2OSN
 
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2QSQ
 | | Crystal structure of the N-terminal domain of carcinoembryonic antigen (CEA) | | Descriptor: | CHLORIDE ION, Carcinoembryonic antigen-related cell adhesion molecule 5, GLYCEROL | | Authors: | Le Trong, I, Korotkova, N, Moseley, S.L, Stenkamp, R.E. | | Deposit date: | 2007-07-31 | | Release date: | 2008-01-01 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Binding of Dr adhesins of Escherichia coli to carcinoembryonic antigen triggers receptor dissociation.
Mol.Microbiol., 67, 2008
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3RY1
 | | Wild-type core streptavidin at atomic resolution | | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, Streptavidin | | Authors: | Stenkamp, R.E, Wang, Z, Le Trong, I, Stayton, P.S, Lybrand, T.P. | | Deposit date: | 2011-05-10 | | Release date: | 2011-08-24 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.03 Å) | | Cite: | Streptavidin and its biotin complex at atomic resolution.
Acta Crystallogr.,Sect.D, 67, 2011
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3RY2
 | | Wild-type core streptavidin-biotin complex at atomic resolution | | Descriptor: | BIOTIN, GLYCEROL, Streptavidin | | Authors: | Stenkamp, R.E, Le Trong, I, Stayton, P.S, Lybrand, T.P. | | Deposit date: | 2011-05-10 | | Release date: | 2011-08-24 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (0.95 Å) | | Cite: | Streptavidin and its biotin complex at atomic resolution.
Acta Crystallogr.,Sect.D, 67, 2011
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3DGI
 | | Crystal structure of F87A/T268A mutant of CYP BM3 | | Descriptor: | Bifunctional P-450/NADPH-P450 reductase, DIMETHYL SULFOXIDE, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Le Trong, I, Katayama, J.H, Totah, R.A, Stenkamp, R.E, Fox, E.P. | | Deposit date: | 2008-06-13 | | Release date: | 2009-06-16 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Homolytic versus heterolytic dioxygen bond cleavage in cytochrome P450 BM3.
To be Published
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3DWS
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3DWR
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3DEU
 | | Crystal structure of transcription regulatory protein slyA from Salmonella typhimurium in complex with salicylate ligands | | Descriptor: | 2-HYDROXYBENZOIC ACID, Transcriptional regulator slyA | | Authors: | Le Trong, I, Brzovic, P.S, Fang, F.C, Libby, S.J, Stenkamp, R.E. | | Deposit date: | 2008-06-10 | | Release date: | 2008-06-24 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | The Evolution of SlyA/RovA Transcription Factors from Repressors to Countersilencers in Enterobacteriaceae .
Mbio, 10, 2019
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7SZO
 | | Structure of a bacterial fimbrial tip containing FocH | | Descriptor: | Chaperone protein FimC, FimF protein, FimG, ... | | Authors: | Stenkamp, R.E, Le Trong, I, Aprikian, P, Sokurenko, E.V. | | Deposit date: | 2021-11-29 | | Release date: | 2021-12-29 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Recombinant FimH Adhesin Demonstrates How the Allosteric Catch Bond Mechanism Can Support Fast and Strong Bacterial Attachment in the Absence of Shear.
J.Mol.Biol., 434, 2022
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3BWY
 | | Crystal Structure of Human 108M Catechol O-methyltransferase bound with S-adenosylmethionine and inhibitor dinitrocatechol | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 3,5-DINITROCATECHOL, COMT protein, ... | | Authors: | Rutherford, K, Le Trong, I, Stenkamp, R.E, Parson, W.W. | | Deposit date: | 2008-01-10 | | Release date: | 2008-06-03 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Crystal structures of human 108V and 108M catechol O-methyltransferase.
J.Mol.Biol., 380, 2008
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3C5R
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1MEP
 | | Crystal Structure of Streptavidin Double Mutant S45A/D128A with Biotin: Cooperative Hydrogen-Bond Interactions in the Streptavidin-Biotin System. | | Descriptor: | BIOTIN, Streptavidin | | Authors: | Hyre, D.E, Le Trong, I, Merritt, E.A, Stenkamp, R.E, Green, N.M, Stayton, P.S. | | Deposit date: | 2002-08-08 | | Release date: | 2003-09-02 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Cooperative hydrogen bond interactions in the streptavidin-biotin system
Protein Sci., 15, 2006
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1MI0
 | | Crystal Structure of the redesigned protein G variant NuG2 | | Descriptor: | immunoglobulin-binding protein G | | Authors: | Nauli, S, Kuhlman, B, Le Trong, I, Stenkamp, R.E, Teller, D.C, Baker, D. | | Deposit date: | 2002-08-21 | | Release date: | 2002-09-18 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Crystal structures and increased stabilization of the protein G variants with switched folding pathways NuG1 and NuG2
Biochemistry, 11, 2002
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3KPA
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4X2Q
 | | Crystal Structure of Human Aldehyde Dehydrogenase, ALDH1a2 | | Descriptor: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Retinal dehydrogenase 2 | | Authors: | Stenkamp, R.E, Le Trong, I, Amory, J.K, Paik, J, Goldstein, A.S. | | Deposit date: | 2014-11-26 | | Release date: | 2015-12-02 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.94 Å) | | Cite: | Synthesis and In Vitro Testing of Bisdichloroacetyldiamine Analogs for Use as a Reversible Male Contraceptive
To Be Published
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4PNF
 | | Glutathione S-Transferase from Drosophila melanogaster - isozyme E6 | | Descriptor: | GLUTATHIONE, RE21095p | | Authors: | Scian, M, Le Trong, I, Mannervik, B, Atkins, W.M, Stenkamp, R.E. | | Deposit date: | 2014-05-23 | | Release date: | 2015-05-27 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.11 Å) | | Cite: | Comparison of epsilon- and delta-class glutathione S-transferases: the crystal structures of the glutathione S-transferases DmGSTE6 and DmGSTE7 from Drosophila melanogaster.
