8DSY
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![BU of 8dsy by Molmil](/molmil-images/mine/8dsy) | PPARg bound to inverse agonist H3B-343 | Descriptor: | Peroxisome proliferator-activated receptor gamma, {5-[(5-{[(4-tert-butylphenyl)methyl]carbamoyl}-2,3-dimethyl-1H-indol-1-yl)methyl]-2-chlorophenoxy}acetic acid | Authors: | Larsen, N.A. | Deposit date: | 2022-07-24 | Release date: | 2022-09-07 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Biochemical and structural basis for the pharmacological inhibition of nuclear hormone receptor PPAR gamma by inverse agonists. J.Biol.Chem., 298, 2022
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5SYB
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![BU of 5syb by Molmil](/molmil-images/mine/5syb) | Crystal structure of human PHF5A | Descriptor: | 1,2-ETHANEDIOL, PHD finger-like domain-containing protein 5A, ZINC ION | Authors: | Tsai, J.H.C, Teng, T, Zhu, P, Fekkes, P, Larsen, N.A. | Deposit date: | 2016-08-10 | Release date: | 2016-09-07 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A-SF3b complex. Nat Commun, 8, 2017
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8C8K
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8C8N
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8C8M
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8C8L
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![BU of 8c8l by Molmil](/molmil-images/mine/8c8l) | |
8C8O
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8C8R
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3J4T
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![BU of 3j4t by Molmil](/molmil-images/mine/3j4t) | Helical model of TubZ-Bt two-stranded filament | Descriptor: | FtsZ/tubulin-related protein | Authors: | Agard, D.A, Montabana, E.A. | Deposit date: | 2013-10-04 | Release date: | 2014-02-19 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (10.8 Å) | Cite: | Bacterial tubulin TubZ-Bt transitions between a two-stranded intermediate and a four-stranded filament upon GTP hydrolysis. Proc.Natl.Acad.Sci.USA, 111, 2014
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7PEO
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![BU of 7peo by Molmil](/molmil-images/mine/7peo) | Structure of the Caulobacter crescentus S-layer protein RsaA N-terminal domain bound to LPS and soaked with Holmium | Descriptor: | 4-acetamido-4,6-dideoxy-alpha-D-mannopyranose-(1-3)-4-acetamido-4,6-dideoxy-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-3)-4-acetamido-4,6-dideoxy-alpha-D-mannopyranose-(1-3)-4-acetamido-4,6-dideoxy-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-3)-4-acetamido-4,6-dideoxy-alpha-D-mannopyranose-(1-3)-4-acetamido-4,6-dideoxy-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-3)-4-acetamido-4,6-dideoxy-alpha-D-mannopyranose-(1-3)-4-acetamido-4,6-dideoxy-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose, CALCIUM ION, HOLMIUM ATOM, ... | Authors: | von Kugelgen, A, Bharat, T.A.M. | Deposit date: | 2021-08-11 | Release date: | 2021-12-01 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (4.37 Å) | Cite: | High-resolution mapping of metal ions reveals principles of surface layer assembly in Caulobacter crescentus cells. Structure, 30, 2022
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4AQP
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![BU of 4aqp by Molmil](/molmil-images/mine/4aqp) | The structure of the AXH domain of ataxin-1. | Descriptor: | ATAXIN-1, DI(HYDROXYETHYL)ETHER, SODIUM ION | Authors: | Rees, M, Chen, Y.W, de Chiara, C, Pastore, A. | Deposit date: | 2012-04-19 | Release date: | 2013-03-27 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.452 Å) | Cite: | Self-Assembly and Conformational Heterogeneity of the Axh Domain of Ataxin-1: An Unusual Example of a Chameleon Fold Biophys.J., 104, 2013
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4APT
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![BU of 4apt by Molmil](/molmil-images/mine/4apt) | The structure of the AXH domain of ataxin-1. | Descriptor: | ATAXIN-1, SODIUM ION | Authors: | Rees, M, Chen, Y.W, de Chiara, C, Pastore, A. | Deposit date: | 2012-04-05 | Release date: | 2013-03-27 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Self-Assembly and Conformational Heterogeneity of the Axh Domain of Ataxin-1: An Unusual Example of a Chameleon Fold Biophys.J., 104, 2013
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1DMS
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![BU of 1dms by Molmil](/molmil-images/mine/1dms) | STRUCTURE OF DMSO REDUCTASE | Descriptor: | 2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE, DMSO REDUCTASE, MOLYBDENUM (IV)OXIDE | Authors: | Schneider, F, Loewe, J, Huber, R, Schindelin, H, Kisker, C, Knaeblein, J. | Deposit date: | 1996-09-03 | Release date: | 1998-07-01 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Crystal structure of dimethyl sulfoxide reductase from Rhodobacter capsulatus at 1.88 A resolution. J.Mol.Biol., 263, 1996
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1OA8
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1RYP
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![BU of 1ryp by Molmil](/molmil-images/mine/1ryp) | CRYSTAL STRUCTURE OF THE 20S PROTEASOME FROM YEAST AT 2.4 ANGSTROMS RESOLUTION | Descriptor: | 20S PROTEASOME, MAGNESIUM ION | Authors: | Groll, M, Ditzel, L, Loewe, J, Stock, D, Bochtler, M, Bartunik, H.D, Huber, R. | Deposit date: | 1997-02-26 | Release date: | 1998-04-15 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure of 20S proteasome from yeast at 2.4 A resolution. Nature, 386, 1997
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1A6E
