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Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1455
Descriptor:	5-amino-1-tert-butyl-3-(quinolin-2-yl)-1H-pyrazole-4-carboxamide, Calmodulin-domain protein kinase 1
Authors:	Merritt, E.A.
Deposit date:	2013-08-12
Release date:	2013-10-02
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (1.998 Å)
Cite:	Potent and selective inhibitors of CDPK1 from T. gondii and C. parvum based on a 5-aminopyrazole-4-carboxamide scaffold. ACS Med Chem Lett, 5, 2014

8FBT

Crystal structure of Cryptosporidium parvum N-myristoyltransferase with bound myristoyl-CoA
Descriptor:	1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:	Staker, B.L, Fenwick, M.K, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2022-11-30
Release date:	2023-05-31
Last modified:	2024-09-04
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Identification of and Structural Insights into Hit Compounds Targeting N -Myristoyltransferase for Cryptosporidium Drug Development. Acs Infect Dis., 9, 2023

8FBM

Crystal structure of Cryptosporidium parvum N-myristoyltransferase with bound myristoyl-CoA and inhibitor 1
Descriptor:	2-chloro-5-[ethyl(phenyl)sulfamoyl]-N-[2-(2-oxopyrrolidin-1-yl)phenyl]benzamide, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:	Staker, B.L, Fenwick, M.K, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2022-11-29
Release date:	2023-05-31
Last modified:	2024-09-04
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Identification of and Structural Insights into Hit Compounds Targeting N -Myristoyltransferase for Cryptosporidium Drug Development. Acs Infect Dis., 9, 2023

8FBU

Crystal structure of Cryptosporidium parvum N-myristoyltransferase with bound myristoyl-CoA and Compound-2
Descriptor:	(2M)-2-[2-(piperazin-1-yl)phenyl]-N-(1,3-thiazol-2-yl)-1H-benzimidazole-4-carboxamide, 1,2-ETHANEDIOL, CHLORIDE ION, ...
Authors:	Staker, B.L, Fenwick, M.K, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2022-11-30
Release date:	2023-05-31
Last modified:	2024-09-04
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Identification of and Structural Insights into Hit Compounds Targeting N -Myristoyltransferase for Cryptosporidium Drug Development. Acs Infect Dis., 9, 2023

6VYE

6-phosphogluconolactonase from Trypanosoma cruzi
Descriptor:	6-phosphogluconolactonase, GLYCEROL, PHOSPHATE ION
Authors:	Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2020-02-26
Release date:	2020-03-18
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	6-phosphogluconolactonase from Trypanosoma cruzi To be published

6UHW

Solution structure of an organic hydroperoxide resistance protein from Burkholderia pseudomallei. Seattle Structural Genomics Center for Infectious Disease target BupsA.00074.a.
Descriptor:	Organic hydroperoxide resistance protein
Authors:	Buchko, G.W, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2019-09-29
Release date:	2019-10-16
Last modified:	2024-05-15
Method:	SOLUTION NMR
Cite:	Backbone and side chain (1)H, (13)C, and (15)N NMR assignments for the organic hydroperoxide resistance protein (Ohr) from Burkholderia pseudomallei. Biomol.Nmr Assign., 3, 2009

1GYQ

CRYSTAL STRUCTURE OF GLYCOSOMAL GLYCERALDEHYDE FROM LEISHMANIA MEXICANA IN COMPLEX WITH N6-BENZYL-NAD
Descriptor:	N6-BENZYL-NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PROTEIN (GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE)
Authors:	Suresh, S, Hol, W.
Deposit date:	1999-03-05
Release date:	1999-03-16
Last modified:	2023-08-09
Method:	X-RAY DIFFRACTION (3.4 Å)
Cite:	Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase. Proc.Natl.Acad.Sci.USA, 96, 1999

5IFU

Crystal Structure of Prolyl-tRNA synthetase (ProRS, Proline--tRNA ligase) from Plasmodium falciparum in complex with Glyburide
Descriptor:	1,2-ETHANEDIOL, 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, CHLORIDE ION, ...
Authors:	Dranow, D.M, Hewitt, S.N, Abendroth, J, Structural Genomics Consortium (SGC)
Deposit date:	2016-02-26
Release date:	2016-11-16
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.45 Å)
Cite:	Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase. ACS Infect Dis, 3, 2017

5K0T

Crystal structure of methionyl-tRNA synthetase MetRS from Brucella melitensis in complex with inhibitor Chem 1415
Descriptor:	1,2-ETHANEDIOL, 1-{3-[(3-chloro-5-methoxybenzyl)amino]propyl}-3-phenylurea, Methionine--tRNA ligase
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2016-05-17
Release date:	2016-05-25
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis. Plos One, 11, 2016

5K0S

Crystal structure of methionyl-tRNA synthetase MetRS from Brucella melitensis in complex with inhibitor Chem 1312
Descriptor:	2-({3-[(3,5-dichlorobenzyl)amino]propyl}amino)quinolin-4(1H)-one, Methionine--tRNA ligase
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2016-05-17
Release date:	2016-05-25
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.45 Å)
Cite:	Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis. Plos One, 11, 2016

5IRD

Solution structure of Rv1466 from Mycobacterium tuberculosis, a protein associated with [Fe-S] complex assembly and repair - Seattle Structural Genomics Center for Infectious Disease target MytuD.17486.a
Descriptor:	Uncharacterized protein
Authors:	Buchko, G.W, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2016-03-13
Release date:	2016-05-25
Last modified:	2024-05-15
Method:	SOLUTION NMR
Cite:	Solution structure of Rv1466, a Mycobacterium tuberculosis protein associated with [Fe-S] cluster assembly and repair. To Be Published

