7BZB
 
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7BZC
 | | Crystal structure of plant sesterterpene synthase AtTPS18 complexed with farnesyl thiolodiphosphate (FSPP) | | Descriptor: | MAGNESIUM ION, S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL] TRIHYDROGEN THIODIPHOSPHATE, Terpenoid synthase 18 | | Authors: | Li, J.X, Wang, G.D, Zhang, P. | | Deposit date: | 2020-04-27 | | Release date: | 2020-09-23 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.303 Å) | | Cite: | Molecular Basis for Sesterterpene Diversity Produced by Plant Terpene Synthases.
Plant Commun., 1, 2020
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8XV9
 | | Fedratinib-bound human SLC19A3 | | Descriptor: | N-tert-butyl-3-{[5-methyl-2-({4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}amino)pyrimidin-4-yl]amino}benzenesulfonamide, Soluble cytochrome b562,Thiamine transporter 2 | | Authors: | Dang, Y, Wang, G.P, Zhang, Z. | | Deposit date: | 2024-01-14 | | Release date: | 2024-03-27 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Substrate and drug recognition mechanisms of SLC19A3.
Cell Res., 34, 2024
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8XV2
 | | Thiamine-bound human SLC19A3 | | Descriptor: | 3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY-ETHYL)-4-METHYL-THIAZOL-3-IUM, Soluble cytochrome b562,Thiamine transporter 2 | | Authors: | Dang, Y, Wang, G.P, Zhang, Z. | | Deposit date: | 2024-01-14 | | Release date: | 2024-03-27 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Substrate and drug recognition mechanisms of SLC19A3.
Cell Res., 34, 2024
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8XV5
 | | Pyridoxamine-bound human SLC19A3 | | Descriptor: | 4-(AMINOMETHYL)-5-(HYDROXYMETHYL)-2-METHYLPYRIDIN-3-OL, Soluble cytochrome b562,Thiamine transporter 2 | | Authors: | Dang, Y, Wang, G.P, Zhang, Z. | | Deposit date: | 2024-01-14 | | Release date: | 2024-03-27 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Substrate and drug recognition mechanisms of SLC19A3.
Cell Res., 34, 2024
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8YQP
 | | Crystal structure of HylD1 in complex with MEP | | Descriptor: | 2-ethoxycarbonylbenzoic acid, Lipase | | Authors: | Wang, N, Li, C.Y. | | Deposit date: | 2024-03-19 | | Release date: | 2024-07-31 | | Method: | X-RAY DIFFRACTION (1.76 Å) | | Cite: | Molecular insights into the catalytic mechanism of a phthalate ester hydrolase.
J Hazard Mater, 476, 2024
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8YQJ
 | | Crystal structure of HylD1 | | Descriptor: | Lipase | | Authors: | Wang, N, Li, C.Y. | | Deposit date: | 2024-03-19 | | Release date: | 2024-07-31 | | Method: | X-RAY DIFFRACTION (1.69 Å) | | Cite: | Molecular insights into the catalytic mechanism of a phthalate ester hydrolase.
J Hazard Mater, 476, 2024
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4XAK
 | | Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Heavy chain of neutralizing antibody m336, ... | | Authors: | Zhou, T, Dimtrov, D.S, Ying, T. | | Deposit date: | 2014-12-15 | | Release date: | 2015-08-26 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Junctional and allele-specific residues are critical for MERS-CoV neutralization by an exceptionally potent germline-like antibody.
Nat Commun, 6, 2015
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8TBF
 | | Tricomplex of RMC-7977, KRAS WT, and CypA | | Descriptor: | (1R,5S,6r)-N-[(1P,7S,9S,13S,20M)-20-{5-(4-cyclopropylpiperazin-1-yl)-2-[(1S)-1-methoxyethyl]pyridin-3-yl}-21-ethyl-17,17-dimethyl-8,14-dioxo-15-oxa-4-thia-9,21,27,28-tetraazapentacyclo[17.5.2.1~2,5~.1~9,13~.0~22,26~]octacosa-1(24),2,5(28),19,22,25-hexaen-7-yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide, 1,2-ETHANEDIOL, GTPase KRas, ... | | Authors: | Tomlinson, A.C.A, Chen, A, Knox, J.E, Yano, J.K. | | Deposit date: | 2023-06-28 | | Release date: | 2024-02-07 | | Last modified: | 2024-06-05 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy.
Nature, 629, 2024
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6LB0
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7XML
 | | Cryo-EM structure of PEIP-Bs_enolase complex | | Descriptor: | Enolase, MAGNESIUM ION, Putative gene 60 protein | | Authors: | Li, S, Zhang, K. | | Deposit date: | 2022-04-26 | | Release date: | 2022-07-27 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Bacteriophage protein PEIP is a potent Bacillus subtilis enolase inhibitor.
Cell Rep, 40, 2022
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8K3K
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2Q3X
 | | The RIM1alpha C2B domain | | Descriptor: | CHLORIDE ION, Regulating synaptic membrane exocytosis protein 1, SODIUM ION, ... | | Authors: | Guan, R, Dai, H, Tomchick, D.R, Machius, M, Sudhof, T.C, Rizo, J. | | Deposit date: | 2007-05-30 | | Release date: | 2007-08-28 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.73 Å) | | Cite: | Crystal Structure of the RIM1alpha C(2)B Domain at 1.7 A Resolution.
