7Q8S
| Leishmania major ADP-actin filament decorated with Leishmania major cofilin | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADF/Cofilin, Actin, ... | Authors: | Kotila, T, Muniyandi, S, Lappalainen, P, Huiskonen, J.T. | Deposit date: | 2021-11-11 | Release date: | 2022-05-18 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural basis of rapid actin dynamics in the evolutionarily divergent Leishmania parasite. Nat Commun, 13, 2022
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8CF9
| Crystal structure of the human PXR ligand-binding domain in complex with sclareol | Descriptor: | GLYCEROL, Nuclear receptor subfamily 1 group I member 2, sclareol | Authors: | Carivenc, C, Derosa, Q, Grimaldi, M, Boulahtouf, A, Balaguer, P, Bourguet, W. | Deposit date: | 2023-02-03 | Release date: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of the human PXR ligand-binding domain in complex with sclareol To Be Published
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8CH8
| Crystal structure of the human PXR ligand-binding domain in complex with liranaftate | Descriptor: | Nuclear receptor subfamily 1 group I member 2, ~{O}-(5,6,7,8-tetrahydronaphthalen-2-yl) ~{N}-(6-methoxypyridin-2-yl)-~{N}-methyl-carbamothioate | Authors: | Carivenc, C, Derosa, Q, Grimaldi, M, Boulahtouf, A, Balaguer, P, Bourguet, W. | Deposit date: | 2023-02-07 | Release date: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Crystal structure of the human PXR ligand-binding domain in complex with liranaftate To Be Published
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2VFG
| Crystal structure of the F96H mutant of Plasmodium falciparum triosephosphate isomerase with 3-phosphoglycerate bound at the dimer interface | Descriptor: | 3-PHOSPHOGLYCERIC ACID, TRIOSEPHOSPHATE ISOMERASE | Authors: | Gayathri, P, Banerjee, M, Vijayalakshmi, A, Balaram, H, Balaram, P, Murthy, M.R.N. | Deposit date: | 2007-11-04 | Release date: | 2008-12-09 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Biochemical and Structural Characterization of Residue 96 Mutants of Plasmodium Falciparum Triosephosphate Isomerase: Active-Site Loop Conformation, Hydration and Identification of a Dimer-Interface Ligand-Binding Site. Acta Crystallogr.,Sect.D, 65, 2009
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2VFD
| Crystal structure of the F96S mutant of Plasmodium falciparum triosephosphate isomerase | Descriptor: | SULFATE ION, TRIOSEPHOSPHATE ISOMERASE | Authors: | Gayathri, P, Banerjee, M, Vijayalakshmi, A, Balaram, H, Balaram, P, Murthy, M.R.N. | Deposit date: | 2007-11-03 | Release date: | 2008-12-09 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Biochemical and Structural Characterization of Residue 96 Mutants of Plasmodium Falciparum Triosephosphate Isomerase: Active-Site Loop Conformation, Hydration and Identification of a Dimer-Interface Ligand-Binding Site. Acta Crystallogr.,Sect.D, 65, 2009
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2VFH
| Crystal structure of the F96W mutant of Plasmodium falciparum triosephosphate isomerase complexed with 3-phosphoglycerate | Descriptor: | 3-PHOSPHOGLYCERIC ACID, TRIOSEPHOSPHATE ISOMERASE | Authors: | Gayathri, P, Banerjee, M, Vijayalakshmi, A, Balaram, H, Balaram, P, Murthy, M.R.N. | Deposit date: | 2007-11-04 | Release date: | 2008-12-09 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Biochemical and Structural Characterization of Residue 96 Mutants of Plasmodium Falciparum Triosephosphate Isomerase: Active-Site Loop Conformation, Hydration and Identification of a Dimer-Interface Ligand-Binding Site. Acta Crystallogr.,Sect.D, 65, 2009
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2VFE
| Crystal structure of F96S mutant of Plasmodium falciparum triosephosphate isomerase with 3- phosphoglycerate bound at the dimer interface | Descriptor: | 3-PHOSPHOGLYCERIC ACID, GLYCEROL, TRIOSEPHOSPHATE ISOMERASE | Authors: | Gayathri, P, Banerjee, M, Vijayalakshmi, A, Balaram, H, Balaram, P, Murthy, M.R.N. | Deposit date: | 2007-11-03 | Release date: | 2008-12-09 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Biochemical and Structural Characterization of Residue 96 Mutants of Plasmodium Falciparum Triosephosphate Isomerase: Active-Site Loop Conformation, Hydration and Identification of a Dimer-Interface Ligand-Binding Site. Acta Crystallogr.,Sect.D, 65, 2009
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2VFF
| Crystal structure of the F96H mutant of Plasmodium falciparum triosephosphate isomerase | Descriptor: | TRIOSEPHOSPHATE ISOMERASE | Authors: | Gayathri, P, Banerjee, M, Vijayalakshmi, A, Balaram, H, Balaram, P, Murthy, M.R.N. | Deposit date: | 2007-11-04 | Release date: | 2008-12-09 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Biochemical and Structural Characterization of Residue 96 Mutants of Plasmodium Falciparum Triosephosphate Isomerase: Active-Site Loop Conformation, Hydration and Identification of a Dimer-Interface Ligand-Binding Site. Acta Crystallogr.,Sect.D, 65, 2009