Acta Crystallogr.,Sect.D, 71, 2015
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4YVB
 | | Structure of D128N streptavidin | | Descriptor: | BIOTIN, Streptavidin | | Authors: | Baugh, L, Le Trong, I, Stayton, P.S, Stenkamp, R.E, Lybrand, T.P. | | Deposit date: | 2015-03-19 | | Release date: | 2016-03-23 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.351 Å) | | Cite: | A Streptavidin Binding Site Mutation Yields an Unexpected Result
To Be Published
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4PNG
 | | Glutathione S-transferase from Drosophila melanogaster - isozyme E7 | | Descriptor: | L-GAMMA-GLUTAMYL-3-SULFINO-L-ALANYLGLYCINE, LD04004p | | Authors: | Scian, M, Le Trong, I, Mannervik, B, Atkins, W.M, Stenkamp, R.E. | | Deposit date: | 2014-05-23 | | Release date: | 2015-05-27 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.53 Å) | | Cite: | Comparison of epsilon- and delta-class glutathione S-transferases: the crystal structures of the glutathione S-transferases DmGSTE6 and DmGSTE7 from Drosophila melanogaster.
Acta Crystallogr.,Sect.D, 71, 2015
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3BWM
 | | Crystal Structure of Human Catechol O-Methyltransferase with bound SAM and DNC | | Descriptor: | 3,5-DINITROCATECHOL, Catechol O-methyltransferase, MAGNESIUM ION, ... | | Authors: | Rutherford, K, Le Trong, I, Stenkamp, R.E, Parson, W.W. | | Deposit date: | 2008-01-09 | | Release date: | 2008-06-03 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.98 Å) | | Cite: | Crystal structures of human 108V and 108M catechol O-methyltransferase.
J.Mol.Biol., 380, 2008
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3BWC
 | | Crystal structure of spermidine synthase from Trypanosoma cruzi in complex with SAM at 2.3 A resolution | | Descriptor: | BETA-MERCAPTOETHANOL, S-ADENOSYLMETHIONINE, Spermidine synthase | | Authors: | Bosch, J, Arakaki, T.L, Le Trong, I, Merritt, E.A, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP) | | Deposit date: | 2008-01-09 | | Release date: | 2008-04-01 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structure of spermidine synthase from Trypanosoma cruzi.
To be Published
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2VER
 | | Structural model for the complex between the Dr adhesins and carcinoembryonic antigen (CEA) | | Descriptor: | AFIMBRIAL ADHESIN AFA-III, ARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 5, S-[(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate | | Authors: | Korotkova, N, Yang, Y, Le Trong, I, Cota, E, Demeler, B, Marchant, J, Thomas, W.E, Stenkamp, R.E, Moseley, S.L, Matthews, S. | | Deposit date: | 2007-10-26 | | Release date: | 2008-01-08 | | Last modified: | 2011-07-13 | | Method: | SOLUTION NMR | | Cite: | Binding of Dr Adhesins of Escherichia Coli to Carcinoembryonic Antigen Triggers Receptor Dissociation.
Mol.Microbiol., 67, 2008
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3UC7
 | | Trp-cage cyclo-TC1 - monoclinic crystal form | | Descriptor: | CHLORIDE ION, Cyclo-TC1 | | Authors: | Scian, M, Le Trong, I, Stenkamp, R.E, Andersen, N.H. | | Deposit date: | 2011-10-26 | | Release date: | 2012-07-18 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.1 Å) | | Cite: | Crystal and NMR structures of a Trp-cage mini-protein benchmark for computational fold prediction.
Proc.Natl.Acad.Sci.USA, 109, 2012
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3UC8
 | | Trp-cage cyclo-TC1 - tetragonal crystal form | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, cyclo-TC1 | | Authors: | Scian, M, Le Trong, I, Stenkamp, R.E, Andersen, N.H. | | Deposit date: | 2011-10-26 | | Release date: | 2012-07-18 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.33 Å) | | Cite: | Crystal and NMR structures of a Trp-cage mini-protein benchmark for computational fold prediction.
Proc.Natl.Acad.Sci.USA, 109, 2012
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1EVU
 | | HUMAN FACTOR XIII WITH CALCIUM BOUND IN THE ION SITE | | Descriptor: | CALCIUM ION, COAGULATION FACTOR XIII, S-1,2-PROPANEDIOL | | Authors: | Garzon, R.J, Pratt, K.P, Bishop, P.D, Le Trong, I, Stenkamp, R.E, Teller, D.C. | | Deposit date: | 2000-04-20 | | Release date: | 2000-05-10 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.01 Å) | | Cite: | Tryptophan 279 is Essential for the Transglutaminase Activity of Coagulation Factor XIII: Functional and Structural Characterization
To Be Published
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1EX0
 | | HUMAN FACTOR XIII, MUTANT W279F ZYMOGEN | | Descriptor: | CALCIUM ION, COAGULATION FACTOR XIII A CHAIN, PHOSPHATE ION, ... | | Authors: | Garzon, R.J, Pratt, K.P, Bishop, P.D, Le Trong, I, Stenkamp, R.E, Teller, D.C. | | Deposit date: | 2000-04-28 | | Release date: | 2003-12-23 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Tryptophan 279 is Essential for the Transglutaminase Activity of Coagulation Factor XIII: Functional and Structural Characterization
To be Published
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