3HV8
 
 | | Crystal structure of FimX EAL domain from Pseudomonas aeruginosa bound to c-di-GMP | | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), Protein FimX | | Authors: | Navarro, M.V.A.S, De, N, Bae, N, Sondermann, H. | | Deposit date: | 2009-06-15 | | Release date: | 2009-08-18 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.445 Å) | | Cite: | Structural analysis of the GGDEF-EAL domain-containing c-di-GMP receptor FimX.
Structure, 17, 2009
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7XBH
 | | The complex structure of RshSTT182/200 RBD bound to human ACE2 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, RshSTT182/200 coronavirus receptor binding domain, ... | | Authors: | Hu, Y, Liu, K.F, Han, P, Qi, J.X. | | Deposit date: | 2022-03-21 | | Release date: | 2023-01-11 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3.02 Å) | | Cite: | Host range and structural analysis of bat-origin RshSTT182/200 coronavirus binding to human ACE2 and its animal orthologs.
Embo J., 42, 2023
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7YFG
 | | Structure of the Rat GluN1-GluN2C NMDA receptor in complex with glycine and glutamate (major class in asymmetry) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, ... | | Authors: | Zhang, M, Zhang, J, Guo, F, Li, Y, Zhu, S. | | Deposit date: | 2022-07-08 | | Release date: | 2023-03-29 | | Last modified: | 2023-05-31 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits.
Nat.Struct.Mol.Biol., 30, 2023
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7YFM
 | | Structure of GluN1b-GluN2D NMDA receptor in complex with agonists glycine and glutamate. | | Descriptor: | Glutamate receptor ionotropic, NMDA 2D, Isoform 6 of Glutamate receptor ionotropic, ... | | Authors: | Zhang, J.L, Zhu, S.J, Zhang, M. | | Deposit date: | 2022-07-08 | | Release date: | 2023-03-29 | | Last modified: | 2023-08-02 | | Method: | ELECTRON MICROSCOPY (5.1 Å) | | Cite: | Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits.
Nat.Struct.Mol.Biol., 30, 2023
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7XAB
 | | Crystal structure of PDE4D catalytic domain complexed with compound 22d | | Descriptor: | 9-(cyclopropylmethoxy)-8-methoxy-2,2-dimethyl-7-(3-methylbut-2-enyl)-5-(pyridin-4-ylmethoxy)pyrano[3,2-b]xanthen-6-one, Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D, MAGNESIUM ION, ... | | Authors: | Huang, Y.-Y, He, X, Luo, H.-B. | | Deposit date: | 2022-03-17 | | Release date: | 2023-02-22 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.00067449 Å) | | Cite: | Discovery of novel PDE4 inhibitors targeting the M-pocket from natural mangostanin with improved safety for the treatment of Inflammatory Bowel Diseases.
Eur.J.Med.Chem., 242, 2022
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7YFH
 | | Structure of the Rat GluN1-GluN2C NMDA receptor in complex with glycine, glutamate and (R)-PYD-106 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, ... | | Authors: | Zhang, M, Zhang, J, Guo, F, Li, Y, Zhu, S. | | Deposit date: | 2022-07-08 | | Release date: | 2023-03-29 | | Last modified: | 2023-05-31 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits.
Nat.Struct.Mol.Biol., 30, 2023
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7XAA
 | | Crystal structure of PDE4D catalytic domain complexed with compound 21d | | Descriptor: | 8-methoxy-2,2-dimethyl-7-(3-methylbut-2-enyl)-9-oxidanyl-5-(pyridin-4-ylmethoxy)pyrano[3,2-b]xanthen-6-one, Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D, MAGNESIUM ION, ... | | Authors: | Huang, Y.-Y, He, X, Luo, H.-B. | | Deposit date: | 2022-03-17 | | Release date: | 2023-02-22 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.100414 Å) | | Cite: | Discovery of novel PDE4 inhibitors targeting the M-pocket from natural mangostanin with improved safety for the treatment of Inflammatory Bowel Diseases.
Eur.J.Med.Chem., 242, 2022
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7YFF
 | | Structure of GluN1a-GluN2D NMDA receptor in complex with agonist glycine and competitive antagonist CPP. | | Descriptor: | (2R)-4-(3-phosphonopropyl)piperazine-2-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Zhang, J.L, Zhu, S.J, Zhang, M. | | Deposit date: | 2022-07-08 | | Release date: | 2023-04-12 | | Last modified: | 2023-08-02 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits.
Nat.Struct.Mol.Biol., 30, 2023
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7YFL
 | | Structure of GluN1a-GluN2D NMDA receptor in complex with agonists glycine and glutamate. | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, ... | | Authors: | Zhang, J.L, Zhu, S.J, Zhang, M. | | Deposit date: | 2022-07-08 | | Release date: | 2023-04-12 | | Last modified: | 2023-08-02 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits.
Nat.Struct.Mol.Biol., 30, 2023
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7YFO
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7YFR
 | | Structure of GluN1a E698C-GluN2D NMDA receptor in cystines non-crosslinked state. | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, ... | | Authors: | Zhang, J.L, Zhu, S.J, Zhang, M. | | Deposit date: | 2022-07-09 | | Release date: | 2023-04-12 | | Last modified: | 2023-08-02 | | Method: | ELECTRON MICROSCOPY (5.1 Å) | | Cite: | Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits.