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2VFI
| Crystal structure of the Plasmodium falciparum triosephosphate isomerase in the loop closed state with 3-phosphoglycerate bound at the active site and interface | Descriptor: | 3-PHOSPHOGLYCERIC ACID, TRIOSEPHOSPHATE ISOMERASE | Authors: | Gayathri, P, Banerjee, M, Vijayalakshmi, A, Balaram, H, Balaram, P, Murthy, M.R.N. | Deposit date: | 2007-11-04 | Release date: | 2008-12-09 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Biochemical and Structural Characterization of Residue 96 Mutants of Plasmodium Falciparum Triosephosphate Isomerase: Active-Site Loop Conformation, Hydration and Identification of a Dimer-Interface Ligand-Binding Site. Acta Crystallogr.,Sect.D, 65, 2009
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6YP9
| Rabbit muscle actin in complex with ADF-H and ATP-ATTO-488 | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Kogan, K, Kotila, T, Lappalainen, P. | Deposit date: | 2020-04-15 | Release date: | 2020-12-09 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.564 Å) | Cite: | A functional family of fluorescent nucleotide analogues to investigate actin dynamics and energetics. Nat Commun, 12, 2021
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1M4J
| CRYSTAL STRUCTURE OF THE N-TERMINAL ADF-H DOMAIN OF MOUSE TWINFILIN ISOFORM-1 | Descriptor: | A6 gene product | Authors: | Paavilainen, V.O, Merckel, M.C, Falck, S, Ojala, P.J, Pohl, E, Wilmanns, M, Lappalainen, P. | Deposit date: | 2002-07-03 | Release date: | 2002-11-13 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural Conservation Between the Actin Monomer-binding Sites of Twinfilin and Actin-depolymerizing Factor (ADF)/Cofilin J.Biol.Chem., 277, 2002
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1M7O
| Plasmodium Falciparum Triosephosphate isomerase (PfTIM) compled to substrate analog 3-phosphoglycerate (3PG) | Descriptor: | 3-PHOSPHOGLYCERIC ACID, Triosephosphate Isomerase | Authors: | Parthasarathy, S, Balaram, H, Balaram, P, Murthy, M.R.N. | Deposit date: | 2002-07-22 | Release date: | 2002-11-29 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structures of Plasmodium falciparum triosephosphate isomerase complexed to substrate analogues: observation of the catalytic loop in the open conformation in the ligand-bound state. Acta Crystallogr.,Sect.D, 58, 2002
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1LZO
| Plasmodium Falciparum Triosephosphate Isomerase-Phosphoglycolate Complex | Descriptor: | 2-PHOSPHOGLYCOLIC ACID, Triosephosphate Isomerase | Authors: | Parthasarathy, S, Balaram, H, Balaram, P, Murthy, M.R. | Deposit date: | 2002-06-11 | Release date: | 2003-01-28 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of the Plasmodium falciparum triosephosphate isomerase-phosphoglycolate complex in two crystal forms: characterization of catalytic loop open and closed conformations in the ligand-bound state Biochemistry, 41, 2002
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1M7P
| Plasmodium Falciparum Triosephosphate isomerase (PfTIM) compled to substrate analog glycerol-3-phosphate (G3P). | Descriptor: | GLYCERALDEHYDE-3-PHOSPHATE, Triosephosphate Isomerase | Authors: | Parthasarathy, S, Balaram, H, Balaram, P, Murthy, M.R.N. | Deposit date: | 2002-07-22 | Release date: | 2002-11-29 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structures of Plasmodium falciparum triosephosphate isomerase complexed to substrate analogues: observation of the catalytic loop in the open conformation in the ligand-bound state. Acta Crystallogr.,Sect.D, 58, 2002
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1LYX
| Plasmodium Falciparum Triosephosphate Isomerase (PfTIM)-Phosphoglycolate complex | Descriptor: | 2-PHOSPHOGLYCOLIC ACID, Triosephosphate Isomerase | Authors: | Parthasarathy, S, Balaram, H, Balaram, P, Murthy, M.R. | Deposit date: | 2002-06-10 | Release date: | 2003-01-28 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure of the Plasmodium falciparum triosephosphate isomerase-phosphoglycolate complex in two crystal forms: characterization of catalytic loop open and closed conformations in the ligand-bound state Biochemistry, 41, 2002
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2QR2
| HUMAN QUINONE REDUCTASE TYPE 2, COMPLEX WITH MENADIONE | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, MENADIONE, PROTEIN (QUINONE REDUCTASE TYPE 2), ... | Authors: | Foster, C, Bianchet, M.A, Talalay, P, Amzel, L.M. | Deposit date: | 1999-04-19 | Release date: | 1999-08-18 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Crystal structure of human quinone reductase type 2, a metalloflavoprotein. Biochemistry, 38, 1999
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2J8A