Biochemistry, 46, 2007
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9AX6
 | | Tricomplex of RMC-6236, KRAS G12D, and CypA | | Descriptor: | (1R,2S)-N-[(1P,7S,9S,13R,20M)-21-ethyl-20-{2-[(1R)-1-methoxyethyl]-5-(4-methylpiperazin-1-yl)pyridin-3-yl}-17,17-dimethyl-8,14-dioxo-15-oxa-4-thia-9,21,27,28-tetraazapentacyclo[17.5.2.1~2,5~.1~9,13~.0~22,26~]octacosa-1(24),2,5(28),19,22,25-hexaen-7-yl]-2-methylcyclopropane-1-carboxamide, GTPase KRas, MAGNESIUM ION, ... | | Authors: | Tomlinson, A.C.A, Saldajeno-Concar, M, Knox, J.E, Yano, J.K. | | Deposit date: | 2024-03-05 | | Release date: | 2024-04-17 | | Last modified: | 2024-06-12 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers.
Cancer Discov, 14, 2024
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6KZ6
 | | Crystal structure of ASFV dUTPase | | Descriptor: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, E165R, MAGNESIUM ION | | Authors: | Guo, Y, Chen, C, Li, G.B, Cao, L, Wang, C.W. | | Deposit date: | 2019-09-23 | | Release date: | 2019-11-13 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.187 Å) | | Cite: | Structural Insight into African Swine Fever Virus dUTPase Reveals a Novel Folding Pattern in the dUTPase Family.
J.Virol., 94, 2020
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7WZ3
 | | Cryo-EM structure of human TRiC-tubulin-S1 state | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, ... | | Authors: | Cong, Y, Liu, C.X. | | Deposit date: | 2022-02-16 | | Release date: | 2023-02-22 | | Last modified: | 2023-07-05 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Pathway and mechanism of tubulin folding mediated by TRiC/CCT along its ATPase cycle revealed using cryo-EM.
Commun Biol, 6, 2023
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7X0V
 | | cryo-EM structure of human TRiC-ADP-AlFx | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, MAGNESIUM ION, ... | | Authors: | Cong, Y, Liu, C.X. | | Deposit date: | 2022-02-22 | | Release date: | 2023-04-12 | | Last modified: | 2024-06-26 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Pathway and mechanism of tubulin folding mediated by TRiC/CCT along its ATPase cycle revealed using cryo-EM.
Commun Biol, 6, 2023
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7X0S
 | | Human TRiC-tubulin-S3 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, MAGNESIUM ION, ... | | Authors: | Cong, Y, Liu, C.X. | | Deposit date: | 2022-02-22 | | Release date: | 2023-04-12 | | Last modified: | 2024-06-26 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Pathway and mechanism of tubulin folding mediated by TRiC/CCT along its ATPase cycle revealed using cryo-EM.
Commun Biol, 6, 2023
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7X0A
 | | Cryo-EM structure of human TRiC-NPP state | | Descriptor: | T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, T-complex protein 1 subunit delta, ... | | Authors: | Cong, Y, Liu, C.X. | | Deposit date: | 2022-02-21 | | Release date: | 2023-04-12 | | Last modified: | 2024-06-26 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Pathway and mechanism of tubulin folding mediated by TRiC/CCT along its ATPase cycle revealed using cryo-EM.
Commun Biol, 6, 2023
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6LPM
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7X3U
 | | cryo-EM structure of human TRiC-ADP | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, ... | | Authors: | Cong, Y, Liu, C.X. | | Deposit date: | 2022-03-01 | | Release date: | 2023-06-07 | | Last modified: | 2024-06-26 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Pathway and mechanism of tubulin folding mediated by TRiC/CCT along its ATPase cycle revealed using cryo-EM.
Commun Biol, 6, 2023
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7X3J
 | | Cryo-EM structure of human TRiC-tubulin-S2 | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, ... | | Authors: | Cong, Y, Liu, C.X. | | Deposit date: | 2022-03-01 | | Release date: | 2023-06-07 | | Last modified: | 2023-07-05 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Pathway and mechanism of tubulin folding mediated by TRiC/CCT along its ATPase cycle revealed using cryo-EM.
Commun Biol, 6, 2023
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7X6Q
 | | cryo-EM structure of human TRiC-ATP-closed state | | Descriptor: | T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, T-complex protein 1 subunit delta, ... | | Authors: | Cong, Y, Liu, C.X. | | Deposit date: | 2022-03-08 | | Release date: | 2023-06-07 | | Last modified: | 2024-06-26 | | Method: | ELECTRON MICROSCOPY (4.5 Å) | | Cite: | Pathway and mechanism of tubulin folding mediated by TRiC/CCT along its ATPase cycle revealed using cryo-EM.
Commun Biol, 6, 2023
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7X7Y
 | | Cryo-EM structure of Human TRiC-ATP-open state | | Descriptor: | T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, T-complex protein 1 subunit delta, ... | | Authors: | Cong, Y, Liu, C.X. | | Deposit date: | 2022-03-10 | | Release date: | 2023-06-07 | | Last modified: | 2024-06-26 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Pathway and mechanism of tubulin folding mediated by TRiC/CCT along its ATPase cycle revealed using cryo-EM.
Commun Biol, 6, 2023
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5QQP
 | | FACTOR XIA IN COMPLEX WITH THE INHIBITOR methyl [(5E,8S)-8-[(4S)-4-(3-chlorophenyl)-2-oxopiperidin-1-yl]-2-oxo-1,3,4,7,8,10-hexahydro-2H-12,9-(azeno)-1,10-benzodiazacyclotetradecin-15-yl]carbamate | | Descriptor: | 1,2-ETHANEDIOL, Coagulation factor XI, SULFATE ION, ... | | Authors: | Sheriff, S. | | Deposit date: | 2019-05-20 | | Release date: | 2019-09-18 | | Last modified: | 2021-05-12 | | Method: | X-RAY DIFFRACTION (2.08 Å) | | Cite: | Structure based design of macrocyclic factor XIa inhibitors: Discovery of cyclic P1 linker moieties with improved oral bioavailability.
Bioorg.Med.Chem.Lett., 29, 2019
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