4PMF
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![BU of 4pmf by Molmil](/molmil-images/mine/4pmf) | Human transthyretin (TTR) complexed with curcumin | Descriptor: | (1Z,4Z,6E)-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-one, 1,2-ETHANEDIOL, SODIUM ION, ... | Authors: | Stura, E.A, Ciccone, L. | Deposit date: | 2014-05-21 | Release date: | 2014-10-08 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Transthyretin complexes with curcumin and bromo-estradiol: evaluation of solubilizing multicomponent mixtures. N Biotechnol, 32, 2014
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4PME
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![BU of 4pme by Molmil](/molmil-images/mine/4pme) | Human transthyretin (TTR) complexed with ferulic acid and curcumin. | Descriptor: | (1Z,4Z,6E)-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-one, 1,2-ETHANEDIOL, 3-(4-HYDROXY-3-METHOXYPHENYL)-2-PROPENOIC ACID, ... | Authors: | Stura, E.A, Ciccone, L. | Deposit date: | 2014-05-21 | Release date: | 2014-10-08 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.264 Å) | Cite: | Transthyretin complexes with curcumin and bromo-estradiol: evaluation of solubilizing multicomponent mixtures. N Biotechnol, 32, 2014
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4TQP
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![BU of 4tqp by Molmil](/molmil-images/mine/4tqp) | Human transthyretin (TTR) complexed with (R)-3-(9H-fluoren-9-ylideneaminooxy)-2-methyl-N-(methylsulfonyl) propionamide in a dual binding mode | Descriptor: | (2R)-3-[(9H-fluoren-9-ylideneamino)oxy]-2-methyl-N-(methylsulfonyl)propanamide, GLYCEROL, Transthyretin | Authors: | Ciccone, L, Nencetti, S, Rossello, A, Orlandini, E, Stura, E.A. | Deposit date: | 2014-06-11 | Release date: | 2015-06-24 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | X-ray crystal structure and activity of fluorenyl-based compounds as transthyretin fibrillogenesis inhibitors. J Enzyme Inhib Med Chem, 2015
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4TQ8
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![BU of 4tq8 by Molmil](/molmil-images/mine/4tq8) | Dual binding mode for 3-(9H-fluoren-9-ylideneaminooxy)propanoic acid binding to Human transthyretin (TTR) | Descriptor: | 1,2-ETHANEDIOL, 3-[(9H-fluoren-9-ylideneamino)oxy]propanoic acid, Transthyretin | Authors: | Ciccone, L, Orlandini, E, Nencetti, S, Rossello, A, Stura, E.A. | Deposit date: | 2014-06-10 | Release date: | 2015-06-24 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.52 Å) | Cite: | X-ray crystal structure and activity of fluorenyl-based compounds as transthyretin fibrillogenesis inhibitors. J Enzyme Inhib Med Chem, 2015
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4TQI
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![BU of 4tqi by Molmil](/molmil-images/mine/4tqi) | Human transthyretin (TTR) complexed with 3-(9H-fluoren-9-ylideneaminooxy)propanoic acid in a dual binding mode | Descriptor: | (2S)-3-[(9H-fluoren-9-ylideneamino)oxy]-2-methylpropanoic acid, GLYCEROL, Transthyretin | Authors: | Stura, E.A, Ciccone, L, Nencetti, S, Rossello, A, Orlandini, E. | Deposit date: | 2014-06-11 | Release date: | 2015-06-24 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | X-ray crystal structure and activity of fluorenyl-based compounds as transthyretin fibrillogenesis inhibitors. J Enzyme Inhib Med Chem, 2015
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4TQH
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![BU of 4tqh by Molmil](/molmil-images/mine/4tqh) | Human transthyretin (TTR) complexed with 3-(9H-fluoren-9-ylideneaminooxy)ethanoic acid | Descriptor: | 1,2-ETHANEDIOL, Transthyretin, [(9H-fluoren-9-ylideneamino)oxy]acetic acid | Authors: | Ciccone, L, Nencetti, S, Rossello, A, Orlandini, E, Stura, E.A. | Deposit date: | 2014-06-11 | Release date: | 2015-06-24 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.511 Å) | Cite: | X-ray crystal structure and activity of fluorenyl-based compounds as transthyretin fibrillogenesis inhibitors. J Enzyme Inhib Med Chem, 2015