| X-ray structure of the N-terminus RRM domain of Set1 | Descriptor: | HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-4 SPECIFIC | Authors: | Tresaugues, L, Dehe, P.M, Guerois, R, Rodriguez-Gil, A, Varlet, I, Salah, P, Pamblanco, M, Luciano, P, Quevillon-Cheruel, S, Sollier, J, Leulliot, N, Couprie, J, Tordera, V, Zinn-Justin, S, Chavez, S, Van Tilbeurgh, H, Geli, V. | Deposit date: | 2006-10-24 | Release date: | 2007-03-20 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | X-Ray Structure of the N-Terminus Rrm Domain of Set1 To be Published
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2H6R
| Crystal Structure of triosephosphate isomerase (TIM) from Methanocaldococcus jannaschii | Descriptor: | Triosephosphate isomerase | Authors: | Gayathri, P, Banerjee, M, Vijayalakshmi, A, Balaram, H, Balaram, P, Murthy, M.R.N. | Deposit date: | 2006-06-01 | Release date: | 2007-02-06 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of triosephosphate isomerase (TIM) from Methanocaldococcus jannaschii Acta Crystallogr.,Sect.D, 63, 2007
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1CYX
| QUINOL OXIDASE (PERIPLASMIC FRAGMENT OF SUBUNIT II WITH ENGINEERED CU-A BINDING SITE)(CYOA) | Descriptor: | CYOA, DINUCLEAR COPPER ION | Authors: | Wilmanns, M, Lappalainen, P, Kelly, M, Sauer-Eriksson, E, Saraste, M. | Deposit date: | 1995-08-22 | Release date: | 1996-03-08 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of the membrane-exposed domain from a respiratory quinol oxidase complex with an engineered dinuclear copper center. Proc.Natl.Acad.Sci.USA, 92, 1995
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1O5X
| Plasmodium falciparum TIM complexed to 2-phosphoglycerate | Descriptor: | 2-PHOSPHOGLYCERIC ACID, 3-HYDROXYPYRUVIC ACID, PHOSPHITE ION, ... | Authors: | Parthasarathy, S, Eaazhisai, K, Balaram, H, Balaram, P, Murthy, M.R. | Deposit date: | 2003-10-06 | Release date: | 2004-01-13 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Structure of Plasmodium falciparum Triose-phosphate Isomerase-2-Phosphoglycerate Complex at 1.1-A Resolution J.Biol.Chem., 278, 2003
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6RSW
| HFD domain of mouse CAP1 bound to the pointed end of G-actin | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ADENOSINE-5'-DIPHOSPHATE, Actin, ... | Authors: | Kotila, T, Kogan, K, Lappalainen, P. | Deposit date: | 2019-05-22 | Release date: | 2019-11-27 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Mechanism of synergistic actin filament pointed end depolymerization by cyclase-associated protein and cofilin. Nat Commun, 10, 2019
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1WOB
| Structure of a loop6 hinge mutant of Plasmodium falciparum Triosephosphate Isomerase, W168F, complexed to sulfate | Descriptor: | SULFATE ION, Triosephosphate isomerase | Authors: | Eaazhisai, K, Balaram, H, Balaram, P, Murthy, M.R.N. | Deposit date: | 2004-08-12 | Release date: | 2004-10-26 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structures of Unliganded and Inhibitor Complexes of W168F, a Loop6 Hinge Mutant of Plasmodium falciparum Triosephosphate Isomerase: Observation of an Intermediate Position of Loop6 J.Mol.Biol., 343, 2004
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1QPV
| YEAST COFILIN | Descriptor: | YEAST COFILIN | Authors: | Fedorov, A.A, Lappalainen, P, Fedorov, E.V, Drubin, D.G, Almo, S.C. | Deposit date: | 1999-05-29 | Release date: | 1999-06-08 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structure determination of yeast cofilin. Nat.Struct.Biol., 4, 1997
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1WOA
| Structure of the loop6 hinge mutant of Plasmodium falciparum Triosephosphate Isomerase, W168F, complexed with Glycerol-2-phosphate | Descriptor: | 2-HYDROXY-1-(HYDROXYMETHYL)ETHYL DIHYDROGEN PHOSPHATE, Triosephosphate isomerase | Authors: | Eaazhisai, K, Balaram, H, Balaram, P, Murthy, M.R.N. | Deposit date: | 2004-08-12 | Release date: | 2004-10-26 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structures of Unliganded and Inhibitor Complexes of W168F, a Loop6 Hinge Mutant of Plasmodium falciparum Triosephosphate Isomerase: Observation of an Intermediate Position of Loop6 J.Mol.Biol., 343, 2004
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1VGA
| Structures of unligated and inhibitor complexes of W168F mutant of Triosephosphate Isomerase from Plasmodium falciparum | Descriptor: | Triosephosphate isomerase | Authors: | Eaazhisai, K, Balaram, H, Balaram, P, Murthy, M.R.N. | Deposit date: | 2004-04-23 | Release date: | 2004-10-26 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structures of Unliganded and Inhibitor Complexes of W168F, a Loop6 Hinge Mutant of Plasmodium falciparum Triosephosphate Isomerase: Observation of an Intermediate Position of Loop6 J.Mol.Biol., 343, 2004
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