7F59
| DNQX-bound GluK2-1xNeto2 complex | Descriptor: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | Authors: | He, L.L, Gao, Y.W, Li, B, Zhao, Y. | Deposit date: | 2021-06-21 | Release date: | 2021-09-29 | Last modified: | 2021-12-01 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Kainate receptor modulation by NETO2. Nature, 599, 2021
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7F56
| DNQX-bound GluK2-1xNeto2 complex, with asymmetric LBD | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, kainate 2, ... | Authors: | He, L.L, Gao, Y.W, Li, B, Zhao, Y. | Deposit date: | 2021-06-21 | Release date: | 2021-09-29 | Last modified: | 2021-12-01 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Kainate receptor modulation by NETO2. Nature, 599, 2021
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7F57
| Kainate-bound GluK2-1xNeto2 complex, at the desensitized state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, kainate 2, ... | Authors: | He, L.L, Gao, Y.W, Li, B, Zhao, Y. | Deposit date: | 2021-06-21 | Release date: | 2021-09-29 | Last modified: | 2021-12-01 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Kainate receptor modulation by NETO2. Nature, 599, 2021
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7F5B
| LBD-TMD focused reconstruction of DNQX-bound GluK2-1xNeto2 complex | Descriptor: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | He, L.L, Gao, Y.W, Li, B, Zhao, Y. | Deposit date: | 2021-06-21 | Release date: | 2021-09-29 | Last modified: | 2021-12-01 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Kainate receptor modulation by NETO2. Nature, 599, 2021
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7F5A
| DNQX-bound GluK2-2xNeto2 complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, kainate 2, ... | Authors: | He, L.L, Gao, Y.W, Li, B, Zhao, Y. | Deposit date: | 2021-06-21 | Release date: | 2021-09-29 | Last modified: | 2021-12-01 | Method: | ELECTRON MICROSCOPY (6.4 Å) | Cite: | Kainate receptor modulation by NETO2. Nature, 599, 2021
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7XAF
| The crystal structure of TrkA kinase in complex with 4^6,14-dimethyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-10-oxo-5-oxa-11,14-diaza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)-benzenacyclo- tetradecaphan-2-yne-45-carboxamide | Descriptor: | 4^6,14-dimethyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-10-oxo-5-oxa-11,14-diaza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)-benzenacyclo-tetradecaphan-2-yne-45-carboxamide, High affinity nerve growth factor receptor | Authors: | Zhang, Z.M, Wang, Y.J. | Deposit date: | 2022-03-17 | Release date: | 2022-06-01 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.001182 Å) | Cite: | Discovery of the First Highly Selective and Broadly Effective Macrocycle-Based Type II TRK Inhibitors that Overcome Clinically Acquired Resistance. J.Med.Chem., 65, 2022
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8HJD
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8HJC
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8HIJ
| The 5-MTHF-bound BRIL-SLC19A1/Fab/Nb ternary complex | Descriptor: | Anti-BRIL Fab heavy chain, Anti-BRIL Fab light chain, Anti-Fab nanobody, ... | Authors: | Zhang, Z, Dang, Y. | Deposit date: | 2022-11-20 | Release date: | 2022-12-21 | Last modified: | 2023-01-11 | Method: | ELECTRON MICROSCOPY (3.54 Å) | Cite: | Molecular mechanism of substrate recognition by folate transporter SLC19A1. Cell Discov, 8, 2022
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8HIK
| The TPP-bound BRIL-SLC19A1/Fab/Nb ternary complex | Descriptor: | Anti-BRIL Fab heavy chain, Anti-BRIL Fab light chain, Anti-Fab nanobody, ... | Authors: | Zhang, Z, Dang, Y. | Deposit date: | 2022-11-20 | Release date: | 2022-12-21 | Last modified: | 2023-01-11 | Method: | ELECTRON MICROSCOPY (3.72 Å) | Cite: | Molecular mechanism of substrate recognition by folate transporter SLC19A1. Cell Discov, 8, 2022
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8HII
| The BRIL-SLC19A1/Fab/Nb ternary complex | Descriptor: | BRIL-SLC19A1 chimera, anti-BRIL Fab heavy chain, anti-BRIL Fab light chain, ... | Authors: | Zhang, Z, Dang, Y. | Deposit date: | 2022-11-20 | Release date: | 2022-12-21 | Last modified: | 2023-01-11 | Method: | ELECTRON MICROSCOPY (3.57 Å) | Cite: | Molecular mechanism of substrate recognition by folate transporter SLC19A1. Cell Discov, 8, 2022
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7YLX
| yeast TRiC-plp2-actin complex at S4 closed TRiC state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, MAGNESIUM ION, ... | Authors: | Han, W.Y. | Deposit date: | 2022-07-27 | Release date: | 2023-03-29 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural basis of plp2-mediated cytoskeletal protein folding by TRiC/CCT. Sci Adv, 9, 2023
