4I01
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![BU of 4i01 by Molmil](/molmil-images/mine/4i01) | Structure of the mutant Catabolite gen activator protein V140L | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Catabolite gene activator | Authors: | Pohl, E, Townsend, P.D, Rodgers, T, Burnell, D, McLeish, T.C.B, Wilson, M.R, Cann, M.J. | Deposit date: | 2012-11-16 | Release date: | 2013-10-30 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Modulation of global low-frequency motions underlies allosteric regulation: demonstration in CRP/FNR family transcription factors. Plos Biol., 11, 2013
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4I0A
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![BU of 4i0a by Molmil](/molmil-images/mine/4i0a) | structure of the mutant Catabolite gene activator protein V132A | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Catabolite gene activator, GLYCEROL | Authors: | Pohl, E, Townsend, P.D, Rodgers, T, Burnell, D, McLeish, T.C.B, Wilson, M.R, Cann, M.J. | Deposit date: | 2012-11-16 | Release date: | 2013-10-30 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Modulation of global low-frequency motions underlies allosteric regulation: demonstration in CRP/FNR family transcription factors. Plos Biol., 11, 2013
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4I09
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![BU of 4i09 by Molmil](/molmil-images/mine/4i09) | structure of the mutant Catabolite gene activator protein V132L | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Catabolite gene activator | Authors: | Pohl, E, Townsend, P.D, Rodgers, T, Burnell, D, McLeish, T.C.B, Wilson, M.R, Cann, M.J. | Deposit date: | 2012-11-16 | Release date: | 2013-10-30 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Modulation of global low-frequency motions underlies allosteric regulation: demonstration in CRP/FNR family transcription factors. Plos Biol., 11, 2013
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4HZF
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![BU of 4hzf by Molmil](/molmil-images/mine/4hzf) | structure of the wild type Catabolite gene Activator Protein | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Catabolite gene activator, GLYCEROL, ... | Authors: | Pohl, E, Townsend, P.D, Rodgers, T, Burnell, D, McLeish, T.C.B, Wilson, M.R, Cann, M. | Deposit date: | 2012-11-15 | Release date: | 2013-10-30 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.48 Å) | Cite: | Modulation of global low-frequency motions underlies allosteric regulation: demonstration in CRP/FNR family transcription factors. Plos Biol., 11, 2013
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4I88
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![BU of 4i88 by Molmil](/molmil-images/mine/4i88) | R107G HSP16.5 | Descriptor: | Small heat shock protein HSP16.5 | Authors: | Pohl, E, Williamson, I.R, Quinlan, R.A. | Deposit date: | 2012-12-03 | Release date: | 2013-11-13 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Changes in the quaternary structure and function of MjHSP16.5 attributable to deletion of the IXI motif and introduction of the substitution, R107G, in the alpha-crystallin domain. PHILOS.TRANS.R.SOC.LOND.B BIOL.SCI., 368, 2013
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5NIM
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![BU of 5nim by Molmil](/molmil-images/mine/5nim) | EthR complex | Descriptor: | HTH-type transcriptional regulator EthR, SULFATE ION, [1-(2-hydroxyethyl)pyrrolo[3,4-c]pyrazol-5-yl]-(5-propyl-1,2-oxazol-3-yl)methanone | Authors: | Pohl, E, Tatum, N.J, Cole, J.C, Baulard, A.R. | Deposit date: | 2017-03-24 | Release date: | 2017-11-15 | Last modified: | 2017-12-27 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | New active leads for tuberculosis booster drugs by structure-based drug discovery. Org. Biomol. Chem., 15, 2017
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5NJ0
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![BU of 5nj0 by Molmil](/molmil-images/mine/5nj0) | EthR complex | Descriptor: | HTH-type transcriptional regulator EthR, SULFATE ION, ~{N}-[(2~{R})-2-(4-nitrophenyl)-2-oxidanyl-ethyl]-1,3-benzodioxole-5-carboxamide | Authors: | Pohl, E, Tatum, N.J, Cole, J.C, Baulard, A.R. | Deposit date: | 2017-03-27 | Release date: | 2017-11-15 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | New active leads for tuberculosis booster drugs by structure-based drug discovery. Org. Biomol. Chem., 15, 2017