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5NBH
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![BU of 5nbh by Molmil](/molmil-images/mine/5nbh) | |
5NC1
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![BU of 5nc1 by Molmil](/molmil-images/mine/5nc1) | |
8STX
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![BU of 8stx by Molmil](/molmil-images/mine/8stx) | |
6FNE
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![BU of 6fne by Molmil](/molmil-images/mine/6fne) | Structure of human Brag2 (Sec7-PH domains) with the inhibitor Bragsin bound to the PH domain | Descriptor: | (2~{S})-6-methyl-5-nitro-2-(trifluoromethyl)-2,3-dihydrochromen-4-one, IQ motif and SEC7 domain-containing protein 1, NONAETHYLENE GLYCOL | Authors: | Nawrotek, A, Zeghouf, M, Cherfils, J. | Deposit date: | 2018-02-03 | Release date: | 2019-03-13 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.501 Å) | Cite: | PH-domain-binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signaling. Nat.Chem.Biol., 15, 2019
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3NFD
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![BU of 3nfd by Molmil](/molmil-images/mine/3nfd) | Chronobacterium ammoniagenes ACPS-CoA complex | Descriptor: | COENZYME A, Phosphopantetheine protein transferase, Ppt1p | Authors: | Gokulan, K. | Deposit date: | 2010-06-10 | Release date: | 2011-01-05 | Last modified: | 2019-07-17 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Mycobacterium tuberculosis acyl carrier protein synthase adopts two different pH-dependent structural conformations. Acta Crystallogr.,Sect.D, 67, 2011
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4D63
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![BU of 4d63 by Molmil](/molmil-images/mine/4d63) | |
4D62
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![BU of 4d62 by Molmil](/molmil-images/mine/4d62) | |
3NE1
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![BU of 3ne1 by Molmil](/molmil-images/mine/3ne1) | |
3NE9
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![BU of 3ne9 by Molmil](/molmil-images/mine/3ne9) | |
3NE3
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![BU of 3ne3 by Molmil](/molmil-images/mine/3ne3) | |
4CW8
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![BU of 4cw8 by Molmil](/molmil-images/mine/4cw8) | |
3RTK
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![BU of 3rtk by Molmil](/molmil-images/mine/3rtk) | Crystal structure of Cpn60.2 from Mycobacterium tuberculosis at 2.8A | Descriptor: | 60 kDa chaperonin 2, MAGNESIUM ION | Authors: | Shahar, A, Melamed-Frank, M, Kashi, Y, Adir, N. | Deposit date: | 2011-05-03 | Release date: | 2011-08-10 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The dimeric structure of the Cpn60.2 chaperonin of Mycobacterium tuberculosis at 2.8 A reveals possible modes of function. J.Mol.Biol., 412, 2011
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3FSR
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![BU of 3fsr by Molmil](/molmil-images/mine/3fsr) | Chimera of alcohol dehydrogenase by exchange of the cofactor binding domain res 153-295 of T. brockii ADH by C. beijerinckii ADH | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, NADP-dependent alcohol dehydrogenase, ... | Authors: | Frolow, F, Greenblatt, H, Goihberg, E, Burstein, Y. | Deposit date: | 2009-01-11 | Release date: | 2010-01-19 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Biochemical and structural properties of chimeras constructed by exchange of cofactor-binding domains in alcohol dehydrogenases from thermophilic and mesophilic microorganisms Biochemistry, 49, 2010
