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Crystal Structure of Lysyl-tRNA Synthetase from Cryptosporidium parvum complexed with L-lysine and a difluoro cyclohexyl chromone ligand
Descriptor:	2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, LYSINE, Lysine--tRNA ligase, ...
Authors:	Robinson, D.A, Baragana, B, Norcross, N, Forte, B, Walpole, C, Gilbert, I.H.
Deposit date:	2018-08-16
Release date:	2019-04-03
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (1.46 Å)
Cite:	Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis. Proc.Natl.Acad.Sci.USA, 116, 2019

6HCV

Crystal Structure of Lysyl-tRNA Synthetase from Plasmodium falciparum complexed with a chromone ligand
Descriptor:	6-fluoranyl-~{N}-[(1-oxidanylcyclohexyl)methyl]-4-oxidanylidene-chromene-2-carboxamide, Lysine--tRNA ligase
Authors:	Robinson, D.A, Baragana, B, Norcross, N, Forte, B, Walpole, C, Gilbert, I.H.
Deposit date:	2018-08-16
Release date:	2019-04-03
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis. Proc.Natl.Acad.Sci.USA, 116, 2019

4YET

X-ray crystal structure of superoxide dismutase from Babesia bovis solved by Sulfur SAD
Descriptor:	FE (III) ION, Superoxide dismutase
Authors:	Fairman, J.W, Clifton, M.C, Abendroth, J, Edwards, T.E, Lorimer, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2015-02-24
Release date:	2015-04-15
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (1.75 Å)
Cite:	Iron superoxide dismutases in eukaryotic pathogens: new insights from Apicomplexa and Trypanosoma structures. Acta Crystallogr.,Sect.F, 71, 2015

4ZDQ

Crystal Structure of 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (IspD) from Burkholderia thailandensis complexed with CTP
Descriptor:	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, ACETATE ION, CACODYLIC ACID, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2015-04-18
Release date:	2015-04-29
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Crystal structure and biophysical characterization of IspD from Burkholderia thailandensis and Mycobacterium paratuberculosis. Acta Crystallogr.,Sect.F, 80, 2024

4YLG

Structure of an ADP ribosylation factor from Entamoeba histolytica HM-1:IMSS bound to Mg-GDP
Descriptor:	ADP-ribosylation factor, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:	Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2015-03-05
Release date:	2015-05-20
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Structure of an ADP-ribosylation factor, ARF1, from Entamoeba histolytica bound to Mg(2+)-GDP. Acta Crystallogr.,Sect.F, 71, 2015

3F0G

Co-crystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase with CMP
Descriptor:	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, CYTIDINE-5'-MONOPHOSPHATE, ZINC ION
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2008-10-24
Release date:	2008-11-04
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (2.08 Å)
Cite:	Leveraging structure determination with fragment screening for infectious disease drug targets: MECP synthase from Burkholderia pseudomallei. J Struct Funct Genomics, 12, 2011

3TL3

Structure of a short-chain type dehydrogenase/reductase from Mycobacterium ulcerans
Descriptor:	SODIUM ION, Short-chain type dehydrogenase/reductase
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2011-08-29
Release date:	2011-09-07
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (1.85 Å)
Cite:	Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015

3TMQ

Crystal structure of a 2-dehydro-3-deoxyphosphooctonate aldolase from Burkholderia pseudomallei in complex with D-arabinose-5-phosphate
Descriptor:	1,2-ETHANEDIOL, 2-dehydro-3-deoxyphosphooctonate aldolase 2, ARABINOSE-5-PHOSPHATE, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2011-08-31
Release date:	2011-09-21
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Combining functional and structural genomics to sample the essential Burkholderia structome. Plos One, 8, 2013

3TX2

Structure of a Probable 6-phosphogluconolactonase from Mycobacterium abscessus
Descriptor:	BENZOIC ACID, GLYCEROL, Probable 6-phosphogluconolactonase, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2011-09-22
Release date:	2011-10-05
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (1.5 Å)
Cite:	Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015

3TRR

Crystal structure of a probable enoyl-CoA hydratase/isomerase from Mycobacterium abscessus
Descriptor:	1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2011-09-09
Release date:	2011-09-21
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (2.09 Å)
Cite:	Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015

3U0E

Crystal structure of beta-ketoacyl synthase from Brucella melitensis in complex with fragment 9320
Descriptor:	8-methylquinolin-4-amine, Beta-ketoacyl synthase, CHLORIDE ION, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2011-09-28
Release date:	2011-10-26
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (1.6 Å)
Cite:	Structural characterization of beta-ketoacyl ACP synthase I bound to platencin and fragment screening molecules at two substrate binding sites. Proteins, 88, 2020

3U7J

Crystal structure of Ribose-5-phosphate isomerase A from Burkholderia thailandensis
Descriptor:	1,2-ETHANEDIOL, POTASSIUM ION, Ribose-5-phosphate isomerase A, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2011-10-13
Release date:	2011-11-16
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Combining functional and structural genomics to sample the essential Burkholderia structome. Plos One, 8, 2013

3TZQ

Crystal structure of a short-chain type dehydrogenase/reductase from Mycobacterium marinum
Descriptor:	1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2011-09-27
Release date:	2011-10-05
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015

3UF8

Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with a G95A surface mutation from Burkholderia pseudomallei complexed with FK506
Descriptor:	8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, Ubiquitin-like protein SMT3, Peptidyl-prolyl cis-trans isomerase
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2011-10-31
Release date:	2011-11-09
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (1.5 Å)
Cite:	A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins. Antimicrob.Agents Chemother., 58, 2014