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7YLY
| yeast TRiC-plp2 complex at S5 closed TRiC state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, MAGNESIUM ION, ... | Authors: | Han, W.Y. | Deposit date: | 2022-07-27 | Release date: | 2023-03-29 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.05 Å) | Cite: | Structural basis of plp2-mediated cytoskeletal protein folding by TRiC/CCT. Sci Adv, 9, 2023
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7YLV
| yeast TRiC-plp2-substrate complex at S2 ATP binding state | Descriptor: | Phosducin-like protein 2, T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, ... | Authors: | Han, W.Y. | Deposit date: | 2022-07-27 | Release date: | 2023-03-29 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.91 Å) | Cite: | Structural basis of plp2-mediated cytoskeletal protein folding by TRiC/CCT. Sci Adv, 9, 2023
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6ATH
| Cdk2/cyclin A/p27-KID-deltaC | Descriptor: | Cyclin-A2, Cyclin-dependent kinase 2, Cyclin-dependent kinase inhibitor 1B, ... | Authors: | White, S.W, Yun, M. | Deposit date: | 2017-08-29 | Release date: | 2018-09-12 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Dynamic anticipation by Cdk2/Cyclin A-bound p27 mediates signal integration in cell cycle regulation. Nat Commun, 10, 2019
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7YLU
| yeast TRiC-plp2-substrate complex at S1 TRiC-NPP state | Descriptor: | Phosducin-like protein 2, T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, ... | Authors: | Han, W.Y. | Deposit date: | 2022-07-27 | Release date: | 2023-03-29 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (4.55 Å) | Cite: | Structural basis of plp2-mediated cytoskeletal protein folding by TRiC/CCT. Sci Adv, 9, 2023
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7YLW
| yeast TRiC-plp2-tubulin complex at S3 closed TRiC state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Han, W.Y. | Deposit date: | 2022-07-27 | Release date: | 2023-03-29 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.39 Å) | Cite: | Structural basis of plp2-mediated cytoskeletal protein folding by TRiC/CCT. Sci Adv, 9, 2023
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6BTM
| Structure of Alternative Complex III from Flavobacterium johnsoniae (Wild Type) | Descriptor: | (2S)-3-hydroxypropane-1,2-diyl ditetradecanoate, Alternative Complex III subunit A, Alternative Complex III subunit B, ... | Authors: | Sun, C, Benlekbir, S, Venkatakrishnan, P, Yuhang, W, Tajkhorshid, E, Rubinstein, J.L, Gennis, R.B. | Deposit date: | 2017-12-07 | Release date: | 2018-05-09 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure of the alternative complex III in a supercomplex with cytochrome oxidase. Nature, 557, 2018
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6APA
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7XML
| Cryo-EM structure of PEIP-Bs_enolase complex | Descriptor: | Enolase, MAGNESIUM ION, Putative gene 60 protein | Authors: | Li, S, Zhang, K. | Deposit date: | 2022-04-26 | Release date: | 2022-07-27 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Bacteriophage protein PEIP is a potent Bacillus subtilis enolase inhibitor. Cell Rep, 40, 2022
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4HIQ
| The Structure of V122I Mutant Transthyretin in Complex with AG10 | Descriptor: | 3-[3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy]-4-fluorobenzoic acid, Transthyretin | Authors: | Connelly, S, Alhamadsheh, M, Graef, I, Wilson, I.A. | Deposit date: | 2012-10-11 | Release date: | 2013-06-05 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.18 Å) | Cite: | AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin. Proc.Natl.Acad.Sci.USA, 110, 2013
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4HIS
| The Structure of V122I Mutant Transthyretin in Complex with Tafamidis | Descriptor: | 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid, Transthyretin | Authors: | Connelly, S, Alhamadsheh, M, Graef, I, Wilson, I.A. | Deposit date: | 2012-10-11 | Release date: | 2013-06-05 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin. Proc.Natl.Acad.Sci.USA, 110, 2013
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7WJ6
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7WJ7
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4IWY
| SeMet-substituted RimK structure | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, GLUTAMIC ACID, Ribosomal protein S6 modification protein, ... | Authors: | Shi, D, Zhao, G, Jin, Z, Allewell, N.M, Tuchman, M. | Deposit date: | 2013-01-24 | Release date: | 2013-05-08 | Last modified: | 2018-01-24 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structure and function of Escherichia coli RimK, an ATP-grasp fold, l-glutamyl ligase enzyme. Proteins, 81, 2013
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