6UPJ

HIV-2 PROTEASE/U99294 COMPLEX

Summary for 6UPJ

• Entry DOI: 10.2210/pdb6upj/pdb
• Descriptor: HIV-2 PROTEASE, 6,7,8,9-TETRAHYDRO-4-HYDROXY-3-(1-PHENYLPROPYL)CYCLOHEPTA[B]PYRAN-2-ONE (3 entities in total)
• Functional Keywords: hydrolase, acid protease, hiv-2 protease-inhibitor complex, protein-substrate interaction, aspartyl protease
• Biological source: Human immunodeficiency virus 2
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04584
• Total number of polymer chains: 2
• Total formula weight: 21723.01

Authors

Watenpaugh, K.D.,Mulichak, A.M.,Finzel, B.C. (deposition date: 1996-12-10, release date: 1997-04-21, Last modification date: 2024-04-03)

• Primary citation: Romines, K.R.,Watenpaugh, K.D.,Tomich, P.K.,Howe, W.J.,Morris, J.K.,Lovasz, K.D.,Mulichak, A.M.,Finzel, B.C.,Lynn, J.C.,Horng, M.-M.,Schwende, F.J.,Ruwart, M.J.,Zipp, G.L.,Chong, K.-T.,Dolak, L.A.,Toth, L.N.,Howard, G.M.,Rush, B.D.,Wilkinson, K.F.,Possert, P.L.,Dalga, R.J.,Hinshaw, R.R.; Use of medium-sized cycloalkyl rings to enhance secondary binding: discovery of a new class of human immunodeficiency virus (HIV) protease inhibitors.; J.Med.Chem., 38:1884-1891, 1995; PubMed: 7783120; DOI: 10.1021/jm00011a008

Experimental method

X-RAY DIFFRACTION (2.34 Å)