowther, W.T, Brot, N, Weissbach, H, Matthews, B.W. | Deposit date: | 2000-09-19 | Release date: | 2000-11-08 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure and mechanism of peptide methionine sulfoxide reductase, an "anti-oxidation" enzyme. Biochemistry, 39, 2000
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1FVA
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![BU of 1fva by Molmil](/molmil-images/mine/1fva) | CRYSTAL STRUCTURE OF BOVINE METHIONINE SULFOXIDE REDUCTASE | Descriptor: | PEPTIDE METHIONINE SULFOXIDE REDUCTASE | Authors: | Lowther, W.T, Brot, N, Weissbach, H, Matthews, B.W. | Deposit date: | 2000-09-19 | Release date: | 2000-11-08 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structure and mechanism of peptide methionine sulfoxide reductase, an "anti-oxidation" enzyme. Biochemistry, 39, 2000
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1B4G
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![BU of 1b4g by Molmil](/molmil-images/mine/1b4g) | CONTROL OF K+ CHANNEL GATING BY PROTEIN PHOSPHORYLATION: STRUCTURAL SWITCHES OF THE INACTIVATION GATE, NMR, 22 STRUCTURES | Descriptor: | POTASSIUM CHANNEL | Authors: | Antz, C, Bauer, T, Kalbacher, H, Frank, R, Covarrubias, M, Kalbitzer, H.R, Ruppersberg, J.P, Baukrowitz, T, Fakler, B. | Deposit date: | 1998-12-22 | Release date: | 1999-04-27 | Last modified: | 2022-02-16 | Method: | SOLUTION NMR | Cite: | Control of K+ channel gating by protein phosphorylation: structural switches of the inactivation gate. Nat.Struct.Biol., 6, 1999
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1B4I
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![BU of 1b4i by Molmil](/molmil-images/mine/1b4i) | Control of K+ Channel Gating by protein phosphorylation: structural switches of the inactivation gate, NMR, 22 structures | Descriptor: | POTASSIUM CHANNEL | Authors: | Antz, C, Bauer, T, Kalbacher, H, Frank, R, Covarrubias, M, Kalbitzer, H.R, Ruppersberg, J.P, Baukrowitz, T, Fakler, B. | Deposit date: | 1998-12-22 | Release date: | 1999-04-27 | Last modified: | 2022-03-23 | Method: | SOLUTION NMR | Cite: | Control of K+ channel gating by protein phosphorylation: structural switches of the inactivation gate. Nat.Struct.Biol., 6, 1999
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1L1D
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![BU of 1l1d by Molmil](/molmil-images/mine/1l1d) | Crystal structure of the C-terminal methionine sulfoxide reductase domain (MsrB) of N. gonorrhoeae pilB | Descriptor: | CACODYLATE ION, peptide methionine sulfoxide reductase | Authors: | Lowther, W.T, Weissbach, H, Etienne, F, Brot, N, Matthews, B.W. | Deposit date: | 2002-02-15 | Release date: | 2002-05-01 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | The mirrored methionine sulfoxide reductases of Neisseria gonorrhoeae pilB. Nat.Struct.Biol., 9, 2002
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2XDP
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![BU of 2xdp by Molmil](/molmil-images/mine/2xdp) | Crystal structure of the tudor domain of human JMJD2C | Descriptor: | LYSINE-SPECIFIC DEMETHYLASE 4C, SULFATE ION | Authors: | Yue, W.W, Gileadi, C, Krojer, T, Weisbach, H, Ugochukwu, E, Daniel, M, Phillips, C, Chaikuad, A, von Delft, F, Allerston, C, Arrowsmith, C, Weigelt, J, Edwards, A, Bountra, C, Oppermann, U. | Deposit date: | 2010-05-06 | Release date: | 2010-06-09 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | Crystal Structure of the Tudor Domain of Human Jmjd2C To be Published
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2H30
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![BU of 2h30 by Molmil](/molmil-images/mine/2h30) | Crystal structure of the N-terminal domain of PilB from Neisseria gonorrhoeae | Descriptor: | Peptide methionine sulfoxide reductase msrA/msrB | Authors: | Brot, N, Collet, J.F, Johnson, L.C, Jonsson, T.J, Weissbach, H, Lowther, W.T. | Deposit date: | 2006-05-20 | Release date: | 2006-08-22 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The Thioredoxin Domain of Neisseria gonorrhoeae PilB Can Use Electrons from DsbD to Reduce Downstream Methionine Sulfoxide Reductases. J.Biol.Chem., 281, 2006
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1W1F
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![BU of 1w1f by Molmil](/molmil-images/mine/1w1f) | SH3 DOMAIN OF HUMAN LYN TYROSINE KINASE | Descriptor: | TYROSINE-PROTEIN KINASE LYN | Authors: | Bauer, F, Schweimer, K, Hoffmann, S, Roesch, P, Sticht, H. | Deposit date: | 2004-06-17 | Release date: | 2005-07-06 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural Characterization of Lyn-SH3 Domain in Complex with a Herpesviral Protein Reveals an Extended Recognition Motif that Enhances Binding Affinity. Protein Sci., 14, 2005
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7PDU
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2KB6
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![BU of 2kb6 by Molmil](/molmil-images/mine/2kb6) | Solution structure of onconase C87A/C104A | Descriptor: | Protein P-30 | Authors: | Weininger, U, Schulenburg, C, Arnold, U, Ulbrich-Hofmann, R, Balbach, J. | Deposit date: | 2008-11-21 | Release date: | 2009-11-24 | Last modified: | 2021-11-10 | Method: | SOLUTION NMR | Cite: | Impact of the C-terminal disulfide bond on the folding and stability of onconase. Chembiochem, 11, 2010
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3FD7
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![BU of 3fd7 by Molmil](/molmil-images/mine/3fd7) | Crystal structure of Onconase C87A/C104A-ONC | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, Protein P-30, ... | Authors: | Neumann, P, Schulenburg, C, Arnold, U, Ulbrich-Hofmann, R, Stubbs, M.T. | Deposit date: | 2008-11-25 | Release date: | 2009-12-08 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.531 Å) | Cite: | Impact of the C-terminal disulfide bond on the folding and stability of onconase. Chembiochem, 11, 2010
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6RSU
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![BU of 6rsu by Molmil](/molmil-images/mine/6rsu) | TBK1 in complex with Inhibitor compound 35 | Descriptor: | 3,3,3-tris(fluoranyl)-1-[4-[(1~{R})-1-[2-[[(2~{S})-5-(5-propan-2-yloxypyrimidin-4-yl)-2,3-dihydro-1~{H}-benzimidazol-2-yl]amino]pyridin-4-yl]ethyl]piperazin-1-yl]propan-1-one, Serine/threonine-protein kinase TBK1 | Authors: | Panne, D, Hillig, R.C, Rengachari, S. | Deposit date: | 2019-05-22 | Release date: | 2020-04-01 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Discovery of BAY-985, a Highly Selective TBK1/IKK epsilon Inhibitor. J.Med.Chem., 63, 2020
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