1QZG
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![BU of 1qzg by Molmil](/molmil-images/mine/1qzg) | Crystal structure of Pot1 (protection of telomere)- ssDNA complex | Descriptor: | Protection of telomeres protein 1, THYMIDINE-5'-PHOSPHATE, telomeric single-stranded DNA | Authors: | Lei, M, Podell, E.R, Baumann, P, Cech, T.R. | Deposit date: | 2003-09-16 | Release date: | 2003-11-18 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA Nature, 426, 2003
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1QZH
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![BU of 1qzh by Molmil](/molmil-images/mine/1qzh) | Crystal structure of Pot1 (protection of telomere)- ssDNA complex | Descriptor: | Protection of telomeres protein 1, telomeric single-stranded DNA | Authors: | Lei, M, Podell, E.R, Baumann, P, Cech, T.R. | Deposit date: | 2003-09-16 | Release date: | 2003-11-25 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA Nature, 426, 2003
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1YHW
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![BU of 1yhw by Molmil](/molmil-images/mine/1yhw) | |
1YHV
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![BU of 1yhv by Molmil](/molmil-images/mine/1yhv) | |
1XJV
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![BU of 1xjv by Molmil](/molmil-images/mine/1xjv) | |
6OGJ
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![BU of 6ogj by Molmil](/molmil-images/mine/6ogj) | MeCP2 MBD in complex with DNA | Descriptor: | DNA (5'-D(*CP*GP*GP*AP*GP*TP*GP*TP*AP*GP*GP*C)-3'), DNA (5'-D(*GP*CP*CP*TP*AP*CP*AP*CP*TP*CP*CP*G)-3'), Methyl-CpG-binding protein 2, ... | Authors: | Lei, M, Tempel, W, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2019-04-02 | Release date: | 2019-05-01 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Plasticity at the DNA recognition site of the MeCP2 mCG-binding domain. Biochim Biophys Acta Gene Regul Mech, 1862, 2019
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6OGK
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![BU of 6ogk by Molmil](/molmil-images/mine/6ogk) | MeCP2 MBD in complex with DNA | Descriptor: | CALCIUM ION, DNA (5'-D(*CP*GP*GP*AP*GP*TP*GP*TP*AP*GP*GP*C)-3'), DNA (5'-D(*GP*CP*CP*TP*AP*(5CM)P*AP*CP*TP*CP*CP*G)-3'), ... | Authors: | Lei, M, Tempel, W, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium, Structural Genomics Consortium (SGC) | Deposit date: | 2019-04-02 | Release date: | 2019-05-01 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Plasticity at the DNA recognition site of the MeCP2 mCG-binding domain. Biochim Biophys Acta Gene Regul Mech, 1862, 2019
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1F3M
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![BU of 1f3m by Molmil](/molmil-images/mine/1f3m) | CRYSTAL STRUCTURE OF HUMAN SERINE/THREONINE KINASE PAK1 | Descriptor: | IODIDE ION, SERINE/THREONINE-PROTEIN KINASE PAK-ALPHA | Authors: | Lei, M, Lu, W, Meng, W, Parrini, M.-C, Eck, M.J, Mayer, B.J, Harrison, S.C. | Deposit date: | 2000-06-05 | Release date: | 2000-06-29 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch. Cell(Cambridge,Mass.), 102, 2000
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7LMT
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![BU of 7lmt by Molmil](/molmil-images/mine/7lmt) | Histone-lysine N-methyltransferase NSD2-PWWP1 with compound MRT10241866a | Descriptor: | Histone-lysine N-methyltransferase NSD2, UNKNOWN ATOM OR ION, ~{N}-cyclopropyl-3-oxidanylidene-~{N}-(thiophen-2-ylmethyl)-4~{H}-1,4-benzoxazine-7-carboxamide | Authors: | Lei, M, Freitas, R.F, Dong, A, Schapira, M, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2021-02-05 | Release date: | 2021-03-10 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.27 Å) | Cite: | Histone-lysine N-methyltransferase NSD2-PWWP1 with compound MRT10241866a To Be Published
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1CTF
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4ACB
