6ZC7
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![BU of 6zc7 by Molmil](/molmil-images/mine/6zc7) | |
6ZC3
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![BU of 6zc3 by Molmil](/molmil-images/mine/6zc3) | Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling | Descriptor: | 1,2-ETHANEDIOL, 5-fluoranyl-2-(methylsulfonylamino)benzoic acid, Dishevelled, ... | Authors: | Roske, Y, Heinemann, U, Oschkinat, H. | Deposit date: | 2020-06-09 | Release date: | 2021-06-23 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling J.Magn.Reson., 2021
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6ZC6
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![BU of 6zc6 by Molmil](/molmil-images/mine/6zc6) | |
6ZC8
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![BU of 6zc8 by Molmil](/molmil-images/mine/6zc8) | |
6ZC4
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![BU of 6zc4 by Molmil](/molmil-images/mine/6zc4) | Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling | Descriptor: | 5-bromanyl-2-(5,6,7,8-tetrahydronaphthalen-2-ylsulfonylamino)benzoic acid, Dishevelled, dsh homolog 3 (Drosophila), ... | Authors: | Roske, Y, Heinemann, U, Oschkinat, H. | Deposit date: | 2020-06-09 | Release date: | 2021-06-23 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling J.Magn.Reson., 2021
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1U06
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![BU of 1u06 by Molmil](/molmil-images/mine/1u06) | crystal structure of chicken alpha-spectrin SH3 domain | Descriptor: | AZIDE ION, Spectrin alpha chain, brain | Authors: | Chevelkov, V, Faelber, K, Diehl, A, Heinemann, U, Oschkinat, H, Reif, B. | Deposit date: | 2004-07-13 | Release date: | 2005-01-13 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.49 Å) | Cite: | Detection of dynamic water molecules in a microcrystalline sample of the SH3 domain of alpha-spectrin by MAS solid-state NMR. J.Biomol.Nmr, 31, 2005
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1SS6
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![BU of 1ss6 by Molmil](/molmil-images/mine/1ss6) | Solution structure of SEP domain from human p47 | Descriptor: | NSFL1 cofactor p47 | Authors: | Soukenik, M, Leidert, M, Sievert, V, Buessow, K, Leitner, D, Labudde, D, Ball, L.J, Oschkinat, H. | Deposit date: | 2004-03-23 | Release date: | 2004-11-09 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | The SEP domain of p47 acts as a reversible competitive inhibitor of cathepsin L FEBS Lett., 576, 2004
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1KQ6
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![BU of 1kq6 by Molmil](/molmil-images/mine/1kq6) | |
2CYK
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![BU of 2cyk by Molmil](/molmil-images/mine/2cyk) | |
2EXG
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![BU of 2exg by Molmil](/molmil-images/mine/2exg) | Making Protein-Protein Interactions Drugable: Discovery of Low-Molecular-Weight Ligands for the AF6 PDZ Domain | Descriptor: | (5R)-2-SULFANYL-5-[4-(TRIFLUOROMETHYL)BENZYL]-1,3-THIAZOL-4-ONE, Afadin | Authors: | Joshi, M, Vargas, C, Boisguerin, P, Krause, G, Schade, M, Oschkinat, H. | Deposit date: | 2005-11-08 | Release date: | 2006-10-17 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Discovery of low-molecular-weight ligands for the AF6 PDZ domain. Angew.Chem.Int.Ed.Engl., 45, 2006
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1A90
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![BU of 1a90 by Molmil](/molmil-images/mine/1a90) | RECOMBINANT MUTANT CHICKEN EGG WHITE CYSTATIN, NMR, 31 STRUCTURES | Descriptor: | CYSTATIN | Authors: | Dieckmann, T, Mitschang, L, Hofmann, M, Kos, J, Turk, V, Auerswald, E.A, Jaenicke, R, Oschkinat, H. | Deposit date: | 1998-04-14 | Release date: | 1998-06-17 | Last modified: | 2022-02-16 | Method: | SOLUTION NMR | Cite: | The structures of native phosphorylated chicken cystatin and of a recombinant unphosphorylated variant in solution. J.Mol.Biol., 234, 1993
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1A67
