2PXC
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![BU of 2pxc by Molmil](/molmil-images/mine/2pxc) | Crystal structure of the Murray Valley Encephalitis Virus NS5 2'-O Methyltransferase domain in complex with SAM and GTPA | Descriptor: | GUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE, Genome polyprotein [Contains: Capsid protein C (Core protein); Envelope protein M (Matrix protein); Major envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Flavivirin protease NS2B regulatory subunit; Flavivirin protease NS3 catalytic subunit; Non-structural protein 4A (NS4A); Non-structural protein 4B (NS4B); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5)], S-ADENOSYLMETHIONINE | Authors: | Assenberg, R, Ren, J, Verma, A, Walter, T.S, Alderton, D, Hurrelbrink, R.J, Fuller, S.D, Owens, R.J, Stuart, D.I, Grimes, J.M, Oxford Protein Production Facility (OPPF) | Deposit date: | 2007-05-14 | Release date: | 2007-05-29 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structure of the Murray Valley encephalitis virus NS5 methyltransferase domain in complex with cap analogues. J.Gen.Virol., 88, 2007
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2PX2
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![BU of 2px2 by Molmil](/molmil-images/mine/2px2) | Crystal structure of the Murray Valley Encephalitis Virus NS5 2'-O Methyltransferase domain in complex with SAH (Monoclinic form 1) | Descriptor: | CHLORIDE ION, Genome polyprotein [Contains: Capsid protein C (Core protein); Envelope protein M (Matrix protein); Major envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Flavivirin protease NS2B regulatory subunit; Flavivirin protease NS3 catalytic subunit; Non-structural protein 4A (NS4A); Non-structural protein 4B (NS4B); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5)], S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Assenberg, R, Ren, J, Verma, A, Walter, T.S, Alderton, D, Hurrelbrink, R.J, Fuller, S.D, Owens, R.J, Stuart, D.I, Grimes, J.M, Oxford Protein Production Facility (OPPF) | Deposit date: | 2007-05-14 | Release date: | 2007-05-29 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of the Murray Valley encephalitis virus NS5 methyltransferase domain in complex with cap analogues. J.Gen.Virol., 88, 2007
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8P1K
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![BU of 8p1k by Molmil](/molmil-images/mine/8p1k) | |
8P1M
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![BU of 8p1m by Molmil](/molmil-images/mine/8p1m) | |
8R1J
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![BU of 8r1j by Molmil](/molmil-images/mine/8r1j) | Structure of avian H5N1 influenza A polymerase dimer in complex with human ANP32B. | Descriptor: | Acidic leucine-rich nuclear phosphoprotein 32 family member B, Polymerase acidic protein, Polymerase basic protein 2, ... | Authors: | Carrique, L, Staller, E, Keown, J.R, Fan, H, Fodor, E, Grimes, J.M. | Deposit date: | 2023-11-02 | Release date: | 2024-05-08 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structures of H5N1 influenza polymerase with ANP32B reveal mechanisms of genome replication and host adaptation. Nat Commun, 15, 2024
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7NFR
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![BU of 7nfr by Molmil](/molmil-images/mine/7nfr) | Fujian capmidlink domain in complex with Nb8194 | Descriptor: | GLYCEROL, NB8194, Polymerase basic protein 2, ... | Authors: | Keown, J.R, Grimes, J.M, Fodor, E. | Deposit date: | 2021-02-07 | Release date: | 2021-12-01 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nat Commun, 13, 2022
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7NK6
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![BU of 7nk6 by Molmil](/molmil-images/mine/7nk6) | 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8204 | Descriptor: | Nb8204, Polymerase acidic protein, Polymerase basic protein 2,Polymerase basic protein 2, ... | Authors: | Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. | Deposit date: | 2021-02-17 | Release date: | 2021-12-01 | Last modified: | 2022-02-09 | Method: | ELECTRON MICROSCOPY (6.72 Å) | Cite: | Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nat Commun, 13, 2022
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7NHX
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![BU of 7nhx by Molmil](/molmil-images/mine/7nhx) | 1918 H1N1 Viral influenza polymerase heterotrimer - full transcriptase (Class1) | Descriptor: | Polymerase acidic protein, Polymerase basic protein 2,Immunoglobulin G-binding protein A, RNA (5'-R(P*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*CP*C)-3'), ... | Authors: | Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. | Deposit date: | 2021-02-11 | Release date: | 2021-12-01 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.23 Å) | Cite: | Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nat Commun, 13, 2022
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7NJ7
