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4N4F
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BU of 4n4f by Molmil
Crystal Structure of the Bromodomain-PHD Finger Module of Human Transcriptional Co-Activator CBP in complex with di-Acetylated Histone 4 Peptide (H412acK16ac).
Descriptor: CREB-binding protein, Histone 4 Peptide, ZINC ION
Authors:Plotnikov, A.N, Zhou, J, Zhou, M.-M.
Deposit date:2013-10-08
Release date:2014-02-19
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Structural Insights into Acetylated-Histone H4 Recognition by the Bromodomain-PHD Finger Module of Human Transcriptional Coactivator CBP.
Structure, 22, 2014
4N3W
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BU of 4n3w by Molmil
Crystal Structure of the Bromodomain-PHD Finger Module of Human Transcriptional Co-Activator CBP in complex with Acetylated Histone 4 Peptide (H4K20ac).
Descriptor: CREB-binding protein, Histone H4 peptide, ZINC ION
Authors:Plotnikov, A.N, Yang, S, Zhou, M.-M.
Deposit date:2013-10-07
Release date:2014-01-29
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Insights into Acetylated-Histone H4 Recognition by the Bromodomain-PHD Finger Module of Human Transcriptional Coactivator CBP.
Structure, 22, 2014
2AQF
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BU of 2aqf by Molmil
Structural and functional analysis of ADA2 alpha swirm domain
Descriptor: transcriptional adaptor 2, Ada2 alpha
Authors:Qian, C, Zhang, Q, Zhou, M.-M, Zeng, L.
Deposit date:2005-08-17
Release date:2006-01-31
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Structure and chromosomal DNA binding of the SWIRM domain.
Nat.Struct.Mol.Biol., 12, 2005
6MNL
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BU of 6mnl by Molmil
NMR solution structures of second bromodomain of BRD4 with FOXO3a peptide
Descriptor: Bromodomain-containing protein 4, FOXO3a peptide
Authors:Zeng, L, Zhou, M.-M.
Deposit date:2018-10-02
Release date:2018-10-31
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:Targeting the BRD4/FOXO3a/CDK6 axis sensitizes AKT inhibition in luminal breast cancer.
Nat Commun, 9, 2018
5Z9C
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BU of 5z9c by Molmil
Solution NMR structures of BRD4 first bromodomain with small compound MMQO
Descriptor: 8-methoxy-6-methylquinolin-4(1H)-one, Bromodomain-containing protein 4
Authors:Zeng, L, Zhou, M.-M.
Deposit date:2018-02-02
Release date:2018-02-14
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:A New Quinoline BRD4 Inhibitor Targets a Distinct Latent HIV-1 Reservoir for Reactivation from Other "Shock" Drugs.
J. Virol., 92, 2018
6BNH
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BU of 6bnh by Molmil
Solution NMR structures of BRD4 ET domain with JMJD6 peptide
Descriptor: Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6, Bromodomain-containing protein 4
Authors:Konuma, T, Yu, D, Zhao, C, Ju, Y, Sharma, R, Ren, C, Zhang, Q, Zhou, M.-M, Zeng, L.
Deposit date:2017-11-16
Release date:2017-12-20
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Structural Mechanism of the Oxygenase JMJD6 Recognition by the Extraterminal (ET) Domain of BRD4.
Sci Rep, 7, 2017
1BVH
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BU of 1bvh by Molmil
SOLUTION STRUCTURE OF A LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE
Descriptor: ACID PHOSPHATASE
Authors:Logan, T.M, Zhou, M.-M, Nettesheim, D.G, Meadows, R.P, Van Etten, R.L, Fesik, S.W.
Deposit date:1994-05-03
Release date:1994-07-31
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Solution structure of a low molecular weight protein tyrosine phosphatase.
Biochemistry, 33, 1994
2MJV
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BU of 2mjv by Molmil
Solution structures of second bromodomain of Brd4 with di-acetylated Twist peptide
Descriptor: Bromodomain-containing protein 4, Twist-related protein 1
Authors:Zeng, L, Zhou, M.
Deposit date:2014-01-16
Release date:2014-03-19
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:Disrupting the Interaction of BRD4 with Diacetylated Twist Suppresses Tumorigenesis in Basal-like Breast Cancer.