Nat.Struct.Mol.Biol., 30, 2023
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7QUO
 | | FimH lectin domain in complex with oligomannose-6 | | Descriptor: | FimH, NICKEL (II) ION, SULFATE ION, ... | | Authors: | Bouckaert, J, Bourenkov, G.P. | | Deposit date: | 2022-01-18 | | Release date: | 2023-02-01 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structural insights into a cooperative switch between one and two FimH bacterial adhesins binding pauci- and high-mannose type N-glycan receptors
J.Biol.Chem., 299, 2023
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8KA8
 | | Cryo-EM structure of SARS-CoV-2 Delta RBD in complex with golden hamster ACE2 (local refinement) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme, ... | | Authors: | Niu, S, Zhao, Z.N, Chai, Y, Gao, G.F. | | Deposit date: | 2023-08-02 | | Release date: | 2024-01-31 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (2.96 Å) | | Cite: | Structural basis and analysis of hamster ACE2 binding to different SARS-CoV-2 spike RBDs.
J.Virol., 98, 2024
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7YFI
 | | Structure of the Rat tri-heteromeric GluN1-GluN2A-GluN2C NMDA receptor in complex with glycine and glutamate | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, ... | | Authors: | Zhang, M, Zhang, J, Guo, F, Li, Y, Zhu, S. | | Deposit date: | 2022-07-08 | | Release date: | 2023-03-29 | | Last modified: | 2023-07-26 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits.
Nat.Struct.Mol.Biol., 30, 2023
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8KC2
 | | Cryo-EM structure of SARS-CoV-2 BA.3 RBD in complex with golden hamster ACE2 (local refinement) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme, ... | | Authors: | Niu, S, Zhao, Z.N, Chai, Y, Gao, G.F. | | Deposit date: | 2023-08-05 | | Release date: | 2024-01-31 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Structural basis and analysis of hamster ACE2 binding to different SARS-CoV-2 spike RBDs.
J.Virol., 98, 2024
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7YG4
 | | Structure of WTAP-VIRMA in the m6A writer complex | | Descriptor: | Pre-mRNA-splicing regulator WTAP, Protein virilizer homolog | | Authors: | Yan, X.H, Guan, Z.Y, Tang, C, Yin, P. | | Deposit date: | 2022-07-11 | | Release date: | 2022-11-23 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | AI-empowered integrative structural characterization of m 6 A methyltransferase complex.
Cell Res., 32, 2022
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8K4U
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5GV2
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7YFJ
 | | Crystal structure of human WTAP | | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, Pre-mRNA-splicing regulator WTAP | | Authors: | Yan, X.H, Guan, Z.Y, Tang, C, Yin, P. | | Deposit date: | 2022-07-08 | | Release date: | 2023-01-25 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | AI-empowered integrative structural characterization of m 6 A methyltransferase complex.
Cell Res., 32, 2022
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4RSU
 | | Crystal structure of the light and hvem complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, GLYCEROL, ... | | Authors: | Liu, W, Ramagoal, U.A, Himmel, D, Bonanno, J.B, Nathenson, S.G, Almo, S.C, Atoms-to-Animals: The Immune Function Network (IFN), New York Structural Genomics Research Consortium (NYSGRC) | | Deposit date: | 2014-11-11 | | Release date: | 2015-02-04 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | HVEM structures and mutants reveal distinct functions of binding to LIGHT and BTLA/CD160.
J.Exp.Med., 218, 2021
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7FIL
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2JQC
 | | A L-amino acid mutant of a D-amino acid containing conopeptide | | Descriptor: | L-mr12 | | Authors: | Huang, F, Du, W, Han, Y, Wang, C, Chi, C. | | Deposit date: | 2007-05-31 | | Release date: | 2008-04-15 | | Last modified: | 2023-12-20 | | Method: | SOLUTION NMR | | Cite: | Purification and structural characterization of a d-amino acid-containing conopeptide, conomarphin, from Conus marmoreus
Febs J., 275, 2008
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7FIK
 | | The cryo-EM structure of the CR subunit from X. laevis NPC | | Descriptor: | MGC154553 protein, MGC83295 protein, MGC83926 protein, ... | | Authors: | Shi, Y, Huang, G, Zhan, X. | | Deposit date: | 2021-07-31 | | Release date: | 2022-11-09 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Structure of the cytoplasmic ring of the Xenopus laevis nuclear pore complex.
Science, 376, 2022
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3M45
 | | Crystal structure of Ig1 domain of mouse SynCAM 2 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cell adhesion molecule 2 | | Authors: | Yue, L, Modis, Y. | | Deposit date: | 2010-03-10 | | Release date: | 2010-09-08 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.21 Å) | | Cite: | N-glycosylation at the SynCAM (synaptic cell adhesion molecule) immunoglobulin interface modulates synaptic adhesion.
J.Biol.Chem., 285, 2010
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5ISY
 | | Crystal structure of Nudix family protein with NAD | | Descriptor: | NADH pyrophosphatase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ZINC ION | | Authors: | Zhang, D, Guan, Z, Zou, T, Yin, P. | | Deposit date: | 2016-03-15 | | Release date: | 2016-09-14 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.354 Å) | | Cite: | Structural basis of prokaryotic NAD-RNA decapping by NudC
Cell Res., 26, 2016
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