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![BU of 7nj7 by Molmil](/molmil-images/mine/7nj7) | 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8200 core | Descriptor: | Nb8200 core, Polymerase acidic protein, Polymerase basic protein 2,Immunoglobulin G-binding protein A, ... | Authors: | Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. | Deposit date: | 2021-02-16 | Release date: | 2021-12-01 | Last modified: | 2022-02-09 | Method: | ELECTRON MICROSCOPY (4.82 Å) | Cite: | Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nat Commun, 13, 2022
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7NIS
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![BU of 7nis by Molmil](/molmil-images/mine/7nis) | 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8192 core | Descriptor: | Nanobody8192 core, Polymerase acidic protein, Polymerase basic protein 2,Immunoglobulin G-binding protein A, ... | Authors: | Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. | Deposit date: | 2021-02-13 | Release date: | 2021-12-01 | Last modified: | 2022-02-09 | Method: | ELECTRON MICROSCOPY (5.96 Å) | Cite: | Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nat Commun, 13, 2022
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7NK1
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![BU of 7nk1 by Molmil](/molmil-images/mine/7nk1) | 1918 Influenza virus polymerase heterotirmer in complex with vRNA promoters and Nb8201 | Descriptor: | Nanobody8201, Polymerase acidic protein, Polymerase basic protein 2,Immunoglobulin G-binding protein A, ... | Authors: | Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. | Deposit date: | 2021-02-17 | Release date: | 2021-12-01 | Last modified: | 2022-02-09 | Method: | ELECTRON MICROSCOPY (4.22 Å) | Cite: | Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nat Commun, 13, 2022
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7NKA
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![BU of 7nka by Molmil](/molmil-images/mine/7nka) | 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8206 | Descriptor: | NB8206, Polymerase acidic protein, Polymerase basic protein 2,Polymerase basic protein 2, ... | Authors: | Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. | Deposit date: | 2021-02-17 | Release date: | 2021-12-01 | Last modified: | 2022-02-09 | Method: | ELECTRON MICROSCOPY (4.07 Å) | Cite: | Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nat Commun, 13, 2022
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7NKI
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![BU of 7nki by Molmil](/molmil-images/mine/7nki) | 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8209 core | Descriptor: | Nb8209, Polymerase acidic protein, Polymerase basic protein 2,Polymerase basic protein 2, ... | Authors: | Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. | Deposit date: | 2021-02-18 | Release date: | 2021-12-01 | Last modified: | 2022-02-09 | Method: | ELECTRON MICROSCOPY (4.67 Å) | Cite: | Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nat Commun, 13, 2022
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7NFQ
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![BU of 7nfq by Molmil](/molmil-images/mine/7nfq) | Fujian capmidlink domain in complex with Nb8193 | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Nb8193, ... | Authors: | Keown, J.R, Grimes, J.M, Fodor, E. | Deposit date: | 2021-02-07 | Release date: | 2021-12-01 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.68 Å) | Cite: | Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nat Commun, 13, 2022
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7NKR
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![BU of 7nkr by Molmil](/molmil-images/mine/7nkr) | 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8210 | Descriptor: | Nb8210, Polymerase acidic protein, Polymerase basic protein 2,Polymerase basic protein 2, ... | Authors: | Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. | Deposit date: | 2021-02-18 | Release date: | 2021-12-01 | Last modified: | 2022-02-09 | Method: | ELECTRON MICROSCOPY (5.6 Å) | Cite: | Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nat Commun, 13, 2022
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7NI0
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![BU of 7ni0 by Molmil](/molmil-images/mine/7ni0) | 1918 H1N1 Viral influenza polymerase heterotrimer - Replicase (class 3) | Descriptor: | Polymerase acidic protein, Polymerase basic protein 2,Immunoglobulin G-binding protein A, RNA (5'-R(P*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*CP*C)-3'), ... | Authors: | Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. | Deposit date: | 2021-02-11 | Release date: | 2021-12-01 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.32 Å) | Cite: | Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nat Commun, 13, 2022
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7NHA