6N1C

Crystal structure of Inorganic pyrophosphatase from Legionella pneumophila Philadelphia 1
Descriptor:	(4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, ALANINE, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2018-11-08
Release date:	2018-12-19
Last modified:	2024-07-17
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Characterization of a family I inorganic pyrophosphatase from Legionella pneumophila Philadelphia 1. Acta Crystallogr.,Sect.F, 79, 2023

6MZA

Solution NMR structure of a putative thioredoxin (trxA) in the reduced state from Rickettsia prowazekii, the etiological agent responsible for typhus. Seattle Structural Genomics Center for Infectious Disease target RiprA.00029.a
Descriptor:	Thioredoxin
Authors:	Buchko, G.W, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2018-11-04
Release date:	2018-12-12
Last modified:	2024-05-01
Method:	SOLUTION NMR
Cite:	Solution NMR structure of reduced Rickettsia prowazekii thioredoxin. To Be Published

6OK4

Crystal Structure of Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from Chlamydia trachomatis with bound NAD
Descriptor:	1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2019-04-12
Release date:	2019-04-24
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Structures of glyceraldehyde 3-phosphate dehydrogenase in Neisseria gonorrhoeae and Chlamydia trachomatis. Protein Sci., 29, 2020

3V5P

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1288
Descriptor:	3-(4-methoxy-3-methylphenyl)-1-(piperidin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1
Authors:	Merritt, E.A, Larson, E.T.
Deposit date:	2011-12-16
Release date:	2012-03-14
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1. J.Med.Chem., 55, 2012

3UPX

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1300
Descriptor:	Calmodulin-domain protein kinase 1, [2-amino-1-(piperidin-4-ylmethyl)-1H-benzimidazol-6-yl](phenyl)methanone
Authors:	Merritt, E.A, Larson, E.T.
Deposit date:	2011-11-18
Release date:	2012-03-14
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (2.27 Å)
Cite:	Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1. J.Med.Chem., 55, 2012

3UPZ

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with bumpless BKI analog UW1243
Descriptor:	1-(piperidin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1
Authors:	Merritt, E.A, Larson, E.T.
Deposit date:	2011-11-18
Release date:	2012-03-14
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1. J.Med.Chem., 55, 2012

3UQF

c-SRC kinase domain in complex with BKI RM-1-89
Descriptor:	3-(6-ethoxynaphthalen-2-yl)-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Proto-oncogene tyrosine-protein kinase Src
Authors:	Merritt, E.A, Larson, E.T.
Deposit date:	2011-11-20
Release date:	2012-03-14
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (2.27 Å)
Cite:	Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1. J.Med.Chem., 55, 2012

3UQG

c-SRC kinase domain in complex with bumpless BKI analog UW1243
Descriptor:	1-(piperidin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Proto-oncogene tyrosine-protein kinase Src
Authors:	Merritt, E.A, Larson, E.T.
Deposit date:	2011-11-20
Release date:	2012-03-14
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1. J.Med.Chem., 55, 2012

3V51

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor RM-1-176
Descriptor:	3-{6-[(3-chlorobenzyl)oxy]naphthalen-2-yl}-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1
Authors:	Merritt, E.A, Larson, E.T.
Deposit date:	2011-12-15
Release date:	2012-03-14
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1. J.Med.Chem., 55, 2012

3V5T

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1299
Descriptor:	1-[(2S)-2-(dimethylamino)-3-methylbutyl]-3-(6-ethoxynaphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1
Authors:	Merritt, E.A, Larson, E.T.
Deposit date:	2011-12-16
Release date:	2012-03-14
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (2.13 Å)
Cite:	Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1. J.Med.Chem., 55, 2012

4WI1

Crystal Structure of Prolyl-tRNA synthetase (ProRS, Proline--tRNA ligase) from Plasmodium falciparum in complex with TCMDC-124506
Descriptor:	1,2-ETHANEDIOL, 1-(4-fluorophenyl)-3-[4-(4-fluorophenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]urea, CHLORIDE ION, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2014-09-25
Release date:	2016-05-04
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (1.65 Å)
Cite:	Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase. Acs Infect Dis., 2016

4YSM

Calcium-Dependent Protein Kinase from Eimeria tenella
Descriptor:	CALCIUM ION, Calmodulin-like domain protein kinase
Authors:	Merritt, E.A.
Deposit date:	2015-03-17
Release date:	2016-04-06
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (3.19 Å)
Cite:	CDPK is a druggable target in the apicomplexan parasite Eimeria to be published

4YZB

CDPK1 from Eimeria tenella in complex with inhibitor UW1521
Descriptor:	4-(6-ethoxynaphthalen-2-yl)-6-(piperazin-1-ylmethyl)-2H-indazol-3-amine, CALCIUM ION, Calmodulin-like domain protein kinase
Authors:	Merritt, E.A.
Deposit date:	2015-03-24
Release date:	2016-04-06
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.9 Å)
Cite:	CDPK is a druggable target in the apicomplexan parasite Eimeria to be published

4YUQ

CDPK1 from Eimeria tenella in complex with inhibitor UW1354
Descriptor:	1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, CALCIUM ION, Calmodulin-like domain protein kinase
Authors:	Merritt, E.A.
Deposit date:	2015-03-19
Release date:	2016-04-06
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.8 Å)
Cite:	CDPK is a druggable target in the apicomplexan parasite Eimeria to be published

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