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![BU of 1a67 by Molmil](/molmil-images/mine/1a67) | CHICKEN EGG WHITE CYSTATIN WILDTYPE, NMR, 16 STRUCTURES | Descriptor: | CYSTATIN | Authors: | Dieckmann, T, Mitschang, L, Hofmann, M, Kos, J, Turk, V, Auerswald, E.A, Jaenicke, R, Oschkinat, H. | Deposit date: | 1998-03-06 | Release date: | 1998-05-27 | Last modified: | 2022-02-16 | Method: | SOLUTION NMR | Cite: | The structures of native phosphorylated chicken cystatin and of a recombinant unphosphorylated variant in solution. J.Mol.Biol., 234, 1993
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5MWV
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![BU of 5mwv by Molmil](/molmil-images/mine/5mwv) | Solid-state NMR Structure of outer membrane protein G in lipid bilayers | Descriptor: | Outer membrane protein G | Authors: | Retel, J.S, Nieuwkoop, A.J, Hiller, M, Higman, V.A, Barbet-Massin, E, Stanek, J, Andreas, L.B, Franks, W.T, van Rossum, B.-J, Vinothkumar, K.R, Handel, L, de Palma, G.G, Bardiaux, B, Pintacuda, G, Emsley, L, Kuelbrandt, W, Oschkinat, H. | Deposit date: | 2017-01-20 | Release date: | 2017-12-27 | Last modified: | 2024-05-15 | Method: | SOLID-STATE NMR | Cite: | Structure of outer membrane protein G in lipid bilayers. Nat Commun, 8, 2017
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1PQS
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![BU of 1pqs by Molmil](/molmil-images/mine/1pqs) | Solution structure of the C-terminal OPCA domain of yCdc24p | Descriptor: | Cell division control protein 24 | Authors: | Leitner, D, Wahl, M, Labudde, D, Diehl, A, Schmieder, P, Pires, J.R, Fossi, M, Leidert, M, Krause, G, Oschkinat, H. | Deposit date: | 2003-06-19 | Release date: | 2003-07-01 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | The solution structure of an N-terminally truncated version of the yeast CDC24p PB1 domain shows a different beta-sheet topology. Febs Lett., 579, 2005
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2NUZ
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![BU of 2nuz by Molmil](/molmil-images/mine/2nuz) | crystal structure of alpha spectrin SH3 domain measured at room temperature | Descriptor: | Spectrin alpha chain, brain | Authors: | Agarwal, V, Faelber, K, Hologne, M, Chevelkov, V, Oschkinat, H, Diehl, A, Reif, B. | Deposit date: | 2006-11-10 | Release date: | 2007-05-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Comparison of MAS solid-state NMR and X-ray crystallographic data in the analysis of protein dynamics in the solid state To be Published
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1NM7
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![BU of 1nm7 by Molmil](/molmil-images/mine/1nm7) | Solution structure of the ScPex13p SH3 domain | Descriptor: | Peroxisomal Membrane Protein PAS20 | Authors: | Pires, J.R, Hong, X, Brockmann, C, Volkmer-Engert, R, Schneider-Mergener, J, Oschkinat, H, Erdmann, R. | Deposit date: | 2003-01-09 | Release date: | 2003-03-04 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | The ScPex13p SH3 Domain Exposes Two Distinct Binding Sites for Pex5p and Pex14p J.Mol.Biol., 326, 2003
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1QGP
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![BU of 1qgp by Molmil](/molmil-images/mine/1qgp) | NMR STRUCTURE OF THE Z-ALPHA DOMAIN OF ADAR1, 15 STRUCTURES | Descriptor: | PROTEIN (DOUBLE STRANDED RNA ADENOSINE DEAMINASE) | Authors: | Schade, M, Turner, C.J, Kuehne, R, Schmieder, P, Lowenhaupt, K, Herbert, A, Rich, A, Oschkinat, H. | Deposit date: | 1999-05-03 | Release date: | 1999-10-19 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | The solution structure of the Zalpha domain of the human RNA editing enzyme ADAR1 reveals a prepositioned binding surface for Z-DNA. Proc.Natl.Acad.Sci.USA, 96, 1999
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2PDZ
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![BU of 2pdz by Molmil](/molmil-images/mine/2pdz) | SOLUTION STRUCTURE OF THE SYNTROPHIN PDZ DOMAIN IN COMPLEX WITH THE PEPTIDE GVKESLV, NMR, 15 STRUCTURES | Descriptor: | PEPTIDE GVKESLV, SYNTROPHIN | Authors: | Schultz, J, Hoffmueller, U, Ashurst, J, Krause, G, Schmieder, P, Macias, M, Schneider-Mergener, J, Oschkinat, H. | Deposit date: | 1997-12-10 | Release date: | 1998-12-30 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Specific interactions between the syntrophin PDZ domain and voltage-gated sodium channels. Nat.Struct.Biol., 5, 1998