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![BU of 7nha by Molmil](/molmil-images/mine/7nha) | 1918 H1N1 Viral influenza polymerase heterotrimer - Endonuclease and priming loop ordered (Class2a) | Descriptor: | Polymerase acidic protein, Polymerase basic protein 2,Immunoglobulin G-binding protein A, RNA (5'-R(P*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*CP*C)-3'), ... | Authors: | Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. | Deposit date: | 2021-02-10 | Release date: | 2021-12-01 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (2.91 Å) | Cite: | Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nat Commun, 13, 2022
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7NIR
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![BU of 7nir by Molmil](/molmil-images/mine/7nir) | 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8191 core | Descriptor: | Nanobody8191 core, Polymerase acidic protein, Polymerase basic protein 2,Immunoglobulin G-binding protein A, ... | Authors: | Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. | Deposit date: | 2021-02-13 | Release date: | 2021-12-01 | Last modified: | 2022-02-09 | Method: | ELECTRON MICROSCOPY (6.7 Å) | Cite: | Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nat Commun, 13, 2022
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7NIK
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![BU of 7nik by Molmil](/molmil-images/mine/7nik) | 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8189 core | Descriptor: | Nanobody8189 core, Polymerase acidic protein, Polymerase basic protein 2,Immunoglobulin G-binding protein A, ... | Authors: | Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. | Deposit date: | 2021-02-12 | Release date: | 2021-12-01 | Last modified: | 2022-02-09 | Method: | ELECTRON MICROSCOPY (6.2 Å) | Cite: | Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nat Commun, 13, 2022
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7NK2
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![BU of 7nk2 by Molmil](/molmil-images/mine/7nk2) | 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8202 core | Descriptor: | Nanobody8202, Polymerase acidic protein, Polymerase basic protein 2,Immunoglobulin G-binding protein A, ... | Authors: | Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. | Deposit date: | 2021-02-17 | Release date: | 2021-12-01 | Last modified: | 2022-02-09 | Method: | ELECTRON MICROSCOPY (4.84 Å) | Cite: | Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nat Commun, 13, 2022
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7NJ5
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![BU of 7nj5 by Molmil](/molmil-images/mine/7nj5) | 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8199 core | Descriptor: | Nb8199 Core, Polymerase acidic protein, Polymerase basic protein 2,Immunoglobulin G-binding protein A, ... | Authors: | Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. | Deposit date: | 2021-02-16 | Release date: | 2021-12-01 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (4.63 Å) | Cite: | Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nat Commun, 13, 2022
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7NKC
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![BU of 7nkc by Molmil](/molmil-images/mine/7nkc) | 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8207 | Descriptor: | Nb8207, Polymerase acidic protein, Polymerase basic protein 2,Polymerase basic protein 2, ... | Authors: | Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. | Deposit date: | 2021-02-17 | Release date: | 2021-12-01 | Last modified: | 2022-02-09 | Method: | ELECTRON MICROSCOPY (4.46 Å) | Cite: | Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nat Commun, 13, 2022
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7NJ4
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![BU of 7nj4 by Molmil](/molmil-images/mine/7nj4) | 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8198 core | Descriptor: | Nb8198 Core, Polymerase acidic protein, Polymerase basic protein 2,Immunoglobulin G-binding protein A, ... | Authors: | Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. | Deposit date: | 2021-02-16 | Release date: | 2021-12-01 | Last modified: | 2022-02-09 | Method: | ELECTRON MICROSCOPY (5.84 Å) | Cite: | Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nat Commun, 13, 2022
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7NFT
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![BU of 7nft by Molmil](/molmil-images/mine/7nft) | |
7NK4
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![BU of 7nk4 by Molmil](/molmil-images/mine/7nk4) | 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8203 core | Descriptor: | Nanobody 8203, Polymerase acidic protein, Polymerase basic protein 2,Polymerase basic protein 2, ... | Authors: | Keown, J.R, Carrique, L, Fodor, E, Grimes, J.M. | Deposit date: | 2021-02-17 | Release date: | 2021-12-01 | Last modified: | 2022-02-09 | Method: | ELECTRON MICROSCOPY (5.32 Å) | Cite: | Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nat Commun, 13, 2022
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