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![BU of 4acb by Molmil](/molmil-images/mine/4acb) | CRYSTAL STRUCTURE OF TRANSLATION ELONGATION FACTOR SELB FROM METHANOCOCCUS MARIPALUDIS IN COMPLEX WITH THE GTP ANALOGUE GPPNHP | Descriptor: | (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-MONOPHOSPHATE, ... | Authors: | Leibundgut, M, Frick, C, Thanbichler, M, Boeck, A, Ban, N. | Deposit date: | 2011-12-14 | Release date: | 2012-11-07 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.34 Å) | Cite: | Selenocysteine tRNA-Specific Elongation Factor Selb is a Structural Chimaera of Elongation and Initiation Factors. Embo J., 24, 2005
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4AC9
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![BU of 4ac9 by Molmil](/molmil-images/mine/4ac9) | CRYSTAL STRUCTURE OF TRANSLATION ELONGATION FACTOR SELB FROM METHANOCOCCUS MARIPALUDIS IN COMPLEX WITH GDP | Descriptor: | (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-MONOPHOSPHATE, ... | Authors: | Leibundgut, M, Frick, C, Thanbichler, M, Boeck, A, Ban, N. | Deposit date: | 2011-12-14 | Release date: | 2012-08-22 | Method: | X-RAY DIFFRACTION (3.03 Å) | Cite: | Selenocysteine tRNA-Specific Elongation Factor Selb is a Structural Chimaera of Elongation and Initiation Factors. Embo J., 24, 2005
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4ACA
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![BU of 4aca by Molmil](/molmil-images/mine/4aca) | CRYSTAL STRUCTURE OF TRANSLATION ELONGATION FACTOR SELB FROM METHANOCOCCUS MARIPALUDIS, APO FORM | Descriptor: | (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID, GUANOSINE-5'-MONOPHOSPHATE, SULFATE ION, ... | Authors: | Leibundgut, M, Frick, C, Thanbichler, M, Boeck, A, Ban, N. | Deposit date: | 2011-12-14 | Release date: | 2012-11-07 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Selenocysteine tRNA-Specific Elongation Factor Selb is a Structural Chimaera of Elongation and Initiation Factors. Embo J., 24, 2005
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1NH2
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![BU of 1nh2 by Molmil](/molmil-images/mine/1nh2) | Crystal structure of a yeast TFIIA/TBP/DNA complex | Descriptor: | 5'-D(*GP*TP*TP*TP*TP*AP*TP*AP*TP*AP*CP*AP*TP*AP*CP*A)-3', 5'-D(*TP*GP*TP*AP*(5IU)P*GP*TP*AP*TP*AP*(5IU)P*AP*AP*AP*AP*C)-3', Transcription initiation factor IIA large chain, ... | Authors: | Bleichenbacher, M, Tan, S, Richmond, T.J. | Deposit date: | 2002-12-18 | Release date: | 2003-10-21 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Novel interactions between the components of human and yeast TFIIA/TBP/DNA complexes. J.Mol.Biol., 332, 2003
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1NVP
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![BU of 1nvp by Molmil](/molmil-images/mine/1nvp) | HUMAN TFIIA/TBP/DNA COMPLEX | Descriptor: | 5'-D(*CP*CP*TP*TP*TP*TP*AP*TP*AP*GP*CP*CP*CP*CP*CP*CP*C)-3', 5'-D(*GP*GP*GP*GP*GP*GP*GP*CP*TP*AP*TP*AP*AP*AP*AP*GP*G)-3', TATA box binding protein, ... | Authors: | Bleichenbacher, M, Tan, S, Richmond, T.J. | Deposit date: | 2003-02-04 | Release date: | 2003-10-21 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Novel interactions between the components of human and yeast TFIIA/TBP/DNA complexes. J.Mol.Biol., 332, 2003
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2UV8
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![BU of 2uv8 by Molmil](/molmil-images/mine/2uv8) | Crystal structure of yeast fatty acid synthase with stalled acyl carrier protein at 3.1 angstrom resolution | Descriptor: | FATTY ACID SYNTHASE SUBUNIT ALPHA (FAS2), FATTY ACID SYNTHASE SUBUNIT BETA (FAS1), FLAVIN MONONUCLEOTIDE | Authors: | Leibundgut, M, Jenni, S, Frick, C, Ban, N. | Deposit date: | 2007-03-09 | Release date: | 2007-04-17 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural Basis for Substrate Delivery by Acyl Carrier Protein in the Yeast Fatty Acid Synthase Science, 316, 2007
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7MDN
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![BU of 7mdn by Molmil](/molmil-images/mine/7mdn) | Histone-lysine N-methyltransferase NSD2-PWWP1 with compound MRT10241866a | Descriptor: | Histone-lysine N-methyltransferase NSD2, UNKNOWN ATOM OR ION, ~{N}-cyclopropyl-3-oxidanylidene-~{N}-(thiophen-2-ylmethyl)-4~{H}-1,4-benzoxazine-7-carboxamide | Authors: | Lei, M, Freitas, R.F, Dong, A, Schapira, M, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2021-04-05 | Release date: | 2021-05-05 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.42 Å) | Cite: | A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization. Nat.Chem.Biol., 18, 2022