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1OYI
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![BU of 1oyi by Molmil](/molmil-images/mine/1oyi) | Solution structure of the Z-DNA binding domain of the vaccinia virus gene E3L | Descriptor: | double-stranded RNA-binding protein | Authors: | Kahmann, J.D, Wecking, D.A, Putter, V, Lowenhaupt, K, Kim, Y.-G, Schmieder, P, Oschkinat, H, Rich, A, Schade, M. | Deposit date: | 2003-04-04 | Release date: | 2004-03-09 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | The solution structure of the N-terminal domain of E3L shows a tyrosine conformation that may explain its reduced affinity to Z-DNA in vitro. Proc.Natl.Acad.Sci.USA, 101, 2004
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1RAX
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![BU of 1rax by Molmil](/molmil-images/mine/1rax) | |
2MBK
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![BU of 2mbk by Molmil](/molmil-images/mine/2mbk) | The Clip-segment of the von Willebrand domain 1 of the BMP modulator protein Crossveinless 2 is preformed | Descriptor: | Crossveinless 2 | Authors: | Mueller, T.D, Fiebig, J.E, Weidauer, S.E, Qiu, L, Bauer, M, Schmieder, P, Beerbaum, M, Zhang, J, Oschkinat, H, Sebald, W. | Deposit date: | 2013-08-02 | Release date: | 2013-10-16 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | The Clip-Segment of the von Willebrand Domain 1 of the BMP Modulator Protein Crossveinless 2 Is Preformed. Molecules, 18, 2013
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2JUP
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![BU of 2jup by Molmil](/molmil-images/mine/2jup) | FBP28WW2 domain in complex with the PPLIPPPP peptide | Descriptor: | Formin-1, Transcription elongation regulator 1 | Authors: | Ramirez-Espain, X, Ruiz, L, Martin-Malpartida, P, Oschkinat, H, Macias, M.J. | Deposit date: | 2007-09-01 | Release date: | 2007-11-06 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structural Characterization of a New Binding Motif and a Novel Binding Mode in Group 2 WW Domains J.Mol.Biol., 373, 2007
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2JTF
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![BU of 2jtf by Molmil](/molmil-images/mine/2jtf) | Solution Structure of the PHF20L1 MBT domain | Descriptor: | PHD finger protein 20-like 1 | Authors: | Brockmann, C, Iberg, A.N, Rehbein, K, Diehl, A, Bedford, M.T, Oschkinat, H. | Deposit date: | 2007-07-30 | Release date: | 2008-08-19 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Structural Analysis of Histone H4K20 Methyllysine Recognition by the MBT Domain of PHF20L1 To be Published
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1K9Q
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![BU of 1k9q by Molmil](/molmil-images/mine/1k9q) | YAP65 WW domain complexed to N-(n-octyl)-GPPPY-NH2 | Descriptor: | 65 kDa Yes-associated protein, N-OCTANE, WW domain binding protein-1 | Authors: | Pires, J.R, Taha-Nejad, F, Toepert, F, Ast, T, Hoffmuller, U, Schneider-Mergener, J, Kuhne, R, Macias, M.J, Oschkinat, H. | Deposit date: | 2001-10-30 | Release date: | 2001-12-28 | Last modified: | 2021-11-10 | Method: | SOLUTION NMR | Cite: | Solution structures of the YAP65 WW domain and the variant L30 K in complex with the peptides GTPPPPYTVG, N-(n-octyl)-GPPPY and PLPPY and the application of peptide libraries reveal a minimal binding epitope. J.Mol.Biol., 314, 2001
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1K9R
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![BU of 1k9r by Molmil](/molmil-images/mine/1k9r) | YAP65 WW domain complexed to Acetyl-PLPPY | Descriptor: | 65 kDa Yes-associated protein, WW domain binding protein-1 | Authors: | Pires, J.R, Taha-Nejad, F, Toepert, F, Ast, T, Hoffmuller, U, Schneider-Mergener, J, Kuhne, R, Macias, M.J, Oschkinat, H. | Deposit date: | 2001-10-30 | Release date: | 2001-12-28 | Last modified: | 2021-11-10 | Method: | SOLUTION NMR | Cite: | Solution structures of the YAP65 WW domain and the variant L30 K in complex with the peptides GTPPPPYTVG, N-(n-octyl)-GPPPY and PLPPY and the application of peptide libraries reveal a minimal binding epitope. J.Mol.Biol., 314, 2001
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