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5NIO
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![BU of 5nio by Molmil](/molmil-images/mine/5nio) | EthR complex | Descriptor: | HTH-type transcriptional regulator EthR, SULFATE ION, ~{N}-butyl-4-methyl-piperidine-1-carboxamide | Authors: | Pohl, E, Tatum, N.J, Cole, J.C, Baulard, A.R. | Deposit date: | 2017-03-24 | Release date: | 2017-11-15 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | New active leads for tuberculosis booster drugs by structure-based drug discovery. Org. Biomol. Chem., 15, 2017
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5NIZ
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![BU of 5niz by Molmil](/molmil-images/mine/5niz) | EthR complex | Descriptor: | 1-[3-[5-[(1~{R},2~{R})-2-methylcyclopropyl]furan-2-yl]propanoyl]piperidine-4-carboxamide, HTH-type transcriptional regulator EthR, SULFATE ION | Authors: | Pohl, E, Tatum, N.J, Cole, J.C, Baulard, A.R. | Deposit date: | 2017-03-27 | Release date: | 2017-11-15 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | New active leads for tuberculosis booster drugs by structure-based drug discovery. Org. Biomol. Chem., 15, 2017
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4BYY
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![BU of 4byy by Molmil](/molmil-images/mine/4byy) | Apo GlxR | Descriptor: | GLYCEROL, PHOSPHATE ION, TRANSCRIPTIONAL REGULATOR, ... | Authors: | Pohl, E, Cann, M.J, Townsend, P.D, Money, V.A. | Deposit date: | 2013-07-21 | Release date: | 2014-07-30 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | The Crystal Structures of Apo and Camp-Bound Glxr from Corynebacterium Glutamicum Reveal Structural and Dynamic Changes Upon Camp Binding in Crp/Fnr Family Transcription Factors. Plos One, 9, 2014
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4CMY
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![BU of 4cmy by Molmil](/molmil-images/mine/4cmy) | Chlorobium tepidum Ferritin | Descriptor: | FE (III) ION, FERRITIN | Authors: | Pohl, E, Arenas, M, Townsend, P.D, Yevenes, A. | Deposit date: | 2014-01-18 | Release date: | 2014-11-26 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | The Crystal Structure of Ferritin from Chlorobium Tepidum Reveals a New Conformation of the 4-Fold Channel for This Protein Family. Biochimie, 106, 2014
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7Z3M
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![BU of 7z3m by Molmil](/molmil-images/mine/7z3m) | |
8B9Y
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![BU of 8b9y by Molmil](/molmil-images/mine/8b9y) | Cysteine Synthase from Trypanosoma cruzi with PLP and OAS | Descriptor: | Cysteine synthase, putative, GLYCEROL, ... | Authors: | Sowerby, K.V, Pohl, E. | Deposit date: | 2022-10-10 | Release date: | 2023-05-31 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Cysteine synthase: multiple structures of a key enzyme in cysteine synthesis and a potential drug target for Chagas disease and leishmaniasis. Acta Crystallogr D Struct Biol, 79, 2023
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8B9W
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![BU of 8b9w by Molmil](/molmil-images/mine/8b9w) | Cysteine Synthase from Trypanosoma theileri with PLP bound | Descriptor: | CHLORIDE ION, GLYCEROL, PYRIDOXAL-5'-PHOSPHATE, ... | Authors: | Sowerby, K.V, Pohl, E. | Deposit date: | 2022-10-10 | Release date: | 2023-05-31 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Cysteine synthase: multiple structures of a key enzyme in cysteine synthesis and a potential drug target for Chagas disease and leishmaniasis. Acta Crystallogr D Struct Biol, 79, 2023
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8B9M
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![BU of 8b9m by Molmil](/molmil-images/mine/8b9m) | Cysteine Synthase from Leishmania Infantum | Descriptor: | CHLORIDE ION, Cysteine synthase, GLYCEROL | Authors: | Sowerby, K.V, Pohl, E. | Deposit date: | 2022-10-06 | Release date: | 2023-05-31 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Cysteine synthase: multiple structures of a key enzyme in cysteine synthesis and a potential drug target for Chagas disease and leishmaniasis. Acta Crystallogr D Struct Biol, 79, 2023