Cancer Cell, 25, 2014
2RO1
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BU of 2ro1 by Molmil
NMR Solution Structures of Human KAP1 PHD finger-bromodomain
Descriptor: Transcription intermediary factor 1-beta, ZINC ION
Authors:Zeng, L, Yap, K.L, Ivanov, A.V, Wang, X, Mujtaba, S, Plotnikova, O, Rauscher, F.J.
Deposit date:2008-03-04
Release date:2008-05-20
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Structural insights into human KAP1 PHD finger-bromodomain and its role in gene silencing
Nat.Struct.Mol.Biol., 15, 2008
1HZM
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BU of 1hzm by Molmil
STRUCTURE OF ERK2 BINDING DOMAIN OF MAPK PHOSPHATASE MKP-3: STRUCTURAL INSIGHTS INTO MKP-3 ACTIVATION BY ERK2
Descriptor: DUAL SPECIFICITY PROTEIN PHOSPHATASE 6
Authors:Farooq, A, Zhou, M.-M.
Deposit date:2001-01-25
Release date:2002-01-25
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Solution structure of ERK2 binding domain of MAPK phosphatase MKP-3: structural insights into MKP-3 activation by ERK2.
Mol.Cell, 7, 2001
1JSP
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BU of 1jsp by Molmil
NMR Structure of CBP Bromodomain in complex with p53 peptide
Descriptor: CREB-BINDING PROTEIN, tumor protein p53
Authors:He, Y, Mujtaba, S, Zeng, L, Yan, S, Zhou, M.-M.
Deposit date:2001-08-17
Release date:2002-08-17
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.
Mol.Cell, 13, 2004
2MFQ
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BU of 2mfq by Molmil
NMR solution structures of FRS2a PTB domain with neurotrophin receptor TrkB
Descriptor: BDNF/NT-3 growth factors receptor, Fibroblast growth factor receptor substrate 2
Authors:Zeng, L, Zhou, M.
Deposit date:2013-10-18
Release date:2014-03-05
Last modified:2014-06-25
Method:SOLUTION NMR
Cite:Structural insights into FRS2 alpha PTB domain recognition by neurotrophin receptor TrkB.
Proteins, 82, 2014
2ND0
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BU of 2nd0 by Molmil
Solution NMR structures of BRD4 ET domain with LANA peptide
Descriptor: Bromodomain-containing protein 4, LANA
Authors:Zeng, L, Zhou, M.
Deposit date:2016-04-18
Release date:2016-06-29
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Structural Mechanism of Transcriptional Regulator NSD3 Recognition by the ET Domain of BRD4.
Structure, 24, 2016
2NCZ
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BU of 2ncz by Molmil
Solution NMR structures of BRD4 ET domain in complex with NSD3_1 peptide
Descriptor: Bromodomain-containing protein 4, Histone-lysine N-methyltransferase NSD3
Authors:Zeng, L, Zhou, M.
Deposit date:2016-04-18
Release date:2016-06-29
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Structural Mechanism of Transcriptional Regulator NSD3 Recognition by the ET Domain of BRD4.
Structure, 24, 2016
2NDF
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BU of 2ndf by Molmil
Solution NMR structures of AF9 yeats domain in complex with histon H3 acetylation at K18
Descriptor: Histone H3 peptide, Protein AF-9
Authors:Zeng, L, Zhou, M.
Deposit date:2016-05-19
Release date:2016-09-07
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:Structural Insights into Histone Crotonyl-Lysine Recognition by the AF9 YEATS Domain.
Structure, 24, 2016
2NDG
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BU of 2ndg by Molmil
Solution NMR structures of AF9 yeats domain in complex with histone H3 crotonylation at K18
Descriptor: Histone H3 peptide, Protein AF-9
Authors:Zeng, L, Zhou, M.
Deposit date:2016-05-19
Release date:2016-09-07
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:Structural Insights into Histone Crotonyl-Lysine Recognition by the AF9 YEATS Domain.
Structure, 24, 2016
2ND1
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BU of 2nd1 by Molmil
Solution NMR structures of BRD4 ET domain in complex with NSD3_3 peptide
Descriptor: Bromodomain-containing protein 4, Histone-lysine N-methyltransferase NSD3
Authors:Zeng, L, Zhou, M.
Deposit date:2016-04-19
Release date:2016-06-29
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Structural Mechanism of Transcriptional Regulator NSD3 Recognition by the ET Domain of BRD4.