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6C1V
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![BU of 6c1v by Molmil](/molmil-images/mine/6c1v) | MBD2 in complex with double-stranded DNA | Descriptor: | 12-mer DNA, Methyl-CpG-binding domain protein 2, UNKNOWN ATOM OR ION | Authors: | Lei, M, Tempel, W, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2018-01-05 | Release date: | 2018-02-14 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA. J. Biol. Chem., 293, 2018
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6C1T
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![BU of 6c1t by Molmil](/molmil-images/mine/6c1t) | MBD2 in complex with a partially methylated DNA | Descriptor: | 12-mer DNA, GLYCEROL, Methyl-CpG-binding domain protein 2, ... | Authors: | Lei, M, Tempel, W, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2018-01-05 | Release date: | 2018-02-14 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA. J. Biol. Chem., 293, 2018
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6C1U
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![BU of 6c1u by Molmil](/molmil-images/mine/6c1u) | MBD2 in complex with a deoxy-oligonucleotide | Descriptor: | 12-mer DNA, Methyl-CpG-binding domain protein 2, UNKNOWN ATOM OR ION | Authors: | Lei, M, Tempel, W, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2018-01-05 | Release date: | 2018-02-14 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA. J. Biol. Chem., 293, 2018
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4P1Q
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![BU of 4p1q by Molmil](/molmil-images/mine/4p1q) | GREEN FLUORESCENT PROTEIN E222H VARIANT | Descriptor: | Green fluorescent protein, SODIUM ION | Authors: | Klein, M, Carius, Y, Auerbach, D, Franz, S, Jung, G, Lancaster, C.R.D. | Deposit date: | 2014-02-27 | Release date: | 2014-07-16 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Replacement of Highly Conserved E222 by the Photostable Non-photoconvertible Histidine in GFP. Chembiochem, 15, 2014
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7B12
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![BU of 7b12 by Molmil](/molmil-images/mine/7b12) | HUMAN IMMUNOPROTEASOME 20S PARTICLE IN COMPLEX WITH [2-(3-ethylphenyl)-1-[(2S)-3-phenyl-2-[(pyrazin-2-yl)formamido]propanamido]ethyl]boronic acid | Descriptor: | ((R)-2-(3-ethylphenyl)-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)ethyl)boronic acid, Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, ... | Authors: | Musil, D, Klein, M, Crosignani, S. | Deposit date: | 2020-11-23 | Release date: | 2021-12-01 | Last modified: | 2023-06-14 | Method: | X-RAY DIFFRACTION (2.43 Å) | Cite: | Structure-Based Optimization and Discovery of M3258, a Specific Inhibitor of the Immunoproteasome Subunit LMP7 ( beta 5i). J.Med.Chem., 64, 2021
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4O26
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![BU of 4o26 by Molmil](/molmil-images/mine/4o26) | |
6L7O
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![BU of 6l7o by Molmil](/molmil-images/mine/6l7o) | cryo-EM structure of cyanobacteria Fd-NDH-1L complex | Descriptor: | 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, BETA-CAROTENE, ... | Authors: | Zhang, C, Shuai, J, Wu, J, Lei, M. | Deposit date: | 2019-11-02 | Release date: | 2020-02-19 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural insights into NDH-1 mediated cyclic electron transfer. Nat Commun, 11, 2020
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6LBS
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![BU of 6lbs by Molmil](/molmil-images/mine/6lbs) | Crystal structure of yeast Stn1 | Descriptor: | KLLA0C11825p | Authors: | Ge, Y, Wu, Z, Wu, J, Lei, M. | Deposit date: | 2019-11-14 | Release date: | 2020-07-15 | Last modified: | 2020-08-19 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural insights into telomere protection and homeostasis regulation by yeast CST complex. Nat.Struct.Mol.Biol., 27, 2020
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