3UE9

Crystal structure of Adenylosuccinate synthetase (AMPSase) (purA) from Burkholderia thailandensis
Descriptor:	ACETATE ION, Adenylosuccinate synthetase, CALCIUM ION, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2011-10-28
Release date:	2011-11-16
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	Combining functional and structural genomics to sample the essential Burkholderia structome. Plos One, 8, 2013

3UK1

Crystal structure of a transketolase from Burkholderia thailandensis with an oxidized cysteinesulfonic acid in the active site
Descriptor:	CHLORIDE ION, SULFATE ION, Transketolase
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2011-11-08
Release date:	2011-11-23
Last modified:	2023-12-06
Method:	X-RAY DIFFRACTION (2.15 Å)
Cite:	Combining functional and structural genomics to sample the essential Burkholderia structome. Plos One, 8, 2013

4O3V

Crystal structure of a VirB8-like protein of type IV secretion system from Rickettsia typhi
Descriptor:	S,R MESO-TARTARIC ACID, VirB8-like protein of type IV secretion system
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2013-12-18
Release date:	2014-03-05
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	Structural Insight into How Bacteria Prevent Interference between Multiple Divergent Type IV Secretion Systems. MBio, 6, 2015

1XN4

PUTATIVE MAR1 RIBONUCLEASE FROM LEISHMANIA MAJOR
Descriptor:	ribonuclease MAR1
Authors:	Caruthers, J, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2004-10-04
Release date:	2004-10-12
Last modified:	2023-08-23
Method:	X-RAY DIFFRACTION (3.8 Å)
Cite:	Crystal structures and proposed structural/functional classification of three protozoan proteins from the isochorismatase superfamily. Protein Sci., 14, 2005

2A0K

Crystal structure of Nucleoside 2-deoxyribosyltransferase from Trypanosoma brucei at 1.8 A resolution
Descriptor:	GLYCEROL, Nucleoside 2-deoxyribosyltransferase, SULFATE ION
Authors:	Bosch, J, Robien, M.A, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2005-06-16
Release date:	2005-07-26
Last modified:	2021-10-20
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase. J.Med.Chem., 49, 2006

1YZV

HYPOTHETICAL PROTEIN FROM TRYPANOSOMA CRUZI
Descriptor:	HYPOTHETICAL PROTEIN, SULFATE ION
Authors:	Caruthers, J, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2005-02-28
Release date:	2005-03-08
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (2.001 Å)
Cite:	Crystal structures and proposed structural/functional classification of three protozoan proteins from the isochorismatase superfamily. Protein Sci., 14, 2005

1X9G

PUTATIVE MAR1 RIBONUCLEASE FROM LEISHMANIA DONOVANI
Descriptor:	PUTATIVE MAR1
Authors:	Caruthers, J, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2004-08-20
Release date:	2004-09-07
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (2.41 Å)
Cite:	Crystal structures and proposed structural/functional classification of three protozoan proteins from the isochorismatase superfamily. Protein Sci., 14, 2005

2A0M

Arginase superfamily protein from Trypanosoma cruzi
Descriptor:	ARGINASE SUPERFAMILY PROTEIN, CHLORIDE ION
Authors:	Arakaki, T.L, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2005-06-16
Release date:	2005-07-05
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (1.603 Å)
Cite:	Structural genomics of pathogenic protozoa: an overview. Methods Mol.Biol., 426, 2008

6ALI

Solution NMR structure of a putative thioredoxin (ECH_0218) in the oxidized state from Ehrlichia chaffeensis, the etiological agent responsible for human monocytic ehrlichiosis. Seattle Structural Genomics Center for Infectious Disease target EhchA.00546.a
Descriptor:	Thioredoxin
Authors:	Buchko, G.W, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2017-08-08
Release date:	2017-09-06
Last modified:	2023-06-14
Method:	SOLUTION NMR
Cite:	Solution NMR structures of oxidized and reduced Ehrlichia chaffeensis thioredoxin: NMR-invisible structure owing to backbone dynamics. Acta Crystallogr F Struct Biol Commun, 74, 2018

6AMR

Solution NMR structure of a putative thioredoxin (ECH_0218) in the reduced state from Ehrlichia chaffeensis, the etiological agent responsible for human monocytic ehrlichiosis. Seattle Structural Genomics Center for Infectious Disease target EhchA.00546.a
Descriptor:	Thioredoxin
Authors:	Buchko, G.W, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2017-08-11
Release date:	2017-09-20
Last modified:	2024-05-15
Method:	SOLUTION NMR
Cite:	Solution NMR structures of oxidized and reduced Ehrlichia chaffeensis thioredoxin: NMR-invisible structure owing to backbone dynamics. Acta Crystallogr F Struct Biol Commun, 74, 2018

6CUM

Crystal structure of a C-terminal proteolytic fragment of a protein annotated as an LAO/AO transport system ATPase but likely MeaB and MMAA-like GTPase from Mycobacterium smegmatis
Descriptor:	1,2-ETHANEDIOL, LAO/AO transport system ATPase
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2018-03-26
Release date:	2018-04-11
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (1.6 Å)
Cite:	Ab initio structure solution of a proteolytic fragment using ARCIMBOLDO. Acta Crystallogr F Struct Biol Commun, 74, 2018

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