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![BU of 1a6e by Molmil](/molmil-images/mine/1a6e) | THERMOSOME-MG-ADP-ALF3 COMPLEX | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, MAGNESIUM ION, ... | Authors: | Ditzel, L, Loewe, J, Stock, D, Stetter, K.-O, Huber, H, Huber, R, Steinbacher, S. | Deposit date: | 1998-02-24 | Release date: | 1999-03-23 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Crystal structure of the thermosome, the archaeal chaperonin and homolog of CCT. Cell(Cambridge,Mass.), 93, 1998
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1A6D
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![BU of 1a6d by Molmil](/molmil-images/mine/1a6d) | THERMOSOME FROM T. ACIDOPHILUM | Descriptor: | THERMOSOME (ALPHA SUBUNIT), THERMOSOME (BETA SUBUNIT) | Authors: | Ditzel, L, Loewe, J, Stock, D, Stetter, K.-O, Huber, H, Huber, R, Steinbacher, S. | Deposit date: | 1998-02-24 | Release date: | 1999-03-23 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structure of the thermosome, the archaeal chaperonin and homolog of CCT. Cell(Cambridge,Mass.), 93, 1998
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1E0R
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![BU of 1e0r by Molmil](/molmil-images/mine/1e0r) | Beta-apical domain of thermosome | Descriptor: | THERMOSOME | Authors: | Bosch, G, Baumeister, W, Essen, L.-O. | Deposit date: | 2000-04-06 | Release date: | 2000-08-19 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal Structure of the Beta-Apical Domain from Thermosome Reveals Structural Plasticity in Protrusion Region J.Mol.Biol., 301, 2000
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5WHR
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![BU of 5whr by Molmil](/molmil-images/mine/5whr) | Discovery of a novel and selective IDO-1 inhibitor PF-06840003 and its characterization as a potential clinical candidate. | Descriptor: | (3R)-3-(5-fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione, Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Greasley, S.E, Kaiser, S.E, Feng, J.L, Stewart, A. | Deposit date: | 2017-07-18 | Release date: | 2017-12-27 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate. J. Med. Chem., 60, 2017
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1TUB
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![BU of 1tub by Molmil](/molmil-images/mine/1tub) | TUBULIN ALPHA-BETA DIMER, ELECTRON DIFFRACTION | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, TAXOTERE, ... | Authors: | Nogales, E, Downing, K.H. | Deposit date: | 1997-09-23 | Release date: | 1998-10-07 | Last modified: | 2024-06-05 | Method: | ELECTRON CRYSTALLOGRAPHY (3.7 Å) | Cite: | Structure of the alpha beta tubulin dimer by electron crystallography. Nature, 391, 1998
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2G83
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![BU of 2g83 by Molmil](/molmil-images/mine/2g83) | Structure of activated G-alpha-i1 bound to a nucleotide-state-selective peptide: Minimal determinants for recognizing the active form of a G protein alpha subunit | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i), alpha-1 subunit, ... | Authors: | Johnston, C.A, Ramer, J.K, Blaesius, R, Kuhlman, B, Arshavsky, V.Y, Siderovski, D.P. | Deposit date: | 2006-03-01 | Release date: | 2006-10-10 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Minimal Determinants for Binding Activated Galpha from the Structure of a Galpha(i1)-Peptide Dimer. Biochemistry, 45, 2006
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3VJE
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![BU of 3vje by Molmil](/molmil-images/mine/3vje) | Crystal structure of the Y248A mutant of C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus in complex with zaragozic acid A | Descriptor: | Dehydrosqualene synthase, Zaragozic acid A | Authors: | Liu, C.I, Jeng, W.Y, Chang, W.J, Wang, A.H.J. | Deposit date: | 2011-10-14 | Release date: | 2012-04-11 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.12 Å) | Cite: | Binding modes of zaragozic acid A to human squalene synthase and staphylococcal dehydrosqualene synthase J.Biol.Chem., 287, 2012
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3VJD
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![BU of 3vjd by Molmil](/molmil-images/mine/3vjd) | Crystal structure of the Y248A mutant of C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus | Descriptor: | Dehydrosqualene synthase, L(+)-TARTARIC ACID | Authors: | Liu, C.I, Jeng, W.Y, Chang, W.J, Wang, A.H.J. | Deposit date: | 2011-10-14 | Release date: | 2012-04-11 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.48 Å) | Cite: | Binding modes of zaragozic acid A to human squalene synthase and staphylococcal dehydrosqualene synthase J.Biol.Chem., 287, 2012
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4IUC
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![BU of 4iuc by Molmil](/molmil-images/mine/4iuc) | Crystal structure of an O2-tolerant [NiFe]-hydrogenase from Ralstonia eutropha in its as-isolated form - oxidized state 2 | Descriptor: | CHLORIDE ION, FE3-S4 CLUSTER, IRON/SULFUR CLUSTER, ... | Authors: | Frielingsdorf, S, Schmidt, A, Fritsch, J, Lenz, O, Scheerer, P. | Deposit date: | 2013-01-20 | Release date: | 2014-04-02 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Reversible [4Fe-3S] cluster morphing in an O2-tolerant [NiFe] hydrogenase. Nat.Chem.Biol., 10, 2014
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4IUB
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![BU of 4iub by Molmil](/molmil-images/mine/4iub) | Crystal structure of an O2-tolerant [NiFe]-hydrogenase from Ralstonia eutropha in its as-isolated form - oxidized state 1 | Descriptor: | CHLORIDE ION, FE3-S4 CLUSTER, IRON/SULFUR CLUSTER, ... | Authors: | Frielingsdorf, S, Schmidt, A, Fritsch, J, Lenz, O, Scheerer, P. | Deposit date: | 2013-01-20 | Release date: | 2014-04-02 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.61 Å) | Cite: | Reversible [4Fe-3S] cluster morphing in an O2-tolerant [NiFe] hydrogenase. Nat.Chem.Biol., 10, 2014
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