7NT8
Influenza virus H3N2 nucleoprotein - R416A mutant
Summary for 7NT8
| Entry DOI | 10.2210/pdb7nt8/pdb |
| Descriptor | Glutathione S-transferase class-mu 26 kDa isozyme,Nucleoprotein (2 entities in total) |
| Functional Keywords | influenza virus, nucleoprotein, rna-binding protein, rna binding protein |
| Biological source | Schistosoma japonicum (Blood fluke) More |
| Total number of polymer chains | 2 |
| Total formula weight | 165777.66 |
| Authors | Keown, J.R.,Knight, M.L.,Grimes, J.M.,Fodor, E. (deposition date: 2021-03-09, release date: 2021-07-07, Last modification date: 2024-01-31) |
| Primary citation | Knight, M.L.,Fan, H.,Bauer, D.L.V.,Grimes, J.M.,Fodor, E.,Keown, J.R. Structure of an H3N2 influenza virus nucleoprotein. Acta Crystallogr.,Sect.F, 77:208-214, 2021 Cited by PubMed Abstract: Influenza A viruses of the H1N1 and H3N2 subtypes are responsible for seasonal epidemic events. The influenza nucleoprotein (NP) binds to the viral genomic RNA and is essential for its replication. Efforts are under way to produce therapeutics and vaccines targeting the NP. Despite this, no structure of an NP from an H3N2 virus has previously been determined. Here, the structure of the A/Northern Territory/60/1968 (H3N2) influenza virus NP is presented at 2.2 Å resolution. The structure is highly similar to those of the A/WSN/1933 (H1N1) and A/Hong Kong/483/97 (H5N1) NPs. Nonconserved amino acids are widely dispersed both at the sequence and structural levels. A movement of the 73-90 RNA-binding loop is observed to be the key difference between the structure determined here and previous structures. The data presented here increase the understanding of structural conservation amongst influenza NPs and may aid in the design of universal interventions against influenza. PubMed: 34196611DOI: 10.1107/S2053230X2100635X PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.22 Å) |
Structure validation
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