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6IA5
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![BU of 6ia5 by Molmil](/molmil-images/mine/6ia5) | Crystal Structure Analysis of Bacillus subtilis 168 XepA | Descriptor: | ACETATE ION, GLYCEROL, Phage-like element PBSX protein XepA | Authors: | Freitag-Pohl, S, Pohl, E. | Deposit date: | 2018-11-26 | Release date: | 2019-11-20 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Crystal structures of the Bacillus subtilis prophage lytic cassette proteins XepA and YomS. Acta Crystallogr D Struct Biol, 75, 2019
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7B3N
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![BU of 7b3n by Molmil](/molmil-images/mine/7b3n) | AmiP amidase-3 from Thermus parvatiensis | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, Cell wall hydrolase, ... | Authors: | Freitag-Pohl, S, Pohl, E. | Deposit date: | 2020-12-01 | Release date: | 2022-06-22 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.793 Å) | Cite: | AmiP from hyperthermophilic Thermus parvatiensis prophage is a thermoactive and ultrathermostable peptidoglycan lytic amidase. Protein Sci., 32, 2023
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1E3O
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![BU of 1e3o by Molmil](/molmil-images/mine/1e3o) | Crystal structure of Oct-1 POU dimer bound to MORE | Descriptor: | 5'-D(*AP*TP*GP*CP*AP*TP*GP*AP*GP*GP*A)-3', 5'-D(*TP*CP*CP*TP*CP*AP*TP*GP*CP*AP*T)-3', OCTAMER-BINDING TRANSCRIPTION FACTOR 1 | Authors: | Remenyi, A, Tomilin, A, Pohl, E, Schoeler, H, Wilmanns, M. | Deposit date: | 2000-06-20 | Release date: | 2001-11-10 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Differential Dimer Activities of the Transcription Factor Oct-1 by DNA-Induced Interface Swapping Mol.Cell, 8, 2001
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2YCE
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![BU of 2yce by Molmil](/molmil-images/mine/2yce) | Structure of an Archaeal fructose-1,6-bisphosphate aldolase with the catalytic Lys covalently bound to the carbinolamine intermediate of the substrate. | Descriptor: | D-MANNITOL-1,6-DIPHOSPHATE, FRUCTOSE-BISPHOSPHATE ALDOLASE CLASS 1 | Authors: | Lorentzen, E, Siebers, B, Hensel, R, Pohl, E. | Deposit date: | 2011-03-14 | Release date: | 2011-04-27 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Mechanism of the Schiff Base Forming Fructose-1,6-Bisphosphate Aldolase: Structural Analysis of Reaction Intermediates. Biochemistry, 44, 2005
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4R8H
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![BU of 4r8h by Molmil](/molmil-images/mine/4r8h) | The role of protein-ligand contacts in allosteric regulation of the Escherichia coli Catabolite Activator Protein | Descriptor: | 6-(6-AMINO-PURIN-9-YL)-2-THIOXO-TETRAHYDRO-2-FURO[3,2-D][1,3,2]DIOXAPHOSPHININE-2,7-DIOL, GLYCEROL, cAMP-activated global transcriptional regulator CRP | Authors: | Townsend, P.D, Pohl, E, McLeish, T.C.B, Rodgers, T.L, Glover, L.C, Korhonen, H.J, Wilson, M.R, Hodgson, D.R.W, Cann, M.J. | Deposit date: | 2014-09-02 | Release date: | 2015-07-22 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.46 Å) | Cite: | The Role of Protein-Ligand Contacts in Allosteric Regulation of the Escherichia coli Catabolite Activator Protein. J.Biol.Chem., 290, 2015
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7OB6
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![BU of 7ob6 by Molmil](/molmil-images/mine/7ob6) | |
7OB7
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![BU of 7ob7 by Molmil](/molmil-images/mine/7ob7) | |
5FMN
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![BU of 5fmn by Molmil](/molmil-images/mine/5fmn) | |
7OXX
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![BU of 7oxx by Molmil](/molmil-images/mine/7oxx) | CrabP2 mutant R30AK31A | Descriptor: | Cellular retinoic acid-binding protein 2, SODIUM ION | Authors: | Tomlinson, C.W.E, Basle, A, Pohl, E. | Deposit date: | 2021-06-23 | Release date: | 2022-07-13 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.33 Å) | Cite: | Structural requirements for the specific binding of CRABP2 to cyclin D3 To Be Published
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7PJO
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![BU of 7pjo by Molmil](/molmil-images/mine/7pjo) | |