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6UPJ
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![BU of 6upj by Molmil](/molmil-images/mine/6upj) | HIV-2 PROTEASE/U99294 COMPLEX | Descriptor: | 6,7,8,9-TETRAHYDRO-4-HYDROXY-3-(1-PHENYLPROPYL)CYCLOHEPTA[B]PYRAN-2-ONE, HIV-2 PROTEASE | Authors: | Watenpaugh, K.D, Mulichak, A.M, Finzel, B.C. | Deposit date: | 1996-12-10 | Release date: | 1997-04-21 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.34 Å) | Cite: | Use of medium-sized cycloalkyl rings to enhance secondary binding: discovery of a new class of human immunodeficiency virus (HIV) protease inhibitors. J.Med.Chem., 38, 1995
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7UPJ
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![BU of 7upj by Molmil](/molmil-images/mine/7upj) | HIV-1 PROTEASE/U101935 COMPLEX | Descriptor: | HIV-1 PROTEASE, N-(3-CYCLOPROPYL(5,6,7,8,9,10-HEXAHYDRO-2-OXO-2H-CYCLOOCTA[B]PYRAN-3-YL)METHYL)PHENYLBENZENSULFONAMIDE | Authors: | Watenpaugh, K.D, Janakiraman, M.N. | Deposit date: | 1996-12-05 | Release date: | 1997-04-21 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure-based design of nonpeptidic HIV protease inhibitors: the sulfonamide-substituted cyclooctylpyramones. J.Med.Chem., 40, 1997
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8J91
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![BU of 8j91 by Molmil](/molmil-images/mine/8j91) | Cryo-EM structure of nucleosome containing Arabidopsis thaliana histones | Descriptor: | DNA (169-MER), HTA13, Histone H2B.6, ... | Authors: | Osakabe, A, Takizawa, Y, Horikoshi, N, Hatazawa, S, Berger, F, Kurumizaka, H, Kakutani, T. | Deposit date: | 2023-05-02 | Release date: | 2024-07-03 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Molecular and structural basis of the chromatin remodeling activity by Arabidopsis DDM1. Nat Commun, 15, 2024
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8J90
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![BU of 8j90 by Molmil](/molmil-images/mine/8j90) | Cryo-EM structure of DDM1-nucleosome complex | Descriptor: | ATP-dependent DNA helicase DDM1, DNA (169-MER), HTA6, ... | Authors: | Osakabe, A, Takizawa, Y, Horikoshi, N, Hatazawa, S, Berger, F, Kurumizaka, H, Kakutani, T. | Deposit date: | 2023-05-02 | Release date: | 2024-07-03 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (4.71 Å) | Cite: | Molecular and structural basis of the chromatin remodeling activity by Arabidopsis DDM1. Nat Commun, 15, 2024
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8J92
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![BU of 8j92 by Molmil](/molmil-images/mine/8j92) | Cryo-EM structure of nucleosome containing Arabidopsis thaliana H2A.W | Descriptor: | DNA (169-MER), HTA6, HTB9, ... | Authors: | Osakabe, A, Takizawa, Y, Horikoshi, N, Hatazawa, S, Berger, F, Kurumizaka, H, Kakutani, T. | Deposit date: | 2023-05-02 | Release date: | 2024-07-03 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Molecular and structural basis of the chromatin remodeling activity by Arabidopsis DDM1. Nat Commun, 15, 2024
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3CCC
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![BU of 3ccc by Molmil](/molmil-images/mine/3ccc) | Crystal Structure of Human DPP4 in complex with a benzimidazole derivative | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 7-(aminomethyl)-6-(2-chlorophenyl)-1-methyl-1H-benzimidazole-5-carbonitrile, ... | Authors: | Wallace, M.B, Skene, R.J. | Deposit date: | 2008-02-25 | Release date: | 2008-10-21 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.71 Å) | Cite: | Structure-based design and synthesis of benzimidazole derivatives as dipeptidyl peptidase IV inhibitors. Bioorg.Med.Chem.Lett., 18, 2008
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