Structure, 24, 2016
3DWH
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BU of 3dwh by Molmil
Structural and Functional Analysis of SRA domain
Descriptor: E3 ubiquitin-protein ligase UHRF1, GLYCEROL, SULFATE ION
Authors:Qian, C, Jakoncic, J, Zhou, M.
Deposit date:2008-07-22
Release date:2008-10-21
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure and Hemimethylated CpG Binding of the SRA Domain from Human UHRF1.
J.Biol.Chem., 283, 2008
4F3I
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BU of 4f3i by Molmil
Crystal structure of the first bromodomain of human BRD4 in complex with MS417 inhibitor
Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, methyl [(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate
Authors:Joshua, J, Zhou, M.-M, Plotnikov, A.N.
Deposit date:2012-05-09
Release date:2012-09-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Down-regulation of NF-{kappa}B Transcriptional Activity in HIV-associated Kidney Disease by BRD4 Inhibition.
J.Biol.Chem., 287, 2012
3QB8
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BU of 3qb8 by Molmil
Paramecium Chlorella Bursaria Virus1 Putative ORF A654L is a Polyamine Acetyltransferase
Descriptor: A654L protein, COENZYME A, IMIDAZOLE
Authors:Charlop-Powers, Z, Zhou, M.-M, Jakoncic, J, Gurnon, J, Van Etten, J.
Deposit date:2011-01-12
Release date:2012-01-25
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Paramecium bursaria chlorella virus 1 encodes a polyamine acetyltransferase.
J. Biol. Chem., 287, 2012
2LXE
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BU of 2lxe by Molmil
S4wyild
Descriptor: Histone-lysine N-methyltransferase SUVR4
Authors:Kristiansen, P, Rahman, M.A, Aalen, R.B.
Deposit date:2012-08-20
Release date:2013-11-20
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:The arabidopsis histone methyltransferase SUVR4 binds ubiquitin via a domain with a four-helix bundle structure.
Biochemistry, 53, 2014
2KFT
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BU of 2kft by Molmil
NMR Solution structure of the first PHD finger domain of human Autoimmune Regulator (AIRE) in complex with Histone H3(1-20Cys) Peptide
Descriptor: Autoimmune regulator, Histone H3, ZINC ION
Authors:Chakravarty, S, Zeng, L, Zhou, M.
Deposit date:2009-02-27
Release date:2009-04-28
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Structure and Site-Specific Recognition of Histone H3 by the PHD Finger of Human Autoimmune Regulator.
Structure, 17, 2009
2KWJ
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BU of 2kwj by Molmil
Solution structures of the double PHD fingers of human transcriptional protein DPF3 bound to a histone peptide containing acetylation at lysine 14
Descriptor: Histone peptide, ZINC ION, Zinc finger protein DPF3
Authors:Zeng, L, Zhang, Q, Li, S, Plotnikov, A.N, Walsh, M.J, Zhou, M.
Deposit date:2010-04-12
Release date:2010-07-14
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:Mechanism and regulation of acetylated histone binding by the tandem PHD finger of DPF3b.
Nature, 466, 2010
2KVM
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BU of 2kvm by Molmil
Solution structure of the CBX7 chromodomain in complex with a H3K27me2 peptide
Descriptor: Chromobox protein homolog 7, histone H3 peptide (residues 15-30) with dimethylated lysine 27
Authors:Yap, K.L, Zeng, L, Zhou, M.
Deposit date:2010-03-17
Release date:2010-06-30
Last modified:2020-02-05
Method:SOLUTION NMR
Cite:Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a.
Mol.Cell, 38, 2010
2KWO
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BU of 2kwo by Molmil
Solution structure of the double PHD (plant homeodomain) fingers of human transcriptional protein DPF3b bound to a histone H4 peptide containing N-terminal acetylation at Serine 1
Descriptor: Histone peptide, ZINC ION, Zinc finger protein DPF3
Authors:Zeng, L, Zhang, Q, Li, S, Plotnikov, A.N, Walsh, M.J, Zhou, M.
Deposit date:2010-04-14
Release date:2010-07-14
Last modified:2013-06-19
Method:SOLUTION NMR
Cite:Mechanism and regulation of acetylated histone binding by the tandem PHD finger of DPF3b.
Nature, 466, 2010

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數據於2024-07-10公開中

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